Clin Epigenetics July 2023 PMID 37415206

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes.

Lyndsey E Shorey-Kendrick, Victoria H J Roberts, Rahul J D'Mello, Elinor L Sullivan, Susan K Murphy, Owen J T Mccarty, Danny J Schust, Jason C Hedges, A J Mitchell, Jose Juanito D Terrobias, Charles A Easley, Eliot R Spindel, Jamie O Lo

Mentions

85
Peak: 25 in Jul 2023
across 6 sources since Jul 2023

Extended reach

792,998
potential audience

Total likes

52

Video views

11

Mentions per month

Jul 2023 – Jan 2025

Where it's discussed

  • News38 articles
  • X / Twitter35 posts
  • Reddit5 posts
  • Blogs4 articles
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

Several discussions emphasize the significance of the research, with users expressing concern about prenatal cannabis use and its genetic effects, such as mentions of 'potential influence on neurobehavioral development' and 'long-term outcomes for offspring.' The tone varies from cautious skepticism to alarm, influenced by words like 'alter,' 'enriched for autism genes,' and 'potential risk,' which convey both scientific curiosity and concern about societal implications.

AgreementModerate agreement

Most discussions acknowledge the findings that prenatal THC exposure affects DNA methylation and its possible links to autism, but often with some skepticism about the current human data, indicating cautious agreement.

InterestHigh interest

Posts demonstrate high curiosity, referencing specific molecular mechanisms and potential health implications, showing users are engaged and eager to explore the topic deeper.

EngagementHigh engagement

Many discussions include detailed references to epigenetic processes and implications for neurodevelopment, reflecting a deep engagement with the scientific content and its relevance.

ImpactModerate impact

While some users highlight the potential risks for offspring, the overall perception suggests that the broader impact is viewed as significant but still needing further direct evidence, especially in humans.

Abstract in brief

  • The study investigates the effects of edible cannabis use during pregnancy on the fetal and placental epigenome, particularly focusing on DNA methylation.
  • In trials, pregnant rhesus macaques consumed either THC-infused edibles or a placebo, revealing that THC exposure resulted in significant differential methylation at 581 CpG sites, mostly in the placenta.
  • The findings suggest that prenatal THC exposure may disrupt gene regulation involved in neurobehavioral development, potentially impacting long-term outcomes for offspring, highlighting the need for better guidance on cannabis use during pregnancy.

Top posts

Most liked on X and Bluesky
Neuroscience News
@NeuroscienceNew · X

“Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes” by Lyndsey Shorey-Kendrick et al. Clinical Epigenetics https://t.co/CIaG1WH6vY 2/2

Jul 6, 2023 · 13 likes · 5 shares · 505,782 followers View post →
Frank Taeger
@Shiyanying · X

@DocDenne Die einzige bekannte Studie, die hier tatsächlich bereits echte mögliche Gefahren gezeigt hat, wurde nicht mal an Menschen durchgeführt, sondern an für Autismus modizierten Affen/Makaken: https://t.co/vZCwGsmIUz

May 2, 2024 · 12 likes · 931 followers View post →
Daniel Park
@Daniel_E_Park · X

Many studies have found exposures linked to these genetic factors and also associated with neurodevelopmental disorders. These include cannabis exposure, pesticides, and air pollution. https://t.co/uZdIdKSDch https://t.co/XUNFf3mJ7c

Oct 21, 2023 · 5 likes · 6,863 followers View post →
KFinn, MD
@CoDoc442 · X

Potential risk of autism via methylation, impacting outcomes. If any "medication" did this, it would be pulled from the shelves https://t.co/KU4PgGTnLC

Jul 10, 2023 · 5 likes · 2 shares · 1,293 followers View post →
ellen snelling
@LNseven5 · X

#THC #Pregnancy "Overall, our findings reveal that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes." https://t.co/XwEhjvzVEx

Jul 12, 2023 · 3 likes · 1 share · 2,254 followers View post →
BMC
@BioMedCentral · X

