Cancer Discov November 2023 PMID 37584601

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.

Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, Sebastian M Waszak, Stefan R Sweha, Mateus Mota, Matthew Pun, Akash Deogharkar, Chan Chung, Rohinton S Tarapore, Samuel Ramage, Andrew Chi, Patrick Y Wen, Isabel Arrillaga-Romany, Tracy T Batchelor

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Mentions

229
Peak: 114 in Aug 2023
across 4 sources since Aug 2023

Extended reach

1,473,841
potential audience

Total likes

271

Video views

1,515

Mentions per month

Aug 2023 – Aug 2025

Where it's discussed

  • X / Twitter144 posts
  • News80 articles
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions frequently mention the improved overall survival rates associated with ONC201, with one poster noting that it nearly doubles survival rates for patients. Another user emphasized that this research represents a major step forward in the fight against DIPG, using phrases like 'incredible step forward' to highlight the transformative potential of the findings. The enthusiastic language and supportive tone across these discussions help convey a strong sense of hope and optimism regarding the treatment's implications in pediatric oncology.

AgreementStrong agreement

The overall tone of the discussions is highly supportive of the findings from the publication, indicating strong agreement with the research conclusions.

InterestHigh interest

The posts reflect a significant level of curiosity and relevance, with many users expressing enthusiasm about the clinical implications of ONC201.

EngagementModerate engagement

While some posts share general announcements, others delve into specific clinical outcomes and comparisons to previous trials, suggesting moderate engagement depth.

ImpactHigh impact

Many users believe that the findings will greatly impact treatment options for pediatric patients, emphasizing the potential for improved survival rates.

Abstract in brief

  • ONC201 shows promise as an effective treatment for patients with H3K27M-mutant diffuse midline glioma (DMG), particularly when administered after initial radiation therapy.
  • Patients treated with ONC201 before cancer recurrence had a significantly longer median overall survival (21.7 months) compared to those treated after recurrence (9.3 months).
  • The drug works by disrupting metabolic and epigenetic pathways, increasing levels of specific metabolic markers, and reversing changes in gene expression associated with tumor development.

Top posts

Most liked on X and Bluesky
Elizabeth McKenna
@ElizSMcKenna · X

Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways @KoschmannLab @vennetilab https://t.co/3yJm8qxteG @umichmedicine @UMRogelCancer @MottChildren #DMG #DIPG https://t.co/mMlIS2N91v

Aug 16, 2023 · 53 likes · 19 shares · 18,071 followers View post →
Cancer Discovery
@CD_AACR · X

Clinical efficacy of ONC201 in H3K27M-DMG, by @vennetilab, Abed Rahman Kawakibi, Sunjong Ji, @sebastianw, Stefan Sweha, Mateus Mota, Matthew Pun, Sharon Gardner, @OdiaYazmin, @KoschmannLab et al. https://t.co/GWtUPsav42 @umichmedicine @UMRogelCancer @MottChildren #DMG #DIPG https://t.co/caRNiVXOfh

Aug 29, 2023 · 33 likes · 12 shares · 22,336 followers View post →
Abed Rahman Kawakibi, MD
@AbedKawakibi · X

Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways https://t.co/Zxx1eekixG

Aug 16, 2023 · 32 likes · 10 shares · 277 followers View post →
Cancer Discovery
@CD_AACR · X

November issue— Clinical efficacy of ONC201 in H3K27M-#DMG, by @vennetilab, @AbedKawakibi, Sunjong Ji, @sebastianw, Stefan Sweha, Mateus Mota, Matthew Pun, Sharon Gardner, @OdiaYazmin, @KoschmannLab et al. https://t.co/fZlXzyjYmt @umichmedicine @UMRogelCancer @MottChildren #DIPG https://t.co/HcD366l8nR

Nov 14, 2023 · 26 likes · 15 shares · 22,336 followers View post →
Sebastian Waszak
@sebastianw · X

Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways". Excited to have worked on this study with the amazing team from @KoschmannLab and @vennetilab.

