Aging (Albany NY) September 2023 PMID 37742294

Biomedical generative pre-trained based transformer language model for age-related disease target discovery.

Diana Zagirova, Stefan Pushkov, Geoffrey Ho Duen Leung, Bonnie Hei Man Liu, Anatoly Urban, Denis Sidorenko, Aleksandr Kalashnikov, Ekaterina Kozlova, Vladimir Naumov, Frank W Pun, Ivan V Ozerov, Alex Aliper, Alex Zhavoronkov

Mentions

56
Peak: 24 in Oct 2023
across 4 sources since Sep 2023

Extended reach

221,006
potential audience

Total likes

68

Video views

306

Mentions per month

Sep 2023 – May 2024

Where it's discussed

  • X / Twitter47 posts
  • News6 articles
  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

The discussions demonstrate strong support for the potential of transformer-based AI models in biomedical research, with examples like identifying targets such as CCR5 and PTH, and use of phrases like 'game changer' and 'novel approach' to express excitement. The tone combines enthusiasm with some skepticism about aspects like funding and training data, reflecting a nuanced view of the publication's significance.

AgreementModerate agreement

Most discussions acknowledge the significance of using large language models like BioGPT for age-related disease target discovery, supporting the study's approach.

InterestHigh interest

Posts express high interest, highlighting the innovative use of AI and mentioning specific targets like CCR5 and PTH, which attract attention.

EngagementModerate engagement

While some posts share summaries and implications, many are brief mentions, indicating moderate engagement rather than deep analysis.

ImpactModerate impact

There is recognition of the potential impact on biomedical research and anti-aging therapies, though some skepticism remains about the actual novelty or direct influence.

Abstract in brief

  • This study introduces a new method for discovering disease targets by using a specialized large language model called BioGPT, trained on biomedical literature to predict proteins related to aging and age-related diseases.
  • The researchers developed a pipeline that improves target prediction performance by fine-tuning the model with task-specific texts, successfully identifying existing and potentially novel targets such as CCR5 and PTH for anti-aging therapies.
  • Overall, the work demonstrates the potential of transformer-based AI models to enhance target discovery processes in biomedicine, paving the way for future integration of AI in developing diagnostics and treatments.

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/sjMrN9vXPj

Oct 14, 2023 · 27 likes · 10 shares · 31,454 followers View post →
Agingdoc
@agingdoc1 · X

Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology https://t.co/yjBXzy7sFT https://t.co/aoQMUxZSwH

Sep 25, 2023 · 17 likes · 8 shares · 43,746 followers View post →
Agingdoc
@agingdoc1 · X

Biomedical generative pre-trained based transformer language model for age-related disease target discovery @InSilicoMeds @DianaZagirova @biogerontology et al https://t.co/yjBXzy6UQl

Oct 9, 2023 · 7 likes · 1 share · 43,746 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Apr 15, 2024 · 5 likes · 2 shares · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Nov 20, 2023 · 2 likes · 2 shares · 4,400 followers View post →
Sreeram Penna
@SreeramPenna · X

Researchers present a novel approach for predicting therapeutic targets using a large language model (LLM) BioGPT. Using this, they identified CCR5 and PTH as potential novel dual-purpose anti-aging and disease targets. #AntiAging #AIClinicalTrials #BioGPT https://t.co/XHp7uTmpb0

Sep 27, 2023 · 2 likes · 72 followers View post →

All mentions

Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

May 15, 2024 · 4,400 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @AgingJrnl: Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as t…

Apr 16, 2024 · 2 shares · 574 followers View post →
YMED-X
@YmedX269 · X

RT @AgingJrnl: Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as t…

Apr 16, 2024 · 2 shares · 229 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Apr 15, 2024 · 5 likes · 2 shares · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Mar 16, 2024 · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Feb 15, 2024 · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Jan 15, 2024 · 1 like · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Dec 29, 2023 · 4,400 followers View post →
Dani ✌️
@danielsil44 · X

RT @AgingJrnl: Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as t…

Dec 15, 2023 · 1 share · 1,207 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Dec 15, 2023 · 1 like · 1 share · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Watch an #agingshort video of a #trendingwithimpact research #paper recently published: “Biomedical generative pre-trained based transformer language model for age-related disease target discovery." @InSilicoMeds https://t.co/JipX9ohoU4 #aging #oa #deeplearning #ai #video https://t.co/ca5TVSu82G

