Nat Neurosci December 2023 PMID 37996529

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage.

Yao Wei, QianQian Miao, Qian Zhang, Shiyu Mao, Mengke Li, Xing Xu, Xian Xia, Ke Wei, Yu Fan, Xinlei Zheng, Yinquan Fang, Meng Mei, Qingyu Zhang, Jianhua Ding, Yi Fan

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Mentions

41
Peak: 31 in Nov 2023
across 3 sources since Nov 2023

Extended reach

101,775
potential audience

Total likes

135

Video views

132

Mentions per month

Nov 2023 – Nov 2024

Where it's discussed

  • X / Twitter37 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Several discussions emphasize the central role of aerobic glycolysis in neuronal health, with mentions of its protective effects against oxidative damage and references to the enzyme PKM2, highlighting a nuanced interest in the metabolic mechanisms. The tone is mostly analytical and supportive, using words like 'important,' 'cited,' and 'protects,' which underscores a positive perception of the study’s significance.

AgreementStrong agreement

Most discussions reinforce the article's findings, emphasizing the idea that aerobic glycolysis in neuronal somata serves a protective role, with multiple posts citing the same statement and expressing validation.

InterestHigh interest

Posts show high interest by referencing specific details like the enzyme PKM2 and the implications for neuronal metabolism, indicating curiosity about the mechanisms and significance.

EngagementModerate engagement

Some users delve into the broader context, comparing this metabolic process to cancer biology and discussing implications, reflecting moderate but meaningful engagement.

ImpactModerate impact

The posts suggest that the publication has the potential to influence future research directions, but some comments are more enthusiastic than conclusively impactful, indicating moderate perceived significance.

Abstract in brief

  • Neurons mainly produce ATP through mitochondrial oxidative phosphorylation (OXPHOS) at rest, but glucose metabolism in somata differs from axon terminals, with somata showing higher levels of aerobic glycolysis.
  • Deleting the enzyme pyruvate kinase 2 (PKM2) in mice causes a switch from glycolysis to OXPHOS in neuronal somata, leading to oxidative damage and loss of dopaminergic neurons.
  • The study challenges the traditional view of uniform energy production in neurons and emphasizes the critical role of somatic aerobic glycolysis in protecting against oxidative stress.

Top posts

Most liked on X and Bluesky
FrezzaLab
@FrezzaLab · X

"Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage" https://t.co/PrtMPeudZ5

Nov 25, 2023 · 92 likes · 20 shares · 26,990 followers View post →
ShorterLab
@ShorterLab · X

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage: https://t.co/zzn674JhEB

Nov 23, 2023 · 26 likes · 5 shares · 12,050 followers View post →
thmonk
@thmonk_pf · X

神経somaの糖代謝は解糖が主である ・somaは解糖が主で酸化的燐酸化(OP)関与は少ない ・pyruvate kinase(PKM2)はsomaで高く発現し欠損時には代謝がOPに切替る➡️ROS↑/Dopaminergic Neuron↓ ・神経終末ではANLSHの為pyrivateが高くOPが主体 #glycolysis #neuron #papers https://t.co/tewDBj3psf https://t.co/8WDWnMCMak

Nov 28, 2023 · 8 likes · 2 shares · 1,633 followers View post →
BrainVTA
@Brain_VTA · X

❗️❗️Honored to be cited in the Nature Neuroscience

Aug 27, 2024 · 6 likes · 2 shares · 1,352 followers View post →
Chao Sun
@LukeChaoSun · X

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage | Nature Neuroscience https://t.co/ohc34xsRev

Nov 2, 2024 · 1 like · 627 followers View post →
Ying Cao
@NeuralGrndState · X

Cancer cells≈Neural cells Aerobic glycolysis (Warburg effect) is one of the hallmarks of cancer metabolism and "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage". https://t.co/NjbCzQ0n15

Nov 25, 2023 · 1 like · 520 followers View post →

All mentions

Chao Sun
@LukeChaoSun · X

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage | Nature Neuroscience https://t.co/ohc34xsRev

Nov 2, 2024 · 1 like · 627 followers View post →
Brenton Laing
@Laing_BrentonT · X

RT @Brain_VTA: ❗️❗️Honored to be cited in the Nature Neuroscience

Aug 27, 2024 · 2 shares · 111 followers View post →
Vanja Tepavcevic
@TepavcevicVanja · X

RT @Brain_VTA: ❗️❗️Honored to be cited in the Nature Neuroscience

Aug 27, 2024 · 2 shares · 892 followers View post →
BrainVTA
@Brain_VTA · X

❗️❗️Honored to be cited in the Nature Neuroscience

Aug 27, 2024 · 6 likes · 2 shares · 1,352 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage https://t.co/p1MvsYqfrg https://t.co/8VIJY8YQWa

