September 2023 PMID 37534597

Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles.

Zhongtang Yu, Xiaoqiang He, Ruiliu Wang, Xinxin Xu, Zhang Zhang, Ke Ding, Zhi-Min Zhang, Yi Tan, Zhengqiu Li

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Mentions

Peak: 23 in Aug 2023

across 2 sources since Aug 2023

Extended reach

220,116

potential audience

Total likes

132

Video views

3,861

Mentions per month

Aug 2023 – Sep 2023

Where it's discussed

X / Twitter23 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions reveal a strong interest in the article's focus on covalent modification of KRas mutations, as seen in remarks like '#KRAS #G12D #Oxirane #Electrophiles,' which indicate technical enthusiasm. The tone is largely positive and forward-looking, emphasizing the novelty and therapeutic potential, although some comments remain more neutral, reflecting an appreciation rather than full endorsement or critique.

AgreementModerate agreement

Most discussions express positive acknowledgment of the research's significance and potential, supporting the importance of the findings.

InterestHigh interest

There is high interest reflected through numerous enthusiastic mentions and use of hashtags like #KRAS and #Oxirane, indicating engagement with the topic.

EngagementModerate engagement

Participants reference specific details such as the dual targeting of KRas mutations and mention methods like tunable electrophiles, suggesting active engagement with the scientific content.

ImpactModerate impact

Followers seem to view the research as impactful, with some discussions implying potential for advance in cancer therapies, though without explicit claims of revolutionizing treatment.

Abstract in brief

Targeted covalent inhibitors (TCIs) are a promising approach for cancer treatment due to their strong pharmaceutical properties compared to noncovalent inhibitors.
The K-Ras(G12D) mutation, common in various cancers, lacks developed covalent inhibitors, possibly due to its weak nucleophilicity.
A new compound has been discovered that can covalently target both K-Ras(G12D) and K-Ras(G12C) mutants, paving the way for potential dual covalent therapies.

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All mentions

Mechanism and Synthesis of Sotorasib for KRAS G12C Mutant Cancer Treatment

Sotorasib is a KRAS inhibitor approved for treating KRAS G12C mutant non-small cell lung cancer. This video explains its mechanism of action and synthesis process, highlighting its role in targeted cancer therapy.

Named Reactions in Organic Chemistry · Sep 9, 2023 3,861 views

Molly20256

@Molly20186 · X

RT @Glaconde34: Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles | Journal of the Ameri…

Aug 10, 2023 · 3 shares · 83 followers View post →

Ranok Therapeutics

@RanokTx · X

RT @Glaconde34: Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles | Journal of the Ameri…

Aug 10, 2023 · 3 shares · 333 followers View post →

Uthpala Seneviratne

@UthpalaISen · X

RT @Glaconde34: Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles | Journal of the Ameri…

Aug 10, 2023 · 3 shares · 145 followers View post →

Guillaume Laconde

@Glaconde34 · X

Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles | Journal of the American Chemical Society

Aug 10, 2023 · 13 likes · 3 shares · 4,815 followers View post →

Ernest A-Williams

@ernest_chemist · X

RT @CovalentMod: Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles https://t.co/8gHSbhba…

Aug 9, 2023 · 4 shares · 422 followers View post →

Invictus Samael

@InvictusSamael · X

RT @CovalentMod: Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles https://t.co/8gHSbhba…

Aug 9, 2023 · 4 shares · 659 followers View post →

Uthpala Seneviratne

@UthpalaISen · X

RT @CovalentMod: Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles https://t.co/8gHSbhba…

Aug 9, 2023 · 4 shares · 145 followers View post →

Covalent Modifiers

@CovalentMod · X

Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles https://t.co/8gHSbhba3y https://t.co/fzMnsfRirR

Aug 9, 2023 · 25 likes · 4 shares · 4,564 followers View post →

Life Science Journal Content

@lsn_jc · X

[ASAP] Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles #science #publication #research #journal https://t.co/MBeDnxQrI3

Aug 7, 2023 · 263 followers View post →

AAMSNS

@AAMSNS_EN · X