Microbiome June 2023 PMID 37386523

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice.

Manfei Zhou, Yichun Fan, Liuting Xu, Zheng Yu, Sizhe Wang, Huaisha Xu, Jiuping Zhang, Linwei Zhang, Wenwei Liu, Linlin Wu, Jing Yu, Honghong Yao, Jun Wang, Rong Gao

Mentions

8
Peak: 4 in Jul 2023
across 2 sources since Jun 2023

Extended reach

26,029
potential audience

Total likes

26

Video views

336

Mentions per month

Jun 2023 – Aug 2023

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions reflect a positive outlook on the research, emphasizing its potential impact on understanding depression and mentioning terms like 'metabolomics' and 'gut-brain axis' that demonstrate a good level of engagement. For example, using phrases like 'significant role' and 'potential new targets' indicates acknowledgment of practical implications, while the tone remains analytical rather than overly emotional.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, especially noting the role of gut microbiota in adolescent depression, which aligns with the study's findings.

InterestHigh interest

Posts show high curiosity, highlighting the novel approach of linking microbiome analysis with behavioral outcomes in depression.

EngagementModerate engagement

Conversations reference specific methods like metabolomics and microbiota transplantation, indicating some depth of engagement.

ImpactModerate impact

There is some recognition that these findings could influence future treatments, but this is expressed cautiously.

Abstract in brief

  • The study highlights that the gut microbiota (GM) in adolescents with depression differs significantly from healthy individuals, especially showing decreased levels of certain bacteria like Roseburia and Faecalibacterium, which can be restored with antidepressant treatment such as sertraline.
  • Fecal microbiota transplants from healthy adolescents to depressed mice improved depressive behaviors, indicating that gut bacteria, particularly Roseburia, may play a key role in regulating mood by affecting neurotransmitters like serotonin (5HT) through the gut-brain axis.
  • The research suggests that specific gut bacteria influence depression by modifying tryptophan metabolism, which impacts neurotransmitter levels and behaviors, offering potential new targets for depression intervention based on microbiome modulation.

Top posts

Most liked on X and Bluesky
Microbiome
@MicrobiomeJ · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice https://t.co/0TFDQtotwn

Jul 1, 2023 · 13 likes · 1 share · 20,366 followers View post →
Huiluo Cao 曹慧荦
@hlcao · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice | Microbiome | Full Text https://t.co/AFaGITsE6e

Jul 2, 2023 · 2 likes · 2,827 followers View post →
Metabolomics Papers
@Metabbot · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice. Microbiome https://t.co/MG4P4GsjZQ #metabolomics

Jun 30, 2023 · 1,489 followers View post →
FMT Articles & Papers
@fmtarticles · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice https://t.co/t4rIbmvbM4

Jun 30, 2023 · 475 followers View post →
Dave Roberts
@CDifficile1 · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice - PubMed: This study is the first to… #cdiff #cdi #fmt https://t.co/AB0zbtGQWp

Jun 30, 2023 · 436 followers View post →
GOURAVBIOME
@GouravBiome · X

RT @MicrobiomeJ: Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of…

Jul 1, 2023 · 1 share · 97 followers View post →

All mentions

Huiluo Cao 曹慧荦
@hlcao · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice | Microbiome | Full Text https://t.co/AFaGITsE6e

Jul 2, 2023 · 2 likes · 2,827 followers View post →
GOURAVBIOME
@GouravBiome · X

RT @MicrobiomeJ: Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of…

Jul 1, 2023 · 1 share · 97 followers View post →
Microbiome
@MicrobiomeJ · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice https://t.co/0TFDQtotwn

Jul 1, 2023 · 13 likes · 1 share · 20,366 followers View post →
Metabolomics Papers
@Metabbot · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice. Microbiome https://t.co/MG4P4GsjZQ #metabolomics

Jun 30, 2023 · 1,489 followers View post →
FMT Articles & Papers
@fmtarticles · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice https://t.co/t4rIbmvbM4

Jun 30, 2023 · 475 followers View post →
Dave Roberts
@CDifficile1 · X

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice - PubMed: This study is the first to… #cdiff #cdi #fmt https://t.co/AB0zbtGQWp

Jun 30, 2023 · 436 followers View post →