September 2023 PMID 37759877

Dose-Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults.

Terence Moriarty, Kelsey Bourbeau, Katie Dorman, Lance Runyon, Noah Glaser, Jenna Brandt, Mallory Hoodjer, Scott C Forbes, Darren G Candow

Mentions

44
Peak: 24 in Sep 2023
across 2 sources since Sep 2023

Extended reach

173,037
potential audience

Total likes

639

Video views

11,759

Mentions per month

Sep 2023 – Dec 2025

Where it's discussed

  • X / Twitter42 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions predominantly agree that the study confirms creatine's minimal effects on cognition in healthy young adults, with phrases like 'no improvement' and 'does not significantly enhance,' demonstrating consensus. The tone remains cautious, referencing meta-analyses and emphasizing the need for more extensive research, which reflects moderate engagement and interest without overstating the findings.

AgreementStrong agreement

Most discussions acknowledge the study's findings that creatine does not significantly improve cognitive function in healthy young adults, showing strong consensus.

InterestModerate interest

There is moderate interest, as many comments focus on confirming existing evidence rather than exploring new implications.

EngagementModerate engagement

Several users reference specific details of the study and related research, indicating thoughtful engagement, but it's not deeply analytical.

ImpactModerate impact

The conversation suggests limited immediate impact on practice, but some discussions highlight the need for further large-scale research, indicating a subtle influence on ongoing scientific discourse.

Abstract in brief

  • The study investigated whether creatine supplementation affects cognitive performance and prefrontal cortex activation in healthy young adults over six weeks, with participants taking either 10 g/day, 20 g/day, or a placebo.
  • Results showed that creatine, regardless of dosage, did not significantly improve cognitive test scores or alter prefrontal cortex activity, although a slight decrease in PFC oxyhemoglobin was observed in the lower dose group.
  • Overall, the findings suggest that six weeks of creatine supplementation at moderate to high doses does not enhance cognitive function or brain activation in young, healthy individuals.

Top posts

Most liked on X and Bluesky
Darren Candow, PhD, CSEP-CEP, FISSN
@darrencandow · X

More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely to have no significant effects on cognition in young adults. https://t.co/qvPmo71qlf

Dec 28, 2023 · 42 likes · 8 shares · 6,768 followers View post →
Jose Antonio PhD
@JoseAntonioPhD · X

Overall, six weeks of Cr supplementation at a moderate or high dose (20 g/d) does not improve cognitive performance or change PFC activation in young adults. https://t.co/P359O0zy9J #mdpibrainsci via @BrainSci_MDPI

Sep 28, 2023 · 34 likes · 7 shares · 22,294 followers View post →
Darren Candow, PhD, CSEP-CEP, FISSN
@darrencandow · X

Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults #creatine #brain @DrCreatine https://t.co/ZlXTSh1qgh “6 wk of Cr supplementation at a moderate or high dose does NOT improve cognitive performance or change PFC activation in young adults”

Sep 4, 2023 · 28 likes · 6 shares · 6,768 followers View post →
Jose Antonio PhD
@JoseAntonioPhD · X

"Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults." Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults https://t.co/P359O0zy9J #mdpibrainsci via

Sep 5, 2023 · 16 likes · 6 shares · 22,294 followers View post →
Hernando Mosso Sánchez
@MossoSanch · X

@adalozzo Pues sobre la creatina son innumerables los metanalisis que no solo no la encuentran lesiva sino que otorga beneficios de todo orden en personas sanas. Candow DG. Dose-Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults.10.3390/brainsci13091276.

Mar 15, 2025 · 9 likes · 1 share · 157 followers View post →
Darren Candow, PhD, CSEP-CEP, FISSN
@darrencandow · X

@mackinprof @theproof @NanciGuestRDPhD @ScepticalDoctor @Veganella_ @EricRawsonPhD We still do not know a reliable dosing protocol. It’s becoming more clear that creatine likely has no cognitive benefits in healthy individuals, especially young. All studies are limited by very low sample sizes. Large scale RCT (using MRS) needed. https://t.co/qvPmo71qlf

Nov 19, 2023 · 6 likes · 6,768 followers View post →

All mentions

toreo1848
@HellJanitzek · X

@theaboagyeboadi @FitFounder @fmfclips A dose–response study comparing 10 g and 20 g/day over 6 weeks in healthy young adults showed no improvement in cognitive performance. https://t.co/dQsg9XlT2M

Aug 27, 2025 · 355 followers View post →
toreo1848
@HellJanitzek · X

@theaboagyeboadi @FitFounder @fmfclips A dose–response study comparing 10 g and 20 g/day over 6 weeks in healthy young adults showed no improvement in cognitive performance.https://t.co/dQsg9XlT2M

Aug 27, 2025 · 355 followers View post →
Catalina Pogany
@pogany54 · X

RT @MossoSanch: @adalozzo Pues sobre la creatina son innumerables los metanalisis que no solo no la encuentran lesiva sino que otorga benef…

Mar 15, 2025 · 1 share · 675 followers View post →
Hernando Mosso Sánchez
@MossoSanch · X

@adalozzo Pues sobre la creatina son innumerables los metanalisis que no solo no la encuentran lesiva sino que otorga beneficios de todo orden en personas sanas. Candow DG. Dose-Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults.10.3390/brainsci13091276.

