Nat Commun July 2023 PMID 37454146

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy.

Fengqiao Li, Xue-Qing Zhang, William Ho, Maoping Tang, Zhongyu Li, Lei Bu, Xiaoyang Xu

Mentions

13
Peak: 6 in Jul 2023
across 4 sources since Jul 2023

Extended reach

20,528
potential audience

Total likes

17

Video views

15

Mentions per month

Jul 2023 – May 2024

Where it's discussed

  • X / Twitter8 posts
  • News2 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects a recognition of the research's potential, with examples like references to increased cell signaling molecules and mentions of conferences and scientific outlets, which demonstrate both scientific curiosity and recognition of the work's importance. Words like 'sensitizes,' and references to immune activation suggest a positive outlook on the therapeutic implications.

AgreementModerate agreement

Most discussions support the significance of the research, highlighting its potential to improve immunotherapy outcomes for cold tumors.

InterestModerate interest

Participants show moderate curiosity, with mentions of biochemical details like increased HMGB1 and ATP, indicating some engagement with the science.

EngagementModerate engagement

Comments include references to experimental results and potential conference discussions, implying a moderate level of in-depth interest.

ImpactModerate impact

The conversation consistently emphasizes the potential of this approach to transform cancer treatment, indicating perceived high impact.

Abstract in brief

  • The study introduces a new treatment approach using mRNA lipid nanoparticles that encode only the N-terminus of gasdermin to induce pyroptosis, a form of inflammatory cell death, helping to activate the immune system against tumors.
  • This strategy effectively turns immunologically "cold" tumors, which typically do not respond well to immunotherapy, into "hot" tumors that are more responsive, and also improves the success of checkpoint inhibitors like anti-PD1.
  • The results show that this method not only fights local tumors but also helps control distant tumors, suggesting it can generate a stronger, systemic anticancer immune response that enhances current immunotherapy treatments.]

Top posts

Most liked on X and Bluesky
Moriarty
@ThingsHiddenn · X

"mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy" "Compared to controls, >>HMGB1<< and ATP levels were significantly increased in all four cell lines after treatment with GSDMBNT mRNA@LNPs for 48 h" https://t.co/GYVAz2rg18

May 18, 2024 · 10 likes · 11,374 followers View post →
The Lipid Chronicles
@lipidchronicles · X

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https://t.co/In5qG0FeP2 (@naturecomms)

Jul 16, 2023 · 7 likes · 2 shares · 5,854 followers View post →
M.Safa Karagoez
@mskaragoez · X

RT @lipidchronicles: mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https:/…

Jul 16, 2023 · 2 shares · 2,000 followers View post →
LUKMAN AFOLABI
@saintlukman · X

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https://t.co/ayLynV74oe https://t.co/E9zNDBKmAr

Jul 16, 2023 · 922 followers View post →
L2P Research Labs
@l2presearch · X

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https://t.co/tkhttbCEZa

Jul 15, 2023 · 149 followers View post →
Anh Cao
@Anh_Immunology · X

RT @lipidchronicles: mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https:/…

Jul 16, 2023 · 2 shares · 127 followers View post →

All mentions

Moriarty
@ThingsHiddenn · X

"mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy" "Compared to controls, >>HMGB1<< and ATP levels were significantly increased in all four cell lines after treatment with GSDMBNT mRNA@LNPs for 48 h" https://t.co/GYVAz2rg18

May 18, 2024 · 10 likes · 11,374 followers View post →
Biotechnology Conference
@Biotechmeetings · X

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy Read more on:https://t.co/hZEdpwF4MH Explore biotechnology news at the conference, Visit: https://t.co/2cpzp22pMJ #biotechnology2023 #biotechnologyconference #madrid https://t.co/GC5px1PpED

Aug 11, 2023 · 3 followers View post →
M.Safa Karagoez
@mskaragoez · X

RT @lipidchronicles: mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https:/…

Jul 16, 2023 · 2 shares · 2,000 followers View post →
Anh Cao
@Anh_Immunology · X

RT @lipidchronicles: mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https:/…

Jul 16, 2023 · 2 shares · 127 followers View post →
The Lipid Chronicles
@lipidchronicles · X

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https://t.co/In5qG0FeP2 (@naturecomms)

Jul 16, 2023 · 7 likes · 2 shares · 5,854 followers View post →
LUKMAN AFOLABI
@saintlukman · X

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https://t.co/ayLynV74oe https://t.co/E9zNDBKmAr

Jul 16, 2023 · 922 followers View post →
minnlab_litbot
@MLitbot · X

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https://t.co/YkGhO6JXEF https://t.co/x8Q6I9onGS

Jul 16, 2023 · 72 followers View post →
L2P Research Labs
@l2presearch · X

mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy https://t.co/tkhttbCEZa

Jul 15, 2023 · 149 followers View post →