PPIと認知量リスク。PPI使用者と非使用者で認知症発症リスクに差はなかった。4.4年以上の使用は33%のリスク上昇がみられた。Neurology. PMID: 37558503. https://t.co/Pxjw5CpDYW
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study.
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Aug 2023 – Jun 2025Where it's discussed
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What people are saying
Discussions frequently highlight the alarming statistic of a 33% increase in dementia risk associated with long-term PPI usage. Posts express concern over the high number of individuals using these medications and suggest alternatives to manage symptoms. Words such as 'terrible side effects' or phrases like 'bandaid solutions' indicate a critical tone towards the existing treatment approaches, reflecting a serious concern for patient health outcomes.
The majority of discussions lean towards acknowledging the findings of the article, with many expressing concerns about the implications of long-term PPI use.
There is evident curiosity in readers about the relationship between PPIs and dementia risk, indicated by the frequency of shared posts and mentions of related findings.
Participants are engaging deeply with the content, analyzing implications, questioning causality, and even referencing other studies and facts about medications.
Many participants believe the research has significant ramifications for public health and personal medication choices, especially for those already using PPIs.
Abstract in brief
- The study analyzed the relationship between cumulative use of proton pump inhibitors (PPIs) and the risk of developing dementia using data from the Atherosclerosis Risk in Communities (ARIC) Study, which tracked participants from 1987 to 2017.
- Results showed that current PPI users at the time of visit 5 did not have a significantly higher risk of developing dementia compared to non-users, but those with over 4 cumulative years of PPI use had a 33% increased risk.
- The findings imply that while short-term PPI use may not affect dementia risk, long-term use could be associated with higher risk, prompting calls for further research to clarify these associations.
Top posts
Most liked on X and BlueskyCumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados presentaron un riesgo de demencia un 33% mayor durante el seguimiento (HR: 1.3 [95% CI 1.0–1.8]) que quienes no los tomaron" https://t.co/SvW3x2RXdE
PPI(胃酸分泌抑制剤)と認知症との関連についての先行研究では一致した結果は得られていませんが、本研究では、累積で4.4年以上使用した人で使用しなかった人と比べて発症リスクが33%上昇し、その関連性を示唆されました。 https://t.co/W2tjY5RxBG
PPIの長期使用が認知症の発症を促すってデータがあるくらいだから、脳に何かしらの影響は与えるんだろうけど、これからの研究結果を待ってみます https://t.co/GThtJI3EXe https://t.co/QHOGdsvTO4
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/nEdNUmlBaE
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study Cutting carb intake helps many with “heartburn.” Why not try that before acid blockers? https://t.co/Gw7PaA14Np
All mentions
Long-Term Omeprazol Use and Associated Health Risks
This video discusses the health risks associated with long-term omeprazol use. We explore how prolonged intake can affect your kidney health and the potential link to increased dementia risk based on recent studies…
Medications Linked to Increased Dementia Risk: Key Findings
This video examines medications that may increase the risk of dementia. It addresses how various cognitive functions deteriorate over time and highlights observational studies that show a correlation between these…
Proton Pump Inhibitors and Dementia Risk Insights from ARIC Study
