Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker.

Martin S Taylor, Connie Wu, Peter C Fridy, Stephanie J Zhang, Yasmeen Senussi, Justina C Wolters, Tatiana Cajuso, Wen-Chih Cheng, John D Heaps, Bryant D Miller, Kei Mori, Limor Cohen, Hua Jiang, Kelly R Molloy, Brian T Chait

December 2023 Cancer Discov

Synopsis of Social media discussions

Several discussions highlight the novel aspects of the LINE-1 ORF1p assay, such as its accuracy and cost-effectiveness, with remarks like 'novel, rapid, cost-effective tools' and expressions of excitement about the potential clinical applications. The tone is generally optimistic, signifying a forward-looking approach in cancer detection, which contributes to the overall positive sentiment conveyed in the discussions.

A
Agreement
 Moderate agreement

Many discussions reflect a consensus on the potential of LINE-1 ORF1p as a useful cancer biomarker, showing general support for the publication's findings.

I
Interest
 High level of interest

Posts exhibit a high level of curiosity regarding the topic, indicating that the research attracts substantial attention within the cancer research community.

E
Engagement
 Moderate level of engagement

While several posts straightforwardly mention the publication, some reference further details or context about its implications, suggesting moderate engagement with the content.

I
Impact
 High level of impact

Users strongly believe that this research could significantly enhance cancer detection and monitoring, with some noting its affordability and effectiveness.

Social Mentions

YouTube

2 Videos

Bluesky

1 Posts

Twitter

123 Posts

Blogs

4 Articles

News

36 Articles

Metrics

Video Views

257

Total Likes

360

Extended Reach

2,379,125

Social Features

166

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Breakthrough Blood Test for Early Detection of Ovarian Cancer

Breakthrough Blood Test for Early Detection of Ovarian Cancer

Most cancers progress without symptoms, leading to late-stage diagnoses. Researchers at Rockefeller University have developed a blood test to detect the LINE-1 ORF1p protein, a promising biomarker for early cancer detection, particularly for ovarian and gastroesophageal cancers.

Rajamanickam Antonimuthu

November 8, 2023

141 views

Groundbreaking Blood Test for Early Cancer Detection and Diagnosis

Groundbreaking Blood Test for Early Cancer Detection and Diagnosis

Researchers at Rockefeller University have developed a highly sensitive blood test capable of detecting the ORF1p protein produced by cancer cells. This innovative method could allow for early cancer detection, including ovarian cancer, before symptoms emerge.

Finite Future

November 3, 2023

116 views

  • Top Biomedical Science
    @imedverse (Twitter)

    RT @ElizSMcKenna: Interested in the #AACR25 session on how to leverage the genome, epigenome, repeatome, and proteome for cancer detection?…
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    April 29, 2025

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  • Top Biomedical Science
    @imedverse (Twitter)

    Ultrasensitive ORF1p assays from as little as 25 μL plasma are novel, rapid, cost-effective tools in cancer detection and monitoring. #AACR25 #TIC2025 https://t.co/WCOGpNpKsE https://t.co/cR1DaKVIK5
    view full post

    April 29, 2025

  • The Innovation | Medicine
    @Innov_Medicine (Twitter)

    RT @ElizSMcKenna: Interested in the #AACR25 session on how to leverage the genome, epigenome, repeatome, and proteome for cancer detection?…
    view full post

    April 28, 2025

    5

  • Dámaris Intriago
    @DamarisIntriago (Twitter)

    RT @ElizSMcKenna: Interested in the #AACR25 session on how to leverage the genome, epigenome, repeatome, and proteome for cancer detection?…
    view full post

    April 28, 2025

    5

  • Kathleen Helen Burns
    @KathleenHBurns (Twitter)

    RT @ElizSMcKenna: Interested in the #AACR25 session on how to leverage the genome, epigenome, repeatome, and proteome for cancer detection?…
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    April 28, 2025