Dec 4, 2023 · 4,400 followers View post →
YMED-X
@YmedX269 · X

RT @AgingJrnl: Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as t…

Nov 21, 2023 · 2 shares · 229 followers View post →
Dechao Feng
@DechaoF · X

RT @AgingJrnl: Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as t…

Nov 21, 2023 · 2 shares · 941 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Nov 20, 2023 · 2 likes · 2 shares · 4,400 followers View post →
Dechao Feng
@DechaoF · X

RT @AgingJrnl: Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as t…

Nov 6, 2023 · 1 share · 941 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Nov 6, 2023 · 1 share · 4,400 followers View post →
Stephen J Williams
@StephenJWillia2 · X

Did #NIH sell your grant application for use in #BioGPT training? A recent article by Insilico Medicine https://t.co/WMSqEgM2PZ on using the GPT to discover targets for aging and cancer may have used 900,000 grant application full texts for training

Nov 5, 2023 · 213 followers View post →
YMED-X
@YmedX269 · X

RT @AgingJrnl: Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as t…

Oct 27, 2023 · 1 share · 229 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Frank Pun, Diana Zagirova, Dr. Anatoly Urban, and Geoffrey Ho Duen Leung from @InSilicoMeds as they discuss “Biomedical generative pre-trained based transformer language model for age-related disease target discovery.” WATCH ⬇️ https://t.co/i6Ajy8sDpU

Oct 26, 2023 · 1 like · 1 share · 4,400 followers View post →
Pavev
@patyverjan · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 17, 2023 · 10 shares · 33 followers View post →
Flower_Girl_2115
@FlowerGirl_2115 · X

https://t.co/c7wwNXvIog Scientists from Insilico Medicine developed a domain-specific version of Microsoft's BioGPT, and turned it into a large language model AI for age-related disease target discovery. They identified CCR5 and PTH... (1/2)

Oct 17, 2023 · 340 followers View post →
Ronnie Cutler
@cutleraging · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 16, 2023 · 10 shares · 468 followers View post →
Science Socks
@SocksScience · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 16, 2023 · 10 shares · 454 followers View post →
Quantix
@ZReacc · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 15, 2023 · 10 shares · 326 followers View post →
Alexander Dakhovnik
@ADakhovnik · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 15, 2023 · 10 shares · 79 followers View post →
Matias Hartman
@HartmanMatias_ · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 14, 2023 · 10 shares · 571 followers View post →
vignesh Jayarajan
@VigneshUCL · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 14, 2023 · 10 shares · 21 followers View post →
Bayar Jaff
@JaffBayar · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 14, 2023 · 10 shares · 606 followers View post →
João Pedro de Magalhães
@jpsenescence · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 14, 2023 · 10 shares · 18,779 followers View post →
BitFuturist
@BitFuturist · X

RT @AgingBiology: Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/…

Oct 14, 2023 · 10 shares · 1,153 followers View post →
Aging Science News
@AgingBiology · X

Biomedical generative pre-trained based transformer language model for age-related disease target discovery https://t.co/sjMrN9vXPj

Oct 14, 2023 · 27 likes · 10 shares · 31,454 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @agingdoc1: Biomedical generative pre-trained based transformer language model for age-related disease target discovery @InSilicoMeds @…

Oct 9, 2023 · 1 share · 6,616 followers View post →
Agingdoc
@agingdoc1 · X

Biomedical generative pre-trained based transformer language model for age-related disease target discovery @InSilicoMeds @DianaZagirova @biogerontology et al https://t.co/yjBXzy6UQl

Oct 9, 2023 · 7 likes · 1 share · 43,746 followers View post →
Aging-US
@AgingJrnl · X

#TrendingWithImpact: On September 22, 2023, researchers from @InSilicoMeds published a new research paper in Aging: “Biomedical generative pre-trained based transformer language model for age-related disease target discovery” DOI: https://t.co/JipX9ohoU4 @biogerontology https://t.co/ilyCOfn0id

Oct 4, 2023 · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Watch an #agingshort video of a #trendingwithimpact research #paper recently published: “Biomedical generative pre-trained based transformer language model for age-related disease target discovery." @InSilicoMeds https://t.co/JipX9ohoU4 #aging #oa #deeplearning #ai #video https://t.co/5iECp2bOzL

