September 2023 PMID 37705910

Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on Vascular Calcification in Hemodialysis Patients (Trevasc-HDK).

Sabrina Haroon, Andrew Davenport, Lieng-Hsi Ling, Bee-Choo Tai, Lynette-Li-San Teo, Leon Schurgers, Zhaojin Chen, Rukshana Shroff, Dagmar-Christiane Fischer, Priyanka Khatri, Sanmay Low, Jia-Neng Tan, Horng-Ruey Chua, Boon-Wee Teo, Ching-Ching Ong

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Mentions

36
Peak: 16 in Oct 2023
across 4 sources since Jul 2023

Extended reach

1,255,441
potential audience

Total likes

21,836

Video views

1,110,242

Mentions per month

Jul 2023 – May 2025

Where it's discussed

  • X / Twitter26 posts
  • YouTube6 videos
  • Facebook2 posts
  • News2 articles

AI synopsis

What people are saying

Discussions underscore skepticism about the study's outcome, with posts like 'no beneficial effect' and 'did not modify calcifications,' highlighting disappointment or validation of prior doubts. Words such as 'no effect' and 'did not reduce' create a dismissive tone, while some comments suggest a curiosity about broader implications but do not signal strong engagement or excitement.

AgreementStrong disagreement

Most discussions clearly reflect skepticism or disappointment toward the study's findings that vitamin K2 does not reduce vascular calcification in hemodialysis patients.

InterestNeutral interest

The posts show neutral interest levels, with some curiosity about related topics but little enthusiasm for the specific results.

EngagementModerate engagement

Some posts elaborate on the methodology or implications, indicating moderate engagement, but few participants delve deeply into alternative interpretations.

ImpactLow impact

The overall tone suggests limited impact, as participants acknowledge the negative results but do not see immediate clinical significance or shifts in practice.

Abstract in brief

  • The study was a randomized controlled trial examining whether vitamin K2 supplementation could slow down vascular calcification in hemodialysis patients, but after 18 months, there was no significant difference in coronary artery calcification scores between the vitamin K2 group and the control group.
  • Although vitamin K2 reduced levels of dephosphorylated undercarboxylated MGP (dpucMGP), a marker related to vitamin K deficiency, it did not lead to improvements in other measures like aortic valve calcification, arterial stiffness, or major cardiac events.
  • Overall, the study concluded that vitamin K2 supplementation at the dose and duration used did not have a beneficial effect on reducing vascular calcification or related cardiovascular outcomes in hemodialysis patients.

Top posts

Most liked on X and Bluesky
Jonathan Chávez
@JonathanNefro · X

En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las calcificaciones, tampoco redujo eventos cardiovasculares, ni mostró algo positivo

Oct 20, 2023 · 43 likes · 14 shares · 37,708 followers View post →
Morgan Pfiffner
@MorganPfiffner · X

Yet another clinical trial finds that vitamin K does not seem to reverse or slow calcification of the coronary arteries or aortic valve. The study used vitamin K2 (MK-7; 360 ug 3x per week) and involved hemodialysis patients. https://t.co/vkeNmGe46c https://t.co/5xQUGV3148

Sep 21, 2023 · 21 likes · 2 shares · 1,113 followers View post →
Int Society of Nephrology
@ISNkidneycare · X

Sep 29, 2023 · 8 likes · 1 share · 29,225 followers View post →
KIReports
@KIReports · X

Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on #Vascular #Calcification in #Hemodialysis Patients (Trevasc-HDK) #VisualAbstract by @thana_susan https://t.co/VWsq64v5z5 https://t.co/Y0NQCyrNIZ

Jul 5, 2023 · 8 likes · 2 shares · 13,593 followers View post →
KIReports
@KIReports · X

Vitamin K in #CKD : A Game-Changer or By-Stander https://t.co/qhLSZty9qP Original Article: https://t.co/Q3hVWknZtU #KIRCommentary #VitaminK https://t.co/QWMN9Tx9kQ

Sep 7, 2023 · 4 likes · 1 share · 13,593 followers View post →
KIReports
@KIReports · X

RT @ISNkidneycare:

Sep 29, 2023 · 1 share · 13,593 followers View post →

All mentions

Leandro Quintana Becker
@BeckerQuintana · X

@DoctorTro Do you know any study about k2 and atherosclerosis reduction? Mainly soft plaques? I was looking forward to see the results of vitak cac trial https://t.co/bDEYNP3Znw. This study below didn't demonstrate any beneficial on vascular calcification. https://t.co/WTISPN90zV

