PubHawk
Am J Psychiatry October 2023 PMID 37644812

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers.

Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F Sullivan, Ralf Kuja-Halkola, Yi Lu

Full text PDF Download social card

Mentions

17
Peak: 8 in Oct 2023
across 4 sources since Sep 2023

Extended reach

69,345
potential audience

Total likes

41

Video views

147

Mentions per month

Sep 2023 – Sep 2025

Where it's discussed

  • X / Twitter12 posts
  • YouTube2 videos
  • News2 articles
  • Reddit1 posts

AI synopsis

What people are saying

The discussions highlight the importance of recognizing genetic diversity in depression, with mentions of studies using large-scale genetic models, and phrases such as 'very interesting approach' and 'partial genetic components,' which reflect both curiosity and appreciation for the research's depth and potential impact.

AgreementModerate agreement

Most discussions recognize the importance of the study, with some explicitly agreeing to its findings about genetic heterogeneity in depression.

InterestHigh interest

The numerous mentions of the study being 'very interesting' and describing its approach as 'large scale' indicate high curiosity and engagement.

EngagementHigh engagement

Participants reference specific aspects like genetic components, subgroups, and the methodology, demonstrating deep engagement with the research details.

ImpactHigh impact

The emphasis on the study's significance and novel approach suggests many see it as a potentially transformative contribution to understanding depression.

Abstract in brief

  • The study analyzed Swedish health data to identify 18 subgroups of Major Depressive Disorder (MDD) based on clinical and psychosocial features, and estimated their heritability, finding it ranged from 30.5% to 58.3%, with higher heritability in youth-onset and disabled subgroups.
  • The research used sibling-based genetic models and found that genetic correlations between subgroups were mostly less than 1, indicating different genetic influences across the subgroups, which suggests heterogeneity in the genetic makeup of MDD.
  • These findings support the idea that MDD is genetically diverse, and understanding this heterogeneity can help improve diagnosis and personalized treatment by recognizing different underlying genetic factors in various clinical subgroups.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Aidan Wright
@aidangcw · X

On the genetic heterogeneity in major depressive disorder: https://t.co/YD0cSmxL0H

Oct 2, 2023 · 22 likes · 5 shares · 15,645 followers View post →
George Dawson
@dawso007 · X

Very interesting approach to study heterogeneity of MDE on a large scale... Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers | American Journal of Psychiatry https://t.co/mQIVcbtgz2

Sep 2, 2023 · 16 likes · 3 shares · 7,828 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Different clinical subgroups of depression have partially distinct genetic components and varying degrees of genetic contribution. https://t.co/fd32sD8Kqp https://t.co/wCmmjH2xGG

Sep 6, 2023 · 2 likes · 1 share · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

4. “Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers,” by Thuy-Dung Nguyen, https://t.co/JKWoDsGIWe., et al. 4/4 https://t.co/v1d3EwWEm1

Oct 19, 2023 · 11,606 followers View post →
Daniel P. Moriarity
@dp_moriarity · X

RT @aidangcw: On the genetic heterogeneity in major depressive disorder: https://t.co/YD0cSmxL0H

Oct 2, 2023 · 5 shares · 5,627 followers View post →
Daniel P. Moriarity
@dp_moriarity · X

RT @APAPubJournals: Different clinical subgroups of depression have partially distinct genetic components and varying degrees of genetic co…

Sep 6, 2023 · 1 share · 5,627 followers View post →

All mentions

Journals of The American Psychiatric Association
@APAPubJournals · X

4. “Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers,” by Thuy-Dung Nguyen, https://t.co/JKWoDsGIWe., et al. 4/4 https://t.co/v1d3EwWEm1

Oct 19, 2023 · 11,606 followers View post →
Amanda R. Merner, PhD
@armerner_psych · X

RT @aidangcw: On the genetic heterogeneity in major depressive disorder: https://t.co/YD0cSmxL0H

Oct 3, 2023 · 5 shares · 1,644 followers View post →
Claudia_La
@ClLazarides · X

RT @aidangcw: On the genetic heterogeneity in major depressive disorder: https://t.co/YD0cSmxL0H

Oct 3, 2023 · 5 shares · 818 followers View post →
HiTOP
@HiTOP_system · X

RT @aidangcw: On the genetic heterogeneity in major depressive disorder: https://t.co/YD0cSmxL0H

Oct 3, 2023 · 5 shares · 4,388 followers View post →
Daniel P. Moriarity
@dp_moriarity · X

RT @aidangcw: On the genetic heterogeneity in major depressive disorder: https://t.co/YD0cSmxL0H

Oct 2, 2023 · 5 shares · 5,627 followers View post →
Aidan Wright
@aidangcw · X

On the genetic heterogeneity in major depressive disorder: https://t.co/YD0cSmxL0H

Oct 2, 2023 · 22 likes · 5 shares · 15,645 followers View post →
Daniel P. Moriarity
@dp_moriarity · X

RT @APAPubJournals: Different clinical subgroups of depression have partially distinct genetic components and varying degrees of genetic co…

Sep 6, 2023 · 1 share · 5,627 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Different clinical subgroups of depression have partially distinct genetic components and varying degrees of genetic contribution. https://t.co/fd32sD8Kqp https://t.co/wCmmjH2xGG

Sep 6, 2023 · 2 likes · 1 share · 11,606 followers View post →
Tony Cleare
@TCleare · X

RT @dawso007: Very interesting approach to study heterogeneity of MDE on a large scale... Genetic Contribution to the Heterogeneity of Maj…

Sep 3, 2023 · 3 shares · 1,052 followers View post →
Doctor_David
@Doctor_David · X

RT @dawso007: Very interesting approach to study heterogeneity of MDE on a large scale... Genetic Contribution to the Heterogeneity of Maj…

Sep 2, 2023 · 3 shares · 2,730 followers View post →
yoshiyuki nishio
@nishiokov · X

RT @dawso007: Very interesting approach to study heterogeneity of MDE on a large scale... Genetic Contribution to the Heterogeneity of Maj…

Sep 2, 2023 · 3 shares · 520 followers View post →
George Dawson
@dawso007 · X

Very interesting approach to study heterogeneity of MDE on a large scale... Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers | American Journal of Psychiatry https://t.co/mQIVcbtgz2

Sep 2, 2023 · 16 likes · 3 shares · 7,828 followers View post →
Using real-world big data from eHealth, biobanks and national ...
News

Publisher: American Psychiatric Publishing, Inc. DOI: 10.1176/appi.ajp.20220906. Associations Between Symptoms of Premenstrual Disorders and ...

Sep 15, 2025 View →
Using real-world big data from eHealth, biobanks and national ...
News

Editor: American Psychiatric Publishing, Inc. DOI: 10.1176/appi.ajp.20220906. Associations Between Symptoms of Premenstrual Disorders and ...

Sep 15, 2025 View →
[Article] Genetic Contribution to the Heterogeneity of Major ... - Reddit
Reddit

AJP Published Online:30 Aug 2023 DOI: https://doi.org/10.1176/appi.ajp.20220906 URL…

Aug 31, 2023 View →