Discussions reflect a nuanced view, with users highlighting safety findings and potential applications, such as mentions of the NAD tests used and future Phase 2 trials. Phrases like 'looking forward' and 'positive safety study' demonstrate cautious optimism and engagement with ongoing research, but the mixed comments suggest a balanced perception of impact.
AgreementNeither agree nor disagree
The discussions show mixed feelings; some posts acknowledge safety and potential, while others highlight limited efficacy, leading to a neutral overall stance.
InterestModerate interest
Participants demonstrate moderate curiosity, especially with mentions of safety and future research phases, but some posts focus on technical aspects or express cautious optimism.
EngagementModerate engagement
Posts engage with the study details, mentioning specific methods like NAD testing and referencing follow-up plans, indicating a moderate level of interest and discussion depth.
ImpactNeutral impact
The overall influence appears moderate; while the study is seen as a step forward, there is recognition that results are preliminary and more research is needed.
Abstract in brief
Nicotinamide riboside (NR) boosts blood NAD+ levels, potentially enhancing brain function, which was tested in a pilot study on older adults with mild cognitive impairment (MCI) to assess its safety and effectiveness.
In the study, 20 participants received either NR or a placebo for 10 weeks, showing significant increases in blood NAD+ levels without notable adverse effects; however, cognitive measures like the Montreal Cognitive Assessment (MoCA) remained stable overall.
Results indicated NR reduced cerebral blood flow in specific brain areas but did not significantly improve cognitive performance compared to placebo, while showing some positive trends in DNA methylation and aging markers.
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
https://t.co/jpZv9FZZ1N https://t.co/7SDpCq4r5H
Nov 25, 2023 · 21 likes · 6 shares · 42,489 followersView post →
CM
Chris Masterjohn
@ChrisMasterjohn · X
@PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) to bring those levels up. This supplementation alone can lower the rate of aging on biological clocks:
https://t.co/0q32qebixn
Dec 16, 2023 · 11 likes · 2 shares · 69,616 followersView post →
A
Agingdoc
@agingdoc1 · X
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
Miranda Orr, @BeckyBPowers
https://t.co/jpZv9FZrcf https://t.co/RDb7xVRZzR
Nov 25, 2023 · 9 likes · 2 shares · 42,489 followersView post →
RC
RaisingNAD.com
@RaisingNad · X
NEW: A randomized placebo-controlled trial of NR in older adults with mild cognitive impairment https://t.co/W3CMXDlHNk A positive safety study. Looking forward to Phase 2
Nov 25, 2023 · 5 likes · 1,067 followersView post →
JM
john morley
@drjohnmorley · X
Orr, M.E., Kotkowski, E., Ramirez, P. et al. A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. GeroScience (2023). https://t.co/w7o1hoJZSN
Nov 25, 2023 · 2 likes · 8,300 followersView post →
SB
Samantha Berg
@Sam10k · X
RT @ChrisMasterjohn: @PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicoti…
Dec 17, 2023 · 2 shares · 10,315 followersView post →
Nicotinamide riboside (NR) boosts blood NAD+ levels, potentially enhancing brain function, which was tested in a pilot study on older adults with mild cognitive impairment to assess its safety and effectiveness. The…
Join Dr Jace and Dr Addy as they explore the science and benefits of NAD therapy, covering cardiovascular health, muscular endurance, cognitive function, anti-aging, and metabolic health, with practical protocols and…
RT @ChrisMasterjohn: @PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicoti…
Dec 17, 2023 · 2 shares · 10,315 followersView post →
ES
Eve.S.
@yeeseak · X
RT @ChrisMasterjohn: @PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicoti…
Dec 16, 2023 · 2 shares · 912 followersView post →
CM
Chris Masterjohn
@ChrisMasterjohn · X
@PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) to bring those levels up. This supplementation alone can lower the rate of aging on biological clocks:
https://t.co/0q32qebixn
Dec 16, 2023 · 11 likes · 2 shares · 69,616 followersView post →
DP
Dr L Boominathan PhD
@DrLBoominathan · X
RT @agingdoc1: A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
Miranda Orr,…
Nov 26, 2023 · 2 shares · 889 followersView post →
A
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X
RT @agingdoc1: A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
https://t.co/…
Nov 26, 2023 · 6 shares · 202 followersView post →
A
Agingdoc
@agingdoc1 · X
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
Miranda Orr, @BeckyBPowers
https://t.co/jpZv9FZrcf https://t.co/RDb7xVRZzR
Nov 25, 2023 · 9 likes · 2 shares · 42,489 followersView post →
RC
RaisingNAD.com
@RaisingNad · X
NEW: A randomized placebo-controlled trial of NR in older adults with mild cognitive impairment https://t.co/W3CMXDlHNk A positive safety study. Looking forward to Phase 2
Nov 25, 2023 · 5 likes · 1,067 followersView post →
M
Mesha
@cosmautic · X
RT @agingdoc1: A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
https://t.co/…
Nov 25, 2023 · 6 shares · 462 followersView post →
JM
john morley
@drjohnmorley · X
Orr, M.E., Kotkowski, E., Ramirez, P. et al. A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. GeroScience (2023). https://t.co/w7o1hoJZSN
Nov 25, 2023 · 2 likes · 8,300 followersView post →
F
frank
@frankwikson · X
RT @agingdoc1: A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
https://t.co/…
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
https://t.co/jpZv9FZZ1N https://t.co/7SDpCq4r5H
Nov 25, 2023 · 21 likes · 6 shares · 42,489 followersView post →
I
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