October 2023 PMID 37709999

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial.

Jennifer M Mitchell, Marcela Ot'alora G, Bessel van der Kolk, Scott Shannon, Michael Bogenschutz, Yevgeniy Gelfand, Casey Paleos, Christopher R Nicholas, Sylvestre Quevedo, Brooke Balliett, Scott Hamilton, Michael Mithoefer, Sarah Kleiman, Kelly Parker-Guilbert, Keren Tzarfaty

Mentions

588
Peak: 51 in Sep 2023
across 7 sources since Sep 2023

Extended reach

659,173
potential audience

Total likes

487

Video views

6,851

Mentions per month

Sep 2023 – Feb 2025

Where it's discussed

  • News467 articles
  • X / Twitter68 posts
  • Blogs30 articles
  • Facebook9 posts
  • Reddit9 posts
  • YouTube3 videos
  • Bluesky2 posts

AI synopsis

What people are saying

The discussions express strong support for the study's promising results, often describing MDMA-assisted therapy as a 'game changer' or 'significant breakthrough,' with users engaging deeply by referencing specifics like the trial's design and potential FDA approval, highlighting both high interest and perceived impact.

AgreementModerate agreement

Most discussions highlight the positive results and support the potential of MDMA-assisted therapy, indicating strong agreement with the study's findings.

InterestHigh interest

Posts show high interest, often emphasizing the significance of the research and its implications for PTSD treatment.

EngagementModerate engagement

Many comments include references to the methodology, success stories, and anticipated future approval, reflecting active and thoughtful engagement.

ImpactHigh impact

Overall conversations suggest this research is seen as a pivotal breakthrough, likely to influence future therapy options and regulatory decisions.

Abstract in brief

  • This phase 3 clinical trial tested whether MDMA-assisted therapy (MDMA-AT) is effective and safe for treating people with moderate to severe PTSD, showing significant symptom reduction compared to placebo.
  • The study involved diverse participants and used independent assessors to measure improvements, with results indicating that those receiving MDMA-AT experienced greater decreases in PTSD severity and functional impairment.
  • Overall, MDMA-AT was well tolerated, with very few serious adverse events, suggesting it could be a promising treatment option for PTSD.]

Top posts

Most liked on X and Bluesky
B.Tabs
@Psilocybrain · X

A successful efficacy trial from ⁦@MAPS⁩ utilizing MDMA for PTSD⁩ has just been published in ⁦Nature⁩: “MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial” https://t.co/hBCrkK8GK5

Sep 14, 2023 · 21 likes · 6 shares · 9,158 followers View post →
Shane Morris
@DrShaneMorris · X

Great news! #MDMA significantly attenuated PTSD symptomology versus placebo with therapy in published data in Nature Medicine, see “MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial” https://t.co/SD3yW1IVD3

Sep 14, 2023 · 20 likes · 4 shares · 6,459 followers View post →
Daniel Kraft, MD
@daniel_kraft · X

#MDMA-assisted therapy for moderate to severe #PTSD: a randomized, placebo-controlled phase 3 trial sponsored by @MAPS Confirms prior findings of efficacy, moving towards submission for FDA approval . In @Nature https://t.co/yO8dWUYOGZ

Sep 18, 2023 · 10 likes · 4 shares · 53,001 followers View post →
Emma Beckerle
@emmabeckerle · X

Sep 15, 2023 · 6 likes · 2,914 followers View post →
E. D. Flynn
@IAmEdieFlynn · X

Sep 15, 2023 · 6 likes · 2,894 followers View post →
高遠 頼@生命科学VTuber(たかとー らい) 定期科学ニュース配信(日)
@takatoh_life · X

【原著論文 (2/2)】 Mitchell, JM, et al. "MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial" Nat Med 29, 2473–2480 Pub 14 Sep 2023 https://t.co/T16V7Ce7Lt

