J Biomol Struct Dyn September 2024 PMID 37539779

High-throughput virtual screening of phenylpyrimidine derivatives as selective JAK3 antagonists using computational methods.

Abdelmoujoud Faris, Ibrahim M Ibrahim, Hanine Hadni, Menana Elhallaoui

Mentions

4
Peak: 2 in Dec 2022
across 2 sources since Dec 2022

Extended reach

5,931
potential audience

Total likes

129

Video views

5,832

Mentions per month

Dec 2022 – Feb 2024

Where it's discussed

  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several posts, including this one, highlight recognition of the publication, such as celebrating its citation and linking it to other significant work, with phrases like 'Delighted to have received a first citation' and references to related publications, illustrating genuine appreciation and interest in the research's academic impact.

AgreementModerate agreement

The discussion shows positive acknowledgment of the publication's significance, especially with the phrase 'Delighted to have received a first citation,' indicating support and recognition.

InterestHigh interest

The mention of the citation and the connection to another author's work demonstrate a high level of curiosity and appreciation for the research's relevance.

EngagementModerate engagement

The post reflects moderate engagement, sharing specific details like DOI numbers and referencing related studies, indicating an active interest but not deep analysis.

ImpactModerate impact

While positive, the discussion primarily celebrates recognition rather than outlining broad implications or transformative potential of the research.

Abstract in brief

  • This research used computational methods, including pharmacophore modeling, 3DQSAR, and molecular docking, to identify phenylpyrimidine derivatives that can selectively inhibit JAK3, an enzyme involved in rheumatoid arthritis.
  • The study validated potential inhibitors by analyzing their pharmacokinetics, stability through molecular dynamics, and binding affinity, ensuring they effectively target JAK3 with minimal adverse effects.
  • Overall, this approach provides a promising pathway for designing new drugs for rheumatoid arthritis, utilizing advanced computer simulations to identify and optimize potential therapeutic compounds.

Top posts

Most liked on X and Bluesky
ABDELMOUJOUD FARIS
@ABDELMOUJO97961 · X

https://t.co/icG9l7vko4 https://t.co/Eo6uyaRWbm https://t.co/KH0E3Jncw5

Feb 13, 2024 · 50 followers View post →
ABDELMOUJOUD FARIS
@ABDELMOUJO97961 · X

Delighted to have received a first citation for the year 2024 for our article (DOI: 10.1080/07391102.2023.2240413) in the excellent work presented by Dr. Anita Ioana Visan (DOI: 10.3390/life14020233) in the journal Life.

Feb 12, 2024 · 50 followers View post →

All mentions

ABDELMOUJOUD FARIS
@ABDELMOUJO97961 · X

https://t.co/icG9l7vko4 https://t.co/Eo6uyaRWbm https://t.co/KH0E3Jncw5

Feb 13, 2024 · 50 followers View post →
ABDELMOUJOUD FARIS
@ABDELMOUJO97961 · X

Delighted to have received a first citation for the year 2024 for our article (DOI: 10.1080/07391102.2023.2240413) in the excellent work presented by Dr. Anita Ioana Visan (DOI: 10.3390/life14020233) in the journal Life.

Feb 12, 2024 · 50 followers View post →