Int J Mol Sci August 2023 PMID 37629202

From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research.

Andrew Jiang, Renee R Handley, Klaus Lehnert, Russell G Snell

Mentions

27
Peak: 9 in Apr 2025
across 6 sources since Aug 2023

Extended reach

50,927
potential audience

Total likes

1

Video views

5

Mentions per month

Aug 2023 – Dec 2025

Where it's discussed

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AI synopsis

What people are saying

The overall discussion reflects appreciation and recognition of the publication's significance, with comments like 'celebratory review' and mentions of the vast past research, emphasizing the value of consolidating 150 years of HD research. The tone and word choices foster a feeling of respect and acknowledgment, but lack detailed critique or calls for immediate action, indicating moderate engagement and perceived impact.

AgreementModerate agreement

Most posts express positive acknowledgment and agreement with the review's thoroughness and significance, indicating shared appreciation for the comprehensive historical overview.

InterestHigh interest

Posts demonstrate high interest, highlighting the importance of the research by calling it a 'celebratory review' and emphasizing its comprehensive nature.

EngagementModerate engagement

The discussion shows moderate engagement, with references to the article's themes but lacking in detailed analysis or critique, as seen in the neutral tone and informal expressions.

ImpactModerate impact

The posts suggest the article is regarded as an important, impactful meta-review that consolidates a century and a half of findings, although no direct implications or transformative claims are made.

Abstract in brief

  • Huntington's disease (HD) is a genetic disorder caused by a CAG repeat expansion in the huntingtin gene, leading to the production of a toxic mutant protein that damages neurons.
  • The disease primarily affects medium spiny neurons in the brain’s caudate nucleus and putamen, resulting in motor, cognitive, and behavioral symptoms; despite understanding its genetic basis, no disease-modifying treatment has been approved.
  • Over 150 years of research have explored various mechanisms behind HD, including excitotoxicity, mitochondrial problems, and neuroinflammation, with ongoing efforts to develop targeted therapies based on these molecular insights.]

Top posts

Most liked on X and Bluesky
Andrew
@Andrew_Jiang_NZ · X

A celebratory review of the past 150 years of HD research! From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington’s Disease Research https://t.co/BM5PQ5EHE8 #mdpiijms via @IJMS_MDPI @MDPIOpenAccess

Aug 22, 2023 · 1 like · 2 shares · 35 followers View post →
MDPI
@MDPIOpenAccess · X

RT @Andrew_Jiang_NZ: A celebratory review of the past 150 years of HD research! From Pathogenesis to Therapeutics: A Review of 150 Years o…

Aug 22, 2023 · 2 shares · 45,290 followers View post →
IJMS MDPI
@IJMS_MDPI · X

RT @Andrew_Jiang_NZ: A celebratory review of the past 150 years of HD research! From Pathogenesis to Therapeutics: A Review of 150 Years o…

Aug 22, 2023 · 2 shares · 5,308 followers View post →
proteostasis_papers
@ProteostasisP · X

From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research https://t.co/UCMloGX34b https://t.co/1KOejKnUK8

Aug 26, 2023 · 58 followers View post →

All mentions

proteostasis_papers
@ProteostasisP · X

From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research https://t.co/UCMloGX34b https://t.co/1KOejKnUK8

Aug 26, 2023 · 58 followers View post →
PolyQReviewPapers
@polyqr_papers · X

Review: From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research - polyQ https://t.co/dut3Gj0VuQ

Aug 26, 2023 · 20 followers View post →
IJMS MDPI
@IJMS_MDPI · X

RT @Andrew_Jiang_NZ: A celebratory review of the past 150 years of HD research! From Pathogenesis to Therapeutics: A Review of 150 Years o…

Aug 22, 2023 · 2 shares · 5,308 followers View post →
MDPI
@MDPIOpenAccess · X

RT @Andrew_Jiang_NZ: A celebratory review of the past 150 years of HD research! From Pathogenesis to Therapeutics: A Review of 150 Years o…

Aug 22, 2023 · 2 shares · 45,290 followers View post →
Andrew
@Andrew_Jiang_NZ · X

A celebratory review of the past 150 years of HD research! From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington’s Disease Research https://t.co/BM5PQ5EHE8 #mdpiijms via @IJMS_MDPI @MDPIOpenAccess

Aug 22, 2023 · 1 like · 2 shares · 35 followers View post →
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