The discussions reflect strong agreement about the promising nature of antihistamines for long-COVID, with users quoting studies and emphasizing the role of mast cell activation, using words like 'confirm,' 'supports,' and 'encouraging.' The tone is both supportive and exploratory, emphasizing the potential clinical impact while acknowledging current limitations.
AgreementStrong agreement
Most discussions support the research, emphasizing positive findings and potential treatment implications.
InterestModerate interest
There is moderate curiosity and skepticism, with some commenters wishing for more studies or sharing personal experiences.
EngagementHigh engagement
Many users actively reference specific studies, share summaries, and discuss scientific details, indicating deep involvement.
ImpactHigh impact
The conversations highlight significant potential for treatment, as many see this research as promising for addressing long-COVID symptoms.
Abstract in brief
The study investigates long-COVID, a complex condition with no effective treatments, particularly focusing on cardiovascular symptoms like high heart rate and palpitations linked to mast cell activation (MCA).
Researchers administered histamine receptor blockers (fexofenadine and famotidine) to 14 patients with long-COVID symptoms over 20 days and compared results with 13 control subjects.
Results showed that 29% of treated patients experienced complete symptom resolution, with significant improvements in all treated individuals, supporting the idea that targeting histamine receptors may be a viable treatment for long-COVID.
"Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation"
https://t.co/SksOoerwIZ
Aug 7, 2023 · 114 likes · 45 shares · 13,821 followersView post →
MS
Michael Stingl
@neurostingl · X
Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entweder Antihistaminika bekamen oder nicht.
Antihistaminika hatten, wie oft im klinischen Alltag beobachtet, positiven Effekt.
https://t.co/GwEQ1M3FAy
Aug 2, 2023 · 89 likes · 17 shares · 16,325 followersView post →
R
rahaeli
@rahaeli.bsky.social · Bluesky
Finally, there's starting to be a really solid link between COVID, long COVID, and mast cell activation, and you might want to look up mast cell activation syndrome (MCAS). Treating long COVID like MCAS causes improvements in about 30% of patients: pubmed.ncbi.nlm.nih.gov/37529714/
Antihistamines improve cardiovascular manifestations and other symptoms of long COVID attributed to mast cell activation. The study involving 14 patients treated with histamine receptor blockers demonstrated significant…
Errata corrects the Lancet article from June 8, 2023, not January 8. The video discusses the impact of COVID on Italian physicians and recent findings that antihistamines can improve long-COVID symptoms related to mast…
This study explores the role of histamine in long COVID and examines how a combination of antihistamines and antiulcer medications may offer a breakthrough treatment. Promising results showed symptom resolution in many…
And more (also small-N) evidence that the combination can help people with a range of PASC symptoms:
pubmed.ncbi.nlm.nih.gov/37529714/
pubmed.ncbi.nlm.nih.gov/37327698/
@healingfromlc 2. “Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation”
https://t.co/UjJiWpN4e2
@LostitNft @dr_ianjackson @Salliepops @JaHo84 @BreezerGalway @SwaledaleMutton @LaymansScience @BerryTartlet I wish there were more studies available.
They are either too old or too small to reach a conclusion.
Seems logical, but unfortunately in medicine it doesn't always go from a hypothesis to an effective treatment.
https://t.co/QzPpH03Lyx
@cnnctngflght @gerdantes Hier zwei Studien https://t.co/jO7eLyrJuO
https://t.co/qOQxwL3wEr
Vielleicht war deshalb auch die hochdosierte Gabe von Vit C i.V. wirksam,da die Mastzellaktivierung erfolgreich unterdrückt wird. Leider wurde diese Studie aus der Ärztezeitung entfernt. Absicht?
RT @bhanlon15: "Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation"…
Jun 20, 2024 · 45 shares · 2,176 followersView post →
M
MarliesKdG
@MarliesKdG · X
@itsMErieke @MEnaced_2016 @BecsTeamplanet Dit is er 1 die ik zo terug kon vinden. Weet niet of dit de sterkste is.
Je kunt @chydorina volgen, zij twittert hier ook veel over. Heeft oom heel duidelijke filmpjes waarin ze het uitlegt.
https://t.co/6cqEJb7jMc
RT @VsLongcovid: Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activ… https…
May 16, 2024 · 8 shares · 3,471 followersView post →
A
Alex
@AxFS_MD · X
La activación de Mastocitos desempeñan un papel en el Sd Post #COVID19, incluso en las manifestaciones cardiovasculares.
Se administró Fexofenadina y Famotidina, ambos antihistamínicos, y los síntomas desaparecieron en un 29% de los pacientes.
https://t.co/yW5CF72SaC
Apr 21, 2024 · 1 like · 1 share · 162 followersView post →
M
MALÉFICA
@MALEFICA1973 · X
RT @VsLongcovid: Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activ… https…
Het was deze, zag dat het al ietsje ouder is (vorig jaar gepubliceerd). Ik weet ook van patiëntenfora dat in andere landen waar deze middelen wel vrij verkrijgbaar veel patiënten dit zelf proberen. Soms met (deels) positief resultaat, soms niet.
pubmed.ncbi.nlm.nih.gov/37529714/
Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation - histamine receptors blockade may be an effective target to successfully treat long-COVID. https://t.co/TCyASrIixZ
RT @Ofmtpocimmz: @JRW_in_the_Keys Most likely you have already tried this but just in case you haven't I thought it worth while to pass it…
Feb 20, 2024 · 1 share · 1,088 followersView post →
EN
Erik Nelson
@Ofmtpocimmz · X
@JRW_in_the_Keys Most likely you have already tried this but just in case you haven't I thought it worth while to pass it - "Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation" - search "fatigue".
https://t.co/amrzrVUjEV.