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  • Hedyeh Ebrahimi
    @EbrahimiHedyeh (Twitter)

    RT @ElizSMcKenna: Interested in the #AACR25 session on how to leverage the genome, epigenome, repeatome, and proteome for cancer detection?…
    view full post

    April 28, 2025

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  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    Interested in the #AACR25 session on how to leverage the genome, epigenome, repeatome, and proteome for cancer detection? Read about speaker @KathleenHBurns's work to use LINE-1 ORF1p for multicancer detection in @CD_AACR: https://t.co/H2gN3WZJKB https://t.co/OWPk46aD9S
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    April 28, 2025

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  • Simona Cristea
    @simocristea (Twitter)

    Cancer biomarker ORF1p is a transposable element protein overexpressed in carcinomas & high-risk precursors during carcinogenesis with negligible expression in normal tissues. Among others, plasma ORF1p shows promise for ovarian cancer early detection. https://t.co/ywMZfUUTd6
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    June 15, 2024

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  • The Innovation | Medicine
    @Innov_Medicine (Twitter)

    RT @CD_AACR: Attending the #AACR24 Educational Session on #TransposableElements? Read recent work by session chair and speaker, @KathleenHB…
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    April 8, 2024

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  • Julie Feldstein,MD
    @feldstej (Twitter)

    RT @CD_AACR: Attending the #AACR24 Educational Session on #TransposableElements? Read recent work by session chair and speaker, @KathleenHB…
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    April 7, 2024

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  • Top Biomedical Science
    @imedverse (Twitter)

    RT @InnovOncology: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker @CD_AACR @AACR @OncoAlert @on…
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    April 7, 2024

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  • The Innovation | Medicine
    @Innov_Medicine (Twitter)

    RT @InnovOncology: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker @CD_AACR @AACR @OncoAlert @on…
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    April 7, 2024

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  • The Innovation Oncology
    @InnovOncology (Twitter)

    Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker @CD_AACR @AACR @OncoAlert @oncodaily @SciLife_ @InnovOncology #MedEd #MedX #Oncology #AACR2024 #AACR24 https://t.co/bYW7LLtlRh https://t.co/Qj1tO0SIJY
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    April 7, 2024

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  • Bailee Sliker, Ph.D
    @DrBaileeSliker (Twitter)

    RT @CD_AACR: Attending the #AACR24 Educational Session on #TransposableElements? Read recent work by session chair and speaker, @KathleenHB…
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    April 6, 2024

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  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    RT @CD_AACR: Attending the #AACR24 Educational Session on #TransposableElements? Read recent work by session chair and speaker, @KathleenHB…
    view full post

    April 6, 2024

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  • Cancer Discovery
    @CD_AACR (Twitter)

    Attending the #AACR24 Educational Session on #TransposableElements? Read recent work by session chair and speaker, @KathleenHBurns: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker. https://t.co/Hjug8ASMM1 https://t.co/hT1zSvuTJV
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    April 6, 2024

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  • Maggie Rawlinson
    @maggietranquila (Twitter)

    Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker | Cancer Discovery | American Association for Cancer Research ~
    view full post

    February 4, 2024

  • Jennifer E. Fairman, CMI, FAMI
    @fairmanstudios (Twitter)

    RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
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    January 29, 2024

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  • Jeeyun Lee MD
    @JeeyunM (Twitter)

    Congrats Martin. This is an excellent work. Hope we can use this test in the clinic someday. Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker https://t.co/4IKp6MMjfJ
    view full post

    January 26, 2024

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  • MGH Pathology
    @MGHPathology (Twitter)

    RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
    view full post

    January 17, 2024

    3

  • SayoStudio
    @SayoStudio (Twitter)

    RT @CD_AACR: From the latest issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3,…
    view full post

    January 16, 2024

    5

  • Stephanie Gomez, PhD
    @ScientistStephG (Twitter)

    RT @DrMartyTaylor: https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their desc…
    view full post