A study published in Clinical Epigenetics finds that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes. https://t.co/9UuSiFlLIo

Jul 27, 2023 · 2 likes · 75,414 followers View post →

All mentions

FrLecardonnel
@FrLecardonnel · X

@lonnibesancon @acadmed @atlantico_fr https://t.co/GDw7wAtDEE Mais, si cet article fait suite à de nombreux travaux in vitro ou chez le rongeur montrant que les cannabinoïdes ont une influence sur la méthylation de l'ADN et potentiellement sur le développement cérébral, aucune étude humaine n'a été publiée

Jan 9, 2025 · 2 likes · 987 followers View post →
rolz expert
@1Rolz · X

@little_lexxi_ @iamdani_15 @DesjuanWynter @organicshorty @BDTRELILBROTHER https://t.co/XHLQ59JAsq https://t.co/oOF7bwK80V https://t.co/CLX82ae5Hq attempt to read and form an actual conclusion rather than just going off ur anecdotes : )

Nov 5, 2024 · 554 followers View post →
No Brainer
@NOBrainer_drugs · X

Cannabis in Pregnancy may prime developing child for Autism? #AutismAwareness Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes #cannabisculture #StonerFam https://t.co/Rr794HjU0v https://t.co/viUjZNF2Xo

May 7, 2024 · 1 like · 2,694 followers View post →
Frank Taeger
@Shiyanying · X

@DocDenne Die einzige bekannte Studie, die hier tatsächlich bereits echte mögliche Gefahren gezeigt hat, wurde nicht mal an Menschen durchgeführt, sondern an für Autismus modizierten Affen/Makaken: https://t.co/vZCwGsmIUz

May 2, 2024 · 12 likes · 931 followers View post →
pjmccoll
@pamelamccoll2 · X

@sagelyspeaking @madras_bertha https://t.co/jPxKOP7AFe

Apr 30, 2024 · 291 followers View post →
pjmccoll
@pamelamccoll2 · X

https://t.co/jPxKOP72PG

Apr 23, 2024 · 291 followers View post →
pjmccoll
@pamelamccoll2 · X

https://t.co/jPxKOP7AFe

Apr 23, 2024 · 291 followers View post →
ARYAN®
@gladeolie · X

https://t.co/1Irbe6G656

Mar 20, 2024 · 1,507 followers View post →
Daniel Park
@Daniel_E_Park · X

Many studies have found exposures linked to these genetic factors and also associated with neurodevelopmental disorders. These include cannabis exposure, pesticides, and air pollution. https://t.co/uZdIdKSDch https://t.co/XUNFf3mJ7c

Oct 21, 2023 · 5 likes · 6,863 followers View post →
Intl. Academy on the Science & Impact of Cannabis
@IASIC3 · X

PRENATAL DELTA-9-TETRAHYDROCANNABINOL EXPOSURE IS ASSOCIATED WITH CHANGES IN RHESUS MACAQUE DNA METHYLATION ENRICHED FOR AUTISM GENES https://t.co/q2cnQBIXgH #delta9 #autism #cannabis

Aug 9, 2023 · 2 likes · 501 followers View post →
BMC
@BioMedCentral · X

A study published in Clinical Epigenetics finds that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes. https://t.co/9UuSiFlLIo

Jul 27, 2023 · 2 likes · 75,414 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes https://t.co/up0vI8PaW6

Jul 20, 2023 · 2,239 followers View post →
Environmental Epigenetics
@EEpigenetics · X

RT @BioMedCentral: A study published in Clinical Epigenetics finds that prenatal THC exposure alters placental and fetal DNA methylation at…

Jul 20, 2023 · 1 share · 207 followers View post →
BMC
@BioMedCentral · X

A study published in Clinical Epigenetics finds that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes. https://t.co/9UuSiFlLIo

Jul 17, 2023 · 2 likes · 1 share · 75,414 followers View post →
Cannabis Risk Alliance
@MythsCannabis · X