This video discusses the relationship between proton pump inhibitors (PPIs) and dementia risk, based on the Atherosclerosis Risk in Communities Study. While short-term use may not elevate risk, long-term utilization…
Proton Pump Inhibitors and Dementia Risk: Key Insights from ARIC Study
This video delves into the Atherosclerosis Risk in Communities Study, analyzing the relationship between proton pump inhibitors (PPIs) and dementia risk. Findings indicate long-term PPI use may increase dementia risk…
Proton Pump Inhibitors and Increased Dementia Risk: A Study Review
Este video analiza la relación entre el uso acumulativo de inhibidores de la bomba de protones y el riesgo de demencia. Los resultados sugieren que el uso a largo plazo podría estar asociado con un riesgo mayor, lo que…
@RhythmDoc01 @IvorEkta @AlecStapp https://t.co/YeAIBJogoI https://t.co/fkFhNVH3Hv https://t.co/rARc6RDM2Q https://t.co/RBABtrugYg Several studies in the last 5 years have linked long-term PPI usage to a massive increase in dementia risk. There's one study and one statement by the american association of
33% INCREASE RISK DEVELOPING #DEMENTIA ASSOCIATED WITH LONG–TERM USE OF COMMON ACID REFLUX DRUG – NEW STUDY https://t.co/B0MpYbysA3 40% UK POPULATION EXPERIENCE REGULAR HEARTBURN MEDICATION PREVIOUSLY LINK HIGHER RISK STROKE BROKEN BONES KIDNEY #DISEASE https://t.co/l90InCOzj2
While PPI meds might relieve SYMPTOMS, they do not resolve the real problem. They act only as a bandaid - hiding the problem - and causing terrible side effects along the way. https://t.co/ONvcL6km4p https://t.co/i5zN24Qj83
While PPI meds might relieve SYMPTOMS, they do not resolve the real problem. They act only as a bandaid - hiding the problem - and causing terrible side effects along the way. https://t.co/ONvcL6km4p https://t.co/kNLQVgWr5W
https://t.co/4ap8fKFmxG https://t.co/uTsJ2n4iw9 https://t.co/UWJIpV7L27 https://t.co/0yKPnTGgFA -"Why stomach acid is good for you" Book. https://t.co/h1LF4LlAOE
Nope. https://t.co/eTC3GtbTVE
@DuthieAlyne And it's not only psychiatric drugs. A lot of drug classes can induce cognitive impairment and/or increase the risk of dementia, e.g., heartburn drugs (PPIs). Tens of millions are taking them year in, year out. https://t.co/zLlm1tiGcm
@StevenMathern I wonder about causality here. I mean if you need to take PPIs for over five years why is that when other's don't? Chronic alcoholism? Really poor diet? etc. https://t.co/AlVOf6Km0a
RT @primastcar: Vía @Montecoya
Vía @Montecoya
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @FAPsGal: Evaluación asociación entre uso actual & acumulado de #IBP y el riesgo de #demencia incidental en el estudio #ARIC Evidencia…
RT @FAPsGal: Evaluación asociación entre uso actual & acumulado de #IBP y el riesgo de #demencia incidental en el estudio #ARIC Evidencia…
Evaluación asociación entre uso actual & acumulado de #IBP y el riesgo de #demencia incidental en el estudio #ARIC Evidencia de Clase III
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
RT @Montecoya: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados…
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia | Neurology "Quienes tomaron IPP duante >4.4 años acumulados presentaron un riesgo de demencia un 33% mayor durante el seguimiento (HR: 1.3 [95% CI 1.0–1.8]) que quienes no los tomaron" https://t.co/SvW3x2RXdE
@ChuckBarry333 @miamivandynyu @BillAckman So are PPIs like Omeprazole (Prilosec) or pantoprazole (protonix) for extended periods of time. Extremely common drug, even OTC; although you shouldn’t take the OTC one for more than 2 weeks without a doctors appointment https://t.co/igLEhm05DI So what’s your point?