Aug 16, 2023 · 26 likes · 7 shares · 426 followers View post →
Cancer Discovery
@CD_AACR · X

Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways, by @KoschmannLab, @vennetilab et al. https://t.co/LswKvOd0i5 @umichmedicine @UMRogelCancer @MottChildren #DMG #DIPG https://t.co/vcSFhXTfQk https://t.co/N8hWNpEoFk

Aug 17, 2023 · 18 likes · 8 shares · 22,336 followers View post →

All mentions

Angelina
@Angelina850511 · X

RT @AbedKawakibi: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Effi…

Aug 28, 2025 · 10 shares · 48 followers View post →
Tu Dan
@TuDDan · X

@StasLazarev JCO paper excluded DIPG but earlier work from Koschmann group included pediatric DIPG pts showing median OS of ~22 months which compares very favorably to prior COG trials (ie PNOC003 had OS of ~13 months) https://t.co/hy2YfQ258o https://t.co/xoK4Bh6Fhk

Aug 8, 2025 · 1 like · 226 followers View post →
Abed Rahman Kawakibi, MD
@AbedKawakibi · X

RT @CD_AACR: Read the study that was part of the basis for this new approval: "Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline…

Aug 8, 2025 · 1 share · 277 followers View post →
Cancer Discovery
@CD_AACR · X

Read the study that was part of the basis for this new approval: "Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways" https://t.co/zv5NdpGnFr https://t.co/sEos5m7OHS

Aug 8, 2025 · 2 likes · 1 share · 22,336 followers View post →
Xarlanna
@xarlanna34623 · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Jul 1, 2025 · 26 shares · 10 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

@Hakanzt50881607 @DKFZ https://t.co/6vbjGxNVcP

Jan 1, 2025 · 1 like · 18,399 followers View post →
Top Biomedical Science
@imedverse · X

RT @InnovOncology: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and…

Apr 7, 2024 · 3 shares · 90,460 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @InnovOncology: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and…

Apr 7, 2024 · 3 shares · 253,983 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @InnovOncology: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and…

Apr 7, 2024 · 3 shares · 11,718 followers View post →
The Innovation Oncology
@InnovOncology · X

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways @CD_AACR @AACR @OncoAlert @oncodaily @SciLife_ @InnovOncology #MedEd #MedX #Oncology #AACR2024 #AACR24 https://t.co/2HsiUM1Quo

Apr 7, 2024 · 2 likes · 3 shares · 2,857 followers View post →
Advanced Therapies for Pediatric Solid Tumors Lab
@Alonso_Lab · X

Parallelly, patients with H3K27M-mutant DMG who underwent the imipridone ONC201 treatment exhibited enhanced outcomes when compared to historical data. Mechanistically, ONC201 disrupts integrated metabolic and epigenetic pathways. More info here: https://t.co/AVPheT7ciE (4/15)

Apr 4, 2024 · 3 likes · 1 share · 436 followers View post →
Koschmann Lab
@KoschmannLab · X

RT @CD_AACR: November issue— Clinical efficacy of ONC201 in H3K27M-#DMG, by @vennetilab, @AbedKawakibi, Sunjong Ji, @sebastianw, Stefan Swe…

Nov 29, 2023 · 4 shares · 765 followers View post →
Cancer Discovery
@CD_AACR · X

November issue— Clinical efficacy of ONC201 in H3K27M-#DMG, by @vennetilab, @AbedKawakibi, Sunjong Ji, @sebastianw, Stefan Sweha, Mateus Mota, Matthew Pun, Sharon Gardner, @OdiaYazmin, @KoschmannLab et al. https://t.co/0aIUiOQWDQ @umichmedicine @UMRogelCancer @MottChildren #DIPG https://t.co/cfeeNejM9f

Nov 29, 2023 · 10 likes · 4 shares · 22,336 followers View post →
Brain tumor ULisboa
@braintumor_UL · X

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways https://t.co/MX4C1oWXDo

Nov 15, 2023 · 248 followers View post →
そら_脳幹部グリオーマ闘病中
@hiro_0729sora · X

H3K27M変異拡散中線神経膠腫におけるONC201の臨床的有効性は、統合された代謝およびエピジェネティックな経路の破壊によって駆動される | がん発見 | 米国がん研究協会 https://t.co/Drowv4Whij

Nov 14, 2023 · 13 likes · 1,139 followers View post →
Sebastian Waszak
@sebastianw · X

