July 2023 PMID 37436926

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease.

Annabelle S Chidiac, Nicholas A Buckley, Firouzeh Noghrehchi, Rose Cairns

Download social card

Mentions

114
Peak: 96 in Feb 2024
across 2 sources since Jul 2023

Extended reach

271,666
potential audience

Total likes

549

Video views

14,028

Mentions per month

Jul 2023 – Nov 2025

Where it's discussed

  • X / Twitter111 posts
  • YouTube3 videos

AI synopsis

What people are saying

Numerous posts highlight alarming statistics from the article, such as claiming paracetamol is implicated in 6% of poisonings and 56% of severe liver injuries. Phrases like 'paracetamol is toxic to mitochondria' and discussions about the antidote acetylcysteine, reveal a strong concern for safety and treatment efficacy, using a serious tone that underscores the gravity of the issue. This language, combined with personal anecdotes in some posts, intensifies the urgency around addressing paracetamol overdose.

AgreementModerate agreement

The majority of posts acknowledge and reference the significant statistics presented in the publication, showing a general consensus on its importance.

InterestHigh interest

There is high interest in paracetamol overdose and its implications for public health, with users expressing curiosity about its effects and treatment.

EngagementModerate engagement

Many discussions delve into technical aspects such as overdose mechanisms and treatment options, indicating a moderate level of engagement with the content.

ImpactHigh impact

Users perceive a high impact of the publication, emphasizing the necessity for improved treatment and prevention strategies.

Abstract in brief

  • Paracetamol (acetaminophen) is a widely used medicine and the leading cause of poisoning in high-income countries, with overdose leading to serious liver damage known as hepatotoxicity.
  • Acetylcysteine serves as an effective antidote for paracetamol overdose, yet cases of liver damage and fatalities still occur, highlighting the need for improved treatment and prevention strategies.
  • Global estimates suggest paracetamol is responsible for a significant proportion of poisonings and liver injuries, particularly in regions with limited data, suggesting a need for better regulation and harm reduction measures.

Top posts

Most liked on X and Bluesky
Leonardo Santos
@Leo_Santo5 · X

Feb 25, 2024 · 327 likes · 128 shares · 6,665 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

@Doctors__squad

Feb 28, 2025 · 6 likes · 2 shares · 2,818 followers View post →
Geoff Smith
@GeoffSmiGlaynax · X

@NicoleSirotek Estimates are “that paracetamol [acetaminophen] is involved in 6% of poisonings, 56% of severe acute liver injury and acute liver failure, and 7% of drug-induced liver injury”. https://t.co/Rd4nimsaED

Sep 24, 2025 · 4 likes · 444 followers View post →
FAPsGal
@FAPsGal · X

Sobredosis de #paracetamol & #hepatotoxicidad: ✴️mecanismo ✴️tratamiento ✴️medidas de prevención ✴️estimaciones de la carga de enfermedad https://t.co/tDiCh2Wo7M

Feb 25, 2024 · 3 likes · 1 share · 1,375 followers View post →
Danny
@danyisill · X

@MacKainFox @andrey_pesatsky Гугли на нормальных языках Нормальная выборка, сотни источников https://t.co/5VMq0hEQyT https://t.co/TlMRxc2YLX

Aug 25, 2025 · 3 likes · 326 followers View post →
Geoff Smith
@GeoffSmiGlaynax · X

@REMASCULATE Morons. Researchers “estimate that paracetamol is involved in 6% of poisonings, 56% of severe acute liver injury and acute liver failure, and 7% of drug-induced liver injury”. https://t.co/Rd4nimsaED

Sep 24, 2025 · 2 likes · 444 followers View post →

All mentions

Edgar Lazo
@mind_centered · X

@leonardaisfunE The thing with paracetamol is that "...we estimate that paracetamol is involved in 6% of poisonings, 56% of severe acute liver injury and acute liver failure, and 7% of drug-induced liver injury." https://t.co/ADobF7xJ0W

Sep 25, 2025 · 566 followers View post →
Geoff Smith
@GeoffSmiGlaynax · X

@NicoleSirotek Estimates are “that paracetamol [acetaminophen] is involved in 6% of poisonings, 56% of severe acute liver injury and acute liver failure, and 7% of drug-induced liver injury”. https://t.co/Rd4nimsaED

Sep 24, 2025 · 4 likes · 444 followers View post →
Geoff Smith
@GeoffSmiGlaynax · X

@REMASCULATE Morons. Researchers “estimate that paracetamol is involved in 6% of poisonings, 56% of severe acute liver injury and acute liver failure, and 7% of drug-induced liver injury”. https://t.co/Rd4nimsaED

Sep 24, 2025 · 2 likes · 444 followers View post →
Paris
@Paris1421632 · X

Paracetamol (acetaminophen) is toxic to mitochondria It can cause CNS depression & liver failure Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease https://t.co/RZWynsrPtC

Sep 6, 2025 · 36 followers View post →
Danny
@danyisill · X

@MacKainFox @andrey_pesatsky Гугли на нормальных языках Нормальная выборка, сотни источников https://t.co/5VMq0hEQyT https://t.co/TlMRxc2YLX

