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PLoS Med June 2023 PMID 37368871

Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low- to middle-income countries: A systematic review.

Charlie C Luchen, Mwelwa Chibuye, Rene Spijker, Michelo Simuyandi, Caroline Chisenga, Samuel Bosomprah, Roma Chilengi, Constance Schultsz, Daniel R Mende, Vanessa C Harris

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Mentions

21
Peak: 8 in Jul 2023
across 5 sources since Jun 2023

Extended reach

171,021
potential audience

Total likes

24

Video views

21

Mentions per month

Jun 2023 – Oct 2023

Where it's discussed

  • X / Twitter10 posts
  • News5 articles
  • Blogs3 articles
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect high interest and perceived significance, with phrases such as 'implications for antimicrobial resistant infections' and tags like #AMR emphasizing their concern. The tone is analytical yet urgent, citing the study’s broad implications for health in low- and middle-income countries, thereby highlighting its high impact and relevance.

AgreementModerate agreement

Most discussions recognize the importance of the review, emphasizing its findings on antibiotic impact and resistance in early childhood.

InterestHigh interest

The discussions demonstrate strong interest, highlighting keywords like 'impact,' 'resistome,' and the relevance to global health issues.

EngagementModerate engagement

Participants engage by quoting the article’s focus on microbiome alterations and resistance implications, indicating thoughtful engagement.

ImpactHigh impact

The widespread mention of antimicrobial resistance and microbiome effects suggests the discussion perceives the study’s findings as highly impactful for future health policies.

Abstract in brief

  • This review examines how antibiotic use affects the gut microbiome and the presence of resistance genes in infants under 2 years old in low- and middle-income countries (LMICs), highlighting that antibiotics can reduce microbial diversity and promote antibiotic-resistant genes.
  • The study analyzed 10 relevant randomized controlled trials and found that antibiotics, especially azithromycin, decrease overall microbiome diversity and increase resistance genes shortly after treatment.
  • The findings underscore the need for better understanding of antibiotic impacts in LMICs, as inappropriate use may contribute to the spread of antimicrobial resistance, which disproportionately affects children in these regions.]
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Top posts

Most liked on X and Bluesky
Int. Centre for Antimicrobial Resistance Solutions
@ICARS_global · X

Jul 31, 2023 · 13 likes · 4 shares · 5,802 followers View post →
PLOS Medicine
@PLOSMedicine · X

Charlie C. Luchen and colleagues review how antibiotic use in children from low- and middle-income countries impacts the gut microbiome and report implications for antimicrobial resistant infections: https://t.co/zBlglW5D49… @CB_Luchen @bwantu @aighd #AMR #microbiota https://t.co/VYva4ChKKc

Jul 12, 2023 · 5 likes · 2 shares · 58,009 followers View post →
PLOS Medicine
@PLOSMedicine · X

Charlie C. Luchen and colleagues review how antibiotic use in children from low- and middle-income countries impacts the gut microbiome and report implications for antimicrobial resistant infections. https://t.co/zBlglW5D49 #AMR #AntimicrobialResistance https://t.co/QBvsI208ps

Jun 28, 2023 · 5 likes · 58,009 followers View post →
Infectious Diseases
@InfectiousDz · X

RT @ICARS_global:

Jul 31, 2023 · 4 shares · 40,880 followers View post →
Michelo Simuyandi
@bwantu · X

RT @PLOSMedicine: Charlie C. Luchen and colleagues review how antibiotic use in children from low- and middle-income countries impacts the…

Jul 13, 2023 · 2 shares · 4,508 followers View post →
APUA
@APUANews · X

RT @ICARS_global:

Jul 31, 2023 · 4 shares · 2,367 followers View post →

All mentions

APUA
@APUANews · X

RT @ICARS_global:

Jul 31, 2023 · 4 shares · 2,367 followers View post →
Jennifer
@JenHgw1 · X

RT @ICARS_global:

Jul 31, 2023 · 4 shares · 293 followers View post →
Infectious Diseases
@InfectiousDz · X

RT @ICARS_global:

Jul 31, 2023 · 4 shares · 40,880 followers View post →
Int. Centre for Antimicrobial Resistance Solutions
@ICARS_global · X

Jul 31, 2023 · 13 likes · 4 shares · 5,802 followers View post →
Constance Schultsz
@CSchultsz · X

RT @PLOSMedicine: Charlie C. Luchen and colleagues review how antibiotic use in children from low- and middle-income countries impacts the…

Jul 26, 2023 · 2 shares · 36 followers View post →
Michelo Simuyandi
@bwantu · X

RT @PLOSMedicine: Charlie C. Luchen and colleagues review how antibiotic use in children from low- and middle-income countries impacts the…

Jul 13, 2023 · 2 shares · 4,508 followers View post →
PLOS Medicine
@PLOSMedicine · X

Charlie C. Luchen and colleagues review how antibiotic use in children from low- and middle-income countries impacts the gut microbiome and report implications for antimicrobial resistant infections: https://t.co/zBlglW5D49… @CB_Luchen @bwantu @aighd #AMR #microbiota https://t.co/VYva4ChKKc

Jul 12, 2023 · 5 likes · 2 shares · 58,009 followers View post →
Life Science Journal Content
@lsn_jc · X

Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low- to middle-income countries: A systematic review #science #publication #research #journal https://t.co/bmPEhXdHJN

Jul 3, 2023 · 263 followers View post →
PLOS Medicine
@PLOSMedicine · X

Charlie C. Luchen and colleagues review how antibiotic use in children from low- and middle-income countries impacts the gut microbiome and report implications for antimicrobial resistant infections. https://t.co/zBlglW5D49 #AMR #AntimicrobialResistance https://t.co/QBvsI208ps

Jun 28, 2023 · 5 likes · 58,009 followers View post →
Abstream
@abstreamme · X

Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low- to middle-income countries: A systematic review #science #publication #research #publications https://t.co/5CSs4iPi40

Jun 28, 2023 · 789 followers View post →