RT @CD_AACR: November issue— Clinical efficacy of ONC201 in H3K27M-#DMG, by @vennetilab, @AbedKawakibi, Sunjong Ji, @sebastianw, Stefan Swe…

Nov 14, 2023 · 15 shares · 426 followers View post →
Abed Rahman Kawakibi, MD
@AbedKawakibi · X

RT @CD_AACR: November issue— Clinical efficacy of ONC201 in H3K27M-#DMG, by @vennetilab, @AbedKawakibi, Sunjong Ji, @sebastianw, Stefan Swe…

Nov 14, 2023 · 15 shares · 277 followers View post →
Samir Barghout, BScPhm, MSc, PhD
@samir_barghout · X

RT @CD_AACR: November issue— Clinical efficacy of ONC201 in H3K27M-#DMG, by @vennetilab, @AbedKawakibi, Sunjong Ji, @sebastianw, Stefan Swe…

Nov 14, 2023 · 15 shares · 133 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

RT @CD_AACR: November issue— Clinical efficacy of ONC201 in H3K27M-#DMG, by @vennetilab, @AbedKawakibi, Sunjong Ji, @sebastianw, Stefan Swe…

Nov 14, 2023 · 15 shares · 18,071 followers View post →
Cancer Discovery
@CD_AACR · X

November issue— Clinical efficacy of ONC201 in H3K27M-#DMG, by @vennetilab, @AbedKawakibi, Sunjong Ji, @sebastianw, Stefan Sweha, Mateus Mota, Matthew Pun, Sharon Gardner, @OdiaYazmin, @KoschmannLab et al. https://t.co/fZlXzyjYmt @umichmedicine @UMRogelCancer @MottChildren #DIPG https://t.co/HcD366l8nR

Nov 14, 2023 · 26 likes · 15 shares · 22,336 followers View post →
Vennetilab
@vennetilab · X

RT @DrBaileeSliker: If you want more on gliomas after the talks at the afternoon session of #TumourLandscape23, don't miss this @CD_AACR by…

Nov 1, 2023 · 4 shares · 1,015 followers View post →
Wolfgang's tensor
@Tensorwg006 · X

RT @DrBaileeSliker: If you want more on gliomas after the talks at the afternoon session of #TumourLandscape23, don't miss this @CD_AACR by…

Oct 31, 2023 · 4 shares · 161 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

RT @DrBaileeSliker: If you want more on gliomas after the talks at the afternoon session of #TumourLandscape23, don't miss this @CD_AACR by…

Oct 30, 2023 · 4 shares · 18,071 followers View post →
Cancer Discovery
@CD_AACR · X

RT @DrBaileeSliker: If you want more on gliomas after the talks at the afternoon session of #TumourLandscape23, don't miss this @CD_AACR by…

Oct 30, 2023 · 4 shares · 22,336 followers View post →
Bailee Sliker, Ph.D
@DrBaileeSliker · X

If you want more on gliomas after the talks at the afternoon session of #TumourLandscape23, don't miss this @CD_AACR by @CarlKoschmann, @vennetilab, et al on the clinical efficacy of ONC201 in H3K27M-DMG https://t.co/ugY6NorWin @chadtough https://t.co/CtVIIJWOc2

Oct 30, 2023 · 4 likes · 4 shares · 1,816 followers View post →
Jiasen He
@Platerowood · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Sep 8, 2023 · 25 shares · 220 followers View post →
The Jonah Finn Foundation
@JonahFoundation · X

https://t.co/lolgP08Tpg https://t.co/yjNCJnk0Pp

Sep 4, 2023 · 112 followers View post →
WCI
@WaltherCancerIn · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Sep 3, 2023 · 25 shares · 1,113 followers View post →
Australian DIPG Families
@AussieDIPG · X

RT @MattDun17: @KoschmannLab @vennetilab @AbedKawakibiMD #sunny @sebastianw et al., in the proofs we added the clinical finding as this pap…

Sep 3, 2023 · 1 share · 52 followers View post →
Matt Dun, PhD
@MattDun17 · X

@KoschmannLab @vennetilab @AbedKawakibiMD #sunny @sebastianw et al., in the proofs we added the clinical finding as this paper was submitted before we all met up in Ann Arbor and accepted some time ago https://t.co/31CAa43Zso

