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Nature October 2023 PMID 37794188

Large-scale plasma proteomics comparisons through genetics and disease associations.

Grimur Hjorleifsson Eldjarn, Egil Ferkingstad, Sigrun H Lund, Hannes Helgason, Olafur Th Magnusson, Kristbjorg Gunnarsdottir, Thorunn A Olafsdottir, Bjarni V Halldorsson, Pall I Olason, Florian Zink, Sigurjon A Gudjonsson, Gardar Sveinbjornsson, Magnus I Magnusson, Agnar Helgason, Asmundur Oddsson

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Mentions

89
Peak: 30 in Oct 2023
across 6 sources since Oct 2023

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2,781,697
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Total likes

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Mentions per month

Oct 2023 – Sep 2025

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AI synopsis

What people are saying

The overall tone reflects strong support and enthusiasm, with comments highlighting the importance of the findings, such as using diverse ancestry groups to improve disease understanding, and questions about related proteomics methods. Words like 'significant,' 'exciting,' and mentions of 'improvement' demonstrate both admiration and a focus on future applications, indicating high engagement and perceived impact.

AgreementModerate agreement

Most discussions recognize the significance of the study, emphasizing its valuable insights into how different plasma proteomics platforms can be utilized to understand disease genetics.

InterestHigh interest

Many replies express high curiosity about applying these findings, especially in relation to diverse genetic backgrounds and advanced methodologies.

EngagementModerate engagement

Participants often reference specific aspects like methodological comparisons and implications for future research, indicating active involvement.

ImpactHigh impact

The widespread attention and mentions of potential advancements and platform refinements suggest that the discussions see this work as having meaningful influence on the field.

Abstract in brief

  • High-throughput proteomics platforms can link genomics to disease insights by analyzing thousands of proteins in plasma, as demonstrated by a study using Olink Explore 3072 data from over 50,000 UK Biobank participants.
  • The study found a modest correlation between the Olink platform and another platform, SomaScan, with notable differences in their assay performances, particularly in the detection of protein quantitative trait loci.
  • By stratifying participants based on ancestry, the research highlighted how diverse genetic backgrounds can uncover new associations and improve our understanding of the genetic basis of diseases, showcasing the complementary nature of these proteomics platforms.
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Most liked on X and Bluesky
nature
@Nature · X

Nature research paper: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/V3AEjU7ds0

Oct 4, 2023 · 27 likes · 6 shares · 2,613,016 followers View post →
Nature Reviews Genetics
@NatureRevGenet · X

Original article 2: Eldjarn, G. H. et al. Large-scale plasma proteomics comparisons through genetics and disease associations. Nature 622, 348–358 (2023)

Nov 1, 2023 · 6 likes · 1 share · 92,675 followers View post →
Phenomics
@Phenomics_J · X

Large-scale plasma proteomics comparisons through genetics and disease associations: Using different ancestry groups for locus refinement. @Nature #Phenomics #plasma #proteomics https://t.co/FK416fBdl7 https://t.co/2E4uHnSgDx

Oct 9, 2023 · 6 likes · 6 shares · 1,526 followers View post →
flora peyvandi
@flora_peyvandi · X

Large-scale plasma #proteomics comparisons through #genetics and disease associations. https://t.co/YFThtzhBH0

Oct 7, 2023 · 4 likes · 1 share · 2,371 followers View post →
Pastel BioScience
@PastelBio · X

Large-scale plasma proteomics comparisons through genetics and disease associations - https://t.co/ICUyVNx4im --- #proteomics #prot-paper https://t.co/Bg9IP6PbZi

Oct 5, 2023 · 3 likes · 3 shares · 5,377 followers View post →
Waggoner Lab
@LabWaggoner · X

Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/JufpkJX2Tx https://t.co/fvPoAzvRc8 https://t.co/PB697gj9eR

Oct 4, 2023 · 2 likes · 1 share · 11,331 followers View post →

All mentions

EZSci
@EZiSci · X

English summary exceeds Twitter's character limit. https://t.co/Pp7haaOkSp https://t.co/LduQGVMSVE

