Curr Atheroscler Rep August 2023 PMID 37358804

LDL Transcytosis by the Arterial Endothelium-Atherosclerosis by a Thousand Cuts?

Tse Wing Winnie Ho, Andria Henry, Warren L Lee

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Mentions

Peak: 22 in Jul 2023

across 3 sources since Jul 2023

Extended reach

350,949

potential audience

Total likes

3,431

Video views

132,122

Mentions per month

Jul 2023 – May 2025

Where it's discussed

X / Twitter39 posts
Bluesky2 posts
YouTube2 videos

AI synopsis

What people are saying

The collection demonstrates a high level of curiosity and acknowledgment of the publication's significance, with mentions of adding to scholarly discourse and critical evaluation of existing paradigms. The tone often highlights the importance of new research, using words like 'must read' and calling for deeper understanding, which underscores perceived potential impact on health science and patient care.

AgreementModerate agreement

Most discussions acknowledge the importance of advanced research into LDL transcytosis and its role in atherosclerosis, with many emphasizing that understanding the process is crucial for future therapies.

InterestHigh interest

Posts indicate high interest, referencing detailed explanations about LDL mechanisms, new therapies, and biomedical discussions, along with encouragement to watch educational videos.

EngagementModerate engagement

Several comments delve into specific concepts like LDL transcytosis, risk markers such as ApoB, and the limitations of traditional viewpoints, showing active cognitive engagement with the research.

ImpactModerate impact

The overall tone conveys that participants see this publication as a potentially transformative piece that could shift how we understand and treat heart disease, though some posts emphasize the importance of access to scholarly info and debate.

Abstract in brief

LDL transcytosis across the intact endothelium plays a crucial role in the initiation of atherosclerosis by allowing LDL to deposit in the arterial wall.
Recent research, aided by advanced live-cell imaging techniques like TIRF microscopy, has identified key players such as SRBI and ALK1 in mediating LDL transcytosis, with hormonal and inflammatory signals influencing this process.
Understanding the mechanisms of LDL transcytosis could lead to new therapies aimed at reducing LDL accumulation and preventing atherosclerosis.

Read the full abstract

All mentions

Understanding LDL Transcytosis and Its Role in Heart Disease Prevention

LDL transcytosis across the endothelium initiates atherosclerosis by depositing LDL into the arterial wall. Recent research highlights crucial mechanisms like SRBI and ALK1 involved in this process, paving the way for…

Nutrition Made Simple! · Oct 30, 2023 131,948 views

Understanding LDL Transcytosis and Its Role in Atherosclerosis

LDL transcytosis across the endothelium contributes to atherosclerosis initiation by depositing cholesterol in arterial walls. Advanced imaging techniques have identified key mediators like SRBI and ALK1, offering…

MedPorium · Jan 16, 2024 174 views

Biomass Bob

@SentientBlobBob · X

@LigmaTSPro @MichaelMindrum Worth watching I'd say. https://t.co/Kla5EaPCxl

May 16, 2025 · 1 like · 812 followers View post →

Precision Health Reports

@precisionhealthreports.com · Bluesky

We were recently revisiting Dr. Cromwell's terrific conversation with Dr. Gil Carvalho. Here's a quick snippet to whet your appetite. As discussed throughout the interview, the old paradigm of "lower cholesterol" isn't enough to complete the conversation. Full

Nov 14, 2024 · 1 like View post →

Peter J Anderson

@PeterJAnderson_ · X

I find @Lipoprotein a great orator, breaking down complex and even controversial areas well- for eg with response to retention vs response to damage Bill states 2/ What causes heart disease? | Dr. William Cromwell https://t.co/D2yxtO8iZE via @YouTube

Mar 13, 2024 · 1,530 followers View post →

Matt Martin

@MattBMartin · X

@awilkinson Understanding (a) what causes heart disease and (b) how to mitigate your own risk to stay out of becoming a statistic. https://t.co/vj5f46LTNQ

Mar 3, 2024 · 2,232 followers View post →

Rx Readmore Livemore

@SopitaSirirata1 · X

RT @drpablocorral: ☝️Must read

Jan 17, 2024 · 22 shares · 171 followers View post →

Matt Martin

@mattbmartin.bsky.social · Bluesky

As I look back on last year, one of the best videos that I learned from was my cofounder, William Cromwell, MD, FAHA, FNLA, answering “What Causes Heart Disease?” Block off ~40 minutes and watch this. Take notes. What you learn will improve your healthspan. youtu.be/IwzNnUhqUzc

Jan 4, 2024 · 1 like View post →

Gil Carvalho MD PhD

@NutritionMadeS3 · X

Nov 21, 2023 · 1 like · 27,933 followers View post →

Sam

@OrionwebsterSam · X

What causes heart disease? | Dr. William Cromwell https://t.co/jaChwuvDFc via @YouTube

Nov 21, 2023 · 4 followers View post →

Biomass Bob

@SentientBlobBob · X

Nov 10, 2023 · 2 likes · 812 followers View post →

Biomass Bob

@SentientBlobBob · X

@AldonSnow48246 @ZahcM Address this expert: https://t.co/lC8BDsPSuz

Nov 9, 2023 · 812 followers View post →

Biomass Bob

@SentientBlobBob · X

@ZahcM Both HOMA-IR and ApoB are important risk factors. Choosing one or the other is inane. https://t.co/lC8BDsPSuz

