Ageing Res Rev December 2023 PMID 37683986

Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging.

Domenico Lapenna

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Peak: 7 in Sep 2023

across 3 sources since Sep 2023

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Sep 2023 – Feb 2025

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The discussions primarily focus on the significance of glutathione as a key antioxidant and its potential role in successful aging, with phrases like 'secret of elegant aging' and 'antioxidant key' indicating interest and recognition of its importance. Participants use moderate language, reflecting curiosity and acknowledgment of the research's relevance without deep technical debate.

AgreementModerate agreement

Most discussions acknowledge the importance of glutathione in aging and cellular health, reflecting a general consensus of agreement.

InterestModerate interest

Participants show moderate interest, often highlighting its role as an antioxidant and its potential in anti-aging strategies.

EngagementModerate engagement

Comments range from simple acknowledgments to mentions of exploring the topic further, indicating a moderate level of engagement.

ImpactModerate impact

The discussions suggest that the article's insights could influence health perspectives and aging practices, though not with a sense of high urgency.

Abstract in brief

Glutathione (GSH) is a vital antioxidant and redox molecule involved in various cellular processes such as detoxification, DNA synthesis, and cell signaling, primarily functioning through interactions with GSH-dependent enzymes like glutathione peroxidase and glutathione transferases.
GSH is synthesized in the cell cytosol through an ATP-dependent process involving enzymes glutamate cysteine ligase (GCL) and glutathione synthase, with cysteine being a key precursor; its production can be supported by supplements like N-acetylcysteine.
Once produced, GSH can be degraded outside the cell by glutamyl transferase or inside the cell by enzymes such as the ChaC family, playing a crucial role in maintaining redox balance and cellular health across organisms, including in aging and disease contexts.

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@heniek_htw · X

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Jan 8, 2024 · 8 likes · 11,281 followers View post →

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#Glutathione and Glutathione-dependent Enzymes: From Biochemistry to Gerontology and Successful #Aging

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Victoria VALPARAISO

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Glutathione and Glutathione-dependent Enzymes: From Biochemistry to Gerontology and Successful Aging https://t.co/R6olwHLyxb

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Ranjan Nanda

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Sep 8, 2023 · 1 share · 383 followers View post →

TheHumanAgingProject

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Sep 8, 2023 · 4 likes · 1 share · 11,027 followers View post →

Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging.

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Effective Supplements for Anti-Aging and Muscle Preservation

Effective Nutritional Supplements for Aging and Muscle Health