Mar 2, 2025 · 732 followers View post →
علمي علمك
@3lmy3elmak · X

دراسة على نطاق واسع تقارن بين منصتين للبروتيوميات عالية الإنتاجية، أولينك وسوماسكان، باستخدام بيانات من بنك الجينات البريطاني والأشخاص الأيسلنديين. النتائج تظهر اختلافات في الرابطات بين البروتين والجينوم، مما يسلط الضوء على أهمية التنوع ال https://t.co/18tyVAyy5K https://t.co/RazZSj8ilI

Mar 2, 2025 · 29 followers View post →
Sciences
@sciences.skyfleet.blue · Bluesky

Author Correction: Large-scale plasma proteomics comparisons through genetics and disease associations

May 22, 2024 View post →
Dean Ephram
@x3deeh · X

Author Correction: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/hY5GHKcHra

May 22, 2024 · 2,661 followers View post →
Igor Wortel
@itwortel · X

Author Correction: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/l9C3ykJyaf

May 22, 2024 · 1,720 followers View post →
Michael W. Deem
@Michael_W_Deem · X

Nature, Published online: 22 May 2024; doi:10.1038/s41586-024-07549-zAuthor Correction: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/BV0HTSb4x0

May 22, 2024 · 190 followers View post →
Karsten Suhre
@ksuhre · X

RT @NatureRevGenet: Original article 2: Eldjarn, G. H. et al. Large-scale plasma proteomics comparisons through genetics and disease associ…

Nov 2, 2023 · 1 share · 2,567 followers View post →
Nature Reviews Genetics
@NatureRevGenet · X

Original article 2: Eldjarn, G. H. et al. Large-scale plasma proteomics comparisons through genetics and disease associations. Nature 622, 348–358 (2023)

Nov 1, 2023 · 6 likes · 1 share · 92,675 followers View post →
ruolan zhang
@ZhangRuola16466 · X

RT @Phenomics_J: Large-scale plasma proteomics comparisons through genetics and disease associations: Using different ancestry groups for l…

Oct 16, 2023 · 6 shares · 7 followers View post →
Wenzhu Zhai
@zhaiwenzhu · X

RT @Phenomics_J: Large-scale plasma proteomics comparisons through genetics and disease associations: Using different ancestry groups for l…

Oct 11, 2023 · 6 shares · 26 followers View post →
Seele Zhao
@SeeleZhaoyr · X

RT @Phenomics_J: Large-scale plasma proteomics comparisons through genetics and disease associations: Using different ancestry groups for l…

Oct 11, 2023 · 6 shares · 8 followers View post →
Yidan Gao
@YidanGao1544591 · X

RT @Phenomics_J: Large-scale plasma proteomics comparisons through genetics and disease associations: Using different ancestry groups for l…

Oct 10, 2023 · 6 shares · 7 followers View post →
michelle_YuexinYu
@omwhocctv · X

RT @Phenomics_J: Large-scale plasma proteomics comparisons through genetics and disease associations: Using different ancestry groups for l…

Oct 10, 2023 · 6 shares · 22 followers View post →
ZC Seeking Postdoc (Mid-2025) @Multi-omics
@zehhhui · X

RT @Phenomics_J: Large-scale plasma proteomics comparisons through genetics and disease associations: Using different ancestry groups for l…

Oct 10, 2023 · 6 shares · 13 followers View post →
Phenomics
@Phenomics_J · X

Large-scale plasma proteomics comparisons through genetics and disease associations: Using different ancestry groups for locus refinement. @Nature #Phenomics #plasma #proteomics https://t.co/FK416fBdl7 https://t.co/2E4uHnSgDx

Oct 9, 2023 · 6 likes · 6 shares · 1,526 followers View post →
Life Science Journal Content
@lsn_jc · X

Large-scale plasma proteomics comparisons through genetics and disease associations #science #publication #research #journal https://t.co/E4Djpv15re

Oct 8, 2023 · 263 followers View post →
Nicola Pozzi
@LabPozzi · X

RT @flora_peyvandi: Large-scale plasma #proteomics comparisons through #genetics and disease associations. https://t.co/YFThtzhBH0

Oct 7, 2023 · 1 share · 350 followers View post →
flora peyvandi
@flora_peyvandi · X

Large-scale plasma #proteomics comparisons through #genetics and disease associations. https://t.co/YFThtzhBH0

Oct 7, 2023 · 4 likes · 1 share · 2,371 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @LabWaggoner: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/JufpkJX2Tx https://t.co/f…

