Cell Rep July 2023 PMID 37437568

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice.

Ramesh K Paidi, Sumita Raha, Avik Roy, Kalipada Pahan

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Mentions

105

Peak: 35 in Jul 2023

across 6 sources since Jul 2023

Extended reach

731,302

potential audience

Total likes

324

Video views

6,533

Mentions per month

Jul 2023 – Oct 2024

Where it's discussed

News52 articles
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Blogs5 articles
YouTube3 videos
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AI synopsis

What people are saying

The group shows substantial interest in HMB's effects on the brain, with discussions highlighting its potential to combat diseases like Alzheimer’s and its neuroprotective properties, as seen in questions asking for opinions and comments about its significance. The tone and words reflect curiosity and recognition of the study's promising implications for health and disease prevention.

AgreementModerate agreement

Most discussions recognize the potential benefits of HMB for brain health, with some explicitly supporting its neuroprotective effects.

InterestHigh interest

Many posts express curiosity and questions regarding the implications of the research, indicating high engagement and interest.

EngagementModerate engagement

Posts include references to mechanisms, potential uses, and further research, showing a moderate level of detailed engagement.

ImpactModerate impact

Participants see the research as promising, with mentions of possible repurposing of HMB and implications for neurodegenerative diseases, signaling a perceived importance.

Abstract in brief

This study shows that the muscle-building supplement HMB interacts with the PPAR receptor in the brain, leading to improved hippocampal plasticity and cognitive functions in mice.
Proteomic analysis reveals that HMB binds specifically to the Y314 residue of PPAR, which is essential for its beneficial effects; altering this site prevents HMB from enhancing neuron plasticity.
Oral HMB also reduces Alzheimer’s-related plaque buildup and improves memory in genetically modified mice, suggesting that HMB could potentially be repurposed as a neuroprotective treatment for Alzheimer's disease.]

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HMB Supplement's Potential in Enhancing Memory and Reducing Alzheimer's Plaques

In a world affected by Alzheimer's disease, new research suggests HMB, a muscle-building supplement, may improve hippocampal function and reduce neural plaques, offering hope for neuroprotection and memory preservation.

Fitness TitBitz · Jul 24, 2023 4,500 views

HMB Enhances Brain Function and May Protect Against Alzheimer's Disease

This study shows that the muscle-building supplement HMB interacts with the PPAR receptor in the brain, leading to improved hippocampal plasticity and cognitive functions in mice. HMB reduces Alzheimer’s-related plaques…

VHFILM · Aug 27, 2023 1,959 views

HMB Supplement Enhances Brain Function and May Help Combat Alzheimer's

VHFILM · Oct 19, 2023 74 views

Joseph

@wethebots_ · X

@Cernovich HMB is great for the brain, not so much the muscles. https://t.co/0sWTovB9Kh

Oct 11, 2024 · 1 like · 204 followers View post →

Jim Holbrook

@JimHolbrook11 · X

@Parsifaler Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/8OiowBlXKS

Sep 5, 2023 · 1 like · 97 followers View post →

Ralph Turchiano

@RalphTurchiano · X

HMB and Alzheimer’s disease Show 1151 AUG 2023 https://t.co/iMxP0DsnmQ via @YouTube

Aug 27, 2023 · 1 like · 128 followers View post →

Altamiro Bottino

@BottinoAltamiro · X

Bodybuilding supplement may help stave off progression of Alzheimer's https://t.co/KrhyZBrLr2 https://t.co/EGTSxeVfWv https://t.co/ktMHDam1hh

Aug 21, 2023 · 93 followers View post →

Eve.S.

@yeeseak · X

https://t.co/MhN2NufoRI

Aug 15, 2023 · 3 likes · 869 followers View post →

Roger Blackwell

@rogerablackwell · X

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/PVyF9V1vyq

Jul 31, 2023 · 2,296 followers View post →

Gholson Lyon

@GholsonLyon · X

interesting: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. Anybody have an opinion on this? https://t.co/fZIqGknLwp https://t.co/cBd7x3A6WL

Jul 28, 2023 · 1 like · 4,884 followers View post →

Mind Your Science!

@MindYourSci · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/…

Jul 24, 2023 · 4 shares · 133 followers View post →

タマさん

@tama_sweets1 · X

RT @SFujita77: マウスの実験で、筋合成系サプリのHMBが脳内の有益なタンパク質を増加させ、記憶と学習を改善。さらにHMBはプラークを減少させ、アルツハイマー病の進行を予防する可能性がある、とCell Repの報告。ヒトで再現されれば、アルツハイマー病の有望な治療…

Jul 24, 2023 · 2 shares · 6,869 followers View post →

Satoshi Fujita（藤田聡）

@SFujita77 · X

Jul 24, 2023 · 34 likes · 2 shares · 7,039 followers View post →

Enea Fioretti

@EneaFioretti · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/…

Jul 24, 2023 · 4 shares · 293 followers View post →

Dr. Kalipada Pahan

@DrPahan · X

RT @NeuroscienceNew: “Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice” by Kal…