Sep 3, 2023 · 2 likes · 1 share · 3,165 followers View post →
WCI
@WaltherCancerIn · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Sep 1, 2023 · 26 shares · 1,113 followers View post →
Rajiv K. Khajuria
@RajKhajur · X

Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways  https://t.co/CuiYRdcIBl

Aug 31, 2023 · 3 likes · 501 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

RT @CD_AACR: Clinical efficacy of ONC201 in H3K27M-DMG, by @vennetilab, Abed Rahman Kawakibi, Sunjong Ji, @sebastianw, Stefan Sweha, Mateus…

Aug 29, 2023 · 12 shares · 18,071 followers View post →
I-Mei (Emay) Siu
@imsmd · X

RT @CD_AACR: Clinical efficacy of ONC201 in H3K27M-DMG, by @vennetilab, Abed Rahman Kawakibi, Sunjong Ji, @sebastianw, Stefan Sweha, Mateus…

Aug 29, 2023 · 12 shares · 1,101 followers View post →
Cancer Discovery
@CD_AACR · X

Clinical efficacy of ONC201 in H3K27M-DMG, by @vennetilab, Abed Rahman Kawakibi, Sunjong Ji, @sebastianw, Stefan Sweha, Mateus Mota, Matthew Pun, Sharon Gardner, @OdiaYazmin, @KoschmannLab et al. https://t.co/GWtUPsav42 @umichmedicine @UMRogelCancer @MottChildren #DMG #DIPG https://t.co/caRNiVXOfh

Aug 29, 2023 · 33 likes · 12 shares · 22,336 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Wow ⁦@CD_AACR⁩: 84 coauthors! Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways | Cancer Discovery | American Association for Cancer Research https://t.co/r5k104Bioy

Aug 26, 2023 · 2 likes · 18,399 followers View post →
Nancy Couturier, DO
@DrNanCout · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 23, 2023 · 22 shares · 95 followers View post →
C.S. Mott Children's
@MottChildren · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 23, 2023 · 22 shares · 8,345 followers View post →
Tali Lev
@TaliLev123 · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 23, 2023 · 19 shares · 1,843 followers View post →
Diaz Laboratory
@diazlaboratory · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 22, 2023 · 19 shares · 292 followers View post →
Fatima Valdes Mora
@FaValdesMora · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 22, 2023 · 19 shares · 1,229 followers View post →
Mariella Filbin
@FilbinMariella · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 22, 2023 · 19 shares · 3,961 followers View post →
サイエンスあれこれ
@sarekore · X

腫瘍細胞によって産生されるL-2HGと呼ばれる代謝産物が増加し、それが腫瘍を定義するエピジェネティックシグナルを逆転させ、腫瘍細胞の分化を促進し、分裂を減少させることがわかりました。https://t.co/vvFeu787io

Aug 21, 2023 · 922 followers View post →
Luis J. Castro-Vega
@LuisJaimeCastr3 · X

https://t.co/8Dcu4ycpIp

Aug 19, 2023 · 1 like · 658 followers View post →
Pavlos Msaouel
@PavlosMsaouel · X

RT @sebastianw: Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of int…

Aug 19, 2023 · 7 shares · 3,526 followers View post →
Anil Adyanthaya
@AnilAdyanthaya · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 18, 2023 · 26 shares · 3,711 followers View post →
Marc Mize
@MizeMarc · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 18, 2023 · 26 shares · 116 followers View post →
Tali Lev
@TaliLev123 · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 18, 2023 · 22 shares · 1,843 followers View post →
Tali Lev
@TaliLev123 · X

RT @AbedKawakibiMD: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Ef…

Aug 18, 2023 · 10 shares · 1,843 followers View post →
Tali Lev
@TaliLev123 · X

RT @sebastianw: Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of int…

Aug 18, 2023 · 7 shares · 1,843 followers View post →
the paper link
@the_paper_link · X

Trend up+4: Venneti S, ..., Koschmann C (Cancer Discov) __Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways__ https://t.co/fZBoUMjsCS

Aug 18, 2023 · 136 followers View post →
NCMBM
@NCMBMnews · X

RT @sebastianw: Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of int…

Aug 18, 2023 · 7 shares · 1,279 followers View post →
Terri Hernandez
@TerriHterri7981 · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 198 followers View post →
Santhosh Ambika
@RenoHemonc · X

