Commun Biol July 2023 PMID 37488344

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5.

Tomokazu Tamura, Daichi Yamasoba, Yoshitaka Oda, Jumpei Ito, Tomoko Kamasaki, Naganori Nao, Rina Hashimoto, Yoichiro Fujioka, Rigel Suzuki, Lei Wang, Hayato Ito, Yukie Kashima, Izumi Kimura, Mai Kishimoto, Masumi Tsuda

Mentions

50
Peak: 18 in Aug 2022
across 3 sources since Aug 2022

Extended reach

551,521
potential audience

Total likes

132

Video views

149

Mentions per month

Aug 2022 – Oct 2024

Where it's discussed

  • X / Twitter45 posts
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

Participants often reference specific findings from the research, like the enhanced fusogenicity of the BA.5 subvariant compared to BA.1 and BA.2. Comments include phrases such as 'urgent investigation' and 'strong inflammatory response,' which convey a tone of concern and urgency. The use of scientific vocabulary and quick-follow-up discussions about implications emphasizes the significance of the publication in the context of ongoing COVID-19 management.

AgreementModerate agreement

The majority of discussions indicate general support for the findings presented in the publication, with users often highlighting the differences between the Omicron subvariants.

InterestHigh interest

There is a strong level of curiosity displayed, with many participants discussing the publication's implications and details, suggesting that the topic resonates significantly with users.

EngagementModerate engagement

While the depth of engagement varies, several comments reference specific scientific findings and their implications, showing that users are not just skimming but are actively processing the information.

ImpactHigh impact

Many believe that the findings of the publication could substantially influence ongoing research and public health strategies, as indicated by the frequent mention of BA.5's heightened pathogenicity.

Abstract in brief

  • The emergence of the Omicron subvariant BA.5 of SARS-CoV-2 requires urgent investigation due to its rapid spread and the need for ongoing control measures.
  • BA.5 exhibits enhanced fusogenicity and a greater ability to disrupt respiratory barriers compared to earlier subvariants BA.1 and BA.2, even though its in vitro growth rates are similar.
  • In a hamster model, BA.5 shows slightly higher pathogenicity than other Omicron variants but less than the ancestral strain, along with improved virus spread and immune response activation.

Top posts

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Emmanuel
@ejustin46 · X

"Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2." https://t.co/p52BpAvDAw https://t.co/0WKmRel9bY

Oct 2, 2023 · 67 likes · 24 shares · 17,287 followers View post →
Michael Wagner
@MichiWagner4 · X

" Importantly, inflammatory response against BA.5 is strong compared with BA.1 and BA.2" Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/vC0WJDh1rg

Aug 7, 2022 · 33 likes · 7 shares · 12,517 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | Communications Biology https://t.co/C0u7j7o8e4

Oct 2, 2023 · 5 likes · 1 share · 34,712 followers View post →
Sandbird
@Sandbird_ · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. https://t.co/sGKK3NWr0n

Jul 28, 2023 · 5 likes · 1,756 followers View post →
bioRxiv Microbiology
@biorxiv_micrbio · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/WoCFP7jDf4 #biorxiv_micrbio

Aug 5, 2022 · 4 likes · 4 shares · 20,871 followers View post →
MI6 ROGUE
@mi6rogue · X

Preliminary report; Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5: Unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants imposes us to continuous control… Read more ↓ https://t.co/vhYlJW4g0R

Aug 6, 2022 · 3 likes · 59,264 followers View post →

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Wappmann 
@KarinWappmann · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Feb 17, 2024 · 24 shares · 819 followers View post →
Pierre CONSTANS/T
@ConstansPierre · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Feb 17, 2024 · 24 shares · 204 followers View post →
Emmanuel
@ejustin46 · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Feb 17, 2024 · 24 shares · 17,287 followers View post →
Martin Mölder
@MolderMartin · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Nov 20, 2023 · 24 shares · 159 followers View post →
Emmanuel
@ejustin46 · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Nov 20, 2023 · 24 shares · 17,287 followers View post →
MarianW
@MarianWert · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 5, 2023 · 24 shares · 68 followers View post →
Kate Moylan
@kate_moylan · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 4, 2023 · 24 shares · 5,609 followers View post →
ヤン・ウェンリー提督
@yangwenli1007 · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 4, 2023 · 24 shares · 17 followers View post →
Emmanuel
@ejustin46 · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 4, 2023 · 24 shares · 17,287 followers View post →
Gerard Hough
@GerardHough · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 3, 2023 · 24 shares · 1,747 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Virological features of Omicron subvariants in vitro. From: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/jsHvLZADPY

Oct 2, 2023 · 34,712 followers View post →
SallyBee87
@Bee87Sally · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 2, 2023 · 24 shares · 33 followers View post →
Clotilde I.
@Cloclozazaprive · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

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cacouteau
@cacouteau · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 2, 2023 · 24 shares · 2,872 followers View post →
Tania
@tsures2 · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 2, 2023 · 24 shares · 428 followers View post →
motiongirlie Ⓥ
@motiongirlie · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 2, 2023 · 24 shares · 872 followers View post →
Florence CL
@Covid19Florence · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

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mig30m6
@mig30m6 · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

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bhPluto
@87transceiver · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 2, 2023 · 24 shares · 270 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | Communications Biology https://t.co/C0u7j7o8e4