Jun 5, 2024 · 5 likes · 1 share · 13,626 followers View post →

All mentions

Legalizziamo!
@parliamdidroghe · X

RT @parliamdidroghe: Curarsi cogli spichedelici? https://t.co/C7r8FsUYia

Feb 27, 2025 · 4 shares · 5,249 followers View post →
Albertini Gloria
@AlbertiniGloria · X

RT @parliamdidroghe: Curarsi cogli spichedelici? https://t.co/C7r8FsUYia

Feb 26, 2025 · 4 shares · 722 followers View post →
Psychedelicare.eu
@PsychedelicarEU · X

RT @parliamdidroghe: Curarsi cogli spichedelici? https://t.co/C7r8FsUYia

Feb 26, 2025 · 4 shares · 151 followers View post →
Marco Perduca
@Perdukistan · X

RT @parliamdidroghe: Curarsi cogli spichedelici? https://t.co/C7r8FsUYia

Feb 26, 2025 · 4 shares · 7,248 followers View post →
Legalizziamo!
@parliamdidroghe · X

Curarsi cogli spichedelici? https://t.co/C7r8FsUYia

Feb 26, 2025 · 5 likes · 4 shares · 5,249 followers View post →
John Platt
@jplatt04 · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/Tkb84iOVXL

Jan 19, 2025 · 2,413 followers View post →
Life Science Journal Content
@lsn_jc · X

Author Correction: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial #science #publication #research #journal https://t.co/EBayIrAp48

Oct 9, 2024 · 260 followers View post →
y
@nsns909090 · X

性的虐待や暴行など、圧倒的な恐怖の体験によって引き起こされる心の病「PTSD(心的外傷後ストレス障害)」。その症状改善に合成麻薬のMDMAが効果があると、米カリフォルニア大などの研究チームが発表した。(https://t.co/jXO5z0Nifq) https://t.co/UIWe1QxdSr https://t.co/Lg8VKhjiSs

Jul 15, 2024 · 1 like · 214 followers View post →
Miguel Á. Huerta
@neurohuerta · X

[2] Mitchell, J.M., Ot’alora G., M., van der Kolk, B. et al. MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial. Nat Med 29, 2473–2480 (2023). https://t.co/fvIfDXCV7E

Jul 14, 2024 · 2,568 followers View post →
銀ハク(シロガネ 白)♀バーチャル風水師/薬剤師
@sirogane_haku · X

RT @takatoh_life: 【原著論文 (2/2)】 Mitchell, JM, et al. "MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled ph…

Jun 5, 2024 · 1 share · 3,494 followers View post →
高遠 頼@生命科学VTuber(たかとー らい) 定期科学ニュース配信(日)
@takatoh_life · X

【原著論文 (2/2)】 Mitchell, JM, et al. "MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial" Nat Med 29, 2473–2480 Pub 14 Sep 2023 https://t.co/T16V7Ce7Lt

Jun 5, 2024 · 5 likes · 1 share · 13,626 followers View post →
Matthew W. Johnson
@Drug_Researcher · X

@NotSoProf0und https://t.co/yClMZvcLTV https://t.co/AGArz6Jtm3

Jun 4, 2024 · 3 likes · 32,851 followers View post →
Артем Єсьман
@ArtemYesman · X

Обмеженість кількості досліджень. Якщо ми звернемось до UpToDate то вони пропонують 2 свіжих рандомізованих дослідження. Але є нюанс. Конфлікт інтересів в кожному з них це цілий список. https://t.co/lDUL0qDUhq https://t.co/FeeYM4PcUD https://t.co/JYLwmnyzyu

Apr 25, 2024 · 3 likes · 1,198 followers View post →
Richard D. Bartlett
@RichDecibels · X

@richmondie e.g. MDMA therapy rapidly expanding as it is very effective with severe PTSD https://t.co/btdxzfr1Od

Mar 6, 2024 · 30,814 followers View post →
Adam Staples
@AdamAimsHigh · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/pfouCmIqnA via @Nature @MAPS @NatureMedicine #MDMA #Psychedelics The study from Nature Medicine involved a diverse group of participants with moderate to severe PTSD. https://t.co/OkMDE2s0DN