ONC201 nearly doubled survival for patients with H3K27M-mutated diffuse midline gliomas (DMG https://t.co/QjtdjkXQKB

Aug 17, 2023 · 2 likes · 4,012 followers View post →
PhiOanh "Leia" NghiemPhu, MD
@Leia_N_MD · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 17, 2023 · 25 shares · 448 followers View post →
Yuan James Rao
@yuanjamesrao · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 17, 2023 · 22 shares · 2,259 followers View post →
Daniel Castellano
@cdanicas · X

RT @CD_AACR: Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Met…

Aug 17, 2023 · 8 shares · 3,677 followers View post →
Daniel Castellano
@cdanicas · X

RT @AbedKawakibiMD: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Ef…

Aug 17, 2023 · 10 shares · 3,677 followers View post →
Angelo Dipasquale
@AngeloDipa_ · X

RT @CD_AACR: Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Met…

Aug 17, 2023 · 8 shares · 1,625 followers View post →
Cancer Discovery
@CD_AACR · X

RT @DrBaileeSliker: Don't miss the new @CD_AACR paper discussed here featuring these amazing @chadtough researchers! Find the link here: ht…

Aug 17, 2023 · 2 shares · 22,336 followers View post →
smashingwalnuts
@smashingwalnuts · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 2,653 followers View post →
Colby
@RadiologyColby · X

RT @AbedKawakibiMD: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Ef…

Aug 17, 2023 · 10 shares · 189 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

RT @DrBaileeSliker: Don't miss the new @CD_AACR paper discussed here featuring these amazing @chadtough researchers! Find the link here: ht…

Aug 17, 2023 · 2 shares · 18,071 followers View post →
Bailee Sliker, Ph.D
@DrBaileeSliker · X

Don't miss the new @CD_AACR paper discussed here featuring these amazing @chadtough researchers! Find the link here: https://t.co/FERWd3tGfL https://t.co/aO4MRsYjsn

Aug 17, 2023 · 4 likes · 2 shares · 1,816 followers View post →
Vivekanand Yadav
@vivekanandVNY · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 122 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @CD_AACR: Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Met…

Aug 17, 2023 · 8 shares · 253,983 followers View post →
Maddie
@MadisenMason · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 17, 2023 · 25 shares · 114 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

RT @CD_AACR: Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Met…

Aug 17, 2023 · 8 shares · 18,071 followers View post →
Jonas Nilsson
@DrJonasANilsson · X

RT @CD_AACR: Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Met…

Aug 17, 2023 · 8 shares · 1,094 followers View post →
Jonas Nilsson
@DrJonasANilsson · X

RT @AbedKawakibiMD: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Ef…

Aug 17, 2023 · 10 shares · 1,094 followers View post →
Carl Koschmann
@CarlKoschmann · X

RT @CD_AACR: Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Met…

Aug 17, 2023 · 8 shares · 474 followers View post →
Koschmann Lab
@KoschmannLab · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 17, 2023 · 22 shares · 765 followers View post →
Koschmann Lab
@KoschmannLab · X

RT @CD_AACR: Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Met…

Aug 17, 2023 · 8 shares · 765 followers View post →
Cancer Discovery
@CD_AACR · X

RT @sebastianw: Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of int…

Aug 17, 2023 · 7 shares · 22,336 followers View post →
Steve Kay
@DrSteveKay · X

RT @CD_AACR: Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Met…

Aug 17, 2023 · 8 shares · 1,495 followers View post →
Cancer Discovery
@CD_AACR · X

RT @AbedKawakibiMD: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Ef…

Aug 17, 2023 · 10 shares · 22,336 followers View post →
Cancer Discovery
@CD_AACR · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 17, 2023 · 22 shares · 22,336 followers View post →
Cancer Discovery
@CD_AACR · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 17, 2023 · 25 shares · 22,336 followers View post →
Cancer Discovery
@CD_AACR · X

Read the paper— Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways, by @KoschmannLab, @vennetilab et al. https://t.co/LswKvOd0i5 @umichmedicine @UMRogelCancer @MottChildren #DMG #DIPG https://t.co/vcSFhXTfQk https://t.co/N8hWNpEoFk

