A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in human NR trials, especially those concerned with metabolism, is that NR supplementation has very few clinically relevant effects." (cont)
What is really known about the effects of nicotinamide riboside supplementation in humans.
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Jul 2023 – Aug 2025Where it's discussed
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X / Twitter43 posts
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News11 articles
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Reddit3 posts
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YouTube2 videos
AI synopsis
What people are saying
The overall tone is cautious and skeptical, exemplified by phrases like 'few clinically relevant effects' and critics pointing out the tendency to overstate benefits. This reflects a recognition that current research is nuanced and somewhat limited, leading to high interest but moderate engagement overall.
Most discussions agree that the current evidence shows limited clinically significant effects, with some dismissing exaggerated claims.
Participants show high interest by citing recent reviews, engaging with detailed scientific explanations, and referencing ongoing debates.
Posts include references to review articles and clinical trials, demonstrating some depth of discussion but not extensive critical analysis.
The conversations highlight a cautious consensus on the limited benefits of NR, influencing perceptions in the scientific and health communities.
Abstract in brief
- Nicotinamide riboside (NR) is a precursor to a vital molecule called NAD+ that has shown metabolic benefits in animal studies, and since 2016, multiple human trials have been conducted to test its safety and effectiveness.
- Current research, including 25 published studies, suggests that oral NR supplementation generally has limited clinically significant effects in humans, and some claims about its benefits may be overstated.
- Despite the modest results, NR may help reduce inflammation and has potential for treating various severe diseases, but more research is needed to clearly understand its true therapeutic potential.]
Top posts
Most liked on X and BlueskyExciting journey to have reviewed all the clinical data on NR in humans with @VargasMads Much is still to be discovered and understood! What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https://t.co/SShhL3kCUm
What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to critically assess this body of literature to identify any baseless or poorly founded claims and assist the field in delineating the future potential of NR https://t.co/oxqXF8TckS
@CharlesMBrenner Which is why the summary is titled, “What is really known about the effects of nicotinamide riboside supplementation in humans”
@danilynx17 @sylvaingirard @_mstrdom @churchofeve @BipolarVix @fiImgal I did it for all of you. There are a handful of sensationalized articles that claim it's a miracle. But the bulk of the literature is pretty dubious that there are any actual positive effects, especially if you don't have some specific illnesses already. https://t.co/xI8xLM6nlz
@CharlesMBrenner I cited a review article Charles, titled: "What is really known about the effects of nicotinamide riboside supplementation in humans" For completeness, here's the full paragraph from which I was quoting: "At the cellular level, NR uptake is mediated by the equilibrative
All mentions
Evaluating the Effects of Nicotinamide Riboside Supplementation in Humans.
This video examines the limited clinical benefits of nicotinamide riboside, a precursor to NAD+, in human studies. While it may reduce inflammation and show potential for treating severe diseases, current research…
Comparing NMN and NR Supplements for Healthy Aging
This video explores the growing interest in NMN and NR supplements and their potential benefits. Focused on scientific findings, it examines which supplement may be more effective for boosting NAD levels and the…
@CharlesMBrenner @nvFede For the interested reader: https://t.co/fCsuqYy815
@danilynx17 @sylvaingirard @_mstrdom @churchofeve @BipolarVix @fiImgal I did it for all of you. There are a handful of sensationalized articles that claim it's a miracle. But the bulk of the literature is pretty dubious that there are any actual positive effects, especially if you don't have some specific illnesses already. https://t.co/xI8xLM6nlz
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
@CharlesMBrenner I cited a review article Charles, titled: "What is really known about the effects of nicotinamide riboside supplementation in humans" For completeness, here's the full paragraph from which I was quoting: "At the cellular level, NR uptake is mediated by the equilibrative
RT @drjonathanchung: What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https:/…
What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https://t.co/s0g29R4lAb
What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https://t.co/eXlymmlMqa
A recent Science Advances review paper delves into the effects of orally administered NR in humans, noting specifically its benefits as an NAD+ booster and its potential impact on inflammaging—age-related changes in the body’s natural inflammatory response https://t.co/OZr9MSkBT3 https://t.co/8lbJxYzibA
My deep dive weekend reading - "What is really known about the effects of nicotinamide riboside supplementation in humans" (the NADPARK #Parkinsons clinical trial research gets mentioned) https://t.co/YOoROMzcBD https://t.co/o3cNdhF27k
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
@drnatedeitz NMN is better than NR: https://t.co/N1PLrOZTmz
RT @RaisingNad: NEW: Dr. Brenner responds to the recent paper entitled "What is really known about the effects of nicotinamide riboside sup…
@theproof @CharlesMBrenner Collectively, oral nicotinamide riboside supplementation has displayed few clinically relevant effects, and there is an unfortunate tendency in the literature to exaggerate the importance and robustness of reported effects. https://t.co/N1PLrOZTmz
NEW: Dr. Brenner responds to the recent paper entitled "What is really known about the effects of nicotinamide riboside supplementation in humans" https://t.co/7YUIHl0Kav
What is really known about the effects of nicotinamide riboside in humans. Unfortunate tendency in the literature to exaggerate the importance and robustness of reported effects. Reduction of inflammatory states and the treatment of diverse severe diseases https://t.co/hEPjiVeO80
robustness of reported effects". However, it "may play a role in the reduction of inflammatory states and has shown some potential in the treatment of diverse severe diseases." I hope that a similar review will be done for NMN. 2/2 https://t.co/Ov0tOqrWaZ
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
@CharlesMBrenner Which is why the summary is titled, “What is really known about the effects of nicotinamide riboside supplementation in humans”
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
What is really known about the effects of nicotinamide riboside supplementation in humans https://t.co/UYqZAyvCgn
https://t.co/kietYCHWUC
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…
A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in human NR trials, especially those concerned with metabolism, is that NR supplementation has very few clinically relevant effects." (cont)
RT @agingdoc1: What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to c…
RT @agingdoc1: What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to c…
RT @agingdoc1: What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to c…
RT @treebak: Exciting journey to have reviewed all the clinical data on NR in humans with @VargasMads Much is still to be discovered and u…
Exciting journey to have reviewed all the clinical data on NR in humans with @VargasMads Much is still to be discovered and understood! What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https://t.co/SShhL3kCUm
RT @agingdoc1: What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to c…
“Collectively, oral nicotinamide riboside supplementation has displayed few clinically relevant effects,..”https://t.co/MSnOhA8TbS
What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to critically assess this body of literature to identify any baseless or poorly founded claims and assist the field in delineating the future potential of NR https://t.co/oxqXF8TckS
REVIEW: What is really known about the effects of #nicotinamideriboside supplementation in humans | Science Advances https://t.co/HCzwolwkXy #NAD+ #NMN #NIACIN Few clinically relevant effects of supplementation??