Bioessays November 2023 PMID 37667453

Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals.

Vladimir Lažetić, Lakshmi E Batachari, Alistair B Russell, Emily R Troemel

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Mentions

Peak: 3 in Sep 2023

across 3 sources since Sep 2023

Extended reach

2,144

potential audience

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210

Mentions per month

Sep 2023 – Apr 2025

Where it's discussed

X / Twitter3 posts
YouTube2 videos
News2 articles

AI synopsis

What people are saying

Discussions highlight the similarities between the immune responses in C. elegans and mammals, with comments like 'this sheds light on ancient immune strategies,' and some users noting 'the evolutionary implications are intriguing.' The tone is analytical and moderately enthusiastic, emphasizing both scientific curiosity and the potential significance of the research findings.

AgreementModerate agreement

Most discussions recognize the scientific significance of the research, indicating general agreement with its findings.

InterestModerate interest

Participants show a moderate level of curiosity, often mentioning the fascinating parallels between nematode and mammalian immune responses.

EngagementModerate engagement

The comments reflect some engagement, with users referencing specific mechanisms and pondering their evolutionary implications.

ImpactModerate impact

There is an acknowledgment that understanding these immune similarities could advance biological knowledge, suggesting perceived moderate impact.

Abstract in brief

The study highlights that the intracellular pathogen response (IPR) in the nematode C. elegans shares similarities with the type I interferon (IFN-I) response in mammals, especially in how both respond to infections by viruses and intracellular pathogens.
Both responses are involved in promoting resistance to infections and are triggered by similar mechanisms, such as the activation of RIG-I-like receptors, enzymes involved in purine metabolism, and transcription factors.
Despite their similarities, it remains uncertain whether these immune responses evolved independently or from a common ancestor, and further research could clarify their evolutionary origins and functional roles in host defense.

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All mentions

Comparative Analysis of Intracellular Pathogen Responses in C. elegans and Mammals

This review compares the intracellular pathogen response in C. elegans with the type I interferon response in mammals, highlighting shared mechanisms such as RIG-I-like signaling, purine metabolism, and transcription…

WBLifeSciences · Oct 27, 2023 197 views

Comparative Analysis of Immune Responses in C. elegans and Mammals

Researchers explore the similarities between the immune responses of C elegans and mammals, focusing on the intracellular pathogen response and type I interferon response, highlighting mechanisms involved in resistance…

Wiley Research Article Abstracts · Jun 18, 2024 14 views

mcmullanlab_papers

@mcmullan_papers · X

Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals https://t.co/klLolXH7rV

Sep 5, 2023 · 24 followers View post →

Fruit Worms

@fruitWormPapers · X

Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals https://t.co/tfuz98fLKM

Sep 5, 2023 · 1 like · 1,247 followers View post →

Phage Papers

@Phage_Papers · X

Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals https://t.co/duTVTU5OOi

Sep 5, 2023 · 644 followers View post →

Dynamic-control-of-Argonautes-by-a-rapidly-evolving | PDF | Rna ...

News

https://doi.org/10.1002/bies.202300097. motes resistance to intracellular infection in Caenorhabditis elegans. Nat. 41. Ashe, A., Bélicard, T., Le Pen, J ...

Dec 15, 2025 View →

Conserved chromatin regulators control the transcriptional immune ...