    January 16, 2024

    3

  • Marty Taylor, MD PhD
    @DrMartyTaylor (Twitter)

    https://t.co/2NUeefEIZX Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”. https://t.co/ucfZvlhiI1
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    January 15, 2024

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  • GT
    @kausnunki (Twitter)

    RT @CD_AACR: From the latest issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3,…
    view full post

    January 12, 2024

    5

  • The Innovation | Medicine
    @Innov_Medicine (Twitter)

    RT @CD_AACR: From the latest issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3,…
    view full post

    January 12, 2024

    5

  • Hailong Liu
    @HarlanHLL (Twitter)

    RT @CD_AACR: From the latest issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3,…
    view full post

    January 12, 2024

    5

  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    RT @CD_AACR: From the latest issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3,…
    view full post

    January 11, 2024

    5

  • Cancer Discovery
    @CD_AACR (Twitter)

    From the latest issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3, Connie Wu, David Walt, @KathleenHBurns et al. https://t.co/sgxBOn3D5C @MassGenBrigham @UMLifeSciences @DanaFarber #LiquidBiopsy #TransposableElement https://t.co/PMvwG5FHAf
    view full post

    January 11, 2024

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  • UMLifeSciences
    @UMLifeSciences (Twitter)

    RT @CD_AACR: From the December issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3…
    view full post

    January 2, 2024

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  • Rita Sherrod
    @Rita_Sherrod (Twitter)

    RT @OwenGregorian: Link to study: https://t.co/4oFIb6TpyU
    view full post

    December 26, 2023

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  • Charles Peterson
    @cwptrsn (Twitter)

    RT @OwenGregorian: Link to study: https://t.co/4oFIb6TpyU
    view full post

    December 26, 2023

    2

  • Owen Gregorian
    @OwenGregorian (Twitter)

    Link to study: https://t.co/4oFIb6TpyU
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    December 26, 2023

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  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    RT @CD_AACR: From the December issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3…
    view full post

    December 19, 2023

    2

  • Cancer Discovery
    @CD_AACR (Twitter)

    From the December issue— Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker, by @mTORC3, Connie Wu, David Walt, @KathleenHBurns et al. https://t.co/sgxBOn3D5C @MassGenBrigham @UMLifeSciences @DanaFarber #LiquidBiopsy #TransposableElement https://t.co/CiJ0g6vhpS
    view full post

    December 19, 2023

    9

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  • Agingdoc
    @agingdoc1 (Twitter)

    Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker LINE-1 ORF1p transposon protein: "Novel, rapid, cost-effective tools in cancer detection and monitoring." @KathleenHBurns @DanaFarber @HarvardMed @broadinstitute https://t.co/xseA2Es3nw https://t.co/V112TWp2qH
    view full post

    December 18, 2023

    5

  • Jennifer E. Fairman, CMI, FAMI
    @fairmanstudios (Twitter)

    RT @DrMartyTaylor: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker…
    view full post

    December 15, 2023

    13

  • Jennifer E. Fairman, CMI, FAMI
    @fairmanstudios (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    December 15, 2023

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  • AlfonsoBuddhaDharma
    @GLopez_rmz (Twitter)

    RT @guty2370:
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    November 28, 2023

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  • Carlos Carl
    @ccarls333 (Twitter)

    RT @guty2370:
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    @CristinaCL14 (Twitter)

    RT @guty2370:
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  • Dr Mario HMG
    @mgmglobal (Twitter)

    RT @guty2370:
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    @Gentianagroga (Twitter)

    RT @guty2370:
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  • Guty Schnauzer
    @guty2370 (Twitter)


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    November 24, 2023

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  • Taylor Evans
    @taylorev_ (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 11, 2023

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  • Jawn Effin' Cleaver
    @isuckatwife (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 6, 2023

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  • Jeeyun Lee MD
    @JeeyunM (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 5, 2023

