A variant in the 5'UTR of ERBB4 is associated with lifespan in Golden Retrievers.

Robert B Rebhun, Daniel York, Flora M D De Graaf, Paula Yoon, Kevin L Batcher, Madison E Luker, Stephanie Ryan, Jamie Peyton, Michael S Kent, Joshua A Stern, Danika L Bannasch

June 2024 Geroscience

Synopsis of Social media discussions

The social discussions feature enthusiastic reactions to the new genetic research, exemplified by posts asking whether golden retrievers can live longer and noting the discovery of a key gene associated with lifespan. Tone words like 'new', 'research', and expressions of curiosity indicate genuine interest, while references to the study's implications highlight a perception of meaningful scientific progress.

A
Agreement
 Moderate agreement

Most discussions express support or interest in the genetic findings, with many posts acknowledging the significance of the ERBB4 variant in lifespan research.

I
Interest
 High level of interest

Posts demonstrate high curiosity, especially with phrases like 'Can golden retrievers live longer?' and references to new discoveries, indicating strong engagement with the topic.

E
Engagement
 Moderate level of engagement

Several comments reference the genetic implications and potential applications, though not deeply analytical, showing moderate involvement.

I
Impact
 Moderate level of impact

The emphasis on the discovery being a 'new' gene associated with longevity suggests they see potential practical or scientific importance, though some posts focus on general excitement rather than detailed impact.

Social Mentions

YouTube

3 Videos

Bluesky

1 Posts

Facebook

2 Posts

Twitter

31 Posts

Blogs

6 Articles

News

88 Articles

Metrics

Video Views

73,758

Total Likes

5,987

Extended Reach

1,433,399

Social Features

131

Timeline: Posts about article

Top Social Media Posts

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  • Rochelle Lesser
    @schoolpsyc.bsky.social (Bluesky)

    A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
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    February 3, 2025

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    @Manuel19003 (Twitter)

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    December 4, 2023

  • Alejandro Montenegro
    @aemonten (Twitter)

    I would have expected this to be in Current Biology https://t.co/QUyDQCj0o7
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    November 26, 2023

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  • Collins Efeizomor
    @C_Gabbi_ (Twitter)

    RT @DocDellaire: "5'UTR of ERBB4 is associated with lifespan in Golden Retrievers"
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    November 26, 2023

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  • Graham Dellaire @docdellaire.bsky.social
    @DocDellaire (Twitter)

    "5'UTR of ERBB4 is associated with lifespan in Golden Retrievers"
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    November 26, 2023

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  • Agingdoc
    @agingdoc1 (Twitter)

    A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers https://t.co/Y6jAPplbeO https://t.co/I7dji00Icz
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    November 12, 2023

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    November 9, 2023

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    A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers https://t.co/nxxnFNjSm6
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    November 9, 2023

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    @np_grwl (Twitter)

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    October 21, 2023

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    @Dog_paper_bot (Twitter)

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    October 20, 2023

  • NPC-VET＠大学院
    @feline_otyvet (Twitter)

    ERBB4(HER4)のシグナル下流は最近ヒトの老化やアルツハイマー病に関連しているのではと注目されているところでもあります。 https://t.co/Xn4ryZl6bY
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    October 20, 2023

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  • Phys.org
    @physorg_com (Twitter)

    Can golden retrievers live longer? Researchers find gene associated with longevity in the breed https://t.co/Odfj8Qinot https://t.co/yxk6Ym0PFM
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Abstract Synopsis

  • The study investigates genetic factors influencing lifespan in Golden Retrievers, focusing on a variant in the 5' untranslated region (UTR) of the ERBB4 gene, which is associated with shorter lifespan, especially in female dogs.
  • A specific haplotype (haplotype 3) in the ERBB4 5'UTR correlates with reduced survival, and dogs homozygous for this haplotype tend to die earlier, suggesting ERBB4 may play a role in longevity.
  • These findings imply that genetic studies within dog breeds can help identify variants that modify aging and disease risk, potentially informing similar research in humans.]