Aging (Albany NY) September 2023 PMID 37702598

Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.

Xiaoyue Mei, Joshua Blanchard, Connor Luellen, Michael J Conboy, Irina M Conboy

Mentions

45
Peak: 15 in Sep 2023
across 4 sources since Sep 2023

Extended reach

216,853
potential audience

Total likes

62

Video views

1,503

Mentions per month

Sep 2023 – Apr 2025

Where it's discussed

  • X / Twitter39 posts
  • YouTube2 videos
  • Facebook2 posts
  • News2 articles

AI synopsis

What people are saying

Discussions largely focus on how this research questions the accuracy of existing epigenetic clocks, with examples mentioning the limitations of linear models and the development of a noise barometer as a promising alternative. The tone reflects both curiosity and recognition of the study's novelty, using words like 'exciting' and 'game-changing,' which convey the potential for significant advancements in aging diagnostics.

AgreementModerate agreement

Most discussions appreciate the research's critique of current DNA methylation clocks and recognize the potential of the new noise barometer, indicating general agreement on its importance.

InterestHigh interest

Social discussions show high interest, with many posts highlighting the innovative approach and significance of the findings for aging research.

EngagementModerate engagement

Posts reference specific concepts such as 'epigenetic pressure' and 'biomarkers of aging,' demonstrating moderate engagement and curiosity about the methods and implications.

ImpactModerate impact

The discussions suggest the research could influence future aging diagnostics and methods, though some emphasize it as a step rather than a final solution.

Abstract in brief

  • The study highlights limitations of Elastic Net DNA methylation clocks for predicting biological age and distinguishing healthy from diseased states, mainly due to their reliance on linear models which don't capture the nonlinear nature of aging processes.
  • Instead of focusing on the methylation changes that define current clocks, the researchers developed a "noise barometer" by measuring the variability (standard deviation) in methylation of certain cytosines that remain stable over time, which they propose as a biomarker of aging and disease.
  • They found that in about 14% of the 450K methylation sites, increased variability with age correlates with biological aging and disease, including cytosines that stay methylated consistently, suggesting this noise is a key indicator of epigenetic pressure and health deterioration.

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease [Xiaoyue Mei with Mike and Irina Conboy lab] https://t.co/P5IRgnt41A https://t.co/dr3fmGRhFK

Oct 10, 2023 · 7 likes · 43,746 followers View post →
Hannah Went
@EverythingEpi · X

Researchers from @UCBerkeley publish on "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease". https://t.co/61VZhsSWLE

Sep 20, 2023 · 5 likes · 1 share · 550 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Jun 8, 2024 · 4 likes · 3 shares · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Mar 1, 2025 · 3 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

May 17, 2024 · 3 likes · 1 share · 4,400 followers View post →
Berkeley Engineering
@Cal_Engineer · X

Research from the Conboy Lab was featured on the cover of the journal “Aging.” Led by Irina Conboy, professor of bioengineering, the lab’s exciting new research centers on the measurement of biological age. View the article: https://t.co/MfbWeRoxZU https://t.co/hRp0g6NBHd

Sep 20, 2023 · 2 likes · 34,789 followers View post →

All mentions

Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Mar 1, 2025 · 3 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Feb 15, 2025 · 2 likes · 4,400 followers View post →
Walid Zahra
@SciFi_Genetics · X

RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…

Jan 13, 2025 · 2 shares · 9 followers View post →
Farah Darwish
@farah_lovescats · X

RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…

Jan 13, 2025 · 2 shares · 11 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Jan 12, 2025 · 2 likes · 2 shares · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Dec 21, 2024 · 2 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Nov 8, 2024 · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Oct 5, 2024 · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Sep 28, 2024 · 2 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Aug 24, 2024 · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Jul 20, 2024 · 4,400 followers View post →
YMED-X
@YmedX269 · X

RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…

Jun 8, 2024 · 3 shares · 229 followers View post →
bizrockstar
@bizrockstar · X

RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…

Jun 8, 2024 · 3 shares · 2,293 followers View post →
Dechao Feng
@DechaoF · X

RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…

Jun 8, 2024 · 3 shares · 941 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Jun 8, 2024 · 4 likes · 3 shares · 4,400 followers View post →
Einstein Aging Center
@EinsteinAging · X

@OMRF @MolinaLab1 @OKNathanShock Irina Conboy @UCBerkeley gives a great talk which questions the basis of current epigenetic clocks and introduces a noise barometer. She also presents on the importance of understanding the effects of old factors causing aging https://t.co/gSPGEDG82w

Jun 5, 2024 · 1 like · 487 followers View post →
YMED-X
@YmedX269 · X

RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…

May 28, 2024 · 2 shares · 229 followers View post →
Dechao Feng
@DechaoF · X

RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…

May 27, 2024 · 2 shares · 941 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

May 27, 2024 · 2 likes · 2 shares · 4,400 followers View post →
YMED-X
@YmedX269 · X

RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…

May 17, 2024 · 1 share · 229 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

May 17, 2024 · 3 likes · 1 share · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

May 3, 2024 · 1 like · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD

Apr 22, 2024 · 1 like · 4,400 followers View post →
Dmitrii Kriukov
@shappiron · X