RT @WalleyRay: .”Prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may…

Jul 16, 2023 · 2 shares · 519 followers View post →
P
@psychopharmacol · X

prenatal THC exposure alters placental and fetal DNA methylation at 581 CpGs (98% identified in placenta) of genes involved in neurobehavioral development (including candidate ASD genes) that may influence longer-term offspring outcomes in rhesus macaque https://t.co/ufL06I3XGh

Jul 13, 2023 · 575 followers View post →
Ray Walley
@WalleyRay · X

RT @WalleyRay: .”Prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may…

Jul 13, 2023 · 2 shares · 7,498 followers View post →
Ray Walley
@WalleyRay · X

.”Prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes” ⁦@MythsCannabis⁩ #cannabis is bad for your child’s health and your own health https://t.co/yrdZnWF5D1

Jul 12, 2023 · 2 likes · 2 shares · 7,498 followers View post →
RAI777
@RAI77784344372 · X

RT @LNseven5: #THC #Pregnancy "Overall, our findings reveal that prenatal THC exposure alters placental and fetal DNA methylation at genes…

Jul 12, 2023 · 1 share · 109 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for aut…

Jul 12, 2023 · 2 shares · 133 followers View post →
ellen snelling
@LNseven5 · X

#THC #Pregnancy "Overall, our findings reveal that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes." https://t.co/XwEhjvzVEx

Jul 12, 2023 · 3 likes · 1 share · 2,254 followers View post →
kathryn ballou
@kathrynballou1 · X

RT @CoDoc442: Potential risk of autism via methylation, impacting outcomes. If any "medication" did this, it would be pulled from the shel…

Jul 11, 2023 · 2 shares · 134 followers View post →
Gene A Cole
@popeye55211 · X

RT @CoDoc442: Potential risk of autism via methylation, impacting outcomes. If any "medication" did this, it would be pulled from the shel…

Jul 11, 2023 · 2 shares · 117 followers View post →
KFinn, MD
@CoDoc442 · X

Potential risk of autism via methylation, impacting outcomes. If any "medication" did this, it would be pulled from the shelves https://t.co/KU4PgGTnLC

Jul 10, 2023 · 5 likes · 2 shares · 1,293 followers View post →
Agingdoc
@agingdoc1 · X

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes https://t.co/4cGstC4iBh @BMC_series · https://t.co/3M30uBbpPA

Jul 8, 2023 · 1 like · 2 shares · 41,720 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes https://t.co/u81ekj2ELD

Jul 7, 2023 · 1 like · 2,239 followers View post →
Autism Spectrum Disorders Articles
@ASD_Articles · X

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes. https://t.co/s2jkuqvF37

Jul 7, 2023 · 35 followers View post →
Environmental Epigenetics
@EEpigenetics · X

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriche… https://t.co/Kt8Pr1vyb6

Jul 7, 2023 · 207 followers View post →
PrimateDNA Papers
@PrimateDNA_Lit · X

Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes https://t.co/gHZtZ1LMXN

Jul 7, 2023 · 54 followers View post →
scrit (nil/acc)
@blursedscrit · X

RT @NeuroscienceNew: “Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched…

Jul 7, 2023 · 5 shares · 209 followers View post →
J P Fanton
@HealthyFellow · X

Free, Full Text: https://t.co/26U5kuP9DN

Jul 6, 2023 · 26,026 followers View post →
Mari Carmen Porres
@LaPorres · X

RT @NeuroscienceNew: “Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched…

Jul 6, 2023 · 5 shares · 10,670 followers View post →
Swoosh
@Katrina5Mm · X

RT @NeuroscienceNew: “Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched…

Jul 6, 2023 · 5 shares · 6,822 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @NeuroscienceNew: “Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched…

Jul 6, 2023 · 5 shares · 10,820 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes” by Lyndsey Shorey-Kendrick et al. Clinical Epigenetics https://t.co/CIaG1WH6vY 2/2

Jul 6, 2023 · 13 likes · 5 shares · 505,782 followers View post →