December 2023 PMID 37498156

The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study.

John M VanBuren, Mark Hall, Athena F Zuppa, Peter M Mourani, Joseph Carcillo, J Michael Dean, Kevin Watt, Richard Holubkov

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Mentions

Peak: 3 in Dec 2023

across 2 sources since Nov 2023

Extended reach

31,267

potential audience

Total likes

Video views

1,908

Mentions per month

Nov 2023 – Dec 2023

Where it's discussed

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YouTube1 videos

AI synopsis

What people are saying

The discussions reveal a strong interest in the innovative trial approaches and personalized treatments presented in the article, with mentions of the potential for improving outcomes in pediatric sepsis. Words like 'possibilities' and references to podcasts suggest a positive tone and curiosity about the research's implications, emphasizing its relevance and potential transformative impact in the field.

AgreementModerate agreement

The discussions reflect general support for the importance of personalized immunomodulation and innovative trial designs, indicating agreement with the publication's approach.

InterestHigh interest

Participants show high interest by engaging with topics like immunology, inflammation, and personalized treatments, demonstrated through enthusiastic language.

EngagementModerate engagement

Comments include praise and references to podcasts discussing the research, suggesting a moderate level of in-depth engagement.

ImpactModerate impact

The discussions highlight the potential significance of adaptive trial designs and personalized treatments in pediatric intensive care, indicating a moderate impact.

Abstract in brief

It includes two main study arms: the GRACE2 trial, testing GMCSF to reverse immunoparalysis, and the TRIPS trial, testing different doses of anakinra to reduce systemic inflammation, both utilizing adaptive statistical frameworks for early stopping based on efficacy or futility.
The trials are conducted across 24 US pediatric intensive care units (PICUs) and measure outcomes mainly through the pediatric logistic organ dysfunction (PELOD) score over 28 days, with data analysis employing non-parametric tests like the Wilcoxon Rank Sum to compare treatment effects.]

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All mentions

Personalized Immunotherapy Approaches for Critically Ill Children with Sepsis

Dr. Mark Hall discusses immunology and inflammation in pediatric sepsis treatment using immune phenotyping to personalize treatment. The talk covers the history of inflammatory responses, distinguishes between…

OPENPediatrics · Nov 27, 2023 1,908 views

Kerri LaRovere MD, MMSc

@KerriLarovere · X

RT @OPENPediatrics: Our Physician World Shared Practice Forum podcast is here. Listen as Dr. Mark Hall discusses immunology, inflammation,…

Dec 1, 2023 · 2 shares · 1,009 followers View post →

Jeffrey Burns, MD

@burns_md · X

RT @OPENPediatrics: Our Physician World Shared Practice Forum podcast is here. Listen as Dr. Mark Hall discusses immunology, inflammation,…

Dec 1, 2023 · 2 shares · 484 followers View post →

OPENPediatrics

@OPENPediatrics · X

Dec 1, 2023 · 6 likes · 2 shares · 13,927 followers View post →