April 2024 PMID 37858867

Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial.

Ali S Omrani, Sulieman H Abujarir, Fatma Ben Abid, Shahd H Shaar, Mesut Yilmaz, Adila Shaukat, Mussad S Alsamawi, Mohamed S Elgara, Mohamed Islam Alghazzawi, Khaled M Shunnar, Ahmed Zaqout, Yasser M Aldeeb, Wadha Alfouzan, Muna A Almaslamani

Mentions

27
Peak: 15 in Mar 2024
across 4 sources since Oct 2023

Extended reach

76,997
potential audience

Total likes

43

Video views

8

Mentions per month

Oct 2023 – Aug 2025

Where it's discussed

  • X / Twitter22 posts
  • News2 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

Discussions highlight the trial’s key findings, such as the safety of switching from IV to oral antibiotics in stable patients, with phrases like 'effective and safe' and 'potentially changing standard care.' The tone is analytical and optimistic, emphasizing the significance of the research and its potential to impact treatment protocols.

AgreementModerate agreement

Most discussions support the idea that switching to oral antibiotics is safe and effective, with several posts citing the trial's positive findings.

InterestHigh interest

Posts show high interest, referencing specific aspects like patient stability and treatment protocols, indicating engagement with clinical details.

EngagementModerate engagement

Many participants reference their own clinical experience or the trial design, showing moderate to deep engagement.

ImpactModerate impact

The conversations suggest that the publication could influence clinical practices, especially in streamlining treatments and reducing hospital stays.

Abstract in brief

  • This study tested whether switching from IV to oral antibiotics after 35 days is safe and effective for patients with bloodstream infections caused by Enterobacterales, and found that oral therapy is not worse than continuing IV treatment in terms of treatment failure.
  • The trial involved hospitalized adult patients who were stable and had no uncontrolled infection source, and compared outcomes between those who switched to oral antibiotics and those who stayed on IV, showing similar rates of treatment failure and adverse events.
  • The results suggest that switching to oral antibiotics after initial IV treatment is a safe and effective option for certain patients, potentially reducing hospital stay and complications associated with IV therapy.]

Top posts

Most liked on X and Bluesky
Leonard Leibovici
@LeonardLeibovi1 · X

Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiology and Infection https://t.co/1OvNaAcX2H

Mar 21, 2024 · 34 likes · 17 shares · 581 followers View post →
Timothy Li
@drtimothyli · X

8. Early switch from IV to oral antibiotics in selected patients with gram-negative bacteremia was found to be effective and safe ⭐SOAB trial Caveats: ➡️>70% of the 1476 patients screened were ineligible ➡️Excluded IE, CNS infections and neutropenia https://t.co/Ws8jBgUGdx

Apr 16, 2024 · 6 likes · 12,860 followers View post →
Walid Alkeridy وليد الكريدي
@WalidAlkeridy · X

Switch to oral antibiotics in Gram-negative bacteraemia: a randomized,... https://t.co/j879IqpIKj

Nov 11, 2023 · 2 likes · 1,285 followers View post →
pinacol
@pinacol · X

【RCT】1つ以上の経口β-ラクタム系、キノロンまたはST合剤への感受性株による腸内細菌科単独の菌血症患者への3-5日間の静注治療後の経口薬への切り替えは、静注治療継続と比較して、治療失敗において非劣性であった。 #ペ読 https://t.co/zgF835pvgV

Oct 21, 2023 · 1 like · 1,616 followers View post →
Bug Pharmacist
@IDstewardship · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 39,155 followers View post →
Jesus Rodriguez Baño
@jesusrbano · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 7,875 followers View post →

All mentions

Adnan Hajjiah
@ph_adnan · X

Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - ScienceDirect https://t.co/ENUhbDuXx2

Jan 30, 2025 · 2,104 followers View post →
Timothy Li
@drtimothyli · X

8. Early switch from IV to oral antibiotics in selected patients with gram-negative bacteremia was found to be effective and safe ⭐SOAB trial Caveats: ➡️>70% of the 1476 patients screened were ineligible ➡️Excluded IE, CNS infections and neutropenia https://t.co/Ws8jBgUGdx

Apr 16, 2024 · 6 likes · 12,860 followers View post →
Rafa López-Bas
@rafalopezbas · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 23, 2024 · 17 shares · 475 followers View post →
BizarrMD
@DrAntonioSilva1 · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 23, 2024 · 17 shares · 306 followers View post →
hervé
@hervejoncour_ · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 23, 2024 · 17 shares · 9 followers View post →
Kim Eunho
@PeraVich · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 55 followers View post →
Alexandre R. Marra
@alexmarra73 · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 143 followers View post →
Bug Pharmacist
@IDstewardship · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 39,155 followers View post →
Thushith Bandara
@ThushithB511 · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 10 followers View post →
Renee Goh Lyn Nee
@ReneeGohLynNee1 · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 11 followers View post →
Jesus Rodriguez Baño
@jesusrbano · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 7,875 followers View post →
PROAZA
@PROAZAMORA · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 327 followers View post →
Ma.Semiglia Chong
@AuxiSemiglia · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 213 followers View post →
lorenzo moja
@lorenzomoja · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 632 followers View post →
PROA_Marañón
@PROA_maran · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 22, 2024 · 17 shares · 4,109 followers View post →
Celia CARDOZO
@CeliaCARDOZO19 · X

RT @LeonardLeibovi1: Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiol…

Mar 21, 2024 · 17 shares · 435 followers View post →
Leonard Leibovici
@LeonardLeibovi1 · X

Switch to oral antibiotics in Gram-negative bacteraemia: a randomized, open-label, clinical trial - Clinical Microbiology and Infection https://t.co/1OvNaAcX2H

Mar 21, 2024 · 34 likes · 17 shares · 581 followers View post →
Walid Alkeridy وليد الكريدي
@WalidAlkeridy · X

Switch to oral antibiotics in Gram-negative bacteraemia: a randomized,... https://t.co/j879IqpIKj

Nov 11, 2023 · 2 likes · 1,285 followers View post →
SMMCmicromadrid
@SMMCmicromadrid · X

Switch to Oral Antibiotics in Gram-negative Bacteraemia; a Randomised, Open-label, Clinical Trial https://t.co/LXAKpIcUon https://t.co/JPnhPXr9U0

Oct 25, 2023 · 2,318 followers View post →
Carlos Vázquez
@Viescabozada9 · X

RT @HucaProa: Estabilidad y control de foco. Continuar con IV no superior a tto oral. https://t.co/Fh13SntRjZ

Oct 23, 2023 · 1 share · 1,140 followers View post →
PROA_HUCA-HMN
@HucaProa · X

Estabilidad y control de foco. Continuar con IV no superior a tto oral. https://t.co/Fh13SntRjZ

Oct 23, 2023 · 1 share · 817 followers View post →
pinacol
@pinacol · X

【RCT】1つ以上の経口β-ラクタム系、キノロンまたはST合剤への感受性株による腸内細菌科単独の菌血症患者への3-5日間の静注治療後の経口薬への切り替えは、静注治療継続と比較して、治療失敗において非劣性であった。 #ペ読 https://t.co/zgF835pvgV

Oct 21, 2023 · 1 like · 1,616 followers View post →