Am J Physiol Endocrinol Metab November 2023 PMID 37672249

The proteasome regulates body weight and systemic nutrient metabolism during fasting.

Henning Tim Langer, Samuel R Taylor, Mujmmail Ahmed, Tiffany Perrier, Tanvir Ahmed, Marcus D Goncalves

Mentions

13
Peak: 8 in Sep 2023
across 2 sources since Sep 2023

Extended reach

36,165
potential audience

Total likes

41

Video views

266

Mentions per month

Sep 2023 – Dec 2024

Where it's discussed

  • X / Twitter11 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall conversations demonstrate strong interest and positive acknowledgment of the article’s significance, with examples like mentions of collections, journal references, and hashtags like #obesity and #autophagy. The tone suggests curiosity and recognition of the proteasome’s importance in metabolic regulation, which contributes to moderate engagement and perceived impact on ongoing research.

AgreementModerate agreement

Most discussions express positive acknowledgment and support for the significance of the research findings about the proteasome's role during fasting.

InterestHigh interest

The discussions show a high level of interest, referencing collections, journal collections, and related research tags, indicating engagement with the research topic.

EngagementModerate engagement

Posts include mentions of specific elements like metabolic pathways, literature collections, and authors, showing active engagement with the scientific findings.

ImpactModerate impact

The discussions highlight the article's relevance for fields such as obesity and metabolism, suggesting that relevant research could influence future studies and approaches.

Abstract in brief

  • The study investigates how the ubiquitin-proteasome system (UPS) and autophagy contribute to tissue breakdown and body weight regulation during fasting in mice, finding that inhibiting the UPS with bortezomib prevents weight and tissue loss.
  • Bortezomib treatment enhances protein synthesis and activates metabolic pathways like PI3K-AKT-mTOR during fasting, which helps maintain tissue health, whereas blocking autophagy with chloroquine accelerates tissue degradation.
  • Overall, inhibiting the UPS during fasting appears to protect against tissue catabolism and influences metabolic responses such as ketogenesis, highlighting the proteasome's key role in managing body and tissue weight during nutrient scarcity.]

Top posts

Most liked on X and Bluesky
APS Publications
@APSPublications · X

New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic nutrient metabolism during fasting (Henning Tim Langer et al.) https://t.co/vj3lPyhPrs @HenningLanger @SamwiseT @MarcusDGon @Cornell https://t.co/lSpavRCKpG

Sep 7, 2023 · 8 likes · 5 shares · 7,364 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

New in our #PhysiologyofObesity collection! LINK: https://t.co/21Ku7GgLd0 @HenningLanger @SamwiseT @MarcusDGon @Cornell @AJPEndoMetab #phdchat #obesity https://t.co/lpxBscubMD

Sep 8, 2023 · 4 likes · 1 share · 2,658 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

Nre in the AJPEndoMetab November issue! The #proteasome regulates body weight and systemic nutrient #metabolism during fasting (Langer et al.) https://t.co/JP0DcXDUJa #autophagy #fasting #glucose #proteasome #proteolysis https://t.co/kxKG8SxBEV

Dec 18, 2023 · 2 likes · 1 share · 2,658 followers View post →
Matías Monsalves-Álvarez
@profemonsalves · X

The proteasome regulates body weight and systemic nutrient metabolism during fasting | American Journal of Physiology-Endocrinology and Metabolism https://t.co/cNZIcdpP8O

Nov 16, 2023 · 1 like · 1,507 followers View post →
APS Publications
@APSPublications · X

RT @AJPEndoMetab: Nre in the AJPEndoMetab November issue! The #proteasome regulates body weight and systemic nutrient #metabolism during f…

Dec 19, 2023 · 1 share · 7,364 followers View post →
Lyssiotis Lab
@LyssiotisLab · X

RT @APSPublications: New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic…

Sep 7, 2023 · 5 shares · 7,067 followers View post →

All mentions

APS Publications
@APSPublications · X

RT @AJPEndoMetab: Nre in the AJPEndoMetab November issue! The #proteasome regulates body weight and systemic nutrient #metabolism during f…

Dec 19, 2023 · 1 share · 7,364 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

Nre in the AJPEndoMetab November issue! The #proteasome regulates body weight and systemic nutrient #metabolism during fasting (Langer et al.) https://t.co/JP0DcXDUJa #autophagy #fasting #glucose #proteasome #proteolysis https://t.co/kxKG8SxBEV

Dec 18, 2023 · 2 likes · 1 share · 2,658 followers View post →
Matías Monsalves-Álvarez
@profemonsalves · X

The proteasome regulates body weight and systemic nutrient metabolism during fasting | American Journal of Physiology-Endocrinology and Metabolism https://t.co/cNZIcdpP8O

Nov 16, 2023 · 1 like · 1,507 followers View post →
Henning Langer
@HenningLanger · X

RT @AJPEndoMetab: New in our #PhysiologyofObesity collection! LINK: https://t.co/21Ku7GgLd0 @HenningLanger @SamwiseT @MarcusDGon @Cornell…

Sep 11, 2023 · 1 share · 1,709 followers View post →
AJP-Endocrinology and Metabolism
@AJPEndoMetab · X

New in our #PhysiologyofObesity collection! LINK: https://t.co/21Ku7GgLd0 @HenningLanger @SamwiseT @MarcusDGon @Cornell @AJPEndoMetab #phdchat #obesity https://t.co/lpxBscubMD

Sep 8, 2023 · 4 likes · 1 share · 2,658 followers View post →
DesignedByNature
@DesignedNature · X

RT @KetosisJournal: #TheJournalOfKetosis "The proteasome regulates body weight and systemic nutrient metabolism during fasting. (Pub Date:…

Sep 8, 2023 · 1 share · 438 followers View post →
TheJournalOfKetosis
@KetosisJournal · X

#TheJournalOfKetosis "The proteasome regulates body weight and systemic nutrient metabolism during fasting. (Pub Date: 2023-09-06)" https://t.co/pATzFdkszW

Sep 8, 2023 · 1 share · 90 followers View post →
Lyssiotis Lab
@LyssiotisLab · X

RT @APSPublications: New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic…

Sep 7, 2023 · 5 shares · 7,067 followers View post →
Marcus Goncalves
@MarcusDGon · X

RT @APSPublications: New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic…

Sep 7, 2023 · 5 shares · 2,555 followers View post →
APS Publications
@APSPublications · X

New addition to our #PhysiologyofObesity collection in @AJPEndoMetab: The proteasome regulates body weight & systemic nutrient metabolism during fasting (Henning Tim Langer et al.) https://t.co/vj3lPyhPrs @HenningLanger @SamwiseT @MarcusDGon @Cornell https://t.co/lSpavRCKpG

Sep 7, 2023 · 8 likes · 5 shares · 7,364 followers View post →
Adipose Papers
@adipose_papers · X

The proteasome regulates body weight and systemic nutrient metabolism during fasting https://t.co/dtqdfL0Vbr https://t.co/OQLZ7maBpK

Sep 6, 2023 · 2,448 followers View post →