"Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage" https://t.co/PrtMPeudZ5
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage.
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Nov 2023 – Nov 2024Where it's discussed
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X / Twitter37 posts
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YouTube2 videos
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News2 articles
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What people are saying
Several discussions emphasize the central role of aerobic glycolysis in neuronal health, with mentions of its protective effects against oxidative damage and references to the enzyme PKM2, highlighting a nuanced interest in the metabolic mechanisms. The tone is mostly analytical and supportive, using words like 'important,' 'cited,' and 'protects,' which underscores a positive perception of the study’s significance.
Most discussions reinforce the article's findings, emphasizing the idea that aerobic glycolysis in neuronal somata serves a protective role, with multiple posts citing the same statement and expressing validation.
Posts show high interest by referencing specific details like the enzyme PKM2 and the implications for neuronal metabolism, indicating curiosity about the mechanisms and significance.
Some users delve into the broader context, comparing this metabolic process to cancer biology and discussing implications, reflecting moderate but meaningful engagement.
The posts suggest that the publication has the potential to influence future research directions, but some comments are more enthusiastic than conclusively impactful, indicating moderate perceived significance.
Abstract in brief
- Neurons mainly produce ATP through mitochondrial oxidative phosphorylation (OXPHOS) at rest, but glucose metabolism in somata differs from axon terminals, with somata showing higher levels of aerobic glycolysis.
- Deleting the enzyme pyruvate kinase 2 (PKM2) in mice causes a switch from glycolysis to OXPHOS in neuronal somata, leading to oxidative damage and loss of dopaminergic neurons.
- The study challenges the traditional view of uniform energy production in neurons and emphasizes the critical role of somatic aerobic glycolysis in protecting against oxidative stress.
Top posts
Most liked on X and BlueskyAerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage: https://t.co/zzn674JhEB
神経somaの糖代謝は解糖が主である ・somaは解糖が主で酸化的燐酸化(OP)関与は少ない ・pyruvate kinase(PKM2)はsomaで高く発現し欠損時には代謝がOPに切替る➡️ROS↑/Dopaminergic Neuron↓ ・神経終末ではANLSHの為pyrivateが高くOPが主体 #glycolysis #neuron #papers https://t.co/tewDBj3psf https://t.co/8WDWnMCMak
❗️❗️Honored to be cited in the Nature Neuroscience
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage | Nature Neuroscience https://t.co/ohc34xsRev
Cancer cells≈Neural cells Aerobic glycolysis (Warburg effect) is one of the hallmarks of cancer metabolism and "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage". https://t.co/NjbCzQ0n15
All mentions
Neuronal Somata Prefer Aerobic Glycolysis for Energy Production
Neurons mainly produce ATP through mitochondrial oxidative phosphorylation at rest, but glucose metabolism in somata differs from axon terminals, with somata showing higher levels of aerobic glycolysis. This process…
Neuronal Somata Prefer Aerobic Glycolysis for Energy Production
Neurons primarily generate ATP through mitochondrial oxidative phosphorylation at rest, but neuronal somata exhibit higher levels of aerobic glycolysis than axon terminals, which helps protect against oxidative damage…
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage | Nature Neuroscience https://t.co/ohc34xsRev
RT @Brain_VTA: ❗️❗️Honored to be cited in the Nature Neuroscience
RT @Brain_VTA: ❗️❗️Honored to be cited in the Nature Neuroscience
❗️❗️Honored to be cited in the Nature Neuroscience
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage https://t.co/p1MvsYqfrg https://t.co/8VIJY8YQWa
好気的解糖は神経細胞体におけるグルコース代謝の主な手段であり、酸化的損傷から保護 https://t.co/mmaLiEdaSX #Jess でターゲット検出と #総タンパク質ノーマライゼーション、弊社グループ企業 #ACD の #RNAScope での in situ hybridization もデータに使用 #VAMP #GFAP #PKM #IBA1 #Histone
RT @thmonk_pf: 神経somaの糖代謝は解糖が主である ・somaは解糖が主で酸化的燐酸化(OP)関与は少ない ・pyruvate kinase(PKM2)はsomaで高く発現し欠損時には代謝がOPに切替る➡️ROS↑/Dopaminergic Neuron↓ ・…
RT @thmonk_pf: 神経somaの糖代謝は解糖が主である ・somaは解糖が主で酸化的燐酸化(OP)関与は少ない ・pyruvate kinase(PKM2)はsomaで高く発現し欠損時には代謝がOPに切替る➡️ROS↑/Dopaminergic Neuron↓ ・…
神経somaの糖代謝は解糖が主である ・somaは解糖が主で酸化的燐酸化(OP)関与は少ない ・pyruvate kinase(PKM2)はsomaで高く発現し欠損時には代謝がOPに切替る➡️ROS↑/Dopaminergic Neuron↓ ・神経終末ではANLSHの為pyrivateが高くOPが主体 #glycolysis #neuron #papers https://t.co/tewDBj3psf https://t.co/8WDWnMCMak
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage #science #publication #research #publications https://t.co/0OsGZbYtYG
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
Cancer cells≈Neural cells Aerobic glycolysis (Warburg effect) is one of the hallmarks of cancer metabolism and "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage". https://t.co/NjbCzQ0n15
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
Trend up+18: Wei Y, ..., Hu G (Nat Neurosci) __Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage__ https://t.co/b9QAzKwqJL
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage #science #publication #research #journal https://t.co/dN4tk18jWA
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @FrezzaLab: "Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
"Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage" https://t.co/PrtMPeudZ5
RT @ShorterLab: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @ShorterLab: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @ShorterLab: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
RT @ShorterLab: Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative dama…
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage: https://t.co/zzn674JhEB