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  • Jennifer Erwin
    @jerwinlab (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
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    November 5, 2023

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  • Gael Cristofari
    @retrogenomics (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
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    November 5, 2023

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  • Teresa Amaral, MD, PhD
    @TeresaSAmaral (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 5, 2023

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  • Harmit S. Malik
    @HarmitMalik (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 5, 2023

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  • Kathleen Helen Burns
    @KathleenHBurns (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

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  • Pat Adams
    @PathologyPat (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

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  • Marty Taylor, MD PhD
    @DrMartyTaylor (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

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  • Samir Amin
    @SBAmin (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

    22

  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

    22

  • Yejing Ge
    @yejingge (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

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  • I-Mei (Emay) Siu
    @imsmd (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

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  • Dr Samriddha Ray
    @samriddha_ray (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

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  • Manoj Mayogi Mishra
    @mayogisense (Twitter)

    RT @gglinskii: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. https://t.co/x03Cd3qOqq
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    November 4, 2023

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  • Dr. Gennadi Glinsky, MD, Ph.D.
    @gglinskii (Twitter)

    Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. https://t.co/x03Cd3qOqq
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    November 4, 2023

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  • Dr. Gennadi Glinsky, MD, Ph.D.
    @gglinskii (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
    view full post

    November 4, 2023

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  • ImmunoSparkle
    @ImmunoSparkle (Twitter)

    RT @RonDePinho: Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) as…
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    November 4, 2023

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  • Dr. Ron DePinho
    @RonDePinho (Twitter)

    Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker. Accurate, fast and cheap ($3) assay detected this endogenous retroviral protein ORF1p in blood of patients with a variety of cancers: Ovarian, esophageal, CRC, etc. https://t.co/yuQW16ByS7
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    November 4, 2023

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  • •ΞHΔß T. BARNAWI | إيهاب بن طلال برناوي
    @iEhabz (Twitter)

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    November 2, 2023

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  • ريان مدِسنْ
    @1rayyanmedicine (Twitter)

    اختبار دم جديد ولكنه باهظ الثمن قادر على الكشف عن البروتينات السرطانية ، منها سرطانات الأمعاء والمبايض. المصدر : https://t.co/3hcrsKK8KQ
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    November 2, 2023

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  • Robert West, PhD ✝️
    @westr (Twitter)

    Ultrasensitive #BloodTest Detects ‘#PanCancer’ Biomarker https://t.co/X6fIyiNdvY) via @wyssinstitute Ultrasensitive detection of circulating LINE-1 #ORF1p as a specific multi-cancer #biomarker https://t.co/BBMw4RfEGf https://t.co/fJCXJGcgYZ
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    October 18, 2023

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  • Jovita Mezquita Pla
    @JovitaMezquita (Twitter)

    Comenta Technology Networks’ daily newsletter. https://t.co/FcU06mKz3D Ref. Taylor MS, Wu C, Fridy PC, et al. Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker. Cancer Biology; 2023. doi: 10.1101/2023.01.25.525462
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    October 10, 2023

  • Pat Adams
    @PathologyPat (Twitter)

    Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker | bioRxiv https://t.co/ls5c2T2qIt
    view full post

    October 10, 2023

  • Whijae Roh
    @whijae (Twitter)

    Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker https://t.co/VPlt5sn2Lb
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    October 6, 2023

  • Bo Rueda
    @target_CANCER (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 19, 2023

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  • MEDNTD
    @medntdj (Twitter)

    OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Connie Wu, David Walt, @KathleenHBurns et al. https://t.co/dccugvQ0Ux @MassGenBrigham @UMLifeSciences @DanaFarber #LiquidBiopsy #TransposableElement https://t.co/rtEEo0Bet2
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    September 18, 2023

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  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    RT @EllisLab_: Interesting findings from ⁦@KathleenHBurns⁩ ⁦@DanaFarber⁩ Ultrasensitive detection of circulating LINE-1 ORF1p as a specifi…
    view full post

