Science August 2023 PMID 37535747

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.

Kai Wang, Zhiwei Zhang, Jing Hang, Jia Liu, Fusheng Guo, Yong Ding, Meng Li, Qixing Nie, Jun Lin, Yingying Zhuo, Lulu Sun, Xi Luo, Qihang Zhong, Chuan Ye, Chuyu Yun

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Mentions

134

Peak: 89 in Aug 2023

across 4 sources since Aug 2023

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537

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What people are saying

Several discussions highlight the enzyme DPP4 derived from gut bacteria and its connection to glucose metabolism in diabetes, with phrases like 'high potential to alter diabetes treatment' and references to specific findings like the effect of daurisoline-d4 on glucose tolerance in diabetic mice. The enthusiastic tone and use of words like 'promising' and 'exciting' underscore the perceived importance of the research.

AgreementStrong agreement

The majority of posts reflect strong support for the findings about microbial DPP4 as an antidiabetic target.

InterestHigh interest

There is a high level of curiosity expressed in most discussions, indicating that users are eager to learn more about the study's implications.

EngagementModerate engagement

While many posts reference the study, discussions tend to hover around summarizing the findings rather than diving deeply into methodologies or nuances.

ImpactHigh impact

Users see the potential for significant developments in diabetes treatment, suggesting they view the publication as impactful.

Abstract in brief

Researchers found that certain gut bacteria produce an enzyme called DPP4, which may contribute to diabetes by disrupting glucose metabolism.
They developed a screening platform to study how these microbial enzymes impact host physiology, revealing that microbial DPP4 can lower effective GLP1 levels in mice with leaky gut.
A new compound, daurisoline-d4 (Daud4), was identified as a selective inhibitor of microbial DPP4, showing potential to improve glucose tolerance in diabetic mice.

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Link Between Gut Bacteria and Diabetic Drug Efficacy

Microbial Matters discusses the relationship between gut microbiota and metabolic diseases. Explore insights into how gut bacteria, such as those producing DPP4, impact glucose metabolism and the potential of new…

Zhenrun Zhang · Aug 8, 2024 3 views

Microbiome Research Centre

@MRC_microbiome · X

RT @DrMFitzmaurice: Dipeptidyl peptidase 4 (#DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 was able to de…

Sep 20, 2023 · 4 shares · 2,916 followers View post →

Kent Willis MD

@KentWillisMD · X

RT @DrMFitzmaurice: Dipeptidyl peptidase 4 (#DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 was able to de…

Sep 18, 2023 · 4 shares · 3,620 followers View post →

Gavin Bewick

@GavBew · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science https://t.co/wl2bDtFApN

Sep 18, 2023 · 1,253 followers View post →

Elisa Haas, MD

@ElisaAHaas · X

“Gut microbial DPP4 isozyme can impair host glucose homeostasis, and variations in microbial DPP4 activities could possibly contribute to the heterogeneous responses to sitagliptin observed among patients with T2D.” https://t.co/6vCY0i3hEc

Sep 18, 2023 · 1 like · 444 followers View post →

Elisa Haas, MD

@ElisaAHaas · X

RT @DrMFitzmaurice: Dipeptidyl peptidase 4 (#DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 was able to de…

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Howard Yim

@Howard__Yim · X

RT @DrMFitzmaurice: Dipeptidyl peptidase 4 (#DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 was able to de…

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The Innovation | Medicine

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RT @ScienceMagazine: In a recent mouse study, researchers identified a microbiota-derived enzyme as a potential antidiabetic target. Learn…

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Elvan Zengin

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RT @ScienceMagazine: In a recent mouse study, researchers identified a microbiota-derived enzyme as a potential antidiabetic target. Learn…

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Juan

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LSU Vet Med Dean

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Antonio J Vallecillo, PhD

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Science Magazine

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In a recent mouse study, researchers identified a microbiota-derived enzyme as a potential antidiabetic target. Learn more in Science: https://t.co/ioFHoBxV70 https://t.co/ciZ1oMRS77

Sep 17, 2023 · 192 likes · 49 shares · 4,515,818 followers View post →

Danxia Yu 俞丹霞

@YuDanxia_Epi · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science https://t.co/MF8l9f8bfk

Sep 5, 2023 · 6 likes · 454 followers View post →

Immunology Podcast

@ImmunoPodcast · X

On this week's episode: how do microbes affect #diabetes drug responses? Researchers at @PKU1898 identified a #microbiota-derived enzyme as a potential antidiabetic target.