Feb 20, 2024 · 1 like · 1 share · 403 followersView post →
R
rahaeli
@rahaeli.bsky.social · Bluesky
Anyway, here's the most recent paper for the antihistamine protocol in LC: it's only n=14 in the treatment arm but 30% had a complete remission of symptoms and every treated patient improved somewhat. pubmed.ncbi.nlm.nih.gov/37529714/
On off chance this nested thread is seen, here's another study re an H1 receptor antagonist (fexofenadine) & famotidine in small group (14 pts/13 controls) w persistent Covid sx (fatigue, brain fog, abdominal disorders & increased heart rate).
Encouraging results.
pubmed.ncbi.nlm.nih.gov/37529714/
RT @Dakota_150: "Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation"…
Dec 11, 2023 · 45 shares · 2,176 followersView post →
R
rahaeli
@rahaeli.bsky.social · Bluesky
Finally, there's starting to be a really solid link between COVID, long COVID, and mast cell activation, and you might want to look up mast cell activation syndrome (MCAS). Treating long COVID like MCAS causes improvements in about 30% of patients: pubmed.ncbi.nlm.nih.gov/37529714/
Oct 2, 2023 · 28 likes · 10 shares · 13,591 followersView post →
KM
Kirk Murphy
@kirkmurphy.bsky.social · Bluesky
"Our data confirm that histamine receptors blockade may be an effective target to successfully treat long-COVID. Our finding supports the underlying role of MCA in the pathophysiology of long-COVID."
pubmed.ncbi.nlm.nih.gov/37529714/
RT @neurostingl: Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entwe…
Aug 3, 2023 · 17 shares · 242 followersView post →
SM
sandee_muc
@dee_munich · X
RT @neurostingl: Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entwe…
Aug 3, 2023 · 17 shares · 718 followersView post →
AV
Aimee Valeur
@AimeeValeur · X
RT @neurostingl: Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entwe…
Aug 3, 2023 · 17 shares · 3,806 followersView post →
S
SunnyDay
@SunnyDayYeah · X
RT @neurostingl: Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entwe…
Aug 3, 2023 · 17 shares · 319 followersView post →
L
LongCovid
@LongCovid8 · X
Nuestros datos confirman que el bloqueo de los receptores de histamina puede ser un objetivo eficaz para tratar con éxito la larga duración de la COVID-19. Nuestro hallazgo respalda el papel subyacente de MCA en la fisiopatología de COVID-19 prolongado.
https://t.co/ueNd1lxhcq
RT @neurostingl: Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entwe…
Aug 2, 2023 · 17 shares · 1,225 followersView post →
DF
Dr. Markus Fraczek
@MarekSJF · X
RT @neurostingl: Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entwe…
Aug 2, 2023 · 17 shares · 3,007 followersView post →
DB
Doris Bleyer
@DorisBleyer · X
RT @neurostingl: Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entwe…
Aug 2, 2023 · 17 shares · 591 followersView post →
MS
Michael Stingl
@neurostingl · X
Leider kein RCT...
Retrospektive Analyse von Pat mit #LongCovid und klinischem Hinweis auf Mastzellaktivierung, die entweder Antihistaminika bekamen oder nicht.
Antihistaminika hatten, wie oft im klinischen Alltag beobachtet, positiven Effekt.
https://t.co/GwEQ1M3FAy
Aug 2, 2023 · 89 likes · 17 shares · 16,325 followersView post →
SH
Sáfárné Hatrágyi Henrietta
@HatragyiSafarne · X
Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation.
Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation #LongCovid #pwLC https://t.co/VDygx9aM90
Aug 2, 2023 · 2 likes · 2,134 followersView post →
OF
Ordo Fraterna Fibonacci
@OrdoFibonacci · X
Frontiers | Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation
https://t.co/pmcU9k1aDw
査読付『抗ヒスタミン薬はマスト細胞の活性化に起因する心血管症状や Long Covid その他の症状を改善する』
Long Covid患者に、フェキソフェナジン(180mg/日)とファモチジン(40mg/日)を20日間投与。
29%の人が症状が消失、その他も有意な改善をみた、と。
https://t.co/QYbSWS9811
Suivie depuis début 2020 pour Long Covid, je n'ai pas toléré les antihistaminiques. Je suis bien placée pour en parler @THAILANDMEDICA1
https://t.co/y9QOLAtSsi https://t.co/36wwfv15UE
Histamine receptors blockade may be an effective target to successfully treat long-COVID. Our finding supports the underlying role of MCA in the pathophysiology of #longCOVID @ProfSchieffer @SchiefferDr https://t.co/emNEVFCtpF
Salvucci F, Codella R, Coppola A, Zacchei I, Grassi G, Anti ML, Nitisoara N, Luzi L and Gazzaruso C (2023) Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation. Front. Cardiovasc. Med. 10:1202696. doi: https://t.co/8YLeD5Tduo https://t.co/EmZGXyjju2
@IchBin_RO @ClausErnst The actual Italian Clinical study
Daily treatment of fexofenadine (180 mg) and famotidine (40 mg) for 20 days found to improve Long COVID conditions
https://t.co/dP0m47KK9W
New Research: Antihistamines improve cardiovascular manifestations and other symptoms of long-COVID attributed to mast cell activation: Introduction
Long-COVID is a broadly defined condition and there are no effective therapies.… #cardiovascular https://t.co/dfxvJ4Yu6d
Study: Antihistamines improve cardiovascular manifestations and ...
Reddit
... , Luzi L and Gazzaruso C (2023) Front. Cardiovasc. Med. 10:1202696. doi: 10.3389/fcvm.2023.1202696. Upvote 16. Downvote 4 Go to comments. Share ...