Feb 16, 2025 · 108 followers View post →
Dra. torpeza
@BellidoFa · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 21, 2023 · 14 shares · 151 followers View post →
Lilia Andrea
@LiliaAndreataf1 · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 21, 2023 · 14 shares · 377 followers View post →
Roberto Gutiérrez
@DrRobertoGuti · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 21, 2023 · 14 shares · 783 followers View post →
Manuel Vazquez V
@ManuelVVidaurre · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 21, 2023 · 14 shares · 277 followers View post →
charmedbross
@charmedbross · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 21, 2023 · 14 shares · 92 followers View post →
Juan Luis
@luisfmor · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 21, 2023 · 14 shares · 104 followers View post →
Jose De La Flor
@josedelaflor4 · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 21, 2023 · 14 shares · 459 followers View post →
Malu Brown
@BrownMalu · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 20, 2023 · 14 shares · 363 followers View post →
Carlos
@de_montecristo · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 20, 2023 · 14 shares · 2,733 followers View post →
Sebastián Tenorio Vargas
@SebasTenorio · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 20, 2023 · 14 shares · 534 followers View post →
Alan QR.
@alanqr · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 20, 2023 · 14 shares · 653 followers View post →
Nutrióloga Clínica Magaly Lizaola
@MaggyLizaola · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 20, 2023 · 14 shares · 1,800 followers View post →
Nutria
@ConocerNutri · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 20, 2023 · 14 shares · 57 followers View post →
Dr. Ronald Caraballo NEFROLOGO
@ronald_nefro · X

RT @JonathanNefro: En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las…

Oct 20, 2023 · 14 shares · 661 followers View post →
Jonathan Chávez
@JonathanNefro · X

En hemodiálisis y con calcificación coronaria, consumir suplemento de vitamina K2, comparado a placebo, no modifico las calcificaciones, tampoco redujo eventos cardiovasculares, ni mostró algo positivo

Oct 20, 2023 · 43 likes · 14 shares · 37,708 followers View post →
Dr Alo, DO, FACC
@MohammedAlo · X

RT @MorganPfiffner: Yet another clinical trial finds that vitamin K does not seem to reverse or slow calcification of the coronary arteries…

Oct 15, 2023 · 2 shares · 12,731 followers View post →
KIReports
@KIReports · X

RT @ISNkidneycare:

Sep 29, 2023 · 1 share · 13,593 followers View post →
Int Society of Nephrology
@ISNkidneycare · X

Sep 29, 2023 · 8 likes · 1 share · 29,225 followers View post →
Michael Joseph
@Nutradvance · X

RT @MorganPfiffner: Yet another clinical trial finds that vitamin K does not seem to reverse or slow calcification of the coronary arteries…

Sep 22, 2023 · 2 shares · 11,779 followers View post →
Morgan Pfiffner
@MorganPfiffner · X

Yet another clinical trial finds that vitamin K does not seem to reverse or slow calcification of the coronary arteries or aortic valve. The study used vitamin K2 (MK-7; 360 ug 3x per week) and involved hemodialysis patients. https://t.co/vkeNmGe46c https://t.co/5xQUGV3148

Sep 21, 2023 · 21 likes · 2 shares · 1,113 followers View post →
Charu Malik
@CharuMalik_ISN · X

RT @KIReports: Vitamin K in #CKD : A Game-Changer or By-Stander https://t.co/qhLSZty9qP Original Article: https://t.co/Q3hVWknZtU #KIRCo…

Sep 8, 2023 · 1 share · 1,169 followers View post →
KIReports
@KIReports · X

Vitamin K in #CKD : A Game-Changer or By-Stander https://t.co/qhLSZty9qP Original Article: https://t.co/Q3hVWknZtU #KIRCommentary #VitaminK https://t.co/QWMN9Tx9kQ

Sep 7, 2023 · 4 likes · 1 share · 13,593 followers View post →
Susan Thanabalasingam
@thana_susan · X

RT @KIReports: Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on #Vascular #Calcification in #Hemodialysis…

Jul 5, 2023 · 2 shares · 355 followers View post →
Kidneyman
@Kidneyman5 · X

RT @KIReports: Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on #Vascular #Calcification in #Hemodialysis…

Jul 5, 2023 · 2 shares · 738 followers View post →
KIReports
@KIReports · X

Randomized Controlled Clinical Trial of the Effect of Treatment with Vitamin K2 on #Vascular #Calcification in #Hemodialysis Patients (Trevasc-HDK) #VisualAbstract by @thana_susan https://t.co/VWsq64v5z5 https://t.co/Y0NQCyrNIZ

Jul 5, 2023 · 8 likes · 2 shares · 13,593 followers View post →