Aug 16, 2023 · 3 likes · 1 share · 4,044 followers View post →

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Shatoo

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Ankit Singla

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Grace Pruksarojanakul

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emmanuel IDEA.eth

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YU TAHARA

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NP AGARWAL世界一フォローを目指しますAiming best in world.

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https://t.co/GjecLAUF5L Microbial-host-isozyme analyses reveal microbial #DPP4 as a potential #antidiabetic target

Aug 15, 2023 · 1,788 followers View post →

Juan

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Animalcules

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Žiga H.

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Thev JayMahan

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Idrees

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Harol D. Rodríguez

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Aug 15, 2023 · 37 shares · 24 followers View post →

Dr. Patrick Kobina Arthur, PhD

@PAKARErst · X

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Aug 15, 2023 · 37 shares · 1,213 followers View post →

Ruiyuan Liu

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Aug 14, 2023 · 37 shares · 172 followers View post →

Eder Andrés

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Lehman Ellis

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Paúl Cárdenas

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Simon St-Onge

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Science Magazine

@ScienceMagazine · X

In a new mouse study, researchers identified a microbiota-derived enzyme as a potential antidiabetic target. Learn more in Science: https://t.co/3VYNsasZD0 https://t.co/sBilYYPsqe

Aug 14, 2023 · 140 likes · 37 shares · 4,515,818 followers View post →

#TechNews

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Animalcules

@bacteriophile · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target https://t.co/dBocLXv5hj

Aug 12, 2023 · 521 followers View post →

proto.life

@protolifemedia · X

Administering Dau-d4 improves glucose tolerance in diabetic mice, and they say it could be the basis for a targeted “drugs for bugs” approach to treating diabetes.

Aug 11, 2023 · 4,818 followers View post →

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@Ambulance_Squad · X

RT @isciverse: researchers identified a microbiota-derived enzyme as a potential antidiabetic target @ScienceMagazine #MedEd #MedTwitter…

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Jijin Xavier

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RT @isciverse: researchers identified a microbiota-derived enzyme as a potential antidiabetic target @ScienceMagazine #MedEd #MedTwitter…

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Maitha

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Bayar Jaff

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Shams Salah Mahdi

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Irene Becker

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Ngoc Hoang

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The Innovation | Medicine

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RT @ScienceMagazine: In a new mouse study, researchers identified a microbiota-derived enzyme as a potential antidiabetic target. Learn mo…

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Yaşar KANTAR, M.D

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José Avendaño

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Ankit Singla

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Zhenrun Jerry Zhang

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researchers identified a microbiota-derived enzyme as a potential antidiabetic target @ScienceMagazine #MedEd #MedTwitter https://t.co/z5XqrM8uHE https://t.co/AwhROHKFCe

Aug 10, 2023 · 19 likes · 6 shares · 40,409 followers View post →

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In a new mouse study, researchers identified a microbiota-derived enzyme as a potential antidiabetic target. Learn more in Science: https://t.co/qghAF3HAKH https://t.co/QRrZ4JdRXB

Aug 10, 2023 · 149 likes · 37 shares · 4,515,818 followers View post →

Yahli Admati

@AdmatiYahli · X

What is making me optimistic today Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target https://t.co/j4gkA5XzE5

Aug 10, 2023 · 66 followers View post →

たなからおもち

@oreomochishun · X

RT @myokoi1962: 北京大学が、腸内細菌由来のジペプチジルペプチダーゼ4（DPP－4）が、糖尿病治療効果を改善する新たな薬剤標的になる可能性があることを発見。 DPP-4酵素を阻害する方法が見つかれば、新たな治療方法につながる可能性もある。研究成果はサイエンス誌で…

