Signal Transduct Target Ther June 2023 PMID 37369642

Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling.

Cong Li, Shi Qiu, Xiaohan Liu, Fengzhu Guo, Jingtong Zhai, Zhijun Li, Linghui Deng, Liming Ge, Haili Qian, Lu Yang, Binghe Xu

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Mentions

2
Peak: 1 in Jun 2023
across 2 sources since Jun 2023

Extended reach

71
potential audience

Total likes

1

Video views

57

Mentions per month

Jun 2023 – Oct 2023

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

Many discussions use phrases like 'important insights' and 'potential for targeted therapies,' indicating appreciation of the study's significance, while some posts mention how understanding matrix forces could impact tumor treatment. The tone remains analytical but not overly technical, emphasizing the relevance of the findings without deep technical debates.

AgreementModerate agreement

Most discussions recognize the significance of mechanical forces and signaling pathways in cancer progression, showing general support for the study's findings.

InterestModerate interest

Participants exhibit a modest level of curiosity, often highlighting the importance of cellular environments but not delving deeply into technical details.

EngagementModerate engagement

Posts tend to reflect surface-level engagement, such as noting the study's implications or expressing opinions without extensive critique or discussion.

ImpactModerate impact

The discussions suggest the research could influence future studies or clinical approaches, but the overall tone remains cautious and preliminary.

Abstract in brief

  • ECM-derived mechanical forces influence breast cancer cell behavior by regulating their stemness and quiescence through integrin DDR signaling pathways, with specific force levels either promoting stem-like properties or inducing cell dormancy.
  • Experiments using 3D matrices and analyses of patient data showed that moderate mechanical forces activate pathways that enhance tumor growth and cancer stemness, while higher forces can push cells into a dormant, quiescent state, impacting tumor progression.
  • A specific ECM signature related to matrix components was developed, which can predict patient prognosis, highlighting the importance of mechanical forces in tumor development and offering potential in clinical outcomes assessment.

Top posts

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Rashim Pal Singh, PhD.
@rashimpalsingh · X

Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling | Signal Transduction and Targeted Therapyt https://t.co/EBX9pIiXZt

Jun 28, 2023 · 14 followers View post →

All mentions

Rashim Pal Singh, PhD.
@rashimpalsingh · X

Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling | Signal Transduction and Targeted Therapyt https://t.co/EBX9pIiXZt

Jun 28, 2023 · 14 followers View post →