Jul 24, 2023 · 3 shares · 43 followers View post →

The Phoenix Lab

@The_Phoenix_Lab · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/…

Jul 24, 2023 · 4 shares · 210 followers View post →

サイエンスあれこれ

@sarekore · X

学習と記憶を保護するニューロンの成長因子を増加させることがわかりました。今後、同様の結果がヒトでも確認されれば、最終的にはアルツハイマー病の進行を防ぐのに役立つ可能性があります。HMB は市販のサプリメントで、長期的に使用しても安全で、副作用は知られていませんhttps://t.co/D6yugT7yyt

Jul 24, 2023 · 2 likes · 922 followers View post →

な bot

@NeuroNNNNN_bot · X

[Cell Rep.] Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/3AwGsKyvSW

Jul 23, 2023 · 26 followers View post →

frank

@frankwikson · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/…

Jul 23, 2023 · 4 shares · 27 followers View post →

Agingdoc

@agingdoc1 · X

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/HqI7LJ3whQ @CellReports https://t.co/kR6G0ceSIw

Jul 23, 2023 · 19 likes · 4 shares · 41,316 followers View post →

Mind Your Science!

@MindYourSci · X

RT @DominicDAgosti2: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https:/…

Jul 22, 2023 · 8 shares · 133 followers View post →

Gerard Hough

@GerardHough · X

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/ImsCLS6Ju2

Jul 22, 2023 · 1,745 followers View post →

System

@liyongcsco12 · X

RT @DominicDAgosti2: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https:/…

Jul 22, 2023 · 8 shares · 65 followers View post →

KetoCN

@KetoCNOfficial · X

RT @DominicDAgosti2: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https:/…

Jul 21, 2023 · 8 shares · 45 followers View post →

Johnny Galtar

@JohnnyGaltar · X

RT @DominicDAgosti2: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https:/…

Jul 21, 2023 · 8 shares · 404 followers View post →

micke_no

@micke_no · X

RT @DominicDAgosti2: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https:/…

Jul 21, 2023 · 8 shares · 1,477 followers View post →

Thom King

@thomking · X

RT @DominicDAgosti2: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https:/…

Jul 21, 2023 · 8 shares · 3,948 followers View post →

Diamond Truths

@DiamondTruths_ · X

RT @DominicDAgosti2: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https:/…

Jul 21, 2023 · 8 shares · 142 followers View post →

Baleandor FA | FO

@Baleandor · X

RT @DominicDAgosti2: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https:/…

Jul 21, 2023 · 8 shares · 208 followers View post →

Dominic D'Agostino

@DominicDAgosti2 · X

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. https://t.co/1MLVkx5JWv

Jul 21, 2023 · 28 likes · 8 shares · 78,014 followers View post →

The Phoenix Lab

@The_Phoenix_Lab · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice “Muscle-build…

Jul 21, 2023 · 9 shares · 210 followers View post →

Mind Your Science!

@MindYourSci · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice “Muscle-build…

Jul 21, 2023 · 9 shares · 133 followers View post →

Enea Fioretti

@EneaFioretti · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice “Muscle-build…

Jul 20, 2023 · 9 shares · 293 followers View post →

Rebecca blitz

@Rebeccablitz1 · X

RT @NeuroscienceNew: “Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice” by Kal…

Jul 20, 2023 · 3 shares · 2,143 followers View post →

Bayar Jaff

@JaffBayar · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice “Muscle-build…

Jul 20, 2023 · 9 shares · 605 followers View post →

Neuroscience News

@NeuroscienceNew · X

“Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice” by Kalipada Pahan et al. Cell Reports https://t.co/AP2J4unVQU 2/2

Jul 20, 2023 · 15 likes · 3 shares · 505,361 followers View post →

Brandon Yates, PhD, CSCS

@DrYatesB · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice “Muscle-build…

Jul 20, 2023 · 9 shares · 1,364 followers View post →

Javed Alam

@jalam1001 · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice “Muscle-build…

Jul 20, 2023 · 9 shares · 1,004 followers View post →

Eve Beavers-Fain BSN MPH

@espacetimeNOT · X

RT @agingdoc1: Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice “Muscle-build…

Jul 20, 2023 · 9 shares · 1,203 followers View post →

Agingdoc

@agingdoc1 · X

Jul 20, 2023 · 43 likes · 9 shares · 41,316 followers View post →

Nick Krontiris

@nick_krontiris · X

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice (open access) https://t.co/J96qwTQ3pS #nutrition #diet #protein #supplements #supplement

Jul 18, 2023 · 2 likes · 18,978 followers View post →

Yasuro Furuichi／古市泰郎

@yasurof2 · X

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice https://t.co/oeELl3ROWp

Jul 14, 2023 · 2 likes · 176 followers View post →

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

HMB Supplement's Potential in Enhancing Memory and Reducing Alzheimer's Plaques

HMB Enhances Brain Function and May Protect Against Alzheimer's Disease

HMB Supplement Enhances Brain Function and May Help Combat Alzheimer's