I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy” has been published today! https://t.co/Ew02vJDl9E
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy.
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Aug 2023 – Aug 2025Where it's discussed
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Several posts highlight the efficacy of CD45 epitope editing in CAR T cells for treating blood cancers, such as discussions around the protective mutation on CD45 and its role in preventing T cell fratricide. The enthusiastic tone, with phrases like 'great news for treatment' and 'excited to share,' further conveys the anticipation and optimism regarding the potential real-world applications and advancements in this area of research.
The majority of discussions express strong support for the findings and innovations presented in the publication.
Participants in the discussions display a high level of curiosity and enthusiasm about the implications of the research for blood cancer treatment.
Most posts reflect a general understanding of the concepts, but few delve deeply into technical details or implications.
Many contributors believe that this research could significantly advance the field of immunotherapy, citing its potential to transform treatments for blood cancers.
Abstract in brief
- Researchers developed a universal CAR T cell therapy targeting the CD45 marker for blood cancers, aimed at overcoming the limitations of current immunotherapies.
- To avoid damaging healthy hematopoietic cells while retaining CD45's essential functions, they used CRISPR adenine base editing to create a protective mutation on the CD45 epitope.
- The edited CAR T cells showed resilience against killing each other and effectiveness against various blood cancers, while allowing healthy stem cells to properly engraft and function in the body.
Top posts
Most liked on X and BlueskyEpitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine https://t.co/sW0SqZFTVt
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine @PennMedicine @parkerici https://t.co/sW0SqZFTVt
How can #BaseEditing improve #CART for blood cancers? Drs. @CarlHJune, Saar Gill, & a team at @PennMedicine developed epitope-edited CD45 CAR T cells that were effective against several hematologic malignancies.
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine https://t.co/C1YdLJVUaj
All mentions
Universal CAR T Cell Therapy Targeting CD45 Marker for Blood Cancer
Researchers developed a universal CAR T cell therapy targeting the CD45 marker in blood cancers. This innovative approach aims to avoid damaging healthy cells while maintaining critical functions, using CRISPR adenine…
Advancements in Universal CAR T Cell Therapy for Blood Cancer
This week, Catriona discusses groundbreaking advancements in universal CAR T cell therapy targeting the CD45 marker for blood cancers. This novel approach utilizes CRISPR adenine base editing to modify the CD45 epitope…
RT @kumaped: https://t.co/WlI2F6QfTl 細胞表面のがん特異的抗原がない場合、キメラ抗原受容体(CAR)T細胞、モノクローナル抗体、二重特異性T細胞誘導抗体などの免疫療法は、通常、系統抗原(CD19など)を標的とする。
https://t.co/WlI2F6QfTl 細胞表面のがん特異的抗原がない場合、キメラ抗原受容体(CAR)T細胞、モノクローナル抗体、二重特異性T細胞誘導抗体などの免疫療法は、通常、系統抗原(CD19など)を標的とする。
リポスト> これ参考文献やけど、抗CD45CAR-Tだと兄弟殺しをするので、ドナーの造血幹・前駆細胞自体のCD45などのエピトープをゲノム編集(同義変異)して移植すると、癌化した白血球だけが死滅する模様 https://t.co/RkQJ2HWzLA
RT @PennMedEVDCSO: Epitope base editing #CD45 in hematopoietic cells enables universal blood cancer immune therapy ft. @wellhausrn, Stefani…
RT @John_E_Connolly: Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational…
I think it is worth reviewing the recently emerging concept of "shielding of hematopoietic stem cells" now: 1. Knock-out of CD33 (https://t.co/RhP9tDiWIB) 2. Epitope editing of CD117 (https://t.co/rSCDRgRBNv), CD45 (https://t.co/4Z6e6nc8Ed) and CD123 (https://t.co/hqXHbfgSZ7)
HAEM: in preclinical studies, CAR T cells directed at the pan-haem antigen CD45 were effective against different haem cancers; CD45 base editing in normal T and blood stem cells protected against T cell fratricide and bone marrow failure, respectively. https://t.co/kZOhLGUegn
RT @PennMedEVDCSO: Epitope base editing #CD45 in hematopoietic cells enables universal blood cancer immune therapy ft. @wellhausrn, Stefani…
RT @ScienceTM: Scientists at @PennMedicine have leveraged epitope #BaseEditing to insert mutations into CD45 in healthy stem cells to avoid…
Scientists at @PennMedicine have leveraged epitope #BaseEditing to insert mutations into CD45 in healthy stem cells to avoid recognition by #CARTcells, leading to strong cell killing against blood cancers in mice while avoiding off-target effects. https://t.co/vfvFd0dZRn https://t.co/gVJsxiv26T
Epitope base editing #CD45 in hematopoietic cells enables universal blood cancer immune therapy ft. @wellhausrn, Stefanie Lesch, Nils Engel, Austin Rennels, Donna Gonzales, Friederike Herbst, Regina Young, @carlhjune & Saar Gill @PennCancer https://t.co/uJo0qMbjPN https://t.co/dhxkd7PY69
RT @John_E_Connolly: Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational…
RT @John_E_Connolly: Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational…
RT @John_E_Connolly: Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational…
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine https://t.co/sW0SqZFTVt
RT @ImmunoPodcast: How can #BaseEditing improve #CART for blood cancers? Drs. @CarlHJune, Saar Gill, & a team at @PennMedicine developed e…
RT @ImmunoPodcast: How can #BaseEditing improve #CART for blood cancers? Drs. @CarlHJune, Saar Gill, & a team at @PennMedicine developed e…
How can #BaseEditing improve #CART for blood cancers? Drs. @CarlHJune, Saar Gill, & a team at @PennMedicine developed epitope-edited CD45 CAR T cells that were effective against several hematologic malignancies.