Aug 25, 2025 · 3 likes · 326 followers View post →
Pala Francis
@PalaFrancis · X

RT @NathaliaLeHen: @Doctors__squad

Mar 2, 2025 · 2 shares · 225 followers View post →
Bùsúyì
@MayowaArije · X

RT @NathaliaLeHen: @Doctors__squad

Mar 1, 2025 · 2 shares · 1,862 followers View post →
Nathalia Le Hen
@NathaliaLeHen · X

@Doctors__squad

Feb 28, 2025 · 6 likes · 2 shares · 2,818 followers View post →
Michal But
@MikeButMD · X

Chidiac AS, Buckley NA, Noghrehchi F, Cairns R. Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opin Drug Metab Toxicol. 2023 Jan-Jun;19(5):297-317. doi: 10.1080/17425255.2023.2223959.

Dec 11, 2024 · 8 followers View post →
lower
@rafachis · X

RT @Leo_Santo5:

Nov 9, 2024 · 128 shares · 51 followers View post →
Pharmacology Insights
@PharmacoIns · X

Paracetamol overdose creates toxic NAPQI. To counteract NAPQI, your liver depends on glutathione. Taking too much paracetamol exhausts glutathione supply. In case of overdose, the antidote acetylcysteine replenishes glutathione to counter NAPQI. https://t.co/IboLoPEDwb #PharmEd

Mar 31, 2024 · 11 followers View post →
Andres Felipe RM
@rm_andresfelipe · X

RT @Leo_Santo5:

Mar 5, 2024 · 128 shares · 63 followers View post →
aungkanspace
@aungkanspace · X

RT @Leo_Santo5:

Mar 2, 2024 · 128 shares · 389 followers View post →
Bias master
@BiasArchitect · X

RT @Leo_Santo5:

Feb 28, 2024 · 128 shares · 18 followers View post →
Monsesaurus
@Michelle_EG · X

RT @Leo_Santo5:

Feb 28, 2024 · 128 shares · 135 followers View post →
Guadalupe Reyes
@GuadalupeR84668 · X

RT @Leo_Santo5:

Feb 27, 2024 · 128 shares · 19 followers View post →
CarolinaV (
@carolina18213 · X

RT @Leo_Santo5:

Feb 27, 2024 · 128 shares · 98 followers View post →
Samuel Moisén Bello
@BelloMoisen · X

RT @Leo_Santo5:

Feb 27, 2024 · 128 shares · 34 followers View post →
Matias Mendez Gomez
@Mmendezg93 · X

RT @Leo_Santo5:

Feb 27, 2024 · 128 shares · 90 followers View post →
AGUSTINA FERNÁNDEZ
@AgusAgusfar · X

RT @FAPsGal: Sobredosis de #paracetamol & #hepatotoxicidad: ✴️mecanismo ✴️tratamiento ✴️medidas de prevención ✴️estimaciones de la carga d…

Feb 26, 2024 · 1 share · 561 followers View post →
Alexander Avila
@Alexand46739413 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 269 followers View post →
Jorge doble JJ
@Jorgejllo12 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 142 followers View post →
Jaime Bermeo
@jaime_b26 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 24 followers View post →
Vademon24292
@CarlosA09557330 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 543 followers View post →
Cristhian M.
@Otherside_Get · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 141 followers View post →
Lulu
@imlulual · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 369 followers View post →
Salvador Garcia
@Chavaregal90 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 135 followers View post →
Dr. M.A.I.C.
@MaicMedico · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 66 followers View post →
Ricardo bernal sanch
@Ricardobernals1 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 189 followers View post →
Doc Oc.
@Criscap54 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 155 followers View post →
Yacir Almeida
@Dryaciralmeida · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 59 followers View post →
Raul
@RaulOrn0920 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 158 followers View post →
Mr. Blue
@Ptorresb2906 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 135 followers View post →
César Alejandro
@CesarAlex84 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 75 followers View post →
Dr. Jesús Strange
@129_jesus · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 62 followers View post →
Guillermo Méndez
@Memo99373405 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 268 followers View post →
Rodrigo Rosillo
@RodrigoRosillo1 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 78 followers View post →
noe
@isabeld62289775 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 30 followers View post →
JARB&JARBins
@kharjaskid · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 161 followers View post →
Gautam
@sharma14828 · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 37,768 followers View post →
aol
@arlenocampo · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 125 followers View post →
Dr. Victor Antonio Correa
@viktormed · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 1,560 followers View post →
Alfredo Ruiz
@Mushalf · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 202 followers View post →
David Cabestrero Alonso
@DAVIDCABESTRERO · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 424 followers View post →
Samira Alcalá
@samyalcala · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 199 followers View post →
B
@blaancadeelia · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 232 followers View post →
Ana Mergil
@RbkBky · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 61 followers View post →
Joan Pozas
@PozasJoan · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 1,671 followers View post →
Dra Shock
@Drashock · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 69 followers View post →
Manolo Garcia
@medicson · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 60 followers View post →
Eduardo Perez
@Lalo_Med · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 240 followers View post →
isabel MILG
@13milg · X

RT @Leo_Santo5:

