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Nat Commun July 2023 PMID 37452023

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization.

Marine Berquez, Zhiyong Chen, Beatrice Paola Festa, Patrick Krohn, Svenja Aline Keller, Silvia Parolo, Mikhail Korzinkin, Anna Gaponova, Endre Laczko, Enrico Domenici, Olivier Devuyst, Alessandro Luciani

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Mentions

85
Peak: 52 in Jul 2023
across 4 sources since Aug 2022

Extended reach

306,629
potential audience

Total likes

212

Video views

77

Mentions per month

Aug 2022 – Oct 2023

Where it's discussed

  • X / Twitter59 posts
  • News23 articles
  • Reddit2 posts
  • YouTube1 videos

AI synopsis

What people are saying

Overall, the digital discussions demonstrate high interest and support for the research, exemplified by remarks such as 'Very cool work!' and mentions of how the publication advances methodology, like incorporating RRIDs for reproducibility. The tone is enthusiastic but not overly detailed, reflecting a community intrigued by the scientific and clinical implications without extensive debate or critique.

AgreementModerate agreement

Most discussions express enthusiasm or approval for the research, emphasizing its importance and potential implications, indicating supportive consensus.

InterestHigh interest

The high interest score reflects curiosity and excitement, as posts highlight novel aspects like the role of lysosomal cystine and mTORC1 in kidney cell differentiation, using positive language like 'very cool work' and 'proud of the team.'

EngagementModerate engagement

Posts show moderate engagement through sharing preprints and discussing method improvements (e.g., RRIDs in the publication), suggesting active but not deeply analytical discussions.

ImpactModerate impact

The discussions imply that the article could influence future research and treatments, especially with mentions of potential for cystinosis therapies and the significance of reproducibility, though specific tangible impacts are not deeply explored.

Abstract in brief

  • This study explains how lysosomal cystine export influences mTORC1 signaling, which is crucial for kidney cell differentiation and function.
  • When cystine transport from lysosomes is faulty, as in cystinosis, kidney cells tend to grow and proliferate abnormally, disrupting their normal roles.
  • Targeting mTORC1 activity with inhibitors can fix these cellular imbalances, suggesting new treatments for cystinosis that restore proper cell function by regulating lysosomal cystine and mTORC1 signaling.]
Read the full abstract

Top posts

Most liked on X and Bluesky
FrezzaLab
@FrezzaLab · X

Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/Ga4RnYhhjK

Jul 16, 2023 · 78 likes · 26 shares · 26,997 followers View post →
Cell Biology J-Club
@cell_club · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communications https://t.co/M8sj9H04Zg

Jul 14, 2023 · 59 likes · 12 shares · 6,112 followers View post →
Katalin Susztak
@KSusztak · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ https://t.co/Lyqphucnie

Jul 16, 2023 · 49 likes · 5 shares · 7,006 followers View post →
Kato
@oxkawaka · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization CTNS、腎臓の分化に重要らしい https://t.co/p3se7gxdgE

Jul 14, 2023 · 10 likes · 1 share · 5,817 followers View post →
bioRxiv
@biorxivpreprint · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/kuGje2V1zR #bioRxiv

Aug 29, 2022 · 4 likes · 1 share · 136,946 followers View post →
Transporters and Solute carriers
@solutecarriers · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/OlVQA2N8mC

Jul 17, 2023 · 4 likes · 1 share · 1,513 followers View post →

All mentions

RRID Robot
@RobotRrid · X

The authors of "Lysosomal cystine export regulates mTORC1 signalin…" (https://t.co/ThdFDdWQa9) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #methodsmatter #STMpublishing

Jul 19, 2023 · 161 followers View post →
Mahmoud Qutb
@MahmoudTony19 · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 18, 2023 · 26 shares · 243 followers View post →
Phenomics
@Phenomics_J · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 18, 2023 · 26 shares · 1,528 followers View post →
Agingdoc
@agingdoc1 · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/cfUwL0TWzd

Jul 18, 2023 · 3 likes · 41,346 followers View post →
RESOLUTE - Research Empowerment on Solute Carriers
@RESOLUTE_IMI · X

RT @solutecarriers: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/Ol…

Jul 18, 2023 · 1 share · 1,197 followers View post →
Jun-Liszt Li
@poppingjun · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 17, 2023 · 26 shares · 1,019 followers View post →
Transporters and Solute carriers
@solutecarriers · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/OlVQA2N8mC

Jul 17, 2023 · 4 likes · 1 share · 1,513 followers View post →
Jiajia Chen, PhD, PMP
@JiajiaChen15 · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 17, 2023 · 26 shares · 380 followers View post →
Shams Salah Mahdi
@ShamsPath · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 17, 2023 · 26 shares · 1,434 followers View post →
Uthpala Seneviratne
@UthpalaISen · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 17, 2023 · 26 shares · 145 followers View post →
triplekon
@Navaraaa · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 17, 2023 · 26 shares · 450 followers View post →
soda_troubles,https://med-mastodon.com/@haysam
@set_fortess · X

