ACS Infect Dis August 2023 PMID 37530426

Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity.

Patrick M Tate, Vincent Mastrodomenico, Christina Cunha, Joshua McClure, Annelise E Barron, Gill Diamond, Bryan C Mounce, Kent Kirshenbaum

Download social card

Mentions

34
Peak: 27 in Aug 2023
across 5 sources since Aug 2023

Extended reach

124,116
potential audience

Total likes

927

Video views

19,235

Mentions per month

Aug 2023 – Nov 2025

Where it's discussed

  • X / Twitter19 posts
  • News9 articles
  • YouTube3 videos
  • Blogs2 articles
  • Facebook1 posts

AI synopsis

What people are saying

Overall, discussions show high interest and moderate engagement, with examples like mentions of the broad antiviral activity of peptidomimetic oligomers and their membrane-specific targeting mechanism. The tone ranges from celebratory acknowledgments to technical explanations, illustrating recognition of the research's significance and potential real-world applications.

AgreementModerate agreement

Most discussions express positive recognition of the study's significance, highlighting its novelty and potential impact, though some innocuous comments suggest general acknowledgment rather than strong endorsement.

InterestHigh interest

The discussions reflect high interest, with many posts emphasizing the broad antiviral activity and innovations in targeting viral membranes, demonstrating engagement with the scientific content.

EngagementModerate engagement

Participants show moderate engagement by referencing specific aspects such as the membrane-specific mechanism and the therapeutic potential, along with personal contributions like PhD work and recognition of the authors.

ImpactModerate impact

The collective tone indicates that the publication is considered to have a notable impact on antiviral research and therapeutic development, especially given references to broad activity and resistance mitigation.

Abstract in brief

  • Peptidomimetic oligomers called peptoids can directly target and disable various enveloped viruses, including Zika and chikungunya, by disrupting their membranes.
  • These peptoids specifically interact with phosphatidylserine (PS), a lipid component in viral membranes, leading to membrane disruption, whereas they don't affect membranes with only phosphatidylcholine (PC).
  • The findings suggest that peptoids work through a membrane-specific mechanism, offering a promising new approach for antiviral therapies that could minimize resistance development.]

Top posts

Most liked on X and Bluesky
Patrick Tate
@PatrickMTate · X

my first first-author paper during my PhD is finally out! thank you so much @bryancmounce for letting me still bother you ( even after you FIRED ME ) to complete some of this work. and obviously thank you to @mastvr1 & @christina_cunha for being a dream https://t.co/PEos2X00gS

Aug 2, 2023 · 31 likes · 5 shares · 351 followers View post →
NYU Chemistry
@nyuchemistry · X

ACS Infectious Diseases study "Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity" is generating attention.  Congrats to  lead author grad student Patrick Tate and Professor Kent Kirshenbaum! @aroralabnyu https://t.co/RMigXxoMtc

Aug 2, 2023 · 8 likes · 3,111 followers View post →
Agingdoc
@agingdoc1 · X

Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity https://t.co/IASm6EOZGv @ACSPublications https://t.co/o43Z0ZQSuO

Aug 3, 2023 · 4 likes · 3 shares · 43,925 followers View post →
J Scotch McClure
@joshuamcclure · X

@therustychemist @MaxwellBiosci Good question. Good answer: Here is our 2023 American Chemical Society publication on that topic: https://t.co/VF8TzpiuJ5 Alright, let's break this down. Imagine viruses as little invaders with either a protective coat, called an enveloped virus, or without one, which we'll

Oct 6, 2023 · 4 likes · 1 share · 18,928 followers View post →
PostX #UniteToFight2024
@TeamPostX · X

Biomimicry with bursting. Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine establishing an avenue for specificity that may enable the development of a new family of therapeutics capable of averting the rapid development of resistance. https://t.co/SvUZR3g7wN

Aug 7, 2023 · 1 like · 2,089 followers View post →
Jayanta Haldar
@jayanta_amr · X

Article Update! This article published in the August issue of ACS ID, shows the antiviral activity of AMP mimetic peptoids against an array of enveloped viruses, acting through a membrane-specific mechanism. https://t.co/WaIAYfq5sI @ACSBioMed #ACSInfectiousDiseases

