Sci Adv July 2023 PMID 37478182

What is really known about the effects of nicotinamide riboside supplementation in humans.

Mads V Damgaard, Jonas T Treebak

Mentions

59
Peak: 29 in Jul 2023
across 4 sources since Jul 2023

Extended reach

915,050
potential audience

Total likes

2,170

Video views

115,151

Mentions per month

Jul 2023 – Aug 2025

Where it's discussed

  • X / Twitter43 posts
  • News11 articles
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone is cautious and skeptical, exemplified by phrases like 'few clinically relevant effects' and critics pointing out the tendency to overstate benefits. This reflects a recognition that current research is nuanced and somewhat limited, leading to high interest but moderate engagement overall.

AgreementModerate agreement

Most discussions agree that the current evidence shows limited clinically significant effects, with some dismissing exaggerated claims.

InterestHigh interest

Participants show high interest by citing recent reviews, engaging with detailed scientific explanations, and referencing ongoing debates.

EngagementModerate engagement

Posts include references to review articles and clinical trials, demonstrating some depth of discussion but not extensive critical analysis.

ImpactModerate impact

The conversations highlight a cautious consensus on the limited benefits of NR, influencing perceptions in the scientific and health communities.

Abstract in brief

  • Nicotinamide riboside (NR) is a precursor to a vital molecule called NAD+ that has shown metabolic benefits in animal studies, and since 2016, multiple human trials have been conducted to test its safety and effectiveness.
  • Current research, including 25 published studies, suggests that oral NR supplementation generally has limited clinically significant effects in humans, and some claims about its benefits may be overstated.
  • Despite the modest results, NR may help reduce inflammation and has potential for treating various severe diseases, but more research is needed to clearly understand its true therapeutic potential.]

Top posts

Most liked on X and Bluesky
Dr Brad Stanfield
@BradStanfieldMD · X

A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in human NR trials, especially those concerned with metabolism, is that NR supplementation has very few clinically relevant effects." (cont)

Jul 22, 2023 · 111 likes · 16 shares · 29,241 followers View post →
Jonas Thue Treebak
@treebak · X

Exciting journey to have reviewed all the clinical data on NR in humans with @VargasMads Much is still to be discovered and understood! What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https://t.co/SShhL3kCUm

Jul 22, 2023 · 29 likes · 1 share · 960 followers View post →
Agingdoc
@agingdoc1 · X

What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to critically assess this body of literature to identify any baseless or poorly founded claims and assist the field in delineating the future potential of NR https://t.co/oxqXF8TckS

Jul 21, 2023 · 23 likes · 4 shares · 41,722 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

@CharlesMBrenner Which is why the summary is titled, “What is really known about the effects of nicotinamide riboside supplementation in humans”

Jul 23, 2023 · 11 likes · 29,240 followers View post →
Muskrat Elmo, Muskrat Don
@HawkInATX · X

@danilynx17 @sylvaingirard @_mstrdom @churchofeve @BipolarVix @fiImgal I did it for all of you. There are a handful of sensationalized articles that claim it's a miracle. But the bulk of the literature is pretty dubious that there are any actual positive effects, especially if you don't have some specific illnesses already. https://t.co/xI8xLM6nlz

Oct 29, 2024 · 7 likes · 447 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

@CharlesMBrenner I cited a review article Charles, titled: "What is really known about the effects of nicotinamide riboside supplementation in humans" For completeness, here's the full paragraph from which I was quoting: "At the cellular level, NR uptake is mediated by the equilibrative

Feb 21, 2024 · 4 likes · 29,240 followers View post →

All mentions

TT
@TT_brain · X

@CharlesMBrenner @nvFede For the interested reader: https://t.co/fCsuqYy815

Aug 12, 2025 · 59 followers View post →
Muskrat Elmo, Muskrat Don
@HawkInATX · X

@danilynx17 @sylvaingirard @_mstrdom @churchofeve @BipolarVix @fiImgal I did it for all of you. There are a handful of sensationalized articles that claim it's a miracle. But the bulk of the literature is pretty dubious that there are any actual positive effects, especially if you don't have some specific illnesses already. https://t.co/xI8xLM6nlz

