Geroscience February 2024 PMID 37994989

A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment.

Miranda E Orr, Eithan Kotkowski, Paulino Ramirez, Darcy Bair-Kelps, Qianqian Liu, Charles Brenner, Mark S Schmidt, Peter T Fox, Anis Larbi, Crystal Tan, Glenn Wong, Jonathan Gelfond, Bess Frost, Sara Espinoza, Nicolas Musi

Mentions

20
Peak: 8 in Nov 2023
across 4 sources since Nov 2023

Extended reach

178,990
potential audience

Total likes

50

Video views

2,085

Mentions per month

Nov 2023 – Dec 2025

Where it's discussed

  • X / Twitter11 posts
  • Instagram5 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Discussions reflect a nuanced view, with users highlighting safety findings and potential applications, such as mentions of the NAD tests used and future Phase 2 trials. Phrases like 'looking forward' and 'positive safety study' demonstrate cautious optimism and engagement with ongoing research, but the mixed comments suggest a balanced perception of impact.

AgreementNeither agree nor disagree

The discussions show mixed feelings; some posts acknowledge safety and potential, while others highlight limited efficacy, leading to a neutral overall stance.

InterestModerate interest

Participants demonstrate moderate curiosity, especially with mentions of safety and future research phases, but some posts focus on technical aspects or express cautious optimism.

EngagementModerate engagement

Posts engage with the study details, mentioning specific methods like NAD testing and referencing follow-up plans, indicating a moderate level of interest and discussion depth.

ImpactNeutral impact

The overall influence appears moderate; while the study is seen as a step forward, there is recognition that results are preliminary and more research is needed.

Abstract in brief

  • Nicotinamide riboside (NR) boosts blood NAD+ levels, potentially enhancing brain function, which was tested in a pilot study on older adults with mild cognitive impairment (MCI) to assess its safety and effectiveness.
  • In the study, 20 participants received either NR or a placebo for 10 weeks, showing significant increases in blood NAD+ levels without notable adverse effects; however, cognitive measures like the Montreal Cognitive Assessment (MoCA) remained stable overall.
  • Results indicated NR reduced cerebral blood flow in specific brain areas but did not significantly improve cognitive performance compared to placebo, while showing some positive trends in DNA methylation and aging markers.

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment https://t.co/jpZv9FZZ1N https://t.co/7SDpCq4r5H

Nov 25, 2023 · 21 likes · 6 shares · 42,489 followers View post →
Chris Masterjohn
@ChrisMasterjohn · X

@PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) to bring those levels up. This supplementation alone can lower the rate of aging on biological clocks: https://t.co/0q32qebixn

Dec 16, 2023 · 11 likes · 2 shares · 69,616 followers View post →
Agingdoc
@agingdoc1 · X

A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment Miranda Orr, @BeckyBPowers https://t.co/jpZv9FZrcf https://t.co/RDb7xVRZzR

Nov 25, 2023 · 9 likes · 2 shares · 42,489 followers View post →
RaisingNAD.com
@RaisingNad · X

NEW: A randomized placebo-controlled trial of NR in older adults with mild cognitive impairment https://t.co/W3CMXDlHNk A positive safety study. Looking forward to Phase 2

Nov 25, 2023 · 5 likes · 1,067 followers View post →
john morley
@drjohnmorley · X

Orr, M.E., Kotkowski, E., Ramirez, P. et al. A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. GeroScience (2023). https://t.co/w7o1hoJZSN

Nov 25, 2023 · 2 likes · 8,300 followers View post →
Samantha Berg
@Sam10k · X

RT @ChrisMasterjohn: @PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicoti…

Dec 17, 2023 · 2 shares · 10,315 followers View post →

All mentions

Samantha Berg
@Sam10k · X

RT @ChrisMasterjohn: @PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicoti…

Dec 17, 2023 · 2 shares · 10,315 followers View post →
Eve.S.
@yeeseak · X

RT @ChrisMasterjohn: @PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicoti…

Dec 16, 2023 · 2 shares · 912 followers View post →
Chris Masterjohn
@ChrisMasterjohn · X

@PeterAttiaMD For example, he uses the Jinfiniti intracellular NAD test, and uses nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) to bring those levels up. This supplementation alone can lower the rate of aging on biological clocks: https://t.co/0q32qebixn

Dec 16, 2023 · 11 likes · 2 shares · 69,616 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

RT @agingdoc1: A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment Miranda Orr,…

Nov 26, 2023 · 2 shares · 889 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @agingdoc1: A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment https://t.co/…

Nov 26, 2023 · 6 shares · 202 followers View post →
Agingdoc
@agingdoc1 · X

A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment Miranda Orr, @BeckyBPowers https://t.co/jpZv9FZrcf https://t.co/RDb7xVRZzR

Nov 25, 2023 · 9 likes · 2 shares · 42,489 followers View post →
RaisingNAD.com
@RaisingNad · X

NEW: A randomized placebo-controlled trial of NR in older adults with mild cognitive impairment https://t.co/W3CMXDlHNk A positive safety study. Looking forward to Phase 2

Nov 25, 2023 · 5 likes · 1,067 followers View post →
Mesha
@cosmautic · X

RT @agingdoc1: A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment https://t.co/…

Nov 25, 2023 · 6 shares · 462 followers View post →
john morley
@drjohnmorley · X

Orr, M.E., Kotkowski, E., Ramirez, P. et al. A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. GeroScience (2023). https://t.co/w7o1hoJZSN

Nov 25, 2023 · 2 likes · 8,300 followers View post →
frank
@frankwikson · X

RT @agingdoc1: A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment https://t.co/…

Nov 25, 2023 · 6 shares · 26 followers View post →
Agingdoc
@agingdoc1 · X

A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment https://t.co/jpZv9FZZ1N https://t.co/7SDpCq4r5H

Nov 25, 2023 · 21 likes · 6 shares · 42,489 followers View post →
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