Mar 15, 2025 · 9 likes · 1 share · 157 followers View post →
Rez Havaei
@HavaeiRez · X

@levelsio https://t.co/FFEHa25ket

Dec 29, 2024 · 188 followers View post →
GDLeahy
@GDLeahy · X

RT @darrencandow: More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely…

Dec 29, 2023 · 8 shares · 672 followers View post →
Argón
@metilargon · X

RT @darrencandow: More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely…

Dec 29, 2023 · 8 shares · 349 followers View post →
Mind Your Science!
@MindYourSci · X

RT @darrencandow: More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely…

Dec 29, 2023 · 8 shares · 129 followers View post →
William Amaral
@_sempreguica · X

RT @darrencandow: More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely…

Dec 28, 2023 · 8 shares · 119 followers View post →
Gregory Miller, Ph.D.
@drdairy50 · X

RT @darrencandow: More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely…

Dec 28, 2023 · 8 shares · 10,723 followers View post →
Matías Monsalves-Álvarez
@profemonsalves · X

RT @darrencandow: More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely…

Dec 28, 2023 · 8 shares · 1,498 followers View post →
Javed Alam
@jalam1001 · X

RT @darrencandow: More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely…

Dec 28, 2023 · 8 shares · 1,007 followers View post →
Scott Forbes
@DrCreatine · X

RT @darrencandow: More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely…

Dec 28, 2023 · 8 shares · 850 followers View post →
Darren Candow, PhD, CSEP-CEP, FISSN
@darrencandow · X

More evidence to suggest that if the brain is NOT metabolically stressed or compromised, even high dose #creatine likely to have no significant effects on cognition in young adults. https://t.co/qvPmo71qlf

Dec 28, 2023 · 42 likes · 8 shares · 6,768 followers View post →
drehman ☕️#ReadWriteThinkCriticallyDaily
@pomdr · X

per day. - The Daily Pump @Schwarzenegger @BornFitness @ketch https://t.co/dwGY4iBTqP https://t.co/Ou8iclpmw0

Dec 5, 2023 · 592 followers View post →
Kat Fu, M.S., M.S.
@thekatfu · X

@theproof @NanciGuestRDPhD @ScepticalDoctor @Veganella_ @EricRawsonPhD @darrencandow Moriarty T, Bourbeau K, Dorman K, Runyon L, Glaser N, Brandt J, Hoodjer M, Forbes SC, Candow DG. Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults. Brain Sciences. 2023; 13(9):1276.

Nov 19, 2023 · 1 like · 17,772 followers View post →
Darren Candow, PhD, CSEP-CEP, FISSN
@darrencandow · X

@mackinprof @theproof @NanciGuestRDPhD @ScepticalDoctor @Veganella_ @EricRawsonPhD We still do not know a reliable dosing protocol. It’s becoming more clear that creatine likely has no cognitive benefits in healthy individuals, especially young. All studies are limited by very low sample sizes. Large scale RCT (using MRS) needed. https://t.co/qvPmo71qlf

Nov 19, 2023 · 6 likes · 6,768 followers View post →
Brady Holmer
@Brady_H · X

Link to full study: "Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults"https://t.co/CsNPf4uLSb

Nov 15, 2023 · 4 likes · 27,868 followers View post →
Scott Forbes
@DrCreatine · X

RT @ExphysPhD: Study finds creatine supplementation doesn't significantly enhance cognitive performance in young adults, despite a slight t…

Sep 29, 2023 · 2 shares · 850 followers View post →
Jeffrey R. Stout
@ExphysPhD · X

Study finds creatine supplementation doesn't significantly enhance cognitive performance in young adults, despite a slight trend in altered brain activation.