Oct 2, 2023 · 5 likes · 1 share · 34,712 followers View post →
Roland Baker
@RolandBakerIII · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 2, 2023 · 24 shares · 8,168 followers View post →
Clannad99
@Clannad992 · X

RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…

Oct 2, 2023 · 24 shares · 2,316 followers View post →
Emmanuel
@ejustin46 · X

"Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2." https://t.co/p52BpAvDAw https://t.co/0WKmRel9bY

Oct 2, 2023 · 67 likes · 24 shares · 17,287 followers View post →
Sandbird
@Sandbird_ · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. https://t.co/sGKK3NWr0n

Jul 28, 2023 · 5 likes · 1,756 followers View post →
Phage Papers
@Phage_Papers · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/RhFTCx1iPJ

Jul 25, 2023 · 646 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Time-course dynamics of Omicron subvariants in vivo. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/Bczp6eMweQ

Jul 24, 2023 · 1 like · 34,712 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Virological features of Omicron subvariants in vitro. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/JG5R33zl2j

Jul 24, 2023 · 2 likes · 34,712 followers View post →
meltypot
@meltypot · X

RT @hichachu: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | bioRxiv 日本から BA.5を他のオミクロン亜系統BA.1…

Aug 8, 2022 · 2 shares · 1,148 followers View post →
ニューロドクター乱夢
@hichachu · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | bioRxiv 日本から BA.5を他のオミクロン亜系統BA.1、BA.2、および祖先のB.1.1と総合的に解析した。BA.5のin vitro成長速度はOmicron変異株の中で同等であるがBA.5はBA.1やBA.2 https://t.co/YDq88A7ALN

Aug 8, 2022 · 2 likes · 2 shares · 4,256 followers View post →
Shirley
@Shirleyinaktiv · X

RT @MichiWagner4: " Importantly, inflammatory response against BA.5 is strong compared with BA.1 and BA.2" Comparative pathogenicity of SA…

Aug 8, 2022 · 7 shares · 3,810 followers View post →
Outbreak Science
@outbreaksci · X

New: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/LTn2VzR7ao read/write/request review https://t.co/RnurTL3DyM #coronavirus #COVID19

Aug 8, 2022 · 1,377 followers View post →
Fred_S_at
@Fred_S_at · X

RT @MichiWagner4: " Importantly, inflammatory response against BA.5 is strong compared with BA.1 and BA.2" Comparative pathogenicity of SA…

Aug 8, 2022 · 7 shares · 529 followers View post →
papers.bar
@papers_bar · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/HRE9gIuQCd New Omicron subvariant named BA.5 is urgently required for characterization. In vitro growth...

Aug 8, 2022 · 1,195 followers View post →
@Flohchen_19
@Flohchen_19 · X

RT @MichiWagner4: " Importantly, inflammatory response against BA.5 is strong compared with BA.1 and BA.2" Comparative pathogenicity of SA…

Aug 8, 2022 · 7 shares · 1,453 followers View post →
Derford
@derford41 · X

RT @MichiWagner4: " Importantly, inflammatory response against BA.5 is strong compared with BA.1 and BA.2" Comparative pathogenicity of SA…

Aug 8, 2022 · 7 shares · 571 followers View post →
A. H.
@angelika_holcik · X

RT @MichiWagner4: " Importantly, inflammatory response against BA.5 is strong compared with BA.1 and BA.2" Comparative pathogenicity of SA…

Aug 8, 2022 · 7 shares · 156 followers View post →
Michael Wagner
@MichiWagner4 · X

" Importantly, inflammatory response against BA.5 is strong compared with BA.1 and BA.2" Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/vC0WJDh1rg

Aug 7, 2022 · 33 likes · 7 shares · 12,517 followers View post →
Liz Szabo
@LizSzabo · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | bioRxiv https://t.co/29gYDi3VA3

Aug 7, 2022 · 65,027 followers View post →
@PetesLibrary
@peteslibrary · X

Coronavirus: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | bioRxiv https://t.co/M7s2Is81Sv

Aug 7, 2022 · 10 followers View post →
Medical Science and Technology #earlytreatments
@MedicalScitech · X

Tomokazu Tamura, Daichi Yamasoba, Yoshitaka Oda et al., The Genotype to Phenotype Japan (G2P-Japan) Consortium, Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5, bioRxiv 2022.08.05.502758; doi: https://t.co/VvWGyHiTnX https://t.co/mlwhapxS9q

Aug 6, 2022 · 632 followers View post →
MI6 ROGUE
@mi6rogue · X

Preliminary report; Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5: Unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants imposes us to continuous control… Read more ↓ https://t.co/vhYlJW4g0R

Aug 6, 2022 · 3 likes · 59,264 followers View post →
Dr. Andrew Ngbede Paul
@Dr_anpdvm4real · X

RT @biorxiv_micrbio: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/WoCFP7jDf4 #b…

Aug 5, 2022 · 4 shares · 106 followers View post →
RogueLemming
@ForgeRat · X

RT @biorxiv_micrbio: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/WoCFP7jDf4 #b…

Aug 5, 2022 · 4 shares · 2,418 followers View post →
bioRxiv Microbiology
@biorxiv_micrbio · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/WoCFP7jDf4 #biorxiv_micrbio

Aug 5, 2022 · 4 likes · 4 shares · 20,871 followers View post →
bioRxiv
@biorxivpreprint · X

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/QutNTmkHdg #bioRxiv

Aug 5, 2022 · 2 likes · 137,307 followers View post →