Aug 9, 2023 · 1 share · 169 followers View post →

China Tips by myokoi

@myokoi1962 · X

北京大学が、腸内細菌由来のジペプチジルペプチダーゼ4（DPP－4）が、糖尿病治療効果を改善する新たな薬剤標的になる可能性があることを発見。 DPP-4酵素を阻害する方法が見つかれば、新たな治療方法につながる可能性もある。研究成果はサイエンス誌で発表。　#中国　 https://t.co/kVKOXf9hdl

Aug 9, 2023 · 5 likes · 1 share · 19,501 followers View post →

Host-microbe papers

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Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target https://t.co/KOCYDlZUKf

Aug 9, 2023 · 605 followers View post →

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ねじ@大人の勉強垢

@crookedscrew · X

本日のアブスト写経 Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target 微生物-宿主-アイソザイム解析により、抗糖尿病標的としての微生物DPP4が明らかになった https://t.co/vFGfh6AdvD

Aug 8, 2023 · 1 like · 19 followers View post →

hardik

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Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science https://t.co/WDmmU8LMIe

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Ayumu。

@ayumu0225 · X

今度読む Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science https://t.co/34fUrjUPxK

Aug 7, 2023 · 168 followers View post →

rebben

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Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science https://t.co/uPyPHJo3Uc

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熊本大学中枢性代謝制御学講座, Neuroscienc for Metablic Control

@kuma_neurometab · X

腸内細菌がGLP1を分解するDPP4を作り、高脂肪食などで腸管バリアが緩くなった時に血中に入って血糖値に影響するという論文。糖尿病治療薬のDPP4阻害剤は腸内細菌のDPP4には効かないので、新しい薬をスクリーニングして見つけたらしい。#血糖値調節 https://t.co/JpKcVzvmvR

Aug 6, 2023 · 2 likes · 22 followers View post →

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Abstream

@abstreamme · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science #science #publication #research #publications https://t.co/7mvhouZZ1z

Aug 5, 2023 · 789 followers View post →

Animalcules

@bacteriophile · X

RT @ravboc: These findings highlight the promise of developing therapies that target both host and gut microbial DPP4 enzymes to achieve gr…

Aug 4, 2023 · 2 shares · 521 followers View post →

Jack C. Drda (He/Him)

@JackCDrda · X

Amazing new Science paper on the intersection of gut microbiota & diabetes by Wang et al. So cool to be in the Gonzalez Lab and talk to these amazing researchers! Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | https://t.co/HPAOMfDKKo.

Aug 4, 2023 · 1 like · 527 followers View post →

Life Science Journal Content

@lsn_jc · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science #science #publication #research #journal https://t.co/eZ0tDaNOUZ

Aug 4, 2023 · 263 followers View post →

HostMicrobiomePapers

@HostMicroPapers · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target https://t.co/wfROUf3BLR https://t.co/Xa31swqImW

Aug 3, 2023 · 190 followers View post →

Kelvin Hui

@kelvinhui_cira · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science https://t.co/SwdN7Opqzd

Aug 3, 2023 · 1 like · 184 followers View post →

D2H2 Bot

@D2H2Bot · X

A #diabetes related paper was just published @ScienceMagazine by Wang et al. Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target https://t.co/loHkPi94i3 #D2H2 #DPP4 #Enrichr #Harmonizome https://t.co/YXcjNsNXYb https://t.co/yvGLHJmGHQ

Aug 3, 2023 · 3 followers View post →

Microbiome Papers

@MicrobiomePaper · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target https://t.co/adQKIQ7WVP https://t.co/DZ475TyN55

Aug 3, 2023 · 1 like · 1 share · 7,291 followers View post →

micropapers

@micro_papers · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target https://t.co/QYcTIjpYGg

Aug 3, 2023 · 332 followers View post →

JB7 LLC

@Jb7Llc · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science https://t.co/6ZPCuakRP2 https://t.co/DrFmo80JPs

Aug 3, 2023 · 7 followers View post →

Engford Education Consultant

@engfordedu · X

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target | Science https://t.co/bkShr9ieAE https://t.co/fdhXKFlagN

Aug 3, 2023 · 794 followers View post →

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.

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