Sci Rep July 2023 PMID 37422571

Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC).

Fabiana Russo, Maria Angela Vandelli, Giuseppe Biagini, Martin Schmid, Livio Luongo, Michela Perrone, Federica Ricciardi, Sabatino Maione, Aldo Laganà, Anna Laura Capriotti, Alfonso Gallo, Luigi Carbone, Elisabetta Perrone, Giuseppe Gigli, Giuseppe Cannazza

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Mentions

Peak: 3 in Jul 2023

across 4 sources since Jul 2023

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3,734

potential audience

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Jul 2023 – Dec 2023

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News12 articles
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AI synopsis

What people are saying

Several discussions highlight the scientific content, such as the mention of the synthesis of HHC epimers and their pharmacological testing in mice, indicating moderate interest and engagement. The tone remains analytical and factual, reflecting curiosity about the synthesis techniques and biological effects, but stops short of emphasizing broad societal or clinical impact.

AgreementNeither agree nor disagree

The discussions show mixed reactions—some acknowledge the scientific significance, while others remain neutral or somewhat skeptical about its implications.

InterestModerate interest

There is a modest level of curiosity, as posts mention specific aspects like the synthesis process and pharmacological testing, but overall engagement remains moderate.

EngagementModerate engagement

Participants refer to detailed scientific methods, such as the tetrad assay and chromatographic techniques, indicating a secondary level of detailed engagement.

ImpactNeutral impact

The conversation suggests a recognition of potential importance for cannabinoid research but does not explicitly demonstrate a shift in opinions or practices.

Abstract in brief

The text discusses the synthesis and pharmacological study of epimers of hexahydrocannabinol (HHC), a semi-synthetic cannabinoid derived from CBD, highlighting its potential psychoactive effects.
It emphasizes the contrasting effects of THC, responsible for psychotropic effects, and CBD, known for its therapeutic benefits, and how derivatives like HHC are now used to mimic THC's effects.
The research involves developing synthetic methods to produce active epimers of HHC, testing their activity, and establishing chromatographic techniques to detect and measure hemp-derived compounds in commercial cannabis samples.

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Synthesis and Pharmacology of Hexahydrocannabinol Epimers Explained

This video examines the synthesis and pharmacological activity of hexahydrocannabinol epimers, semi-synthetic cannabinoids derived from CBD, highlighting their psychoactive potential and detection methods in cannabis…

Medicine RTCL TV · Oct 15, 2023 53 views

Krolli

@Krolli5 · X

Dec 31, 2023 · 1 like · 290 followers View post →

Kermit Murray

@kermitmurray · X

(Nature MS) Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC) (RSS) #nature #MassSpecRSS https://t.co/kWQhJqc5sN https://t.co/U5kRwkb61d

Jul 21, 2023 · 1,971 followers View post →

Craig Mckenzie

@itsdrmac · X

RT @IUjvary: Synthesis and pharmacological activity in the mouse tetrad assay of the 9R and 9S epimers of hexahydrocannabinol (HHC) https:/…

Jul 10, 2023 · 1 share · 957 followers View post →

István Ujváry

@IUjvary · X

Synthesis and pharmacological activity in the mouse tetrad assay of the 9R and 9S epimers of hexahydrocannabinol (HHC) https://t.co/46ZhjoffFK

Jul 10, 2023 · 2 likes · 1 share · 460 followers View post →