    September 17, 2023

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  • Johan Jakobsson
    @JakobssonLab (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
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    September 16, 2023

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  • Turelli Priscilla
    @Turelli_EPFL (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 16, 2023

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  • Cancer Discovery
    @CD_AACR (Twitter)

    RT @KlempnerSam: Out in @CD_AACR from @mTORC3, @KathleenHBurns and many others. supported by @AACR and @SU2C @SU2Cscience. https://t.co…
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    September 15, 2023

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  • Sandra Ryeom
    @swr_sws (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 15, 2023

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  • Tom Watkins
    @tbkwatkins (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
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    September 15, 2023

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  • Tom Watkins
    @tbkwatkins (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 15, 2023

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  • Pradeepa Madapura
    @PradeepMadapura (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
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    September 15, 2023

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  • Alfredo I. Sagredo
    @ASagredo3 (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

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  • OncoPapers
    @sccancerres (Twitter)

    RT @EllisLab_: Interesting findings from ⁦@KathleenHBurns⁩ ⁦@DanaFarber⁩ Ultrasensitive detection of circulating LINE-1 ORF1p as a specifi…
    view full post

    September 14, 2023

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  • Victoria Hendry
    @HendryVictoria (Twitter)

    RT @EllisLab_: Interesting findings from ⁦@KathleenHBurns⁩ ⁦@DanaFarber⁩ Ultrasensitive detection of circulating LINE-1 ORF1p as a specifi…
    view full post

    September 14, 2023

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  • EllisLab_
    @EllisLab_ (Twitter)

    Interesting findings from ⁦@KathleenHBurns⁩ ⁦@DanaFarber⁩ Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker | Cancer Discovery | American Association for Cancer Research https://t.co/m3nG2w4Hsn
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    September 14, 2023

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  • Cedric
    @CedricFeschotte (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

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  • Ronny Drapkin
    @ronny_drapkin (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
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    September 14, 2023

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  • Nicolas Robine
    @notSoJunkDNA (Twitter)

    RT @ElizSMcKenna: Now online in @CD_AACR: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker by Mart…
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    September 14, 2023

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  • 田舎者(天草地方出身者)
    @imoame0801 (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

    13

  • I-Mei (Emay) Siu
    @imsmd (Twitter)

    RT @KlempnerSam: Out in @CD_AACR from @mTORC3, @KathleenHBurns and many others. supported by @AACR and @SU2C @SU2Cscience. https://t.co…
    view full post

    September 14, 2023

    3

  • Marty Taylor, MD PhD
    @DrMartyTaylor (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 14, 2023

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  • Matt Yousefzadeh
    @MattYousefzadeh (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

    13

  • Carlos Mendez-Dorantes
    @CarlosMendezPhD (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

    13

  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    RT @KlempnerSam: Out in @CD_AACR from @mTORC3, @KathleenHBurns and many others. supported by @AACR and @SU2C @SU2Cscience. https://t.co…
    view full post

    September 14, 2023

    3

  • Sam Klempner
    @KlempnerSam (Twitter)

    Out in @CD_AACR from @mTORC3, @KathleenHBurns and many others. supported by @AACR and @SU2C @SU2Cscience. https://t.co/pjhJ3Qs4oq https://t.co/VTaIFWW9su
    view full post

    September 14, 2023

    12

    3

  • RoweLab
    @LabRowe (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 14, 2023

    26

  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

    13

  • Kentsis Research Group
    @KentsisResearch (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

    13

  • Kathleen Helen Burns
    @KathleenHBurns (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

    13

  • Cancer Discovery
    @CD_AACR (Twitter)

    RT @mTORC3: So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful…
    view full post

    September 14, 2023

    13

  • Marty Taylor, MD PhD
    @DrMartyTaylor (Twitter)