Feb 17, 2024 · 1 like · 4,745 followers View post →
AAPP
@psychpharm · X

The 2/9/2024 #JournalClub presented "MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial." The recording is available free to all AAPP members. https://t.co/9ziXh7cU2H https://t.co/xhLKYkpFrJ

Feb 16, 2024 · 1 like · 969 followers View post →
UCSF Psychiatry and Behavioral Sciences
@UCSFPsychiatry · X

#Research reading: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/2teqDgwtIq

Nov 3, 2023 · 1 like · 5,298 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/h4uBQKk7aM Therapy vs MDMA + therapy - improvements in both groups, but more so with MDMA

Oct 9, 2023 · 1 like · 8,761 followers View post →
塩川宏郷
@ddtsubucafe · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/mOAXxvWTxl

Oct 4, 2023 · 644 followers View post →
HealthyBuilds
@JamesSw70043542 · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/rUvk2rMWuD

Sep 22, 2023 · 16 followers View post →
Matt Elrod
@melrod42 · X

@NOBrainer_drugs MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/dLeHN2Zvmm https://t.co/kcJzmo9odw

Sep 21, 2023 · 645 followers View post →
Andy_Weeble_Weaver
@AndrewW66619812 · X

The second, (September 2023), "Nature Medicine" paper the above "Nature" article is based upon, & links to: “MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial” 3/3 https://t.co/MKzEcAX2C5

Sep 20, 2023 · 1 like · 4,315 followers View post →
Life Science Journal Content
@lsn_jc · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial #science #publication #research #journal https://t.co/UahMUKb0Hq

Sep 20, 2023 · 260 followers View post →
Jeffrey Ventre
@jeffrey_ventre · X

RT @jeffrey_ventre: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine h…

Sep 19, 2023 · 1 share · 16,842 followers View post →
Jeffrey Ventre
@jeffrey_ventre · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/v1aUI6dKW1

Sep 18, 2023 · 1 like · 1 share · 16,842 followers View post →
Garry Golden
@garrygolden · X

RT @daniel_kraft: #MDMA-assisted therapy for moderate to severe #PTSD: a randomized, placebo-controlled phase 3 trial sponsored by @MAPS…

Sep 18, 2023 · 4 shares · 5,944 followers View post →
EP⚡️
@ertjie88 · X

RT @daniel_kraft: #MDMA-assisted therapy for moderate to severe #PTSD: a randomized, placebo-controlled phase 3 trial sponsored by @MAPS…

Sep 18, 2023 · 4 shares · 437 followers View post →
NextMed Health
@NextMedHealth · X

RT @daniel_kraft: #MDMA-assisted therapy for moderate to severe #PTSD: a randomized, placebo-controlled phase 3 trial sponsored by @MAPS…

Sep 18, 2023 · 4 shares · 26,805 followers View post →
GB
@greenbranch · X

RT @daniel_kraft: #MDMA-assisted therapy for moderate to severe #PTSD: a randomized, placebo-controlled phase 3 trial sponsored by @MAPS…

Sep 18, 2023 · 4 shares · 502 followers View post →
Daniel Kraft, MD
@daniel_kraft · X

#MDMA-assisted therapy for moderate to severe #PTSD: a randomized, placebo-controlled phase 3 trial sponsored by @MAPS Confirms prior findings of efficacy, moving towards submission for FDA approval . In @Nature https://t.co/yO8dWUYOGZ

Sep 18, 2023 · 10 likes · 4 shares · 53,001 followers View post →
Abstream
@abstreamme · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial #science #publication #research #publications https://t.co/skucqbijoc

Sep 18, 2023 · 788 followers View post →
NEUROADS Lab
@neuroads_lab · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/Ew6BMUeT1k

Sep 18, 2023 · 3 likes · 1,068 followers View post →
manishikuma/манішікума
@manishikuma · X

RT @theradelics: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/1HN9rgtHfV…

