Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5.

Tomokazu Tamura, Daichi Yamasoba, Yoshitaka Oda, Jumpei Ito, Tomoko Kamasaki, Naganori Nao, Rina Hashimoto, Yoichiro Fujioka, Rigel Suzuki, Lei Wang, Hayato Ito, Yukie Kashima, Izumi Kimura, Mai Kishimoto, Masumi Tsuda

July 2023 Commun Biol

Synopsis of Social media discussions

Participants often reference specific findings from the research, like the enhanced fusogenicity of the BA.5 subvariant compared to BA.1 and BA.2. Comments include phrases such as 'urgent investigation' and 'strong inflammatory response,' which convey a tone of concern and urgency. The use of scientific vocabulary and quick-follow-up discussions about implications emphasizes the significance of the publication in the context of ongoing COVID-19 management.

A
Agreement
 Moderate agreement

The majority of discussions indicate general support for the findings presented in the publication, with users often highlighting the differences between the Omicron subvariants.

I
Interest
 High level of interest

There is a strong level of curiosity displayed, with many participants discussing the publication's implications and details, suggesting that the topic resonates significantly with users.

E
Engagement
 Moderate level of engagement

While the depth of engagement varies, several comments reference specific scientific findings and their implications, showing that users are not just skimming but are actively processing the information.

I
Impact
 High level of impact

Many believe that the findings of the publication could substantially influence ongoing research and public health strategies, as indicated by the frequent mention of BA.5's heightened pathogenicity.

Social Mentions

YouTube

2 Videos

Twitter

45 Posts

Reddit

3 Posts

Metrics

Video Views

149

Total Likes

132

Extended Reach

551,521

Social Features

50

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Pathogenicity Analysis of SARS-CoV-2 Omicron Subvariants

Pathogenicity Analysis of SARS-CoV-2 Omicron Subvariants

This video presents an analysis of the comparative pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5. Using animated race charts, we contrast their relative progressions over a 72-hour period, highlighting BA.5's enhanced fusogenicity and improved immune response activation.

Mike Honey

October 18, 2024

86 views

Comparative Pathogenicity of SARS-CoV-2 Omicron Subvariants

Comparative Pathogenicity of SARS-CoV-2 Omicron Subvariants

This video analyzes the comparative pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5. It highlights the enhanced fusogenicity and greater respiratory barrier disruption of BA.5, alongside its slightly higher pathogenicity in animal models.

Mike Honey

October 18, 2024

63 views

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    RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…
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  • Prof. Dr. Sanjeev Bagai
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    Virological features of Omicron subvariants in vitro. From: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/jsHvLZADPY
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    October 2, 2023

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  • Prof. Dr. Sanjeev Bagai
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    Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | Communications Biology https://t.co/C0u7j7o8e4
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    October 2, 2023

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    RT @ejustin46: "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kine…
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  • Emmanuel
    @ejustin46 (Twitter)

    "Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5" "Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2." https://t.co/p52BpAvDAw https://t.co/0WKmRel9bY
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    October 2, 2023

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  • Sandbird
    @Sandbird_ (Twitter)

    Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. https://t.co/sGKK3NWr0n
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    July 28, 2023

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    Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/RhFTCx1iPJ
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    July 25, 2023

  • Prof. Dr. Sanjeev Bagai
    @BagaiDr (Twitter)

    Time-course dynamics of Omicron subvariants in vivo. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/Bczp6eMweQ
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    July 24, 2023

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  • Prof. Dr. Sanjeev Bagai
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    Virological features of Omicron subvariants in vitro. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/JG5R33zl2j
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    July 24, 2023

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  • meltypot
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    RT @hichachu: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | bioRxiv 日本から BA.5を他のオミクロン亜系統BA.1…
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    August 8, 2022

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    Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 | bioRxiv 日本から BA.5を他のオミクロン亜系統BA.1、BA.2、および祖先のB.1.1と総合的に解析した。BA.5のin vitro成長速度はOmicron変異株の中で同等であるがBA.5はBA.1やBA.2 https://t.co/YDq88A7ALN
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    New: Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/LTn2VzR7ao read/write/request review https://t.co/RnurTL3DyM #coronavirus #COVID19
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    Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/HRE9gIuQCd New Omicron subvariant named BA.5 is urgently required for characterization. In vitro growth...
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  • Michael Wagner
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    " Importantly, inflammatory response against BA.5 is strong compared with BA.1 and BA.2" Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 https://t.co/vC0WJDh1rg
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    Tomokazu Tamura, Daichi Yamasoba, Yoshitaka Oda et al., The Genotype to Phenotype Japan (G2P-Japan) Consortium, Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5, bioRxiv 2022.08.05.502758; doi: https://t.co/VvWGyHiTnX https://t.co/mlwhapxS9q
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Abstract Synopsis

  • - The emergence of the Omicron subvariant BA.5 of SARS-CoV-2 requires urgent investigation due to its rapid spread and the need for ongoing control measures.
  • - BA.5 exhibits enhanced fusogenicity and a greater ability to disrupt respiratory barriers compared to earlier subvariants BA.1 and BA.2, even though its in vitro growth rates are similar.
  • - In a hamster model, BA.5 shows slightly higher pathogenicity than other Omicron variants but less than the ancestral strain, along with improved virus spread and immune response activation.