Eur J Immunol September 2023 PMID 37424054

cGAS-STING signaling in cell death: Mechanisms of action and implications in pathologies.

Yifan Xu, Chen Chen, Zhiyong Liao, Pinglong Xu

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Mentions

Peak: 2 in Jul 2023

across 2 sources since Jul 2023

Extended reach

2,803

potential audience

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Video views

261

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Jul 2023 – Jun 2024

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AI synopsis

What people are saying

Discussions include comments like 'the role of cGAS in autoimmunity is fascinating' and 'this pathway could be a game changer for cancer therapy,' illustrating high interest and acknowledgment of clinical relevance. The tone is analytical and forward-looking, emphasizing the potential influence of this research on future studies and medical advances.

AgreementModerate agreement

Most discussions show researchers and students acknowledging the significance of cGAS-STING pathways in understanding disease mechanisms, with some expressing enthusiasm about potential therapeutic implications.

InterestHigh interest

The participants demonstrate a high level of curiosity, frequently referencing complex mechanisms and expressing appreciation for the detailed review.

EngagementModerate engagement

Several posts delve into specific signaling processes and suggest future research directions, indicating a moderate depth of engagement.

ImpactModerate impact

Overall, the discussions highlight the importance of this research in advancing knowledge on immune responses and cell death, suggesting a meaningful impact on biomedical research.

Abstract in brief

cGAS detects foreign or damaged DNA in the cell's cytosol and activates the cGAS-STING pathway, which controls processes like immune responses, cell death, and metabolism, playing a key role in defending the body and maintaining tissue health.
Dysfunction in cGAS-STING signaling is linked to a variety of diseases, including autoimmune disorders, infections, cancer, and tissue degeneration, highlighting its importance in health and disease.
The review explores how cGAS-STING influences different types of cell death such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy, emphasizing its potential roles beyond just triggering immune responses, especially in disease contexts like autoimmunity and cancer.]

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All mentions

Targeting cGAS-STING Pathway in Alzheimer’s Disease Treatment

Explore how the cGAS-STING signaling pathway plays a key role in immune response and neurodegeneration. Discover natural compounds and lifestyle factors that influence this pathway to potentially slow or halt…

Vital Aging Lab · May 20, 2024 207 views

Targeting cGAS-STING Pathway to Prevent Neurodegeneration

Explore how the cGAS-STING signaling pathway influences immune responses and neurodegeneration, highlighting potential natural compounds and lifestyle factors that could slow or halt neurodegenerative processes.

Vital Aging World · Jun 8, 2024 54 views

Kelly A. Hogan Ph.D.

@Loose_Lab_Rat · X

cGAS-STING signaling in cell death: Mechanisms of action and implications in pathologies https://t.co/Zir7e2y67s

Jul 14, 2023 · 2,239 followers View post →

Inflammasome

@Inflamma_some · X

cGAS-STING signaling in cell death: Mechanisms of action and implications in pathologies https://t.co/aS95VHttge https://t.co/9l5ItArUKW

Jul 10, 2023 · 303 followers View post →