Sci Rep August 2023 PMID 37633982

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet.

Mathilde Meyenberg, Anna Hakobyan, Nikolina Papac-Milicevic, Laura Göderle, Franziska L Langner, Mateo Markovic, Ji-Hyun Lee, Bon-Kyoung Koo, Georg A Busslinger, Israel Tojal da Silva, Christoph J Binder, Jörg Menche, Joanna I Loizou

Mentions

9
Peak: 6 in Aug 2023
across 3 sources since Aug 2023

Extended reach

140,049
potential audience

Total likes

22

Video views

74

Mentions per month

Aug 2023 – Jul 2025

Where it's discussed

  • X / Twitter6 posts
  • Reddit2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a balanced perspective, mentioning that despite high-fat diets and obesity impacting intestinal health, they may not directly cause harmful mutations, as noted in phrases like 'similar mutational patterns' and 'may not directly induce mutations.' The tone varies from neutral sharing to cautious optimism about the study's implications, illustrating a moderate level of engagement and impact.

AgreementModerate agreement

Most discussions agree that the study provides valuable insights into how high-fat diets influence intestinal cell genetics without significantly increasing mutation rates associated with cancer.

InterestModerate interest

The discussions show moderate interest by highlighting key topics such as obesity, mutation patterns, and potential cancer links, though some posts mainly share the publication's titles or summaries.

EngagementModerate engagement

Posts demonstrate moderate engagement through sharing article titles, hashtags, and brief comments or questions, indicating some level of thoughtful interaction rather than superficial sharing.

ImpactModerate impact

The overall tone suggests that the publication has a meaningful impact on understanding obesity and cancer risk, emphasizing the importance of genetic stability research in this context.

Abstract in brief

  • The study investigates how long-term exposure to a high-fat diet affects the genetic stability of intestinal crypt cells in a mouse model, focusing on mutational signatures to understand potential links to cancer risk.
  • Results show that both high-fat diet and normal conditions have similar mutational patterns, indicating that a high-fat diet by itself does not cause increased genomic instability or mutations associated with cancer development.
  • The findings suggest that while obesity and a high-fat diet influence intestinal cell homeostasis, they may not directly induce the genetic mutations linked to colorectal cancer, emphasizing the complexity of obesity-related cancer development.

Top posts

Most liked on X and Bluesky
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet #obesity #cancer #CRC @SciReports https://t.co/Ifj0HvsKgt

Aug 27, 2023 · 9 likes · 3 shares · 6,435 followers View post →
Neil Floch MD
@NeilFlochMD · X

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet | Scientific Reports https://t.co/TPPz2yRexn

Aug 27, 2023 · 3 likes · 130,110 followers View post →
CeMM Papers
@CeMM_papers · X

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet https://t.co/6DrM8UpkZu

Aug 27, 2023 · 1 like · 541 followers View post →
Adipose Papers
@adipose_papers · X

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet https://t.co/uLjOQCtpiB https://t.co/NCg7czXiPN

Aug 27, 2023 · 2,444 followers View post →
Amaya Lopez-Pascual
@amayalpzp · X

RT @Brunorm84: Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet #obesity #cancer #CRC @SciR…

Aug 28, 2023 · 3 shares · 273 followers View post →
Javier Martínez-García, PhD
@MartnezGarcia_J · X

RT @Brunorm84: Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet #obesity #cancer #CRC @SciR…

Aug 27, 2023 · 3 shares · 155 followers View post →

All mentions

Amaya Lopez-Pascual
@amayalpzp · X

RT @Brunorm84: Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet #obesity #cancer #CRC @SciR…

Aug 28, 2023 · 3 shares · 273 followers View post →
CeMM Papers
@CeMM_papers · X

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet https://t.co/6DrM8UpkZu

Aug 27, 2023 · 1 like · 541 followers View post →
Neil Floch MD
@NeilFlochMD · X

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet | Scientific Reports https://t.co/TPPz2yRexn

Aug 27, 2023 · 3 likes · 130,110 followers View post →
Javier Martínez-García, PhD
@MartnezGarcia_J · X

RT @Brunorm84: Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet #obesity #cancer #CRC @SciR…

Aug 27, 2023 · 3 shares · 155 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet #obesity #cancer #CRC @SciReports https://t.co/Ifj0HvsKgt

Aug 27, 2023 · 9 likes · 3 shares · 6,435 followers View post →
Adipose Papers
@adipose_papers · X

Mutational landscape of intestinal crypt cells after long-term in vivo exposure to high fat diet https://t.co/uLjOQCtpiB https://t.co/NCg7czXiPN

Aug 27, 2023 · 2,444 followers View post →