PPIの長期使用が認知症の発症を促すってデータがあるくらいだから、脳に何かしらの影響は与えるんだろうけど、これからの研究結果を待ってみます https://t.co/GThtJI3EXe https://t.co/QHOGdsvTO4
Long-term use of proton pump inhibitors (a common active ingredient in acid reflux medication) may contribute to dementia risk, according to a novel study
RT @b6Ah3b5EjU44445: PPI(胃酸分泌抑制剤)と認知症との関連についての先行研究では一致した結果は得られていませんが、本研究では、累積で4.4年以上使用した人で使用しなかった人と比べて発症リスクが33%上昇し、その関連性を示唆されました。 https://t…
PPI(胃酸分泌抑制剤)と認知症との関連についての先行研究では一致した結果は得られていませんが、本研究では、累積で4.4年以上使用した人で使用しなかった人と比べて発症リスクが33%上昇し、その関連性を示唆されました。 https://t.co/W2tjY5RxBG
IMHO, PPIs are one of the most abused drugs with total disregard to its side effect profile. Stumbled upon this eye opening paper today. Please go through. https://t.co/ptGhBxREvN #neuroscience, #NeuroTwitter #MedTwitter
Este estudo fornece evidência de Classe III de que o uso de inibidores da bomba de prótons prescritos por >4,4 anos por indivíduos com 45 anos ou mais está associado a uma maior incidência de demência recém-diagnosticada. https://t.co/ExzBzjIDFT
RT @DrPalmquist: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study Cutting carb…
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study Cutting carb intake helps many with “heartburn.” Why not try that before acid blockers? https://t.co/Gw7PaA14Np
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia https://t.co/jG7xl8WGvL
平均年齢75.4±5.1歳の5,712人を平均5.5年調査したAtherosclerosis Risk in Communities(ARIC)研究において、45歳以上の人が処方されたプロトンポンプ阻害薬を4.4年以上使用することが、新たに診断された認知症の高い発生率(HR=1.3)と関連 #PPI #dementia #papers https://t.co/dqOKjq3eBC
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia https://t.co/jSy3Bvygvi
RT @CamiloSalinasOF: El uso prolongado (>4.4 años) de inhibidores de bomba de protones (p. ej. omeprazol): ⬆️ el riesgo de demencia en adul…
RT @samcosamsam: 使うにしてもやっぱりPPIは短期間、、そもそも必要だから使う、必要がなくなれば使用しないの原則に変わりなし… Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The…
使うにしてもやっぱりPPIは短期間、、そもそも必要だから使う、必要がなくなれば使用しないの原則に変わりなし… Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/28VgjeW9Ze
RT @CamiloSalinasOF: El uso prolongado (>4.4 años) de inhibidores de bomba de protones (p. ej. omeprazol): ⬆️ el riesgo de demencia en adul…
El uso prolongado (>4.4 años) de inhibidores de bomba de protones (p. ej. omeprazol): ⬆️ el riesgo de demencia en adultos mayores (promedio de edad 75.4 años) en un 33-42%
Source: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study Carin Northuis, Elizabeth Bell, Pamela Lutsey, Kristen M George, Rebecca F. Gottesmann et al Neurology Aug 2023, DOI: 10.1212/WNL.0000000000207747 doi.org/10.1212/WNL....
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study - PubMed///❤️
RT @37phoenix: PPIと認知量リスク。PPI使用者と非使用者で認知症発症リスクに差はなかった。4.4年以上の使用は33%のリスク上昇がみられた。Neurology. PMID: 37558503. https://t.co/Pxjw5CpDYW
PPIと認知量リスク。PPI使用者と非使用者で認知症発症リスクに差はなかった。4.4年以上の使用は33%のリスク上昇がみられた。Neurology. PMID: 37558503. https://t.co/Pxjw5CpDYW
Mide koruyucuların, demans gelistirme riskini %33 oranında arttırdığı ile ilgili bir çalışma. #Neurology #MedTwitter #Pharmacology #neuropharmacology https://t.co/thTId7y6qO
Mide koruyucuların, demans gelistirme riskini %33 arttırdığı ile ilgili bir çalışma. #Neurology #MedTwitter #Pharmacology #neuropharmacology https://t.co/thTId7y6qO
RT @thmonk_pf: 4.4年以上のPPI服用歴は将来の認知障害のriskが上昇 Atherosclerosis Risk in Communities (ARIC) Studyの5712人を対象とし追跡期間中央値5.5年で、4.4年以上のPPI服用歴はHR1.3…
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study.(PMID:37558503) https://t.co/j3GgPhF58f
RT @nvillain_alz: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co…
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/VnUNQ78rwH
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study n.neurology.org/content/early/…
PPIの長期内服は認知症のリスクが高まる可能性があるのね。やっぱ漫然と続けたらダメね https://t.co/W9QMeKG3rR
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study - PubMed https://t.co/j4QnNxCOuG
RT @alvaro_casasher: The use of prescribed PPIs for > 4.4 years by individuals ages 45 years and older is associated with a higher incidenc…
Une exposition pendant plus de 4 ans pourrait augmenter le risque de démence Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/Nxzs0pq2Lb
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: ARIC Study. Neurology Aug 2023. Clear possible consequences of prolonged use of these antiacids. Acidity is key for nitric oxide production and digestion. The microbiota needs be treated instead.