Oct 6, 2023 · 1 share · 6,641 followers View post →
Jan Schejbal
@SchejbalJLab · X

RT @PastelBio: Large-scale plasma proteomics comparisons through genetics and disease associations - https://t.co/ICUyVNx4im --- #proteomi…

Oct 5, 2023 · 3 shares · 275 followers View post →
Andrea Petretto
@Angrist_Fusion · X

RT @PastelBio: Large-scale plasma proteomics comparisons through genetics and disease associations - https://t.co/ICUyVNx4im --- #proteomi…

Oct 5, 2023 · 3 shares · 580 followers View post →
Jan Schejbal
@schejbaljlab.bsky.social · Bluesky

Source: Eldjarn, G.H., Ferkingstad, E., Lund, S.H. et al. Large-scale plasma proteomics comparisons through genetics and disease associations. Nature (2023). doi.org/10.1038/s415...

Oct 5, 2023 View post →
Jan Schejbal
@schejbaljlab.bsky.social · Bluesky

Ok team #proteomics, I have been wondering this for a while. Is there a similar comparison with MS-based plasma proteomics (SEER?) out there? I am sure we can do better than this.

Oct 5, 2023 · 1 like · 2 shares View post →
Silvia Brusco
@SilviaBrusco6 · X

Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/NJVm0yKY0z

Oct 5, 2023 · 1 like · 45 followers View post →
Abstream
@abstreamme · X

Large-scale plasma proteomics comparisons through genetics and disease associations #science #publication #research #publications https://t.co/VevcWgtuVm

Oct 5, 2023 · 789 followers View post →
Timothy D. Cummins
@TD_Cummins_PhD · X

RT @PastelBio: Large-scale plasma proteomics comparisons through genetics and disease associations - https://t.co/ICUyVNx4im --- #proteomi…

Oct 5, 2023 · 3 shares · 364 followers View post →
Pastel BioScience
@PastelBio · X

Large-scale plasma proteomics comparisons through genetics and disease associations - https://t.co/ICUyVNx4im --- #proteomics #prot-paper https://t.co/Bg9IP6PbZi

Oct 5, 2023 · 3 likes · 3 shares · 5,377 followers View post →
PastelBio
@pastelbio.bsky.social · Bluesky

Large-scale plasma proteomics comparisons through genetics and disease associations - www.nature.com/artic... --- #proteomics #prot-paper

Oct 5, 2023 · 1 like · 1 share View post →
Marit B. Veierød
@MaritBVeierod · X

RT @Nature: Nature research paper: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/V3AEjU…

Oct 4, 2023 · 6 shares · 515 followers View post →
Waggoner Lab
@LabWaggoner · X

Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/JufpkJX2Tx https://t.co/fvPoAzvRc8 https://t.co/PB697gj9eR

Oct 4, 2023 · 2 likes · 1 share · 11,331 followers View post →
Martin Cornillet, PhD
@MartinCornillet · X

RT @Nature: Nature research paper: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/V3AEjU…

Oct 4, 2023 · 6 shares · 206 followers View post →
Dervis Salih
@DervisSalih1 · X

RT @Nature: Nature research paper: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/V3AEjU…

Oct 4, 2023 · 6 shares · 4,513 followers View post →
Jen Li
@DrJenLi_Renal · X

RT @Nature: Nature research paper: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/V3AEjU…

Oct 4, 2023 · 6 shares · 714 followers View post →
Sciences
@sciences.skyfleet.blue · Bluesky

Large-scale plasma proteomics comparisons through genetics and disease associations

Oct 4, 2023 · 1 like View post →
Dr. Turki Mohammed Aldawoud د. تركي محمد الداود
@DTaldawoud · X

Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/XGGXJ0TX7Q

Oct 4, 2023 · 1 like · 1,238 followers View post →
nature
@Nature · X

Nature research paper: Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/V3AEjU7ds0

Oct 4, 2023 · 27 likes · 6 shares · 2,613,016 followers View post →
FrezzaLab
@FrezzaLab · X

"Large-scale plasma proteomics comparisons through genetics and disease associations" https://t.co/nWuIS2iN4m

Oct 4, 2023 · 1 like · 26,994 followers View post →
Igor Wortel
@itwortel · X

Large-scale plasma proteomics comparisons through genetics and disease associations https://t.co/UyGd2NGiLT

Oct 4, 2023 · 1,720 followers View post →