Feb 13, 2024 · 24,152 followers View post →
プロテインシンプル
@ProteinSimpleJ · X

好気的解糖は神経細胞体におけるグルコース代謝の主な手段であり、酸化的損傷から保護 https://t.co/mmaLiEdaSX #Jess でターゲット検出と #総タンパク質ノーマライゼーション、弊社グループ企業 #ACD の #RNAScope での in situ hybridization もデータに使用 #VAMP #GFAP #PKM #IBA1 #Histone

Dec 5, 2023 · 1 like · 301 followers View post →
thmonk
@thmonk_pf · X

RT @thmonk_pf: 神経somaの糖代謝は解糖が主である ・somaは解糖が主で酸化的燐酸化(OP)関与は少ない ・pyruvate kinase(PKM2)はsomaで高く発現し欠損時には代謝がOPに切替る➡️ROS↑/Dopaminergic Neuron↓ ・…

Nov 28, 2023 · 2 shares · 1,633 followers View post →
yoshiyuki nishio
@nishiokov · X

RT @thmonk_pf: 神経somaの糖代謝は解糖が主である ・somaは解糖が主で酸化的燐酸化(OP)関与は少ない ・pyruvate kinase(PKM2)はsomaで高く発現し欠損時には代謝がOPに切替る➡️ROS↑/Dopaminergic Neuron↓ ・…

Nov 28, 2023 · 2 shares · 512 followers View post →
thmonk
@thmonk_pf · X

神経somaの糖代謝は解糖が主である ・somaは解糖が主で酸化的燐酸化(OP)関与は少ない ・pyruvate kinase(PKM2)はsomaで高く発現し欠損時には代謝がOPに切替る➡️ROS↑/Dopaminergic Neuron↓ ・神経終末ではANLSHの為pyrivateが高くOPが主体 #glycolysis #neuron #papers https://t.co/tewDBj3psf https://t.co/8WDWnMCMak

Nov 28, 2023 · 8 likes · 2 shares · 1,633 followers View post →
Rutter Lab
@RutterLab · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 26, 2023 · 20 shares · 8,731 followers View post →
Andromache Tziamou
@MaggieTziamou · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 26, 2023 · 20 shares · 2,820 followers View post →
Abstream
@abstreamme · X

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage #science #publication #research #publications https://t.co/0OsGZbYtYG

Nov 26, 2023 · 787 followers View post →
Matthew Merrins
@merrinslab · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 398 followers View post →
Ying Cao
@NeuralGrndState · X

Cancer cells≈Neural cells Aerobic glycolysis (Warburg effect) is one of the hallmarks of cancer metabolism and "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage". https://t.co/NjbCzQ0n15

Nov 25, 2023 · 1 like · 520 followers View post →
BrendenMHorn
@BrendenMHorn · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 256 followers View post →
Xiaorong Gu, PhD
@GUX_beachwood · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 66 followers View post →
Mingqi Dong
@Mingqi7up · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 375 followers View post →
Kate M.
@KateM000000 · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 158 followers View post →
Dylan Ryan
@RyanLab_TCD · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 2,382 followers View post →
Barbara Mensah
@Aramens9 · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 296 followers View post →
the paper link
@the_paper_link · X

Trend up+18: Wei Y, ..., Hu G (Nat Neurosci) __Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage__ https://t.co/b9QAzKwqJL

Nov 25, 2023 · 136 followers View post →
Life Science Journal Content
@lsn_jc · X

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage #science #publication #research #journal https://t.co/dN4tk18jWA

Nov 25, 2023 · 263 followers View post →
nanoneuron
@nanoneuron2019 · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 87 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 4,743 followers View post →
SNZK
@shinopp · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 720 followers View post →
Diana
@PharmphoodTM · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 555 followers View post →
Motori Lab
@LabMotori · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 550 followers View post →
Glenn Bantug
@gbantug2000 · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 124 followers View post →
Babis Rallis
@rallislab · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 301 followers View post →
Federico Bernuzzi, PhD
@FedericoBernuzz · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 625 followers View post →
Bruna Martins Garcia
@BrunaMartinsGa2 · X

RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 25, 2023 · 20 shares · 1,191 followers View post →
FrezzaLab
@FrezzaLab · X

"Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage" https://t.co/PrtMPeudZ5

Nov 25, 2023 · 92 likes · 20 shares · 26,990 followers View post →
Mauricio Oliveira
@Mauricio_Neuro · X

RT @ShorterLab: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 24, 2023 · 5 shares · 793 followers View post →
Christian LLC
@lacks22 · X

RT @ShorterLab: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 24, 2023 · 5 shares · 420 followers View post →
Zoë Catchpole
@zoe_catchpole · X

RT @ShorterLab: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 24, 2023 · 5 shares · 238 followers View post →
Mychael Lourenco
@mvlourenco · X

RT @ShorterLab: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…

Nov 23, 2023 · 5 shares · 3,022 followers View post →
ShorterLab
@ShorterLab · X

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage: https://t.co/zzn674JhEB

Nov 23, 2023 · 26 likes · 5 shares · 12,050 followers View post →