Oct 29, 2024 · 7 likes · 447 followers View post →
Sophia
@tatianataylor32 · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jun 12, 2024 · 16 shares · 18 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

@CharlesMBrenner I cited a review article Charles, titled: "What is really known about the effects of nicotinamide riboside supplementation in humans" For completeness, here's the full paragraph from which I was quoting: "At the cellular level, NR uptake is mediated by the equilibrative

Feb 21, 2024 · 4 likes · 29,240 followers View post →
Laurence Badgley, M.D.
@BadgleyLaurence · X

RT @drjonathanchung: What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https:/…

Dec 6, 2023 · 1 share · 1,112 followers View post →
Jon Chung
@drjonathanchung · X

What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https://t.co/s0g29R4lAb

Dec 6, 2023 · 2 likes · 1 share · 2,071 followers View post →
Christioph
@GlibChristoph · X

What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https://t.co/eXlymmlMqa

Oct 19, 2023 · 109 followers View post →
Tru Niagen
@truniagen · X

A recent Science Advances review paper delves into the effects of orally administered NR in humans, noting specifically its benefits as an NAD+ booster and its potential impact on inflammaging—age-related changes in the body’s natural inflammatory response https://t.co/OZr9MSkBT3 https://t.co/8lbJxYzibA

Sep 26, 2023 · 3 likes · 4,376 followers View post →
The Science of Parkinson's
@ScienceofPD · X

My deep dive weekend reading - "What is really known about the effects of nicotinamide riboside supplementation in humans" (the NADPARK #Parkinsons clinical trial research gets mentioned) https://t.co/YOoROMzcBD https://t.co/o3cNdhF27k

Aug 25, 2023 · 4 likes · 10,905 followers View post →
schdx.btc
@S111504 · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Aug 23, 2023 · 16 shares · 92 followers View post →
GeekContext
@banqjdon · X

@drnatedeitz NMN is better than NR: https://t.co/N1PLrOZTmz

Aug 16, 2023 · 2 likes · 218 followers View post →
Bill Walker
@BWalkerTTAGGG · X

RT @RaisingNad: NEW: Dr. Brenner responds to the recent paper entitled "What is really known about the effects of nicotinamide riboside sup…

Aug 11, 2023 · 1 share · 1,385 followers View post →
GeekContext
@banqjdon · X

@theproof @CharlesMBrenner Collectively, oral nicotinamide riboside supplementation has displayed few clinically relevant effects, and there is an unfortunate tendency in the literature to exaggerate the importance and robustness of reported effects. https://t.co/N1PLrOZTmz

Aug 2, 2023 · 218 followers View post →
RaisingNAD.com
@RaisingNad · X

NEW: Dr. Brenner responds to the recent paper entitled "What is really known about the effects of nicotinamide riboside supplementation in humans" https://t.co/7YUIHl0Kav

Aug 2, 2023 · 4 likes · 1 share · 1,066 followers View post →
Orlando_uy
@Orlando_uy · X

What is really known about the effects of nicotinamide riboside in humans. Unfortunate tendency in the literature to exaggerate the importance and robustness of reported effects. Reduction of inflammatory states and the treatment of diverse severe diseases https://t.co/hEPjiVeO80

Jul 29, 2023 · 694 followers View post →
Chris Linnell
@ChrisPollyanna1 · X

robustness of reported effects". However, it "may play a role in the reduction of inflammatory states and has shown some potential in the treatment of diverse severe diseases." I hope that a similar review will be done for NMN. 2/2 https://t.co/Ov0tOqrWaZ

Jul 25, 2023 · 2 likes · 703 followers View post →
Adri
@atri2adrian · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 25, 2023 · 16 shares · 69 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Jul 24, 2023 · 700 followers View post →
Greenlandshark
@greenlandsharky · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 326 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