    So excited to share our paper, now in press @CD_AACR -- new, cheap, rapid blood assays show LINE-1 ORF1p is a biomarker useful for (early) detection of cancers (pan-carcinoma) & prognostics. ORF1p is highly specific and also appears useful in tissue. https://t.co/tKpufayVUx
    view full post

    September 14, 2023

    46

    13

  • Petros Grivas
    @PGrivasMDPhD (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26


  • @rahulbh12 (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • The Innovation | Medicine
    @Innov_Medicine (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • Elad Sharon
    @EladSharonMD (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • Tali Lev
    @TaliLev123 (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • Victoria Hendry
    @HendryVictoria (Twitter)

    RT @ElizSMcKenna: Now online in @CD_AACR: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker by Mart…
    view full post

    September 13, 2023

    5

  • Victoria Hendry
    @HendryVictoria (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • Carlos Mendez-Dorantes
    @CarlosMendezPhD (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • UMLifeSciences
    @UMLifeSciences (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • Kathleen Helen Burns
    @KathleenHBurns (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • Elizabeth McKenna
    @elizsmckenna.bsky.social (Bluesky)

    Now online in Cancer Discovery: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker - by Martin Taylor, Connie Wu, David Walt, Kathleen Burns, and colleagues doi.org/10.1158/2159... #LiquidBiopsy #TransposableElement
    view full post

    September 13, 2023

    6

    8

  • Jonathan Dudley, M.D.
    @jonathandudley (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • 田舎者(天草地方出身者)
    @imoame0801 (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • Sarada Achyutuni
    @SaradaAchyutuni (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 13, 2023

    26

  • Xiekui Cui
    @MarkTransposon (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 12, 2023

    26

  • Christopher Hergott
    @CBHergott (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 12, 2023

    26

  • Lisanne Mout
    @Lisanne_M1 (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 12, 2023

    26

  • Anirban Maitra
    @Aiims1742 (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 12, 2023

    26

  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 12, 2023

    26

  • womens-rights
    @medscicomms1920 (Twitter)

    RT @CD_AACR: OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Conn…
    view full post

    September 12, 2023

    26

  • Cancer Discovery
    @CD_AACR (Twitter)

    OnlineFirst: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific #MultiCancer Biomarker, by Martin Taylor, Connie Wu, David Walt, @KathleenHBurns et al. https://t.co/ykHNzOJjCd @MassGenBrigham @UMLifeSciences @DanaFarber #LiquidBiopsy #TransposableElement https://t.co/SYrjntIGHI
    view full post

    September 12, 2023

    64

    26

  • Benjamin D. Greenbaum
    @bengrbm (Twitter)

    RT @ElizSMcKenna: Now online in @CD_AACR: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker by Mart…
    view full post

    September 12, 2023

    5

  • Duane Hassane
    @DrDuaneHassane (Twitter)

    RT @ElizSMcKenna: Now online in @CD_AACR: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker by Mart…
    view full post

    September 12, 2023

    5

  • Charles Ishak
    @CharlesIshak (Twitter)

    RT @ElizSMcKenna: Now online in @CD_AACR: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker by Mart…
    view full post

    September 12, 2023

    5

  • Elizabeth McKenna
    @ElizSMcKenna (Twitter)

    Now online in @CD_AACR: Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multi-Cancer Biomarker by Martin Taylor, Connie Wu, David Walt, @KathleenHBurns et al https://t.co/H2gN3WZbV3 @MassGenBrigham @UMLifeSciences @DanaFarber #LiquidBiopsy #TransposableElement https://t.co/7j4VbY3fpD
    view full post

    September 12, 2023

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Abstract Synopsis

  • * The LINE-1 ORF1p protein is overexpressed in various cancers and has negligible expression in normal tissues, indicating its potential as a highly specific blood-based cancer biomarker.
  • * Advanced digital immunoassays can detect low levels of ORF1p in plasma, showing promise for early detection of ovarian cancer and monitoring treatment responses in gastroesophageal cancers, suggesting it could be a valuable tool for cancer diagnosis and prognosis.