Nov 9, 2023 · 812 followers View post →

Matt Martin

@MattBMartin · X

@APompliano Continuing to reset the discussion about what causes heart disease. @NutritionMadeS3 & @Lipoprotein https://t.co/PNtpVx77mg

Nov 4, 2023 · 1 like · 2,232 followers View post →

NutshellNutritionUK

@uk_nutshell · X

@JoeClough19 @Paddy_Barrett https://t.co/pEqiZv7XV1

Nov 4, 2023 · 98 followers View post →

NutshellNutritionUK

@uk_nutshell · X

@staticcowboy @Paddy_Barrett Apparently not (if you listen to this): https://t.co/pEqiZv7XV1

Nov 4, 2023 · 1 like · 98 followers View post →

Homero

@Homero_M · X

What causes heart disease? | Dr. William Cromwell https://t.co/648mHACKrx via @YouTube

Oct 31, 2023 · 94 followers View post →

Dr Alo, DO, FACC

@MohammedAlo · X

RT @NutritionMadeS3: https://t.co/A57MGifz8m

Oct 30, 2023 · 1 share · 12,735 followers View post →

NutshellNutritionUK

@uk_nutshell · X

Required listening! Particle number! @NutritionMadeS3 @Lipoprotein https://t.co/GG6fUbyRmK

Oct 30, 2023 · 1 like · 98 followers View post →

Gil Carvalho MD PhD

@NutritionMadeS3 · X

https://t.co/A57MGifz8m

Oct 30, 2023 · 13 likes · 1 share · 27,933 followers View post →

vasc_phys_papers

@vascphyspapers · X

LDL Transcytosis by the Arterial Endothelium-Atherosclerosis by a Thousand Cuts? https://t.co/JlCMyiW9NR

Aug 10, 2023 · 136 followers View post →

Niki K

@nikharlov · X

RT @drpablocorral: ☝️Must read

Jul 8, 2023 · 22 shares · 61 followers View post →

Tse Wing Winnie Ho

@TseWingWinnieHo · X

RT @drpablocorral: ☝️Must read

Jul 5, 2023 · 22 shares · 18 followers View post →

WarrenLeeLab

@WarrenLeeLab · X

RT @drpablocorral: ☝️Must read

Jul 5, 2023 · 22 shares · 153 followers View post →

Rx Readmore Livemore

@SopitaSirirata1 · X

RT @drpablocorral: ☝️Must read

Jul 4, 2023 · 22 shares · 171 followers View post →

Rosa Fernandez

@MAROSFO · X

RT @drpablocorral: ☝️Must read

Jul 4, 2023 · 22 shares · 3,313 followers View post →

@m_hassanshuaibu · X

RT @drpablocorral: ☝️Must read

Jul 3, 2023 · 22 shares · 304 followers View post →

Jamie Wang

@jamiewang1228 · X

RT @drpablocorral: ☝️Must read

Jul 3, 2023 · 22 shares · 10 followers View post →

Natsir Ramadhan

@natsiradhan · X

RT @drpablocorral: ☝️Must read

Jul 3, 2023 · 22 shares · 564 followers View post →

Hagai Tavori, Ph.D., FAHA

@TavoriH · X

RT @drpablocorral: ☝️Must read

Jul 3, 2023 · 22 shares · 40 followers View post →

Armando Oterino Manzanas

@ArmandoOterino · X

RT @drpablocorral: ☝️Must read

Jul 3, 2023 · 22 shares · 1,441 followers View post →

Hany Ragy

@Hragy · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 80,493 followers View post →

Dr. Hugo Corrales - Endocrinología.

@hugoendocrino · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 6,472 followers View post →

endocrinogustavoparra

@gustavendocrino · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 13,499 followers View post →

Jorge Demartino

@JorgeDemartino1 · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 314 followers View post →

Hector Ortiz

@drhectorortiz · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 760 followers View post →

Dr. Swapneil Parikh

@swapneilparikh · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 6,508 followers View post →

Magma Purnawan

@magmapurnawan · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 390 followers View post →

Luis diaz

@CsarRui86346276 · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 88 followers View post →

Peter J Anderson

@PeterJAnderson_ · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 1,532 followers View post →

Khalid Minhas, MD FACC

@minhaskh · X

RT @drpablocorral: ☝️Must read

Jul 2, 2023 · 22 shares · 11,359 followers View post →

LibKey

@libkey_io · X

@drpablocorral @lipo_fan @JohnKastelein @Drlipid @lipiddoc @society_eas @LipidosSal @alavallecobo @lschreier1 Get access rather than a paywall: https://t.co/t3xp0sjlzA Add https://t.co/SXSePSX5De to the DOI URL when sharing articles to promote scholarly communication

Jul 2, 2023 · 1 like · 556 followers View post →

Pablo Corral MD

@drpablocorral · X

☝️Must read

Jul 2, 2023 · 85 likes · 22 shares · 11,268 followers View post →

LDL Transcytosis by the Arterial Endothelium-Atherosclerosis by a Thousand Cuts?

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Understanding LDL Transcytosis and Its Role in Heart Disease Prevention

Understanding LDL Transcytosis and Its Role in Atherosclerosis