@CharlesMBrenner Which is why the summary is titled, “What is really known about the effects of nicotinamide riboside supplementation in humans”

Jul 23, 2023 · 11 likes · 29,240 followers View post →
frank
@frankwikson · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 28 followers View post →
Lifespan News
@LifespanNews · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 22,434 followers View post →
Boris Carikeo
@BCarikeo · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 677 followers View post →
Matt Kaeberlein
@mkaeberlein · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 29,710 followers View post →
hyperlex
@hyperlex2k · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 90 followers View post →
Mathias Herstad Øverås
@Dr_Overas · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 139 followers View post →
John Best
@noobestjohn · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 460 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

What is really known about the effects of nicotinamide riboside supplementation in humans https://t.co/UYqZAyvCgn

Jul 23, 2023 · 2,240 followers View post →
Piyali Mukherjee
@Piyali_neuro · X

https://t.co/kietYCHWUC

Jul 23, 2023 · 1 like · 353 followers View post →
Faselhase
@CarlGustav42 · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 23, 2023 · 16 shares · 148 followers View post →
Jack Henderson
@JackJhe42 · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 22, 2023 · 16 shares · 3,684 followers View post →
Deplorable Dissident
@DeplorableDiss · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 22, 2023 · 16 shares · 27 followers View post →
CRISPR GLENN
@CrisprGlenn · X

RT @BradStanfieldMD: A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in huma…

Jul 22, 2023 · 16 shares · 2,708 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

A good summary of the Nicotinamide Riboside research in humans: https://t.co/SPLZ4u4MnN "The general finding in human NR trials, especially those concerned with metabolism, is that NR supplementation has very few clinically relevant effects." (cont)

Jul 22, 2023 · 111 likes · 16 shares · 29,241 followers View post →
Bayar Jaff
@JaffBayar · X

RT @agingdoc1: What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to c…

Jul 22, 2023 · 4 shares · 606 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to c…

Jul 22, 2023 · 4 shares · 41,722 followers View post →
aesthebi
@103_Takashi · X

RT @agingdoc1: What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to c…

Jul 22, 2023 · 4 shares · 1,760 followers View post →
Jens Lund
@jens_lund · X

RT @treebak: Exciting journey to have reviewed all the clinical data on NR in humans with @VargasMads Much is still to be discovered and u…

Jul 22, 2023 · 1 share · 2,090 followers View post →
Jonas Thue Treebak
@treebak · X

Exciting journey to have reviewed all the clinical data on NR in humans with @VargasMads Much is still to be discovered and understood! What is really known about the effects of nicotinamide riboside supplementation in humans | Science Advances https://t.co/SShhL3kCUm

Jul 22, 2023 · 29 likes · 1 share · 960 followers View post →
The Longevist
@Dr_coachbear · X

RT @agingdoc1: What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to c…

Jul 22, 2023 · 4 shares · 514,751 followers View post →
George Vlasuk
@GVlasuk · X

“Collectively, oral nicotinamide riboside supplementation has displayed few clinically relevant effects,..”https://t.co/MSnOhA8TbS

Jul 21, 2023 · 3 likes · 1,421 followers View post →
Agingdoc
@agingdoc1 · X

What is really known about the effects of nicotinamide riboside supplementation in humans “Specifically, the intent is to critically assess this body of literature to identify any baseless or poorly founded claims and assist the field in delineating the future potential of NR https://t.co/oxqXF8TckS

Jul 21, 2023 · 23 likes · 4 shares · 41,722 followers View post →
Robert West, PhD ✝️
@westr · X

REVIEW: What is really known about the effects of #nicotinamideriboside supplementation in humans | Science Advances https://t.co/HCzwolwkXy #NAD+ #NMN #NIACIN Few clinically relevant effects of supplementation??

Jul 21, 2023 · 1 like · 19,317 followers View post →