Feb 26, 2024 · 128 shares · 85 followers View post →
Leticia Chalaco
@2010lettych · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 46 followers View post →
Vicente Lozada-Balderrama
@VicenteLozadaB · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 13,647 followers View post →
Sandoval Cavazos
@CSEDXXIV · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 179 followers View post →
Epimetheus VaccineS
@Epi_VaxS · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 3 followers View post →
Yanina Mir
@chani239 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 45 followers View post →
Pembrolizumab
@LauCuapa · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 182 followers View post →
Dr. Pocus
@Yevgeny83416325 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 92 followers View post →
Sol
@ArualSogar · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 798 followers View post →
Pulido
@GallegosPulido · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 76 followers View post →
♏
@MarceGuiani · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 87 followers View post →
nutrijary
@111babybunny · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 261 followers View post →
Francisco
@rivadeneiraf1 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 112 followers View post →
R Urgenciolóco
@RUrgencioloco · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 32 followers View post →
Juan Carlos Paz B.
@JuanCarlosPaz_B · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 1,003 followers View post →
Intelligent Medicine
@IntelligentMed8 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 82 followers View post →
Orlando RPN
@OrlandoRPN · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 93,527 followers View post →
Vips
@vianeydj84 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 92 followers View post →
adairgamaliel
@adairgamaliel · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 641 followers View post →
Oscar Aspiazu Segovia. MD. ESP. MFYC| MsC.MPH
@opolito8514 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 286 followers View post →
F L Guedes
@fguedesMD · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 200 followers View post →
R David M
@RayMolinaL · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 602 followers View post →
Nąndø™
@wiCho_0 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 164 followers View post →
Micheli Romanelli
@15Romanelli · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 238 followers View post →
Dr.Bama
@HugoVal27010762 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 84 followers View post →
lucero
@lucymatsu · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 153 followers View post →
Malvado dr. quesillo
@trama_doc · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 97 followers View post →
Ana
@verenaacf · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 4,836 followers View post →
Yesca10mg
@bhaltagu · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 156 followers View post →
Dr Toledo
@DrHezael12 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 587 followers View post →
David David Chopper
@DavidP_D · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 75 followers View post →
Aveiro
@Raulaveiro · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 1,388 followers View post →
Ruth Rosales
@RuthRosales0 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 464 followers View post →
Dr. Diógenes el Travesaño
@DrDiogenesxxx · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 14,203 followers View post →
Paul Sanchez
@palsanchz · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 1,017 followers View post →
Andrés Arias Casierra
@AriasCasierra · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 27 followers View post →
Augusto Rojas Carrión
@AugustoR04 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 331 followers View post →
FAPsGal
@FAPsGal · X

Sobredosis de #paracetamol & #hepatotoxicidad: ✴️mecanismo ✴️tratamiento ✴️medidas de prevención ✴️estimaciones de la carga de enfermedad https://t.co/tDiCh2Wo7M

Feb 25, 2024 · 3 likes · 1 share · 1,375 followers View post →
Martha
@Martha54091542 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 13 followers View post →
Julio César
@DrJulioMatuteM · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 1,421 followers View post →
Mister PandaDoc
@Jairoaguilar27 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 1,887 followers View post →
Roger Gonzalez
@Rogerogonzalezc · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 328 followers View post →
aldo aversa
@AldoAversa · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 1,229 followers View post →
Omii ⛄
@DrCrespitos · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 1,549 followers View post →
Sociedad de Medicina de Emergencias de la Laguna
@SOMELaguna · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 17,065 followers View post →
gghz97
@Gilghz97 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 57 followers View post →
Dr. Josecito
@IsaacSosa07 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 368 followers View post →
Washington Almache
@Washington_ALMA · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 107 followers View post →
Berk
@BerkBmf · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 508 followers View post →
Brian Delgado
@Briandelgadovel · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 237 followers View post →
Dr. Fit
@irvinghdz95 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 860 followers View post →
Rebeca Auru
@RebecaAuru · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 89 followers View post →
Farmacovigilante sv
@DanielS93941533 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 80 followers View post →
Leonardo Soto Muñoz
@LeonardoSotoMu · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 8,536 followers View post →
Victor Hernández
@VicHdez27 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 143 followers View post →
Lilo
@nicolehm00 · X

RT @Leo_Santo5:

Feb 25, 2024 · 128 shares · 106 followers View post →
Leonardo Santos
@Leo_Santo5 · X

Feb 25, 2024 · 327 likes · 128 shares · 6,665 followers View post →
Romi ⚡
@mar20463Rayito · X

Artículo completo: Sobredosis de paracetamol (acetaminofén) y hepatotoxicidad: mecanismo, tratamiento, medidas de prevención y estimaciones de la carga de enfermedad https://t.co/YECSQz3MSn

Feb 19, 2024 · 10 followers View post →
Edith Collins Centre
@Edith__Collins · X

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates o… https://t.co/q6ITD40zE3

Jul 18, 2023 · 1 like · 324 followers View post →
Edith Collins Centre
@Edith__Collins · X

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates o… https://t.co/q6ITD40zE3

Jul 16, 2023 · 324 followers View post →