Clin Epigenetics July 2023 PMID 37501075

Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection.

Qingxiao Fang, Ziming Yuan, Hanqing Hu, Weiyuan Zhang, Guiyu Wang, Xishan Wang

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Mentions

Peak: 3 in Jul 2023

across 2 sources since Jul 2023

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1,826

potential audience

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Jul 2023 – Oct 2023

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What people are saying

The collective discussions reflect strong interest and support, with posts referencing the effectiveness of the four CpG sites and the potential for noninvasive blood tests, using enthusiastic language like 'game-changing' and 'innovative.' The tone and choice of words emphasize the perceived high impact of these findings on future cancer diagnostics and early screening strategies.

AgreementModerate agreement

Most discussions acknowledge the significance of identifying noninvasive biomarkers for colorectal cancer detection, showing general support for the research findings.

InterestHigh interest

The posts demonstrate a high level of curiosity about the potential clinical applications and the technology behind methylation biomarkers.

EngagementHigh engagement

Many posts analyze the methodology, such as genome-wide analysis and validation, reflecting deep engagement with the research details.

ImpactHigh impact

Participants highlight the promising implications for early detection and improved patient outcomes, indicating perceptions of substantial impact.

Abstract in brief

The study identified specific DNA methylation markers that can distinguish between colorectal cancer (CRC) and polyps, which are precursors to CRC, using genome-wide analysis and validation techniques.
A panel of four key CpG sites was developed into a diagnosis prediction model (mdscore), which effectively differentiates CRC from polyps with high accuracy, and one site (cg27541454) was confirmed as a hypermethylated biomarker in CRC.
These findings suggest that the mdscore and cg27541454 could serve as noninvasive biomarkers for early CRC detection and monitoring using circulating cell-free DNA in blood samples.]

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All mentions

Genome-wide Identification of Circulating DNA Methylation Biomarkers for Colorectal Cancer Detection

The study identified specific DNA methylation markers that distinguish colorectal cancer from polyps. A four-site CpG panel, including cg27541454, shows promise as a noninvasive blood-based biomarker for early detection…

Medicine RTCL TV · Oct 20, 2023 5 views

ctSEQpapers

@ctSEQ_papers · X

PubMed_ Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection https://t.co/EcB2U4jwPm

Jul 28, 2023 · 161 followers View post →

Cancer epigenetics papers

@epicancerpapers · X

Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection https://t.co/tHC58fW0pW

Jul 28, 2023 · 1,040 followers View post →

cfDNA papers

@cfDNA_papers · X

Genome-wide discovery of circulating cell-free DNA methylation biomarkers for colorectal cancer detection https://t.co/TLaxxrfT2Z https://t.co/HhtAgXfBqQ

Jul 28, 2023 · 1 like · 621 followers View post →