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Nat Commun July 2023 PMID 37468521

Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi.

Sine Yaganoglu, Konstantinos Kalyviotis, Christina Vagena-Pantoula, Dörthe Jülich, Benjamin M Gaub, Maaike Welling, Tatiana Lopes, Dariusz Lachowski, See Swee Tang, Armando Del Rio Hernandez, Victoria Salem, Daniel J Müller, Scott A Holley, Julien Vermot, Jian Shi

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Mentions

26
Peak: 9 in Jul 2023
across 4 sources since Jul 2023

Extended reach

20,598
potential audience

Total likes

50

Video views

9

Mentions per month

Jul 2023 – Jun 2024

Where it's discussed

  • X / Twitter12 posts
  • News10 articles
  • Blogs3 articles
  • YouTube1 videos

AI synopsis

What people are saying

Discussions highlight the novelty and applicability of GenEPi, with expressions like 'highly specific and non-invasive' emphasizing its technological advancement, and mentions of applications in zebrafish demonstrate its broad potential in biological research. The tone is enthusiastic and recognizes the study's significance, indicating deep engagement and perceived high impact.

AgreementModerate agreement

Most discussions praise the publication’s innovative approach, as seen in comments like 'Thank you for making your #methodsmatter,' indicating strong support for the significance of the research.

InterestHigh interest

The discussions generate high interest, with mentions of the technique being 'highly specific and non-invasive' and its application across biological scales, capturing attention of those interested in imaging and mechanobiology.

EngagementModerate engagement

Participants actively discuss the methods and implications, such as referencing transgenic zebrafish models and the potential to study mechanotransduction, showing thoughtful engagement.

ImpactHigh impact

The publication is viewed as a breakthrough, especially in offering new tools (

Abstract in brief

  • The text introduces GenEPi, a genetically encoded fluorescent reporter that allows for noninvasive, high-resolution imaging of Piezo1 ion channel activity across different biological scales, from single cells to whole organisms.
  • Unlike traditional methods that are invasive or indirect (such as electrophysiology or calcium imaging), GenEPi provides a real-time, optical way to monitor mechanical stimuli and Piezo1 activity in living tissues.
  • This tool can be used to study mechanotransduction processes involved in development, homeostasis, and disease by revealing how cells respond to mechanical forces in various biological contexts.]
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Top posts

Most liked on X and Bluesky
Pantazis_Lab
@Pantazis_Lab · X

Jul 20, 2023 · 35 likes · 8 shares · 261 followers View post →
Society for Developmental Biology
@SocDevBio · X

.@KKalyviotis of @imperialcollege will round out the #SDBPostdocSeminar with his talk "Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi" Image: Transgenic zebrafish expressing GenEPi, the Piezo1-dependent activity biosensor https://t.co/Gv0X3UEIbj

May 8, 2024 · 14 likes · 1 share · 13,106 followers View post →
Marie Held
@MaKaefer · X

Rapidly followed by Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi presented by Periklis (Laki) Pantazis #elmi2024 https://t.co/KdrvqCOl3c

Jun 7, 2024 · 1 like · 756 followers View post →
Christina Vagena-Pantoula
@CVagenaPantoula · X

RT @Pantazis_Lab:

Jul 21, 2023 · 8 shares · 1,701 followers View post →
Marie Breau
@MarieBreau1 · X

RT @Pantazis_Lab:

Jul 20, 2023 · 8 shares · 1,319 followers View post →
KKalyviotis
@KKalyviotis · X

RT @Pantazis_Lab:

Jul 20, 2023 · 8 shares · 1,017 followers View post →

All mentions

Marie Held
@MaKaefer · X

Rapidly followed by Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi presented by Periklis (Laki) Pantazis #elmi2024 https://t.co/KdrvqCOl3c

Jun 7, 2024 · 1 like · 756 followers View post →
KKalyviotis
@KKalyviotis · X

RT @SocDevBio: .@KKalyviotis of @imperialcollege will round out the #SDBPostdocSeminar with his talk "Highly specific and non-invasive imag…

May 8, 2024 · 1 share · 1,017 followers View post →
Society for Developmental Biology
@SocDevBio · X

.@KKalyviotis of @imperialcollege will round out the #SDBPostdocSeminar with his talk "Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi" Image: Transgenic zebrafish expressing GenEPi, the Piezo1-dependent activity biosensor https://t.co/Gv0X3UEIbj

May 8, 2024 · 14 likes · 1 share · 13,106 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Nature Communications paper "Highly specific and non-invasive imaging of Piezo1…" (https://t.co/G01GAfkC50). Thank you for making your #methodsmatter. #RRID

Jul 23, 2023 · 161 followers View post →
Yi Feng
@YiFeng_Fishlab · X

RT @Pantazis_Lab:

Jul 21, 2023 · 8 shares · 498 followers View post →
Christina Vagena-Pantoula
@CVagenaPantoula · X

RT @Pantazis_Lab:

Jul 21, 2023 · 8 shares · 1,701 followers View post →
Inyoung Jeong (Jung)
@InyoungJeong2 · X

RT @Pantazis_Lab:

Jul 21, 2023 · 8 shares · 315 followers View post →
A del Rio Hernandez
@adriohernandez · X

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Jul 20, 2023 · 8 shares · 263 followers View post →
Clara Gordillo Pi
@claragordillopi · X

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Jul 20, 2023 · 8 shares · 43 followers View post →
Marie Breau
@MarieBreau1 · X

RT @Pantazis_Lab:

Jul 20, 2023 · 8 shares · 1,319 followers View post →
KKalyviotis
@KKalyviotis · X

RT @Pantazis_Lab:

Jul 20, 2023 · 8 shares · 1,017 followers View post →
Pantazis_Lab
@Pantazis_Lab · X

Jul 20, 2023 · 35 likes · 8 shares · 261 followers View post →