Aug 17, 2023 · 18 likes · 8 shares · 22,336 followers View post →
Koschmann Lab
@KoschmannLab · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 765 followers View post →
Marilyn C. Silverman
@MarilynCSilver2 · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 16 followers View post →
Marilyn C. Silverman
@MarilynCSilver2 · X

RT @chadtough: ChadTough Defeat DIPG Foundation is honored to support this work and witness this incredible step forward in the fight to #D…

Aug 17, 2023 · 1 share · 16 followers View post →
UMichNeurosciences
@UMneurosciences · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 17, 2023 · 22 shares · 1,837 followers View post →
Monica-Amit Mishra
@PancanMonica · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 782 followers View post →
U-M Medical School Research
@UMichMedScience · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 17, 2023 · 22 shares · 5,721 followers View post →
Mehdi Touat
@MTouatMD · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 17, 2023 · 25 shares · 411 followers View post →
Katherine Masih, MD, PhD
@katherineemasih · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 17, 2023 · 25 shares · 859 followers View post →
Peter Truong, PhD
@iampetertruong · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 17, 2023 · 22 shares · 123 followers View post →
Abbie's Army - Fight DIPG Brain Cancer
@AbbiesArmy · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 17, 2023 · 25 shares · 4,762 followers View post →
Susannah Koontz, PharmD, BCOP
@KoontzOncology · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 17, 2023 · 22 shares · 2,938 followers View post →
Sara Labiano
@sara_labiano · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 81 followers View post →
Ana Patiño García
@AnaPatinoGarcia · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 757 followers View post →
Roel Verhaak
@roelverhaak · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 17, 2023 · 25 shares · 5,041 followers View post →
Imran
@DocImu20 · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 17, 2023 · 19 shares · 3 followers View post →
Caryn
@OneEyedCrn · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 17, 2023 · 26 shares · 28 followers View post →
王力德實驗室(leowanglab)
@leowanglab · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 17, 2023 · 25 shares · 1,238 followers View post →
Rachel O'Reggio
@RROReggio · X

RT @AbedKawakibiMD: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Ef…

Aug 17, 2023 · 10 shares · 480 followers View post →
Varun Vijay Prabhu
@vvpeaceful · X

RT @AbedKawakibiMD: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Ef…

Aug 16, 2023 · 10 shares · 83 followers View post →
#sophiastrong
@mightysophia · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 1,075 followers View post →
UCSF Pediatric Brain Center
@UCSF_PBC · X

RT @sebastianw: Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of int…

Aug 16, 2023 · 7 shares · 914 followers View post →
Rajan Jain, MD
@CoolAsANeuroRad · X

great job by @koschmannlab congratulations! https://t.co/cPo6cvmNKZ https://t.co/lBeFJykRZr

Aug 16, 2023 · 4,974 followers View post →
Peter Hofland
@PeterHofland11 · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 109 followers View post →
Pascal Duijf
@DuijfLab · X

RT @sebastianw: Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of int…

Aug 16, 2023 · 7 shares · 449 followers View post →
Erik Peterson
@erikrpeterson92 · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 16, 2023 · 25 shares · 132 followers View post →
Erik Peterson
@erikrpeterson92 · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 132 followers View post →
Defeat DIPG®
@DefeatDIPG · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 16, 2023 · 26 shares · 2,212 followers View post →
Defeat DIPG®
@DefeatDIPG · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 2,212 followers View post →
Samir Barghout, BScPhm, MSc, PhD
@samir_barghout · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 133 followers View post →
Amanda Valyko
@amvalyko · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 45 followers View post →
Katie Manzeck (she/her)
@katie_manzeck · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 266 followers View post →
I-Mei (Emay) Siu
@imsmd · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 16, 2023 · 26 shares · 1,101 followers View post →
Joanna Lum
@_JoannaLum · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 16, 2023 · 26 shares · 71 followers View post →
CKellyKishy
@CKellyKish · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 16, 2023 · 26 shares · 23 followers View post →
Allison Cheney
@allisonrcheney · X

