Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization.

Marine Berquez, Zhiyong Chen, Beatrice Paola Festa, Patrick Krohn, Svenja Aline Keller, Silvia Parolo, Mikhail Korzinkin, Anna Gaponova, Endre Laczko, Enrico Domenici, Olivier Devuyst, Alessandro Luciani

July 2023 Nat Commun

Synopsis of Social media discussions

Overall, the digital discussions demonstrate high interest and support for the research, exemplified by remarks such as 'Very cool work!' and mentions of how the publication advances methodology, like incorporating RRIDs for reproducibility. The tone is enthusiastic but not overly detailed, reflecting a community intrigued by the scientific and clinical implications without extensive debate or critique.

A
Agreement
 Moderate agreement

Most discussions express enthusiasm or approval for the research, emphasizing its importance and potential implications, indicating supportive consensus.

I
Interest
 High level of interest

The high interest score reflects curiosity and excitement, as posts highlight novel aspects like the role of lysosomal cystine and mTORC1 in kidney cell differentiation, using positive language like 'very cool work' and 'proud of the team.'

E
Engagement
 Moderate level of engagement

Posts show moderate engagement through sharing preprints and discussing method improvements (e.g., RRIDs in the publication), suggesting active but not deeply analytical discussions.

I
Impact
 Moderate level of impact

The discussions imply that the article could influence future research and treatments, especially with mentions of potential for cystinosis therapies and the significance of reproducibility, though specific tangible impacts are not deeply explored.

Social Mentions

YouTube

1 Videos

Twitter

59 Posts

News

23 Articles

Reddit

2 Posts

Metrics

Video Views

77

Total Likes

212

Extended Reach

306,629

Social Features

85

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Lysosomal Cystine Export and mTORC1 Signaling in Kidney Cells

Lysosomal Cystine Export and mTORC1 Signaling in Kidney Cells

This video discusses how lysosomal cystine export regulates mTORC1 signaling in kidney epithelial cells. It highlights the implications of CTNS cystinosin mutations that lead to genetic disorders. Explore the research by Berquez et al. published in Nature.

STEM RTCL TV

October 25, 2023

77 views

  • RRID Robot
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    The authors of "Lysosomal cystine export regulates mTORC1 signalin…" (https://t.co/ThdFDdWQa9) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #methodsmatter #STMpublishing
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    July 19, 2023

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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • soda_troubles,https://med-mastodon.com/@haysam
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Daniel Thomson
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Francesco Puzzo
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Dr. Naveen Kumar Tangudu
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • JQ
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Szu Shuo Lee
    @ShuoSzu (Twitter)

    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Carmen De Miguel, PhD, MS, FAHA
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    RT @KSusztak: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ htt…
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  • RESOLUTE - Research Empowerment on Solute Carriers
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Mashun ONISHI
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    Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communications https://t.co/DlBO9wtPf8
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  • Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
    @Alexis_Lomakin (Twitter)

    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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    July 16, 2023

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  • Le Tran Phuc Khoa
    @LeTranPhucKhoa1 (Twitter)

    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Josselin Nespoux
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    RT @KSusztak: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ htt…
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    July 16, 2023

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  • Ivan Alfaro
    @alfobioq (Twitter)

    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Katalin Susztak
    @KSusztak (Twitter)

    Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ https://t.co/Lyqphucnie
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  • Mark Borris Aldonza (@precursorcell.bsky.social
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Longevity for everyone
    @Happy_Long_Life (Twitter)

    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • Dylan Ryan
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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    July 16, 2023

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  • Ashish Kumar
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    RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…
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  • FrezzaLab
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    Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/Ga4RnYhhjK
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  • Vladimir Taskaev MD
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    RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…
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    July 15, 2023

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    RT @oxkawaka: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization CTNS、腎臓の分化に重要らしい ht…
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  • Dr. Shashank Joshi
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    RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…
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    Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization CTNS、腎臓の分化に重要らしい https://t.co/p3se7gxdgE
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  • MIKADO Group
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    Now available in preprint: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization by dr. Marine Berquez et al. Proud of the team for this great piece of work! #cystinosis #lysosomes
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Abstract Synopsis

  • This study explains how lysosomal cystine export influences mTORC1 signaling, which is crucial for kidney cell differentiation and function.
  • When cystine transport from lysosomes is faulty, as in cystinosis, kidney cells tend to grow and proliferate abnormally, disrupting their normal roles.
  • Targeting mTORC1 activity with inhibitors can fix these cellular imbalances, suggesting new treatments for cystinosis that restore proper cell function by regulating lysosomal cystine and mTORC1 signaling.]