Sep 18, 2023 · 348 followers View post →
サイエンスあれこれ
@sarekore · X

述べました。承認されれば、米国はオーストラリアに次いで2番目の治療用MDMA承認国となります。Nature Medicine誌https://t.co/Saz1ibqrks

Sep 18, 2023 · 1 like · 922 followers View post →
Culture of Health Eq
@CofHEQ · X

RT @GlobalPHObserv: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine htt…

Sep 17, 2023 · 2 shares · 1,095 followers View post →
Lucia Ruggiero EALR
@luciaruggiero · X

RT @GlobalPHObserv: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine htt…

Sep 17, 2023 · 2 shares · 1,028 followers View post →
Global Health Observ
@GlobalPHObserv · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/N0Bqv7ReNb

Sep 17, 2023 · 3 likes · 2 shares · 6,542 followers View post →
Cat
@lillyc.bsky.social · Bluesky

rdcu.be/dmlBU MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial

Sep 17, 2023 View post →
THERADELICS
@theradelics · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/1HN9rgtHfV https://t.co/xRfC4MFzef

Sep 16, 2023 · 3 likes · 3,392 followers View post →
Cati
@cati3910 · X

@arprisonchap MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/uO6eKdtagK

Sep 15, 2023 · 1 like · 2,354 followers View post →
OxS
@splusoh · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/ZJdFUkTAaj

Sep 15, 2023 · 641 followers View post →
Khaliya
@Khaliya · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/khDnfw1CL9

Sep 15, 2023 · 2 likes · 147,985 followers View post →
Emma Beckerle
@emmabeckerle · X

Sep 15, 2023 · 6 likes · 2,914 followers View post →
E. D. Flynn
@IAmEdieFlynn · X

Sep 15, 2023 · 6 likes · 2,894 followers View post →
Springer Nature
@SpringerNature · X

"MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial" published in @NatureMedicine was one of our top rated articles on @altmetric this past week. You can read the #OpenAccess article here: https://t.co/NEpDHXafvF https://t.co/8bZiUCnLkR

Sep 15, 2023 · 1 like · 82,595 followers View post →
Leonhard Schilbach
@leoschilbach · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/oGX0AUb3Pw

Sep 15, 2023 · 5 likes · 6,741 followers View post →
Blossom
@blossomact · X

This Phase IIIb trial (n=104) evaluated the efficacy and safety of MDMA-assisted therapy for individuals with moderate to severe PTSD. https://t.co/ck5BM5LS8f

Sep 15, 2023 · 2 likes · 3,362 followers View post →
Reddit Journal of Science
@rsciencejournal · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial https://t.co/YMOIpuPUVk #science #health #therapy #ptsd #phase #trial

Sep 15, 2023 · 335 followers View post →
Crusader
@Crusade05626773 · X

RT @DrShaneMorris: Great news! #MDMA significantly attenuated PTSD symptomology versus placebo with therapy in published data in Nature Med…

Sep 14, 2023 · 4 shares · 232 followers View post →
Barry Bunin
@barrybunin · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/CqKhst9Bes

Sep 14, 2023 · 1,480 followers View post →
memeorandum
@memeorandum.com · Bluesky

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial (Jennifer M. Mitchell/Nature) Main Link | memeorandum Permalink

Sep 14, 2023 · 1 like View post →
qnp
@qnp · X

RT @DrShaneMorris: Great news! #MDMA significantly attenuated PTSD symptomology versus placebo with therapy in published data in Nature Med…

Sep 14, 2023 · 4 shares · 24,244 followers View post →
David Purcell
@itsdavidpurcell · X

RT @DrShaneMorris: Great news! #MDMA significantly attenuated PTSD symptomology versus placebo with therapy in published data in Nature Med…

Sep 14, 2023 · 4 shares · 2,891 followers View post →
ironfeet
@ironfeet_nfts · X

RT @Psilocybrain: A successful efficacy trial from ⁦@MAPS⁩ utilizing MDMA for PTSD⁩ has just been published in ⁦Nature⁩: “MDMA-assisted th…

