October 2023 PMID 37598453

Acute effects of Δ9-tetrahydrocannabinol (THC) on resting state connectivity networks and impact of COMT genotype: A multi-site pharmacological fMRI study.

Teuntje A D Pelgrim, Johannes G Ramaekers, Matthew B Wall, Tom P Freeman, Matthijs G Bossong

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Mentions

Peak: 1 in Aug 2023

across 2 sources since Aug 2023

Extended reach

21,119

potential audience

Total likes

372

Video views

14,367

Mentions per month

Aug 2023 – Apr 2025

Where it's discussed

X / Twitter2 posts
YouTube2 videos

AI synopsis

What people are saying

The discussions reflect curiosity and acknowledgment of the study’s implications, with users referencing the genetic influence of COMT on THC’s effects and using terms like 'significant' and 'impactful,' which show moderate engagement and interest. The tone combines scientific curiosity with an appreciation for personalized approaches, contributing to the overall moderate agreement and impact perceptions.

AgreementModerate agreement

Most discussions acknowledge the significance of the study’s findings on THC’s effects on brain connectivity, showing moderate support.

InterestHigh interest

Posts express a strong curiosity about how genetics, like the COMT genotype, influence brain responses to THC.

EngagementModerate engagement

Comments vary; some delve into the study’s methodology and implications, indicating active engagement, but many mention the topic casually.

ImpactModerate impact

Discussions indicate some recognition of the research’s importance, especially regarding personalized medicine and neuropsychiatric effects, but see it as part of ongoing scientific discourse.

Abstract in brief

The study investigated how THC (the main psychoactive component of cannabis) affects brain connectivity during rest, focusing on different brain networks linked to psychosis, such as the salience, executive, default mode, and hippocampus-midbrain-striatum networks.
THC was found to decrease connectivity specifically in the salience network and the hippocampus-midbrain-striatum network, with effects being stronger in individuals with the Met/Met variation of the COMT genotype, which also corresponded to more intense dysphoric feelings.
These findings suggest that THC influences brain communication related to awareness and psychotic-like effects, and that genetic differences (COMT genotype) can modify how strongly these effects occur in the brain and in subjective experiences.]

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All mentions

Impact of COMT Gene on Brain Connectivity and THC Response

This video explains how the COMT gene affects brain connectivity and individual responses to THC, highlighting the gene's role in stress management, dopamine regulation, and psychiatric risk factors.

Levelheaded Mind · Apr 13, 2025 14,142 views

Effects of THC on Brain Connectivity and Genetic Influence in fMRI Study

This study investigates how THC affects brain connectivity during rest, focusing on networks linked to psychosis, and examines how genetic variations influence these effects.

practiCal fMRI · Jun 29, 2024 225 views

Blair Curless

@blair_curless · X

May 19, 2024 · 1 like · 6 followers View post →

Leonhard Schilbach

@leoschilbach · X

Acute effects of Δ9-tetrahydrocannabinol (THC) on resting state connectivity networks and impact of COMT genotype: A multi-site pharmacological fMRI study https://t.co/NHpPPPbm2M

Aug 18, 2023 · 1 like · 6,746 followers View post →