Oct 4, 2023 · 4,400 followers View post →
Sreeram Penna
@SreeramPenna · X

Researchers present a novel approach for predicting therapeutic targets using a large language model (LLM) BioGPT. Using this, they identified CCR5 and PTH as potential novel dual-purpose anti-aging and disease targets. #AntiAging #AIClinicalTrials #BioGPT https://t.co/XHp7uTmpb0

Sep 27, 2023 · 2 likes · 72 followers View post →
Daniel
@daniels0 · X

RT @agingdoc1: Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology…

Sep 26, 2023 · 8 shares · 172 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

BioGPT model: predict age-related diseases Identify and validate disease-relevant targets @AgingJrnl @InSilicoMeds https://t.co/SUQnFFYppf

Sep 25, 2023 · 1 like · 773 followers View post →
Science
@Long_life_sci · X

RT @agingdoc1: Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology…

Sep 25, 2023 · 8 shares · 36 followers View post →
Bayar Jaff
@JaffBayar · X

RT @agingdoc1: Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology…

Sep 25, 2023 · 8 shares · 606 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @agingdoc1: Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology…

Sep 25, 2023 · 8 shares · 198 followers View post →
St.George’s Knight@S.F. BayArea
@bayarea489 · X

#CCR5 #leronlimab #cytodyn #aging #cancer #nash #mtnbc #oncology $cydy #AI #BIOGPT https://t.co/vFCxFN79n6

Sep 25, 2023 · 224 followers View post →
Slobodan Fuletic
@FuleticSlobodan · X

RT @agingdoc1: Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology…

Sep 25, 2023 · 8 shares · 101 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @agingdoc1: Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology…

Sep 25, 2023 · 8 shares · 6,616 followers View post →
Marta Noya (Martouta)
@MartoutaTech · X

RT @agingdoc1: Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology…

Sep 25, 2023 · 8 shares · 1,175 followers View post →
Agingdoc
@agingdoc1 · X

Biomedical generative pre-trained based transformer language model for age-related disease target discovery @biogerontology https://t.co/yjBXzy7sFT https://t.co/aoQMUxZSwH

Sep 25, 2023 · 17 likes · 8 shares · 43,746 followers View post →
Vladimir Naumov
@vovalive · X

New approach leverages LLMs to predict novel therapeutic targets for aging and age-related diseases. Our pipeline retrieved known targets & proposed CCR5 & PTH as potential dual-purpose anti-aging/disease targets not previously identified as age-related. https://t.co/pdPqsVO1De

Sep 25, 2023 · 1 like · 115 followers View post →
The intersection of aging and disease [IMAGE] | EurekAlert! Science ...
News

Insilico Medicine discovers novel dual targets for aging and disease using Microsoft BioGPT. InSilico Medicine. Journal: Aging-US; DOI: 10.18632/aging.205055 ...

Dec 15, 2025 View →
New AI Language Model for Finding Age-Related Disease Targets
News

... age-related disease target discovery” was published in the journal Aging. ... doi:10.18632/aging.205055. Source: https://www.impactjournals.com ...

Oct 9, 2023 View →
New AI model predicts therapeutic targets for age-related diseases
Blogs

Applying the developed pipeline, the researchers retrieved prospective aging and age ... doi.org/10.18632/aging.205055. Be the first to rate this ...

Oct 4, 2023 View →
AI model for age-related disease target discovery | EurekAlert!
News

... 10.18632%2Faging.https://doi.org/10.18632/aging.205055. About Aging: Launched in 2009, Aging publishes papers of general interest and ...

Oct 4, 2023 View →
Team trains AI model for age-related disease target discovery
News

... age-related disease target discovery, Aging (2023). DOI: 10.18632/aging.205055. Provided by Impact Journals LLC. + Explore further. Team ...

Oct 4, 2023 View →
Insilico Medicine discovers novel dual targets for aging and disease ...
News

... aging-related diseases. For more information, visit www.insilico.com. Journal. Aging-US. DOI. 10.18632/aging.205055. Article Title. Biomedical ...

Sep 27, 2023 View →
英矽智能基于微软BioGPT发现多个新颖双效靶点,利用LLMs驱动 ...
News

Aging-US; DOI: 10.18632/aging.205055. Keywords. /Life sciences/Biochemistry/Pharmacology/Drug targets/Molecular targets; /Life sciences ...

Sep 27, 2023 View →