Sep 29, 2023 · 4 likes · 2 shares · 3,525 followers View post →
Jason Crawhorn
@JCrawhorn · X

RT @JoseAntonioPhD: Overall, six weeks of Cr supplementation at a moderate or high dose (20 g/d) does not improve cognitive performance or…

Sep 28, 2023 · 7 shares · 122 followers View post →
Fitcart.com
@fitcartofficial · X

RT @JoseAntonioPhD: Overall, six weeks of Cr supplementation at a moderate or high dose (20 g/d) does not improve cognitive performance or…

Sep 28, 2023 · 7 shares · 251 followers View post →
Brain Sciences MDPI
@BrainSci_MDPI · X

RT @JoseAntonioPhD: Overall, six weeks of Cr supplementation at a moderate or high dose (20 g/d) does not improve cognitive performance or…

Sep 28, 2023 · 7 shares · 2,118 followers View post →
William Amaral
@_sempreguica · X

RT @JoseAntonioPhD: Overall, six weeks of Cr supplementation at a moderate or high dose (20 g/d) does not improve cognitive performance or…

Sep 28, 2023 · 7 shares · 119 followers View post →
Allison Ethier Fitness & Physique
@AllisonEthier · X

RT @JoseAntonioPhD: Overall, six weeks of Cr supplementation at a moderate or high dose (20 g/d) does not improve cognitive performance or…

Sep 28, 2023 · 7 shares · 11,860 followers View post →
Jose Antonio PhD
@JoseAntonioPhD · X

Overall, six weeks of Cr supplementation at a moderate or high dose (20 g/d) does not improve cognitive performance or change PFC activation in young adults. https://t.co/P359O0zy9J #mdpibrainsci via @BrainSci_MDPI

Sep 28, 2023 · 34 likes · 7 shares · 22,294 followers View post →
Alessandra
@AminelliVr · X

RT @JoseAntonioPhD: "Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change P…

Sep 7, 2023 · 6 shares · 650 followers View post →
Brain Sciences MDPI
@BrainSci_MDPI · X

RT @JoseAntonioPhD: "Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change P…

Sep 7, 2023 · 6 shares · 2,118 followers View post →
Mind Your Science!
@MindYourSci · X

RT @darrencandow: Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults #creatine #brain @DrCreatine ht…

Sep 6, 2023 · 6 shares · 129 followers View post →
Mind Your Science!
@MindYourSci · X

RT @JoseAntonioPhD: "Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change P…

Sep 6, 2023 · 6 shares · 129 followers View post →
Tarik Fehmi
@Tarik_Fehmi · X

RT @darrencandow: Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults #creatine #brain @DrCreatine ht…

Sep 5, 2023 · 6 shares · 816 followers View post →
Creatine For Health
@Creatine4Health · X

RT @darrencandow: Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults #creatine #brain @DrCreatine ht…

Sep 5, 2023 · 6 shares · 1,328 followers View post →
Creatine For Health
@Creatine4Health · X

RT @JoseAntonioPhD: "Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change P…

Sep 5, 2023 · 6 shares · 1,328 followers View post →
Brain Sciences MDPI
@BrainSci_MDPI · X

RT @jheilesonRD: Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults "6-weeks of Cr suppl at a modera…

Sep 5, 2023 · 2 shares · 2,118 followers View post →
Scott Forbes
@DrCreatine · X

RT @JoseAntonioPhD: "Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change P…

Sep 5, 2023 · 6 shares · 850 followers View post →
Jose Antonio PhD
@JoseAntonioPhD · X

"Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults." Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults https://t.co/P359O0zy9J #mdpibrainsci via

Sep 5, 2023 · 16 likes · 6 shares · 22,294 followers View post →
Lance Runyon™
@LanceRunyon1 · X

RT @darrencandow: Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults #creatine #brain @DrCreatine ht…

Sep 4, 2023 · 6 shares · 1,404 followers View post →
Dr T
@MoriartyTerence · X

RT @darrencandow: Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults #creatine #brain @DrCreatine ht…

Sep 4, 2023 · 6 shares · 76 followers View post →
Scott Forbes
@DrCreatine · X

RT @darrencandow: Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults #creatine #brain @DrCreatine ht…

Sep 4, 2023 · 6 shares · 850 followers View post →
Darren Candow, PhD, CSEP-CEP, FISSN
@darrencandow · X

Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults #creatine #brain @DrCreatine https://t.co/ZlXTSh1qgh “6 wk of Cr supplementation at a moderate or high dose does NOT improve cognitive performance or change PFC activation in young adults”

Sep 4, 2023 · 28 likes · 6 shares · 6,768 followers View post →
docholiday5: ✨️FF7 Part 3! Name?? ✨️
@docholiday_5 · X

RT @jheilesonRD: Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults "6-weeks of Cr suppl at a modera…

Sep 3, 2023 · 2 shares · 1,180 followers View post →
Jeffery Heileson
@jheilesonRD · X

Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults "6-weeks of Cr suppl at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults." https://t.co/Z8xXqb1ib1 #mdpibrainsci via @BrainSci_MDPI

Sep 3, 2023 · 4 likes · 2 shares · 849 followers View post →