New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic nutrient metabolism during fasting (Henning Tim Langer et al.) https://t.co/vj3lPyhPrs @HenningLanger @SamwiseT @MarcusDGon @Cornell https://t.co/lSpavRCKpG
The proteasome regulates body weight and systemic nutrient metabolism during fasting.
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Sep 2023 – Dec 2024Where it's discussed
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X / Twitter11 posts
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YouTube2 videos
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What people are saying
The overall conversations demonstrate strong interest and positive acknowledgment of the article’s significance, with examples like mentions of collections, journal references, and hashtags like #obesity and #autophagy. The tone suggests curiosity and recognition of the proteasome’s importance in metabolic regulation, which contributes to moderate engagement and perceived impact on ongoing research.
Most discussions express positive acknowledgment and support for the significance of the research findings about the proteasome's role during fasting.
The discussions show a high level of interest, referencing collections, journal collections, and related research tags, indicating engagement with the research topic.
Posts include mentions of specific elements like metabolic pathways, literature collections, and authors, showing active engagement with the scientific findings.
The discussions highlight the article's relevance for fields such as obesity and metabolism, suggesting that relevant research could influence future studies and approaches.
Abstract in brief
- The study investigates how the ubiquitin-proteasome system (UPS) and autophagy contribute to tissue breakdown and body weight regulation during fasting in mice, finding that inhibiting the UPS with bortezomib prevents weight and tissue loss.
- Bortezomib treatment enhances protein synthesis and activates metabolic pathways like PI3K-AKT-mTOR during fasting, which helps maintain tissue health, whereas blocking autophagy with chloroquine accelerates tissue degradation.
- Overall, inhibiting the UPS during fasting appears to protect against tissue catabolism and influences metabolic responses such as ketogenesis, highlighting the proteasome's key role in managing body and tissue weight during nutrient scarcity.]
Top posts
Most liked on X and BlueskyNew in our #PhysiologyofObesity collection! LINK: https://t.co/21Ku7GgLd0 @HenningLanger @SamwiseT @MarcusDGon @Cornell @AJPEndoMetab #phdchat #obesity https://t.co/lpxBscubMD
Nre in the AJPEndoMetab November issue! The #proteasome regulates body weight and systemic nutrient #metabolism during fasting (Langer et al.) https://t.co/JP0DcXDUJa #autophagy #fasting #glucose #proteasome #proteolysis https://t.co/kxKG8SxBEV
The proteasome regulates body weight and systemic nutrient metabolism during fasting | American Journal of Physiology-Endocrinology and Metabolism https://t.co/cNZIcdpP8O
RT @AJPEndoMetab: Nre in the AJPEndoMetab November issue! The #proteasome regulates body weight and systemic nutrient #metabolism during f…
RT @APSPublications: New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic…
All mentions
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RT @AJPEndoMetab: Nre in the AJPEndoMetab November issue! The #proteasome regulates body weight and systemic nutrient #metabolism during f…
Nre in the AJPEndoMetab November issue! The #proteasome regulates body weight and systemic nutrient #metabolism during fasting (Langer et al.) https://t.co/JP0DcXDUJa #autophagy #fasting #glucose #proteasome #proteolysis https://t.co/kxKG8SxBEV
The proteasome regulates body weight and systemic nutrient metabolism during fasting | American Journal of Physiology-Endocrinology and Metabolism https://t.co/cNZIcdpP8O
RT @AJPEndoMetab: New in our #PhysiologyofObesity collection! LINK: https://t.co/21Ku7GgLd0 @HenningLanger @SamwiseT @MarcusDGon @Cornell…
New in our #PhysiologyofObesity collection! LINK: https://t.co/21Ku7GgLd0 @HenningLanger @SamwiseT @MarcusDGon @Cornell @AJPEndoMetab #phdchat #obesity https://t.co/lpxBscubMD
RT @KetosisJournal: #TheJournalOfKetosis "The proteasome regulates body weight and systemic nutrient metabolism during fasting. (Pub Date:…
#TheJournalOfKetosis "The proteasome regulates body weight and systemic nutrient metabolism during fasting. (Pub Date: 2023-09-06)" https://t.co/pATzFdkszW
RT @APSPublications: New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic…
RT @APSPublications: New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic…
New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic nutrient metabolism during fasting (Henning Tim Langer et al.) https://t.co/vj3lPyhPrs @HenningLanger @SamwiseT @MarcusDGon @Cornell https://t.co/lSpavRCKpG
The proteasome regulates body weight and systemic nutrient metabolism during fasting https://t.co/dtqdfL0Vbr https://t.co/OQLZ7maBpK