RT @AgingJrnl: The cover of Aging's latest issue features Figure 1, "Basic principles of the 1st and next gen DNAme EN clocks," by Mei et a…

Feb 12, 2024 · 1 share · 84 followers View post →
Agingdoc
@agingdoc1 · X

Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease [Xiaoyue Mei with Mike and Irina Conboy lab] https://t.co/P5IRgnt41A https://t.co/dr3fmGRhFK

Oct 10, 2023 · 7 likes · 43,746 followers View post →
Greg Macpherson
@gregmacpherson · X

Elastic net (EN) #dnamethylation clocks tend to have low accuracy in predicting #biologicalage. This research seeks to circumvent that by focusing on certain cytosines - the dysregulation of which serves as a biomarker for #aging. https://t.co/9QEVOPmxPF

Oct 3, 2023 · 442 followers View post →
Agingdoc
@agingdoc1 · X

Enhanced osteochondral repair with hyaline cartilage formation using an extracellular matrix-inspired natural scaffold https://t.co/P5IRgnswc2 https://t.co/Cqp279qsmW

Sep 29, 2023 · 1 like · 43,746 followers View post →
Aging-US
@AgingJrnl · X

#PaperoftheDay: "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease" DOI: https://t.co/4dTqGIecaO #aging #openaccess #openscience #peerreviewed #meded #researchpaper #research

Sep 27, 2023 · 4,400 followers View post →
TruDiagnostic
@TruDiagnostic · X

RT @EverythingEpi: Researchers from @UCBerkeley publish on "Fail-tests of DNA methylation clocks, and development of a noise barometer for…

Sep 20, 2023 · 1 share · 1,356 followers View post →
Hannah Went
@EverythingEpi · X

Researchers from @UCBerkeley publish on "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease". https://t.co/61VZhsSWLE

Sep 20, 2023 · 5 likes · 1 share · 550 followers View post →
Berkeley Engineering
@Cal_Engineer · X

Research from the Conboy Lab was featured on the cover of the journal “Aging.” Led by Irina Conboy, professor of bioengineering, the lab’s exciting new research centers on the measurement of biological age. View the article: https://t.co/MfbWeRoxZU https://t.co/hRp0g6NBHd

Sep 20, 2023 · 2 likes · 34,789 followers View post →
Nutriop Longevity
@nutriop · X

Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease https://t.co/j2sxscnhax

Sep 19, 2023 · 81 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Noise barometer to measure #epigenetic pressure of #aging and disease. @AgingJrnl https://t.co/IYzzrljJpy

Sep 18, 2023 · 1 like · 773 followers View post →
Aging-US
@AgingJrnl · X

#PaperSpotlight: @UCBerkeley researchers published a new priority research paper on the cover of Aging's latest issue: “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease” DOI: https://t.co/4dTqGIecaO https://t.co/KERCLzMLfN

Sep 18, 2023 · 1 like · 4,400 followers View post →
Aging-US
@AgingJrnl · X

#PaperSpotlight: Researchers from @UCBerkeley published a new priority research paper on Aging's cover: “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.” #PressRelease: https://t.co/QGZdKXfrZy

Sep 18, 2023 · 4,400 followers View post →
Aging-US
@AgingJrnl · X

#PaperoftheDay: "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease" DOI: https://t.co/4dTqGIecaO #aging #openaccess #openscience #peerreviewed #meded #researchpaper #research

Sep 18, 2023 · 4,400 followers View post →
Aging-US
@AgingJrnl · X

The cover of Aging's latest issue features Figure 1, "Basic principles of the 1st and next gen DNAme EN clocks," by Mei et al. DOI: https://t.co/4dTqGIecaO #DNA #methylation #epigenetics #aging #agingclocks #biology #openaccess #peerreviewed #medEd #OA https://t.co/bjWRE5as7J

Sep 15, 2023 · 2 likes · 1 share · 4,400 followers View post →
I gotta change my name but I haven't
@epi_boto · X

Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease https://t.co/ige2uoX1CQ

Sep 14, 2023 · 13 followers View post →
DNAMethylationPapers
@DNAmPapers · X

Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease https://t.co/AwnOmNVvVc https://t.co/KIMLksaUrV

Sep 13, 2023 · 701 followers View post →
Figure 1 [IMAGE] | EurekAlert! Science News Releases
News

Development of a noise barometer for measuring epigenetic pressure of aging and disease. Impact Journals LLC. Journal: Aging-US; DOI: 10.18632/aging.205046 ...

Dec 15, 2025 View →
DNA methylation entropy is a biomarker for aging Epigenetic clocks ...
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Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging ... 10.18632/aging. 205046 This study shows that Elastic ...

Apr 19, 2025 View →
DNA methylation changes and aging: “…we analyzed DNA ...
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... age by lifespan simultaneously brings together aging trajectories of transcription and survival curves. ... 10.18632/aging. 205046 This study ...

Mar 17, 2024 View →
Development of a noise barometer for measuring epigenetic ...
News

... age show increased SDs and can be used as noise detectors of the barometer. Read the full study: DOI: https://doi.org/10.18632/aging.205046.

Sep 18, 2023 View →