Discussions largely focus on how this research questions the accuracy of existing epigenetic clocks, with examples mentioning the limitations of linear models and the development of a noise barometer as a promising alternative. The tone reflects both curiosity and recognition of the study's novelty, using words like 'exciting' and 'game-changing,' which convey the potential for significant advancements in aging diagnostics.
AgreementModerate agreement
Most discussions appreciate the research's critique of current DNA methylation clocks and recognize the potential of the new noise barometer, indicating general agreement on its importance.
InterestHigh interest
Social discussions show high interest, with many posts highlighting the innovative approach and significance of the findings for aging research.
EngagementModerate engagement
Posts reference specific concepts such as 'epigenetic pressure' and 'biomarkers of aging,' demonstrating moderate engagement and curiosity about the methods and implications.
ImpactModerate impact
The discussions suggest the research could influence future aging diagnostics and methods, though some emphasize it as a step rather than a final solution.
Abstract in brief
The study highlights limitations of Elastic Net DNA methylation clocks for predicting biological age and distinguishing healthy from diseased states, mainly due to their reliance on linear models which don't capture the nonlinear nature of aging processes.
Instead of focusing on the methylation changes that define current clocks, the researchers developed a "noise barometer" by measuring the variability (standard deviation) in methylation of certain cytosines that remain stable over time, which they propose as a biomarker of aging and disease.
They found that in about 14% of the 450K methylation sites, increased variability with age correlates with biological aging and disease, including cytosines that stay methylated consistently, suggesting this noise is a key indicator of epigenetic pressure and health deterioration.
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease
[Xiaoyue Mei with Mike and Irina Conboy lab]
https://t.co/P5IRgnt41A https://t.co/dr3fmGRhFK
Oct 10, 2023 · 7 likes · 43,746 followersView post →
HW
Hannah Went
@EverythingEpi · X
Researchers from @UCBerkeley publish on "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease".
https://t.co/61VZhsSWLE
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Jun 8, 2024 · 4 likes · 3 shares · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Mar 1, 2025 · 3 likes · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
May 17, 2024 · 3 likes · 1 share · 4,400 followersView post →
BE
Berkeley Engineering
@Cal_Engineer · X
Research from the Conboy Lab was featured on the cover of the journal “Aging.”
Led by Irina Conboy, professor of bioengineering, the lab’s exciting new research centers on the measurement of biological age.
View the article: https://t.co/MfbWeRoxZU https://t.co/hRp0g6NBHd
This study shows that Elastic Net DNA methylation clocks have low accuracy for individual age prediction. Instead, researchers developed a noise barometer measuring variability in methylation, which correlates with…
This study highlights limitations of Elastic Net DNA methylation clocks for predicting biological age and distinguishing healthy from diseased states, mainly due to their reliance on linear models which don't capture…
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Mar 1, 2025 · 3 likes · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Feb 15, 2025 · 2 likes · 4,400 followersView post →
WZ
Walid Zahra
@SciFi_Genetics · X
RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Jan 12, 2025 · 2 likes · 2 shares · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Dec 21, 2024 · 2 likes · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Jun 8, 2024 · 4 likes · 3 shares · 4,400 followersView post →
EC
Einstein Aging Center
@EinsteinAging · X
@OMRF @MolinaLab1 @OKNathanShock Irina Conboy @UCBerkeley gives a great talk which questions the basis of current epigenetic clocks and introduces a noise barometer. She also presents on the importance of understanding the effects of old factors causing aging
https://t.co/gSPGEDG82w
RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…
May 28, 2024 · 2 shares · 229 followersView post →
DF
Dechao Feng
@DechaoF · X
RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…
May 27, 2024 · 2 shares · 941 followersView post →
AU
Aging-US
@AgingJrnl · X
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
May 27, 2024 · 2 likes · 2 shares · 4,400 followersView post →
YX
YMED-X
@YmedX269 · X
RT @AgingJrnl: Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discus…
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
May 17, 2024 · 3 likes · 1 share · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Season 2 Premiere Episode of the Longevity & Aging Series: Dr. Irina Conboy & Xiaoyue (Serafina) Mei from @UCBerkeley discuss “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”https://t.co/dKWTuUlJqD
Apr 22, 2024 · 1 like · 4,400 followersView post →
DK
Dmitrii Kriukov
@shappiron · X
RT @AgingJrnl: The cover of Aging's latest issue features Figure 1, "Basic principles of the 1st and next gen DNAme EN clocks," by Mei et a…
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease
[Xiaoyue Mei with Mike and Irina Conboy lab]
https://t.co/P5IRgnt41A https://t.co/dr3fmGRhFK
Oct 10, 2023 · 7 likes · 43,746 followersView post →
GM
Greg Macpherson
@gregmacpherson · X
Elastic net (EN) #dnamethylation clocks tend to have low accuracy in predicting #biologicalage. This research seeks to circumvent that by focusing on certain cytosines - the dysregulation of which serves as a biomarker for #aging. https://t.co/9QEVOPmxPF
Enhanced osteochondral repair with hyaline cartilage formation using an extracellular matrix-inspired natural scaffold
https://t.co/P5IRgnswc2 https://t.co/Cqp279qsmW
Sep 29, 2023 · 1 like · 43,746 followersView post →
AU
Aging-US
@AgingJrnl · X
#PaperoftheDay: "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease"
DOI: https://t.co/4dTqGIecaO
#aging #openaccess #openscience #peerreviewed #meded #researchpaper #research
Researchers from @UCBerkeley publish on "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease".
https://t.co/61VZhsSWLE
Research from the Conboy Lab was featured on the cover of the journal “Aging.”
Led by Irina Conboy, professor of bioengineering, the lab’s exciting new research centers on the measurement of biological age.
View the article: https://t.co/MfbWeRoxZU https://t.co/hRp0g6NBHd
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease https://t.co/j2sxscnhax
#PaperSpotlight: @UCBerkeley researchers published a new priority research paper on the cover of Aging's latest issue: “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease”
DOI: https://t.co/4dTqGIecaO https://t.co/KERCLzMLfN
Sep 18, 2023 · 1 like · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
#PaperSpotlight: Researchers from @UCBerkeley published a new priority research paper on Aging's cover: “Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease.”
#PressRelease: https://t.co/QGZdKXfrZy
#PaperoftheDay: "Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease"
DOI: https://t.co/4dTqGIecaO
#aging #openaccess #openscience #peerreviewed #meded #researchpaper #research
The cover of Aging's latest issue features Figure 1, "Basic principles of the 1st and next gen DNAme EN clocks," by Mei et al.
DOI: https://t.co/4dTqGIecaO
#DNA #methylation #epigenetics #aging #agingclocks #biology #openaccess #peerreviewed #medEd #OA https://t.co/bjWRE5as7J
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease https://t.co/ige2uoX1CQ
Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease https://t.co/AwnOmNVvVc https://t.co/KIMLksaUrV
Development of a noise barometer for measuring epigenetic pressure of aging and disease. Impact Journals LLC. Journal: Aging-US; DOI: 10.18632/aging.205046 ...