Sep 5, 2023 · 1 like · 459 followers View post →

All mentions

Darian Draught.
@98Draught98 · X

RT @PatrickMTate: my first first-author paper during my PhD is finally out! thank you so much @bryancmounce for letting me still bother you…

Nov 25, 2023 · 5 shares · 177 followers View post →
J Scotch McClure
@joshuamcclure · X

RT @joshuamcclure: @therustychemist @MaxwellBiosci Good question. Good answer: Here is our 2023 American Chemical Society publication on t…

Oct 6, 2023 · 1 share · 18,928 followers View post →
J Scotch McClure
@joshuamcclure · X

@therustychemist @MaxwellBiosci Good question. Good answer: Here is our 2023 American Chemical Society publication on that topic: https://t.co/VF8TzpiuJ5 Alright, let's break this down. Imagine viruses as little invaders with either a protective coat, called an enveloped virus, or without one, which we'll

Oct 6, 2023 · 4 likes · 1 share · 18,928 followers View post →
Jayanta Haldar
@jayanta_amr · X

Article Update! This article published in the August issue of ACS ID, shows the antiviral activity of AMP mimetic peptoids against an array of enveloped viruses, acting through a membrane-specific mechanism. https://t.co/WaIAYfq5sI @ACSBioMed #ACSInfectiousDiseases

Sep 5, 2023 · 1 like · 459 followers View post →
Miguel Ángel Sogorb
@MASogorb · X

Imitar las defensas del organismo para destruir virus envueltos https://t.co/u7nO7G4raO Más información: Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity https://t.co/ZDZdBP06vu ⬇️

Aug 12, 2023 · 158 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity | ACS Infectious Diseases https://t.co/2u1v2vY9Rc

Aug 8, 2023 · 2,565 followers View post →
PostX #UniteToFight2024
@TeamPostX · X

Biomimicry with bursting. Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine establishing an avenue for specificity that may enable the development of a new family of therapeutics capable of averting the rapid development of resistance. https://t.co/SvUZR3g7wN

Aug 7, 2023 · 1 like · 2,089 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @agingdoc1: Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity https://t.co/IASm6EOZGv @A…

Aug 5, 2023 · 3 shares · 6,617 followers View post →
CD BioSciences
@CDBioSciences · X

Researchers have now developed a new antiviral treatment that ignores the rapidly mutating proteins on the surface of the virus and instead targets the lipids in the enveloped virus membrane, destroying its protective layer. https://t.co/5iqjyv0zyC

Aug 4, 2023 · 32 followers View post →
No Horizons
@1stmousecheese · X

RT @agingdoc1: Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity https://t.co/IASm6EOZGv @A…

Aug 3, 2023 · 3 shares · 1,443 followers View post →
Gohsuke Takama
@gohsuket · X

RT @agingdoc1: Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity https://t.co/IASm6EOZGv @A…

Aug 3, 2023 · 3 shares · 2,984 followers View post →
Agingdoc
@agingdoc1 · X

Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity https://t.co/IASm6EOZGv @ACSPublications https://t.co/o43Z0ZQSuO

Aug 3, 2023 · 4 likes · 3 shares · 43,925 followers View post →
NYU Chemistry
@nyuchemistry · X

ACS Infectious Diseases study "Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity" is generating attention.  Congrats to  lead author grad student Patrick Tate and Professor Kent Kirshenbaum! @aroralabnyu https://t.co/RMigXxoMtc

Aug 2, 2023 · 8 likes · 3,111 followers View post →
Johannes Morstein
@mo_hannes · X

RT @PatrickMTate: my first first-author paper during my PhD is finally out! thank you so much @bryancmounce for letting me still bother you…

Aug 2, 2023 · 5 shares · 1,304 followers View post →
J
@fraaannk · X

RT @PatrickMTate: my first first-author paper during my PhD is finally out! thank you so much @bryancmounce for letting me still bother you…

Aug 2, 2023 · 5 shares · 129 followers View post →
Jonathan Sun
@JonasunSun · X

RT @PatrickMTate: my first first-author paper during my PhD is finally out! thank you so much @bryancmounce for letting me still bother you…

