Źródło: “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et al, Nature Biomedical Engineering, September 7, 2023. DOI: 10.1038/s41551-023-01086-2. https://t.co/DCIfBON8an End.
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses.
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Sep 2023 – Aug 2025Where it's discussed
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X / Twitter129 posts
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The discussions reflect strong enthusiasm about the research's potential to revolutionize autoimmune disease treatment, as exemplified by mentions of its ability to reverse symptoms of multiple sclerosis in animal models and the optimism about future clinical applications; the tone is optimistic and technical, with references to mechanisms, clinical trials, and related novel therapies, indicating high interest and perceived impact.
Most discussions are highly supportive, emphasizing the promising potential of the research for autoimmune treatments.
Posts display a high level of curiosity, referencing mechanisms, clinical implications, and related innovations like inverse vaccines.
The discussions incorporate detailed references, technical comments, and expressions of excitement, indicating deep engagement.
Multiple comments suggest that this research could be transformative for autoimmune therapies, with some calling it 'huge' and a 'game changer'.
Abstract in brief
- The paper discusses a new approach to suppress specific immune responses by using a specially designed glycosylated polymer (pGal-antigen) that can dissociate and present antigens in a way that promotes immune tolerance, avoiding the need for broad immunosuppression.
- The researchers demonstrated that this therapy effectively induced antigen-specific tolerance in mice with autoimmune encephalomyelitis and also suppressed responses to a DNA-based vaccine in nonhuman primates, involving mechanisms like programmed cell death and inhibitory signals.
- This method offers a promising strategy for treating autoimmune diseases by selectively calming harmful immune responses without weakening the entire immune system.]
Top posts
Most liked on X and Bluesky“Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et al, Nature Biomedical Engineering, September 7, 2023. DOI: 10.1038/s41551-023-01086-2. https://t.co/gwqRnpuPNn
bez osłabiania całej odpowiedzi odpornościowej. https://t.co/fThLEpRWBC i “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et al, Nature Biomedical Engineering, September 7, 2023. DOI: 10.1038/s41551-023-01086-2
Another related paper: Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses https://t.co/iyRY49Ape0
3. Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et al, Nature Biomedical Engineering, September 7, 2023. DOI: 10.1038/s41551-023-01086-2. https://t.co/bxuHAuiEMD
All mentions
Targeted Immune Tolerance: New Approach to Autoimmune Disease Treatment
Vaccines teach the immune system to recognize threats; some researchers now aim to delete harmful immune memories responsible for autoimmune diseases using a glycosylated polymer to promote immune tolerance.
Innovative Inverse Vaccine Approach for Multiple Sclerosis Treatment
This new development could be a gamechanger or a zero. It involves a glycosylated polymer that selectively suppresses harmful immune responses, promoting immune tolerance without broad immunosuppression, showing promise…
Reversing Autoimmune Diseases with Inverse Vaccination Approach
This video explores a novel strategy to suppress specific immune responses using synthetically glycosylated antigens, promoting immune tolerance and offering potential for treating autoimmune diseases without broad…
RT @AgnieszkaSzust3: 3. Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain…
3. Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et al, Nature Biomedical Engineering, September 7, 2023. DOI: 10.1038/s41551-023-01086-2. https://t.co/bxuHAuiEMD
@REV_Insulin_Res @ryanattar Have you heard of Inverse vaccine? It’s in clinical trials right now but looks like a promising “cure” for many autoimmune diseases like diabetes, ms, and others. https://t.co/ubgSxbWBKG https://t.co/Y36biVlool
RT @CDeBonrostro: @Nature ⚠️ Este mecanismo ha demostrado REVERTIR LOS SÍNTOMAS DE ESCLEROSIS MÚLTIPLE en ratones en un estudio publicado e…
@Nature ⚠️ Este mecanismo ha demostrado REVERTIR LOS SÍNTOMAS DE ESCLEROSIS MÚLTIPLE en ratones en un estudio publicado en 2023
RT @natBME: Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses https://t.co/xMOHUmDI…
RT @AgnieszkaSzust3: “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et…
“Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et al, Nature Biomedical Engineering, September 7, 2023. DOI: 10.1038/s41551-023-01086-2. https://t.co/gwqRnpuPNn
The actual paper goes way further to demonstrate how pGal can be used to suppress inflammatory T-cell responses. DOI: https://t.co/buSu4gKKk4 And a slick writeup from @UChicagoMag: https://t.co/tRXLOM9Mqg
Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life & more.
@Stanzupforit If this has any viability, it is very far from becoming a reality. This is one study without supporting evidence prior to or since, and it only used mice and non-human primates. Synthetically glycosylated antigens for the antigen-specific suppression of established immune
RT @AgnieszkaSzust3: Źródło: “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tr…
RT @AgnieszkaSzust3: Źródło: “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tr…
RT @AgnieszkaSzust3: Źródło: “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tr…
Źródło: “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et al, Nature Biomedical Engineering, September 7, 2023. DOI: 10.1038/s41551-023-01086-2. https://t.co/DCIfBON8an End.
