J Immunother Cancer September 2023 PMID 37678918

Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts.

Margaret Veitch, Kimberly Beaumont, Rebecca Pouwer, Hui Yi Chew, Ian H Frazer, H Peter Soyer, Scott Campbell, Brian W Dymock, Andrew Harvey, Terrie-Anne Cock, James W Wells

Mentions

16
Peak: 15 in Sep 2023
across 2 sources since Sep 2023

Extended reach

38,498
potential audience

Total likes

29

Video views

116

Mentions per month

Sep 2023 – Oct 2023

Where it's discussed

  • X / Twitter15 posts
  • YouTube1 videos

AI synopsis

What people are saying

The consensus reveals a shared appreciation for the potential of local tacrolimus blockade to enhance immune responses against tumors, with posts highlighting aspects like T-cell reactivation and tumor regression. The tone varies from enthusiastic support to neutral dissemination, demonstrating moderate interest and respectful engagement with the research's possibilities.

AgreementModerate agreement

Most social discussions express general support and interest in the findings, reflecting positive views on the potential clinical implications.

InterestModerate interest

Participants display moderate curiosity, with discussions about the implications for cancer treatment and immunosuppression, though some posts remain neutral or primarily informative.

EngagementModerate engagement

Several discussions cite specific details from the publication, such as the role of Q2361 and T-cell activity, indicating active engagement with the scientific content.

ImpactModerate impact

Posts imply the research could be significant for advancing cancer therapy, though some tone discussions as cautiously optimistic rather than conclusive.

Abstract in brief

  • The study explores a new approach to boost the immune system's ability to fight skin cancer in people taking immunosuppressants like tacrolimus, which are necessary for organ transplants but suppress T-cell activity.
  • Researchers identified a compound called Q2361 that can counteract the suppressive effects of tacrolimus on T cells, restoring their ability to attack tumor cells when applied directly to the skin.
  • In experiments with mice, delivering Q2361 locally led to tumor shrinkage by reactivating T cells within the tumors, but it was ineffective when CD8 T cells were depleted, highlighting the importance of these immune cells in tumor rejection.

Top posts

Most liked on X and Bluesky
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts https://t.co/214nYVsdeX https://t.co/hLZooh8gk2

Sep 7, 2023 · 20 likes · 8 shares · 9,304 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Let’s take a deeper dive into the recent #JITC article “Local blockade of tacrolimus promotes T cell-mediated tumor regression in systemically immunosuppressed hosts,” from authors at QEDDI - Queensland Emory Drug Discovery Initiative. 1/11 https://t.co/JrMMhC7eOm

Sep 15, 2023 · 5 likes · 3 shares · 9,304 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Meet the Author: Dr. Kimberley Beaumont, a Team Leader at QEDDI @UniQuestUQ, is an author of “Local blockade of tacrolimus promotes T cell-mediated tumor regression in systemically immunosuppressed hosts,” recently published in #JITC! 1/7 https://t.co/iGCSo8Xo17

Oct 31, 2023 · 2 likes · 9,304 followers View post →
Andrew Brooks
@CytokineSignal · X

Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts https://t.co/4PQ2cbYg0K

Sep 8, 2023 · 1 like · 1,400 followers View post →
Elad Sharon
@EladSharonMD · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 7, 2023 · 8 shares · 3,844 followers View post →
janakbihari
@janakbihari1 · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 7, 2023 · 8 shares · 3,066 followers View post →

All mentions

Journal for ImmunoTherapy of Cancer
@jitcancer · X

Meet the Author: Dr. Kimberley Beaumont, a Team Leader at QEDDI @UniQuestUQ, is an author of “Local blockade of tacrolimus promotes T cell-mediated tumor regression in systemically immunosuppressed hosts,” recently published in #JITC! 1/7 https://t.co/iGCSo8Xo17

Oct 31, 2023 · 2 likes · 9,304 followers View post →
Ningjy
@Ningjy2Ningjy · X

RT @jitcancer: Let’s take a deeper dive into the recent #JITC article “Local blockade of tacrolimus promotes T cell-mediated tumor regressi…

Sep 16, 2023 · 3 shares · 32 followers View post →
Hiroaki Kanemura
@hirokane05 · X

RT @jitcancer: Let’s take a deeper dive into the recent #JITC article “Local blockade of tacrolimus promotes T cell-mediated tumor regressi…

Sep 16, 2023 · 3 shares · 120 followers View post →
Yang yang
@Yangyan95709958 · X

RT @jitcancer: Let’s take a deeper dive into the recent #JITC article “Local blockade of tacrolimus promotes T cell-mediated tumor regressi…

Sep 15, 2023 · 3 shares · 7 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

Let’s take a deeper dive into the recent #JITC article “Local blockade of tacrolimus promotes T cell-mediated tumor regression in systemically immunosuppressed hosts,” from authors at QEDDI - Queensland Emory Drug Discovery Initiative. 1/11 https://t.co/JrMMhC7eOm

Sep 15, 2023 · 5 likes · 3 shares · 9,304 followers View post →
MelbImmunoNetwork
@MelbImmunoNet · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 11, 2023 · 8 shares · 412 followers View post →
Shoaib Anwaar
@ShoaibAnwaar2 · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 11, 2023 · 8 shares · 85 followers View post →
Mitchell Stark
@TheStarkLab · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 10, 2023 · 8 shares · 685 followers View post →
Andrea Kunz
@dreandea · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 8, 2023 · 8 shares · 414 followers View post →
Andrew Brooks
@CytokineSignal · X

Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts https://t.co/4PQ2cbYg0K

Sep 8, 2023 · 1 like · 1,400 followers View post →
janakbihari
@janakbihari1 · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 7, 2023 · 8 shares · 3,066 followers View post →
Forrest Baker
@forrest_lee06 · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 7, 2023 · 8 shares · 180 followers View post →
feverfew
@feifeverfew · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 7, 2023 · 8 shares · 58 followers View post →
Elad Sharon
@EladSharonMD · X

RT @jitcancer: New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed h…

Sep 7, 2023 · 8 shares · 3,844 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC article: Local blockade of tacrolimus promotes T-cell-mediated tumor regression in systemically immunosuppressed hosts https://t.co/214nYVsdeX https://t.co/hLZooh8gk2

Sep 7, 2023 · 20 likes · 8 shares · 9,304 followers View post →