The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation.

Claudia Fierro, Veronica Gatti, Veronica La Banca, Sara De Domenico, Stefano Scalera, Giacomo Corleone, Maurizio Fanciulli, Francesca De Nicola, Alessandro Mauriello, Manuela Montanaro, George A Calin, Gerry Melino, Angelo Peschiaroli

June 2023 Nat Commun

Synopsis of Social media discussions

The discussions highlight the regulatory relationship between Np63 and NEAT1, with mentions of how decreasing Np63 levels increase NEAT1 during epidermal differentiation. The tone suggests recognition of the gene’s role in skin development, with references to institutions and organizations underscoring its scientific relevance, using phrases like 'modulating epidermal differentiation' and 'important role in epidermal development.'

A
Agreement
 Moderate agreement

Most discussions acknowledge the research findings, with some explicitly supporting the role of NEAT1 in epidermal differentiation.

I
Interest
 Moderate level of interest

Posts show moderate interest, referencing the regulatory mechanisms and potential implications without deep technical details.

E
Engagement
 Moderate level of engagement

Comments demonstrate some engagement by mentioning related organizations and emphasizing the significance of gene regulation.

I
Impact
 Moderate level of impact

Users recognize the importance of understanding NEAT1’s function, hinting at its potential impact on skin biology and disease research.

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1 Posts

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Posts referencing the article

Regulation of epidermal differentiation by NEAT1 and Np63 in skin development

Regulation of epidermal differentiation by NEAT1 and Np63 in skin development

The transcription factor Np63 regulates the long noncoding RNA NEAT1 in keratinocytes, repressing it via HDAC1. During epidermal differentiation, Np63 decreases, increasing NEAT1 expression, which promotes paraspeckle formation and supports skin development.

STEM RTCL TV

October 15, 2023

63 views

  • Dr L Boominathan PhD
    @DrLBoominathan (Twitter)

    The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation https://t.co/BgwjbyVjcb -> ∆Np63 represses the expression of the lncRNA NEAT1 @NMC_IND @WHO @NIH @ICMRDELHI @NITIAayog @NobelPrize @iitmadras @NCBS https://t.co/HaeymGbhOR
    view full post

    September 22, 2023

Abstract Synopsis

  • The transcription factor Np63 regulates the expression of the long noncoding RNA NEAT1 in human keratinocytes, repressing it by recruiting HDAC1 to its promoter.
  • During epidermal differentiation, Np63 levels decrease, leading to an increase in NEAT1 RNA, which promotes paraspeckle formation and supports the expression of key epithelial transcription factors.
  • NEAT1 plays an important role in epidermal development by helping organize gene regulation necessary for proper skin layer formation, with its depletion impairing normal epidermal differentiation.