Sep 14, 2023 · 6 shares · 1,779 followers View post →
PharmAla Biotech
@PharmAlaBiotech · X

RT @DrShaneMorris: Great news! #MDMA significantly attenuated PTSD symptomology versus placebo with therapy in published data in Nature Med…

Sep 14, 2023 · 4 shares · 940 followers View post →
Joe Moore
@jomo137 · X

RT @Psilocybrain: A successful efficacy trial from ⁦@MAPS⁩ utilizing MDMA for PTSD⁩ has just been published in ⁦Nature⁩: “MDMA-assisted th…

Sep 14, 2023 · 6 shares · 3,039 followers View post →
David B. Yaden
@ExistWell · X

RT @psychedelethics: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine ht…

Sep 14, 2023 · 1 share · 7,182 followers View post →
Olivia H. Scharfman
@OliviaHelenS · X

History in the making. ⁦@MAPS⁩ MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/3kaZgizhgs

Sep 14, 2023 · 4 likes · 3,582 followers View post →
shoei
@shoei_101 · X

RT @Psilocybrain: A successful efficacy trial from ⁦@MAPS⁩ utilizing MDMA for PTSD⁩ has just been published in ⁦Nature⁩: “MDMA-assisted th…

Sep 14, 2023 · 6 shares · 3,082 followers View post →
Christophe Stove
@christophestove · X

New in @NatureMedicine: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial

Sep 14, 2023 · 2 likes · 1,543 followers View post →
klöss
@kloss_xyz · X

RT @Psilocybrain: A successful efficacy trial from ⁦@MAPS⁩ utilizing MDMA for PTSD⁩ has just been published in ⁦Nature⁩: “MDMA-assisted th…

Sep 14, 2023 · 6 shares · 32,697 followers View post →
Antoinette Miric
@DrMiric · X

RT @wendyburn: MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://…

Sep 14, 2023 · 1 share · 600 followers View post →
HOPE
@psychedelethics · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/a1x0J2IhHM

Sep 14, 2023 · 4 likes · 1 share · 279 followers View post →
PJ08
@MrJalili5 · X

RT @Psilocybrain: A successful efficacy trial from ⁦@MAPS⁩ utilizing MDMA for PTSD⁩ has just been published in ⁦Nature⁩: “MDMA-assisted th…

Sep 14, 2023 · 6 shares · 3,588 followers View post →
Stav P
@Stav_Ps · X

RT @Psilocybrain: A successful efficacy trial from ⁦@MAPS⁩ utilizing MDMA for PTSD⁩ has just been published in ⁦Nature⁩: “MDMA-assisted th…

Sep 14, 2023 · 6 shares · 3,263 followers View post →
Arnþór
@arnthorjon · X

#MDMA -assisted therapy for moderate to severe #PTSD : a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/q4kIh3prlx

Sep 14, 2023 · 1,399 followers View post →
Wendy Burn CBE (She/her)
@wendyburn · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine https://t.co/dRgBrzlIb6

Sep 14, 2023 · 4 likes · 1 share · 27,267 followers View post →
B.Tabs
@Psilocybrain · X

A successful efficacy trial from ⁦@MAPS⁩ utilizing MDMA for PTSD⁩ has just been published in ⁦Nature⁩: “MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial” https://t.co/hBCrkK8GK5

Sep 14, 2023 · 21 likes · 6 shares · 9,158 followers View post →
Shane Morris
@DrShaneMorris · X

Great news! #MDMA significantly attenuated PTSD symptomology versus placebo with therapy in published data in Nature Medicine, see “MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial” https://t.co/SD3yW1IVD3

Sep 14, 2023 · 20 likes · 4 shares · 6,459 followers View post →
Harpreet Kaur
@Hkaur_p · X

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial | Nature Medicine #MDMA #MAPS https://t.co/ennKDbycvG

Sep 14, 2023 · 2 likes · 300 followers View post →