Virol J November 2023 PMID 37950261

Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro.

Ying Lin Chi, Yuan Xie, Shu Qing Liu, Wu Yang Zhu

Download social card

Mentions

Peak: 10 in Mar 2025

across 2 sources since Nov 2023

Extended reach

156,656

potential audience

Total likes

Video views

839

Mentions per month

Nov 2023 – Aug 2025

Where it's discussed

X / Twitter20 posts
YouTube2 videos

AI synopsis

What people are saying

The comments reflect a positive outlook, with many posters emphasizing the potential of Bardoxolone methyl to fight rabies, such as references to 'significant reduction' and 'promising candidate.' The tone and choice of words indicate curiosity and cautious optimism, portraying the study as impactful and relevant to future medical advances.

AgreementModerate agreement

Many discussions express support or approval, interpreting the research as promising or optimistic about the potential of Bardoxolone methyl.

InterestHigh interest

The discussions show high interest, with posters engaging deeply by asking questions and sharing experimental insights.

EngagementModerate engagement

Posts demonstrate some level of detailed engagement, such as mentioning the mechanisms involving Nrf2 pathway and potential treatments.

ImpactModerate impact

The collective tone suggests the research could have meaningful implications, though broader consensus on its significance isn't fully established.

Abstract in brief

Bardoxolone methyl (CDDOMe), an FDA-approved drug known for its antioxidant and anti-inflammatory properties, can inhibit rabies virus infection in nerve cells by activating the Nrf2 pathway.
Experiments showed that CDDOMe significantly reduced rabies virus infection in mouse nerve cells (N2a) across different virus strains, and this effect was linked to increased activation of the Nrf2 pathway, marked by higher levels of specific protective proteins.
The study suggests that CDDOMe could be a promising candidate for developing new treatments against rabies, especially since current antiviral options are limited and no specific drugs are approved for clinical use after symptoms appear.

Read the full abstract

All mentions

Role of C-terminal Domain in Rabies Virus RNA Polymerase Function

This study explores the function of the C-terminal domain of the rabies virus L protein, emphasizing its role in P cofactor binding, L protein stability, and viral RNA replication. Key amino acids are crucial for these…

高遠_頼生命科学Channel · Mar 17, 2025 440 views

Rabies Virus L Protein C-terminal Domain and Its Role in RNA Replication

This study investigates the C-terminal domain of the rabies virus L protein, emphasizing its role in binding the P cofactor, stabilizing the L protein, and aiding viral RNA replication. Key amino acids are crucial for…

高遠_頼生命科学Channel · Mar 25, 2025 399 views

月夜野　桜

@tsukiyonosakura · X

Aug 14, 2025 · 1 like · 409 followers View post →

月夜野　桜

@tsukiyonosakura · X

RT @takatoh_life: @tsukiyonosakura ご確認ありがとうございます。そういう意味では以前のサムネイルでは治せるのか？という疑問形で示して、治療への展望を示した形となります。狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治…

Aug 14, 2025 · 1 share · 409 followers View post →

高遠頼@生命科学VTuber(たかとーらい) 定期科学ニュース配信(日)

@takatoh_life · X

Aug 14, 2025 · 1 like · 1 share · 14,333 followers View post →

月夜野　桜

@tsukiyonosakura · X

狂犬病は致死率ほぼ100％で治療薬はありません詳しくは⬇️高遠頼さんが動画で解説されています「狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える #たかとー研究室」 https://t.co/vOdoy57tAD https://t.co/iARZl3rxjW

Apr 25, 2025 · 409 followers View post →

bxFLgfubBCvHa5B

@bxFLgfubBCvHa5B · X

RT @tsukiyonosakura: 狂犬病って感染とかの詳しいメカニズムを知らなかったので勉強になりました弱点は見付かったけど薬は出来てないので予防一択ということなんですね高遠頼「狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える…

Apr 16, 2025 · 4 shares · 1,104 followers View post →

【RIKI】ごりくん

@rikigoli · X

Apr 16, 2025 · 4 shares · 319 followers View post →

大芝鉄蔵

@Diesirae41 · X

Apr 16, 2025 · 4 shares · 1,033 followers View post →

高遠頼@生命科学VTuber(たかとーらい) 定期科学ニュース配信(日)

@takatoh_life · X

Apr 16, 2025 · 4 shares · 14,333 followers View post →

月夜野　桜

@tsukiyonosakura · X

Apr 16, 2025 · 4 likes · 4 shares · 409 followers View post →

Yamanami

@yamanamitakeshi · X

RT @takatoh_life: 狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える #たかとー研究室 https://t.co/oncds7OVS3

Mar 19, 2025 · 4 shares · 924 followers View post →

AstrayOkada

@m_o_astray · X

@kitagunikokona 朝活お疲れ様でした！ウン気が上がれば良いですね！w ご存知かもですが、昨日、高遠先生が狂犬病の配信をなさってました。興味深いお話でしたよ！ https://t.co/NdzXCZjNfW

Mar 16, 2025 · 1 like · 84 followers View post →

かのん

@Bellrose15 · X

RT @takatoh_life: 狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える #たかとー研究室 https://t.co/oncds7OVS3

Mar 16, 2025 · 4 shares · 110 followers View post →

nkq10

@nk9q10 · X

狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える #たかとー研究室 https://t.co/ahC6BLvv51 @YouTubeより

Mar 16, 2025 · 1 like · 4 followers View post →

はくび

@hakubi · X

狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える #たかとー研究室 https://t.co/nglj7Wxun5 @YouTubeより

Mar 16, 2025 · 1 like · 2,013 followers View post →

海月亭浮遊彦

@floatjelly7731 · X

RT @takatoh_life: 狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える #たかとー研究室 https://t.co/oncds7OVS3

Mar 16, 2025 · 4 shares · 1,719 followers View post →

bxFLgfubBCvHa5B

@bxFLgfubBCvHa5B · X

RT @takatoh_life: 狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える #たかとー研究室 https://t.co/oncds7OVS3

Mar 15, 2025 · 4 shares · 1,104 followers View post →

高遠頼@生命科学VTuber(たかとーらい) 定期科学ニュース配信(日)

@takatoh_life · X

狂犬病致死率ほぼ100% 発症後でも治せるようになるのか? 最新治療研究から考える #たかとー研究室 https://t.co/oncds7OVS3

Mar 15, 2025 · 11 likes · 4 shares · 14,333 followers View post →

Heather McEwen

@HeatherMcEwen3 · X

RT @outbreakupdates:

Nov 12, 2023 · 1 share · 698 followers View post →

Outbreak Updates

@outbreakupdates · X

Nov 12, 2023 · 3 likes · 1 share · 101,336 followers View post →

Phage Papers

@Phage_Papers · X

Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro https://t.co/yDju087k5z

Nov 11, 2023 · 647 followers View post →

Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Role of C-terminal Domain in Rabies Virus RNA Polymerase Function

Rabies Virus L Protein C-terminal Domain and Its Role in RNA Replication