Aug 2, 2023 · 5 shares · 29 followers View post →
Phage Papers
@Phage_Papers · X

Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity https://t.co/u7NHvJw3Wn

Aug 2, 2023 · 645 followers View post →
Rasa Valiauga, PhD
@RasaValiauga · X

RT @PatrickMTate: my first first-author paper during my PhD is finally out! thank you so much @bryancmounce for letting me still bother you…

Aug 2, 2023 · 5 shares · 800 followers View post →
Patrick Tate
@PatrickMTate · X

my first first-author paper during my PhD is finally out! thank you so much @bryancmounce for letting me still bother you ( even after you FIRED ME ) to complete some of this work. and obviously thank you to @mastvr1 & @christina_cunha for being a dream https://t.co/PEos2X00gS

Aug 2, 2023 · 31 likes · 5 shares · 351 followers View post →
"Cannabis only produces carbon-based secondary metabolites. Of ...
Facebook

... 10.1021/acsinfecdis. 3c00063 https://youtu. be/MfwRbyJT8gY?si=Cc2yQ2fsWAc9MJDo "liposomes containing phosphatidylserine (PS) were markedly ...

Jan 6, 2024 View →
Synthetic peptide mimics can act as antivirals | Research | Chemistry ...
News

' References. P M Tate et al, ACS Infect. Dis., 2023, 9, 1508 (DOI: 10.1021/acsinfecdis.3c00063). Ada McVean. Follow. Ada has been ...

Aug 25, 2023 View →
Synthetic molecules can burst virus membranes
News

They called these peptide-like molecules peptoids (ACS Infect. Dis. 2023, DOI: 10.1021/acsinfecdis.3c00063). Using AMPs against viruses isn't ...

Aug 18, 2023 View →
Peptoids Target Virus Membranes - BioTechniques
News

doi: 10.1021/acsinfecdis.3c00063 (2023) (Epub ahead of print). Click here to view the press release. Top content. CRISPR for improving ...

Aug 14, 2023 View →
The Peptoid Approach to Antiviral Resistance
News

doi.org/10.1021/acsinfecdis.3c00063. Be the first to rate this article. Posted in: Life Sciences News | Disease/Infection News. Comments (0).

Aug 3, 2023 View →
Novel molecules fight viruses by bursting their bubble-like ...
News

10.1021/acsinfecdis.3c00063. Subject of Research. Cells. Article Publication Date. 2-Aug-2023. Disclaimer: AAAS and EurekAlert! are not ...

Aug 2, 2023 View →
Novel molecules fight viruses by bursting their bubble-like membranes
Blogs

DOI. 10.1021/acsinfecdis.3c00063. Subject of Research. Cells. Article Publication Date. 2-Aug-2023. Share12 Tweet8Share2ShareShareShare2 ...

Aug 2, 2023 View →
Imitar las defensas del organismo para destruir virus envueltos ...
News

10.1021/acsinfecdis.3c00063. Article Title. Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity ...

Aug 2, 2023 View →
Mimicking the body's own defenses to destroy enveloped viruses ...
News

... 10.1021/acsinfecdis.3c00063. For more of the latest research news, register for our upcoming meeting, ACS Fall 2023. Journalists and public ...

Aug 2, 2023 View →
Peptoid antiviral therapy inactivates three viruses in lab tests
Blogs

doi.org/10.1021/acsinfecdis.3c00063. Be the first to rate this article. Posted in: Medical Science News | Medical Research News | Disease ...

Aug 2, 2023 View →
Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine ...
News

At all concentrations of MXB. ACS Infectious Diseases pubs.acs.org/journal/aidcbc. Article https://doi.org/10.1021/acsinfecdis.3c00063. ACS ...

Aug 2, 2023 View →
Novel molecules fight viruses by bursting their bubble-like ...
News

ACS Infectious Diseases, 2023; DOI: 10.1021/acsinfecdis.3c00063. Cite This Page: MLA; APA; Chicago. New York University. "Novel molecules ...

Aug 2, 2023 View →