Circulation January 2024 PMID 37961903

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.

Weiyi Xu, Cyrielle Billon, Hui Li, Andrea Wilderman, Lei Qi, Andrea Graves, Jernie Rae Dela Cruz Rideb, Yuanbiao Zhao, Matthew Hayes, Keyang Yu, McKenna Losby, Carissa S Hampton, Christiana M Adeyemi, Seok Jae Hong, Eleni Nasiotis

Mentions

20
Peak: 3 in Dec 2023
across 4 sources since Nov 2023

Extended reach

188,906
potential audience

Total likes

609

Video views

25,953

Mentions per month

Nov 2023 – Jul 2025

Where it's discussed

  • X / Twitter9 posts
  • News6 articles
  • YouTube3 videos
  • Blogs2 articles

AI synopsis

What people are saying

The collective discussions demonstrate strong endorsement and enthusiasm for the research, supported by detailed mentions of improved cardiac functions and mitochondrial benefits, as well as references to the therapeutic potential of Pan-ERR agonists, with phrases like 'significantly improved' and 'potential new therapy' highlighting their impact and relevance.

AgreementStrong agreement

Most comments acknowledge and support the findings, emphasizing the potential benefits of Pan-ERR agonists in heart failure treatment.

InterestHigh interest

Discussions consistently highlight enthusiasm for new therapies and mechanisms, reflecting high curiosity about the research.

EngagementHigh engagement

Posts reference specific experimental results, such as improved ejection fraction and fibrosis reduction, indicating deep interest.

ImpactHigh impact

The majority recognize the significance of the approach, describing it as a promising therapeutic strategy that could transform treatment for heart failure.

Abstract in brief

  • The study explores novel panERR agonists, SLUPP332 and SLUPP915, which activate estrogen-related receptors to improve heart function and survival in a mouse model of heart failure caused by pressure overload.
  • These agonists enhance cardiac energy metabolism by boosting fatty acid breakdown and mitochondrial activity, leading to better cardiac function and reduced fibrosis without affecting heart size.
  • The research confirms that ERR activation is key to these benefits, providing a potential new therapeutic approach for treating heart failure by improving metabolic and mitochondrial health in the heart.]

Top posts

Most liked on X and Bluesky
Circulation
@CircAHA · X

#OriginalResearch: A novel therapeutic strategy uses Pan-ERR agonists to improve mitochondrial energetics and fatty acid metabolism and protects from pressure overload-associated heart failure @WeiyiXu9 @BCMHouston https://t.co/DLqHGTaVvU

Dec 5, 2023 · 8 likes · 2 shares · 77,561 followers View post →
Circulation
@CircAHA · X

#OriginalResearch: ERR agonists improve mitochondrial function and enhance fatty acid oxidation, which confers cardiac protection against pressure overload-induced heart failure. @WeiyiXu9 @BCMHouston https://t.co/DLqHGTaVvU

Jan 18, 2024 · 3 likes · 1 share · 77,561 followers View post →
dan ryan
@fireobserver32 · X

@RickyBaker_2111 @TheGenCatton https://t.co/qCIuD5pHd2 Slu pp 332 can as well. Throwing in bpc157 with dac and tb500 is just another overall winning move

Apr 23, 2025 · 1 like · 939 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: #OriginalResearch: ERR agonists improve mitochondrial function and enhance fatty acid oxidation, which confers cardiac protect…

Jan 18, 2024 · 1 share · 2,424 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: #OriginalResearch: A novel therapeutic strategy uses Pan-ERR agonists to improve mitochondrial energetics and fatty acid metab…

Dec 5, 2023 · 2 shares · 2,424 followers View post →
AASraw.co
@AasrawCo · X

In experiments in mice, SLU-PP-332 significantly improved ejection fraction, improved fibrosis, and increased survival associated with HF caused by pressure overload without affecting cardiac hypertrophy. (https://t.co/9x7bz9viDO) #slupp332 #slupp332benefits #aasraw https://t.co/AyucKjYlci

Oct 29, 2024 · 1,528 followers View post →

All mentions

dan ryan
@fireobserver32 · X

@RickyBaker_2111 @TheGenCatton https://t.co/qCIuD5pHd2 Slu pp 332 can as well. Throwing in bpc157 with dac and tb500 is just another overall winning move

Apr 23, 2025 · 1 like · 939 followers View post →
AASraw
@aasrawcom · X

In experiments in mice, SLU-PP-332 significantly improved ejection fraction, improved fibrosis, and increased survival associated with HF caused by pressure overload without affecting cardiac hypertrophy. (https://t.co/0AWuEwH1eP) #slupp332 #slupp332benefits #aasraw https://t.co/a1ZeQ7YOx2

Nov 1, 2024 · 77 followers View post →
AASraw.co
@AasrawCo · X

In experiments in mice, SLU-PP-332 significantly improved ejection fraction, improved fibrosis, and increased survival associated with HF caused by pressure overload without affecting cardiac hypertrophy. (https://t.co/9x7bz9viDO) #slupp332 #slupp332benefits #aasraw https://t.co/AyucKjYlci

Oct 29, 2024 · 1,528 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: #OriginalResearch: ERR agonists improve mitochondrial function and enhance fatty acid oxidation, which confers cardiac protect…

Jan 18, 2024 · 1 share · 2,424 followers View post →
Circulation
@CircAHA · X

#OriginalResearch: ERR agonists improve mitochondrial function and enhance fatty acid oxidation, which confers cardiac protection against pressure overload-induced heart failure. @WeiyiXu9 @BCMHouston https://t.co/DLqHGTaVvU

Jan 18, 2024 · 3 likes · 1 share · 77,561 followers View post →
Joseph hill
@josephahill · X

RT @CircAHA: #OriginalResearch: A novel therapeutic strategy uses Pan-ERR agonists to improve mitochondrial energetics and fatty acid metab…

Dec 5, 2023 · 2 shares · 2,424 followers View post →
Gerardo García Rivas
@g_garcia_rivas · X

RT @CircAHA: #OriginalResearch: A novel therapeutic strategy uses Pan-ERR agonists to improve mitochondrial energetics and fatty acid metab…

Dec 5, 2023 · 2 shares · 364 followers View post →
Circulation
@CircAHA · X

#OriginalResearch: A novel therapeutic strategy uses Pan-ERR agonists to improve mitochondrial energetics and fatty acid metabolism and protects from pressure overload-associated heart failure @WeiyiXu9 @BCMHouston https://t.co/DLqHGTaVvU

Dec 5, 2023 · 8 likes · 2 shares · 77,561 followers View post →
Cardiology Papers
@Cardiology_P · X

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function https://t.co/WSJrWP5WFF

Nov 20, 2023 · 59 followers View post →