https://t.co/PCT8duHV7H
RT @CDeBonrostro: ⚠️ Este mecanismo ha demostrado REVERTIR LOS SÍNTOMAS DE ESCLEROSIS MÚLTIPLE en ratones en un estudio publicado en 2023…
⚠️ Este mecanismo ha demostrado REVERTIR LOS SÍNTOMAS DE ESCLEROSIS MÚLTIPLE en ratones en un estudio publicado en 2023
RT @RolandBakerIII: Another related paper: Synthetically glycosylated antigens for the antigen-specific suppression of established immune…
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses https://t.co/z9ZfwtpHcg
RT @RolandBakerIII: Another related paper: Synthetically glycosylated antigens for the antigen-specific suppression of established immune…
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses | Nature Biomedical Engineering https://t.co/h8yKuq7tnt
Another related paper: Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses https://t.co/iyRY49Ape0
@VirusesImmunity Could be used to make an Alpha-gal allergy treatment? https://t.co/Aq8tbaVIGR Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses https://t.co/z9ZfwtpHcg
@Nervardia have you seen this video? I thought you’d find extremely interesting https://t.co/qGmI2d8wEd
And finally in this section, this is not #IBD specific, but nonetheless interesting: Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses. By Tremain, et al. https://t.co/8mIgmd6XnV
https://t.co/GHHZflQjUR
A Vaccine That Makes Your Immune System ... Forget? https://t.co/kxrXEoio2x via @YouTube
A Vaccine That Makes Your Immune System ... Forget? https://t.co/98K89Allno via @YouTube
https://t.co/bl4FqgqTVq
https://t.co/binyIqVVFf
If this works I will be over the moon. A vaccine that makes your immune system stop attacking? My MS? Gone. My allergies? Likely also gone. The results so far are promising and trials are already underway. https://t.co/08w5EPcj22
A Vaccine That Makes Your Immune System ... Forget? https://t.co/WQTE1v1SUO via @YouTube #scishow
This could lead to treatment for MS and other autoimmune diseases https://t.co/5sVKDEyzCQ @slothgrlslowly @shannonq
SciShow https://t.co/m6onVpQJeF
https://t.co/DbpfF8X0Gx
RT @ejvillablanca: Glyco-engineering to promote tolerance towards antigens with established pro-inflammatory responses - huge
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
https://t.co/wf8Pv9uL3V
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
自己免疫疾患等治療のために免疫反応を抑制する、修飾抗原を用いた逆ワクチン(Inverse vaccine)がマウス実験で治療効果を示した。 反ワクさん(敵か…?味方か…?) https://t.co/eQxLdoPoEv 「逆ワクチン」は自己免疫疾患の治療を根本から変えるか? https://t.co/ouLYxWZOY5
Treatment for autoimmune diseases on the order of "curing cancer". Synthetic polymers are glycosylated with the "friendly" antigens that the immune system is incorrectly attacking. Change the antigen to change the disease you're treating. https://t.co/GQuFcNYO09
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @hbdchick: Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses: can completely reve…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
bez osłabiania całej odpowiedzi odpornościowej. https://t.co/fThLEpRWBC i “Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,” Tremain et al, Nature Biomedical Engineering, September 7, 2023. DOI: 10.1038/s41551-023-01086-2
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses | Nature Biomedical Engineering. https://t.co/pwjyWmBhyG
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses https://t.co/BGKQoskngv
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @UCDMouseBio:
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @SABOURETCardio: Synthetically glycosylated antigens for the antigen-specific suppression of established #immune responses. https://t.c…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @ejvillablanca: Glyco-engineering to promote tolerance towards antigens with established pro-inflammatory responses - huge
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @RolandBakerIII: This is huge! ❤️ Synthetically glycosylated antigens for the antigen-specific suppression of established immune respon…
RT @ejvillablanca: Glyco-engineering to promote tolerance towards antigens with established pro-inflammatory responses - huge
https://gregory-ms.com/articles/61862/ Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses #MSchat #Neurology #MultipleSclerosis
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses Can the immune response, instead of generally tuned down, be reduced against specific antigens, leaving immunity to infection fully functional? www.nature.com/artic... 2/6
逆に↓では花粉症とかは治せないのかな。 Tremain, A.C., Wallace, R.P., Lorentz, K.M. et al. Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses. Nat. Biomed. Eng 7, 1142–1155 (2023). https://t.co/CvGRkDKDmm
@localizedlesion.bsky.social @rheumcat.bsky.social @transplntmdphd.bsky.social Wasn't sure if you had seen this yet; it just came out. Silencing immune responce to autoantigens. I suppose system likely wouldn't react to original foreign antigen, either. Pubmed
ring 7 (9): 1142–55. DOI:10.1038/s41551-023-01086-2
Tremain, Andrew C., Rachel P. Wallace, Kristen M. Lorentz, Thomas B. Thornley, Jennifer T. Antane, Michal R. Raczy, Joseph W. Reda, et al. 2023. “Synthetically Glycosylated Antigens for the Antigen-Specific Suppression of Established Immune Responses.” Nature Biomedical Enginee
RT @K9FCR: Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses - PubMed https://t.co/4…
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses - PubMed https://t.co/4q6ZEVC0W5
RT @EARL_med_tw:
RT @EARL_med_tw:
RT @MMRRC:
わお https://t.co/8S6sGuEI2b
Les #Vacunesinverses (VI) molt a prop de donar respostes al tractament de les entitats #autoimmunitàries. https://t.co/C8k15vyYLq Referència. Tremain, A.C., et al. Nat. Biomed. Eng 2023. https://t.co/dnCaqfLbbD
ために必要な免疫反応もブロックしてしまうため、多くの副作用が生じます。現在、セリアック病の患者を対象とした初期の第I相安全性試験はすでに実施されており、多発性硬化症を対象とした第I相安全性試験は進行中です。Nature Biomedical Engineering 誌https://t.co/JM9G0Jo0eP
Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses https://t.co/sq1ZOU5r2g
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