RT @KSusztak: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ htt…

Jul 16, 2023 · 5 shares · 2,542 followers View post →
Sophia
@SophiaPMSok · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 1 followers View post →
Sirui Li
@SiruiLi10 · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 339 followers View post →
Daniel Thomson
@djthomson · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 2,073 followers View post →
Francesco Puzzo
@cicciopuz · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 1,390 followers View post →
Dr. Naveen Kumar Tangudu
@naveengw · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 255 followers View post →
aimed analytics
@AimedAnalytics · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 74 followers View post →
JQ
@d_jq863 · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 101 followers View post →
Szu Shuo Lee
@ShuoSzu · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 155 followers View post →
Carmen De Miguel, PhD, MS, FAHA
@Carmendemigue12 · X

RT @KSusztak: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ htt…

Jul 16, 2023 · 5 shares · 3,347 followers View post →
RESOLUTE - Research Empowerment on Solute Carriers
@RESOLUTE_IMI · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 1,197 followers View post →
Maryada Sharma
@sharma_maryada · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 356 followers View post →
Mashun ONISHI
@Mashun_Onishi · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communications https://t.co/DlBO9wtPf8

Jul 16, 2023 · 3 likes · 1,531 followers View post →
hr_wksh
@hr_wksh · X

RT @KSusztak: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ htt…

Jul 16, 2023 · 5 shares · 2,504 followers View post →
Shefali
@iam_shef · X

RT @KSusztak: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ htt…

Jul 16, 2023 · 5 shares · 493 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 3,646 followers View post →
Le Tran Phuc Khoa
@LeTranPhucKhoa1 · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 264 followers View post →
Josselin Nespoux
@JosselinNespoux · X

RT @KSusztak: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ htt…

Jul 16, 2023 · 5 shares · 306 followers View post →
Ivan Alfaro
@alfobioq · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 821 followers View post →
Katalin Susztak
@KSusztak · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | ⁦@NatureComms⁩ https://t.co/Lyqphucnie

Jul 16, 2023 · 49 likes · 5 shares · 7,006 followers View post →
Mark Borris Aldonza (@precursorcell.bsky.social
@PrecursorCell · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 1,384 followers View post →
Longevity for everyone
@Happy_Long_Life · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 125 followers View post →
Dylan Ryan
@RyanLab_TCD · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 2,376 followers View post →
Ashish Kumar
@CddrAshu · X

RT @FrezzaLab: Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization ht…

Jul 16, 2023 · 26 shares · 16 followers View post →
FrezzaLab
@FrezzaLab · X

Very cool work! Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/Ga4RnYhhjK

Jul 16, 2023 · 78 likes · 26 shares · 26,997 followers View post →
Vladimir Taskaev MD
@TaskaevVladimir · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 15, 2023 · 12 shares · 29 followers View post →
DTHSTR
@CDADeathStar · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate null https://t.co/ktuJOBEZoP #DTHSTR

Jul 15, 2023 · 113 followers View post →
Muhammad Naeem
@naeempunia · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 563 followers View post →
Grace Hernandez
@graceah9 · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 346 followers View post →
Elmira Khabusheva
@drkhabusheva · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 735 followers View post →
hmap
@hmap01337406 · X

RT @oxkawaka: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization CTNS、腎臓の分化に重要らしい ht…

Jul 14, 2023 · 1 share · 742 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 32,527 followers View post →
Jun-Liszt Li
@poppingjun · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 1,019 followers View post →
herera
@eradotvera · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 9 followers View post →
Le Tran Phuc Khoa
@LeTranPhucKhoa1 · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 264 followers View post →
Kato
@oxkawaka · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization CTNS、腎臓の分化に重要らしい https://t.co/p3se7gxdgE

Jul 14, 2023 · 10 likes · 1 share · 5,817 followers View post →
qicy
@qicy11 · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 381 followers View post →
SNZK
@shinopp · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 723 followers View post →
Tomogotchi, PhD
@tomogolgier · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 263 followers View post →
もろふし
@morofushi1230 · X

RT @cell_club: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communicati…

Jul 14, 2023 · 12 shares · 369 followers View post →
Cell Biology J-Club
@cell_club · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization | Nature Communications https://t.co/M8sj9H04Zg

Jul 14, 2023 · 59 likes · 12 shares · 6,112 followers View post →
Silvia Parolo
@ParoloSilvia · X

RT @biorxiv_cellbio: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/…

Sep 15, 2022 · 2 shares · 23 followers View post →
MIKADO Group
@MIKADOlab · X

Now available in preprint: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization by dr. Marine Berquez et al. Proud of the team for this great piece of work! #cystinosis #lysosomes

Sep 2, 2022 · 1 like · 60 followers View post →
Junyi Zou
@JunyiZou · X

RT @biorxiv_cellbio: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/…

Aug 30, 2022 · 2 shares · 115 followers View post →
Jeanne Bark
@marc_herb · X

@luciani_lab @biorxivpreprint Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/aMspx1Bwd3

Aug 30, 2022 · 644 followers View post →
ｍ
@m5196245258 · X

RT @biorxivpreprint: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/…

Aug 29, 2022 · 1 share · 695 followers View post →
bioRxiv Cell Biology
@biorxiv_cellbio · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/zTlvdZ3sOa #biorxiv_cellbio

Aug 29, 2022 · 1 like · 2 shares · 7,647 followers View post →
bioRxiv
@biorxivpreprint · X

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization https://t.co/kuGje2V1zR #bioRxiv

Aug 29, 2022 · 4 likes · 1 share · 136,946 followers View post →