RT @alvaro_casasher: The use of prescribed PPIs for > 4.4 years by individuals ages 45 years and older is associated with a higher incidenc…
RT @alvaro_casasher: The use of prescribed PPIs for > 4.4 years by individuals ages 45 years and older is associated with a higher incidenc…
The use of prescribed PPIs for > 4.4 years by individuals ages 45 years and older is associated with a higher incidence of newly diagnosed dementia. https://t.co/5UpBXaDAjF
Simply taking a #PPI did not necessarily result in a higher risk, as the key was the amount of time that a person took one of the #medicines . “Cumulative Use of Proton Pump Inhibitors and #Risk of #Dementia” https://t.co/RltCUmAqPW
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/ycohKxMm8R
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study Carin Northuis and al. Neurology August 09, 2023 https://t.co/LYQwwk2OBB
overmedicated and undernourished: #Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study | Neurology https://t.co/zd6YBGxXJa
all acid blockers (PPI’s) for the gut- “Cumulative Use of Proton Pump Inhibitors and Risk of Dementia..” get to root cause instead-fix your gut! https://t.co/KW4DlpTyif
Congrats to Dr. Lakshminarayan and team on their publication: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/4DNrFYbcvX
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/c2Jj7OrQ7r
RT @dr_cottrell: Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/…
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/NuItW5vbYo
RT @thmonk_pf: 4.4年以上のPPI服用歴は将来の認知障害のriskが上昇 Atherosclerosis Risk in Communities (ARIC) Studyの5712人を対象とし追跡期間中央値5.5年で、4.4年以上のPPI服用歴はHR1.3…
4.4年以上のPPI服用歴は将来の認知障害のriskが上昇 Atherosclerosis Risk in Communities (ARIC) Studyの5712人を対象とし追跡期間中央値5.5年で、4.4年以上のPPI服用歴はHR1.3 議論になっているPPIについて今回はクロという報告 Open Access #PPI #dementia #papers https://t.co/dqOKjq3eBC
RT @pinacol: 【観察研究】ARIC研究参加者において、訪問5回目前に累積4.4年を超えてPPIを使用していた参加者は、不使用の参加者と比較して、追跡期間中の認知症発症リスク増加と関連した。 #ペ読 https://t.co/5fKodZnof2
【観察研究】ARIC研究参加者において、訪問5回目前に累積4.4年を超えてPPIを使用していた参加者は、不使用の参加者と比較して、追跡期間中の認知症発症リスク増加と関連した。 #ペ読 https://t.co/5fKodZnof2
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/V8fjfPUXi1
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/aFGVsdNjbo this is yet another study that confirms the increased risk of dementia in long term PPI users https://t.co/mBeqzFPXos
RT @CAlejandroneuro: ⚠️ Usuarios acumulados de IBP a largo plazo tenían un 33% más de riesgo de desarrollar demencia en una etapa avanzada…
ない人に比べて、認知症のリスクが33%高い可能性があることがわかりました。薬の服用期間が4年半未満の人ではリスクの上昇は認められませんでした。これまでの研究ではプロトンポンプ阻害剤の長期使用は脳卒中、骨折、慢性腎臓病のリスクの増加と関連付けられていました。https://t.co/3SfC0CxEDz
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study | Neurology https://t.co/gYma3VmylO
⚠️ Usuarios acumulados de IBP a largo plazo tenían un 33% más de riesgo de desarrollar demencia en una etapa avanzada de la vida ✅Obviamente es 1 estudio, pero es una alerta! "nos parecería considerar mejor ese Omeprazol eterno???..." DOI: 10.1212/WNL.0000000000207747
プロトンポンプ阻害剤を4.4年以上飲んでた人は痴呆を発症するリスクが33%も高いそうだ。ときどきこの話出るよね。 Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/bcDIluQpnI
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/nEdNUmlBaE
Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study https://t.co/1u3j3LQw6J