RT @AbedKawakibiMD: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Ef…

Aug 16, 2023 · 10 shares · 128 followers View post →
Nicole Zollinger
@ZollingerNicole · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 113 followers View post →
Peter Truong, PhD
@iampetertruong · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 16, 2023 · 25 shares · 123 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 18,071 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

RT @AbedKawakibi: Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Effi…

Aug 16, 2023 · 10 shares · 18,071 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

RT @sebastianw: Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of int…

Aug 16, 2023 · 7 shares · 18,071 followers View post →
Cheng-Chia Wu
@DrWuRadOnc · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 16, 2023 · 26 shares · 759 followers View post →
Amanda
@astro_manda · X

RT @chadtough: A new manuscript published today reports ONC201 nearly doubles survival rates for patients with DIPG/DMG. Carl Koschmann, M…

Aug 16, 2023 · 26 shares · 274 followers View post →
Dr. Renee Read
@RRead_Lab · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 16, 2023 · 25 shares · 729 followers View post →
Sebastian Waszak
@sebastianw · X

Now online in @CD_AACR "Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways". Excited to have worked on this study with the amazing team from @KoschmannLab and @vennetilab.

Aug 16, 2023 · 26 likes · 7 shares · 426 followers View post →
Sebastian Waszak
@sebastianw · X

Link to article: https://t.co/8VLVMNDPwl

Aug 16, 2023 · 2 likes · 426 followers View post →
Gerry Tye
@GerryTye · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 1,549 followers View post →
Salendra Singh
@Salendra_Singh_ · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 793 followers View post →
Carl Koschmann
@CarlKoschmann · X

RT @UMRogelCancer: For the first time, researchers have found a potential drug candidate that improved outcomes for patients with pediatric…

Aug 16, 2023 · 22 shares · 474 followers View post →
Abed Rahman Kawakibi, MD
@AbedKawakibi · X

Excited to finally share this important work! Thanks to @KoschmannLab @vennetilab Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways https://t.co/Zxx1eekixG

Aug 16, 2023 · 32 likes · 10 shares · 277 followers View post →
Brett Taylor
@brettmaxtaylor · X

RT @vennetilab: Super excited to share our paper in collaboration with @KoschmannLab on ONC201 in H3K27M #DIPG #DMG! ONC201 is therapeuti…

Aug 16, 2023 · 25 shares · 163 followers View post →
The Innovation | Medicine
@Innov_Medicine · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 253,983 followers View post →
Analiz Rodriguez MD, PhD, MBA, FAANS
@ARODMDPHD · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 6,596 followers View post →
Elmira Khabusheva
@drkhabusheva · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 735 followers View post →
Imran Noorani
@drimrannoorani · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 824 followers View post →
U-M Rogel Cancer Center
@UMRogelCancer · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 7,235 followers View post →
I-Mei (Emay) Siu
@imsmd · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 1,101 followers View post →
Koschmann Lab
@KoschmannLab · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 765 followers View post →
ChadTough Defeat DIPG Foundation
@chadtough · X

ChadTough Defeat DIPG Foundation is honored to support this work and witness this incredible step forward in the fight to #DefeatDIPG. Watch the full video to learn about the next steps to build upon this research: https://t.co/eWpiPv0i23

Aug 16, 2023 · 12 likes · 1 share · 6,807 followers View post →
EANO
@EANOassociation · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 4,279 followers View post →
Sebastian Waszak
@sebastianw · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 426 followers View post →
Carl Koschmann
@CarlKoschmann · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 474 followers View post →
Siva Kumar Natarajan
@shiva251993 · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 224 followers View post →
Lyssiotis Lab
@LyssiotisLab · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 7,057 followers View post →
Vennetilab
@vennetilab · X

RT @ElizSMcKenna: Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of I…

Aug 16, 2023 · 19 shares · 1,015 followers View post →
Elizabeth McKenna
@ElizSMcKenna · X

Now online in @CD_AACR: Clinical Efficacy of ONC201 in H3K27M-mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways @KoschmannLab @vennetilab https://t.co/3yJm8qxteG @umichmedicine @UMRogelCancer @MottChildren #DMG #DIPG https://t.co/mMlIS2N91v

Aug 16, 2023 · 53 likes · 19 shares · 18,071 followers View post →