RT @GCessak: Wyniki bad. przedklinicznego: modyfikcja epitopów komórek macierzystych (HSC) i komórek T umożliwia bezpieczne i skuteczne zas…
Wyniki bad. przedklinicznego: modyfikcja epitopów komórek macierzystych (HSC) i komórek T umożliwia bezpieczne i skuteczne zastosowanie komórek CAR-T kierowanych na markery CD45 w uniwersalnej immunoterapii nowotworów hematologicznych. https://t.co/k5MclKsXHP
Drs. @CarlHJune, Saar Gill, and their labs at @PennMedicine used #BaseEditing to develop CAR T cells that are effective against patient-derived #AcuteMyeloidLeukemia, B cell #lymphoma, and acute T cell leukemia.
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine https://t.co/QLvCaymSoS
Epitope editing enables the safe and effective targeting of the pan-leukocyte marker CD45 while preserving function @ScienceTM @carlhjune Gill @wellhausrn https://t.co/UAEpWsYVoy
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
"Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy" Wellhausen N, O’Connell RP [..] June CH, Gill SI. Sci Transl Med 2023-08-31. https://t.co/7lgLVtoO2t #CRISPR; ABE
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine https://t.co/F23AQR8HbO
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine https://t.co/KOpqnlqfks
'Two-pronged immunotherapy approach could treat most blood cancers'. 'Strategy using genetically engineered T cells would attack cancer while sparing healthy blood stem cells'. Paper: https://t.co/r7ByLxigkr https://t.co/wIafOTUmva
#HSC #汎白血球CD45 の #エピトープベース編集 による #広汎CART治療 の概念を実証した、と主張。血液癌一般への有効性をみた、化学療法コンディショニングにも使える、P1に進む、と:UPenn。 https://t.co/UIfs086A9V
@dikokaz @DrOlaLandgren @SylvesterCancer @oncodaily Hi Diko, Do you think the new strtegy in CAR T*** theraph my be cure for leukemia? Below is the link about the study; https://t.co/33WB0nv8yz
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @ilyassahinMD: * https://t.co/PoZrLpDx9U
* https://t.co/PoZrLpDx9U
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @TxaviManCat: Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Med…
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy https://t.co/Nj0UJimcWz
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
Great news for the treatment of haematological malignancies thanks to base editing! https://t.co/ccVpBXV5Fz
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @John_E_Connolly: Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
Trend up+12: Wellhausen N, ..., Gill SI (Sci Transl Med) __Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy__ https://t.co/eGaBI7w3Qp
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
Trend up+37: Wellhausen N, ..., Gill SI (Sci Transl Med) __Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy__ https://t.co/eGaBI7w3Qp
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine @PennMedicine @parkerici https://t.co/sW0SqZFTVt
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
@wellhausrn @PennMedicine @Penn For those interested - here is a link to @wellhausrn’s full article that was published yesterday on @ScienceMagazine - “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy”. https://t.co/dODO80dtGP
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine https://t.co/C1YdLJVUaj
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @1000genes: Dos avances enormes para las terapias contra prácticamente todos los cánceres hematológicos: 1-Edición de epítopos 2- Dis…
Dos avances enormes para las terapias contra prácticamente todos los cánceres hematológicos: 1-Edición de epítopos 2- Diseño de epítopos para receptores de superficie. Ambas permiten el uso seguro y eficaz de células CAR-T https://t.co/U4x2sXsCIp https://t.co/087IBmwk73
RT @doctorpemm: Epitope base editing #CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Med…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @BowTiedBiotech:
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy https://t.co/RiE04SiMhM https://t.co/Vbu7J9eDfB
https://t.co/mRpoHnzuEM
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
Epitope base editing #CD45 in hematopoietic cells enables universal blood cancer immune therapy | Science Translational Medicine https://t.co/SXvT5IjJnZ
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
https://t.co/6tGmAgkP5f
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
RT @wellhausrn: I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer…
I am excited to share that my PhD work on “Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy” has been published today! https://t.co/Ew02vJDl9E
Expanding the impact of #CARTcelltherapy: An immunotherapy strategy against all #bloodcancers @pennmedicine @sciencetm https://t.co/cQPP4YG2C1 https://t.co/GTwLV3Xdpx