Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME.

Abstract in brief

• The text explains how myeloid immune cells (MICs), which are early responders to pathogens and cellular changes, recognize altered cellular homeostasis, particularly through the cGAS-STING signaling pathway that detects cytosolic double-stranded DNA and triggers immune responses.
• It discusses how changes in the tumor microenvironment (TME) and tumor immune microenvironment (TIME) can lead to dysfunction of MICs, specifically through alterations in cGAS-STING signaling, which then influence tumor-supportive immune changes.
• The article suggests that targeting or modulating cGAS-STING signaling in MICs could serve as a promising approach for tumor immunotherapy, aiming to modify the TIME to improve anti-cancer immune responses.]